RU93044225A - Новые производные метиленбисфосфоновой кислоты, способ их получения, композиция - Google Patents
Новые производные метиленбисфосфоновой кислоты, способ их получения, композицияInfo
- Publication number
- RU93044225A RU93044225A RU93044225/04A RU93044225A RU93044225A RU 93044225 A RU93044225 A RU 93044225A RU 93044225/04 A RU93044225/04 A RU 93044225/04A RU 93044225 A RU93044225 A RU 93044225A RU 93044225 A RU93044225 A RU 93044225A
- Authority
- RU
- Russia
- Prior art keywords
- methylenbisphosphone
- acid
- composition
- receiving
- new derivatives
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- KUFMXPZUZBPFCT-UHFFFAOYSA-L [O-]P(=O)OCOP([O-])=O Chemical class [O-]P(=O)OCOP([O-])=O KUFMXPZUZBPFCT-UHFFFAOYSA-L 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Предлагаются новые фармацевтически-активные метиленбисфосфонаты, их стереоизомеры, такие, как геометрические изомеры и оптически-активные изомеры, а также фармакологически-приемлемые соли.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI906294 | 1990-12-20 | ||
FI906294A FI89364C (fi) | 1990-12-20 | 1990-12-20 | Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
PCT/FI1991/000394 WO1992011267A1 (en) | 1990-12-20 | 1991-12-18 | Novel methylenebisphosphonic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93044225A true RU93044225A (ru) | 1996-06-20 |
RU2079504C1 RU2079504C1 (ru) | 1997-05-20 |
Family
ID=8531619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9193044225A RU2079504C1 (ru) | 1990-12-20 | 1991-12-18 | Новые производные бисфосфоновой кислоты и способ их получения |
Country Status (25)
Country | Link |
---|---|
US (1) | US5438048A (ru) |
EP (1) | EP0563096B1 (ru) |
JP (1) | JP3347324B2 (ru) |
KR (1) | KR100233986B1 (ru) |
CN (1) | CN1030609C (ru) |
AT (1) | ATE192451T1 (ru) |
AU (1) | AU665342B2 (ru) |
CA (1) | CA2098732C (ru) |
CZ (1) | CZ287453B6 (ru) |
DE (1) | DE69132163T2 (ru) |
DK (1) | DK0563096T3 (ru) |
EE (1) | EE02948B1 (ru) |
ES (1) | ES2147183T3 (ru) |
FI (1) | FI89364C (ru) |
HU (1) | HUT64546A (ru) |
IE (1) | IE914388A1 (ru) |
IL (1) | IL100338A (ru) |
NO (1) | NO301590B1 (ru) |
NZ (1) | NZ241041A (ru) |
PL (1) | PL169772B1 (ru) |
RU (1) | RU2079504C1 (ru) |
SK (1) | SK281788B6 (ru) |
TW (1) | TW203054B (ru) |
WO (1) | WO1992011267A1 (ru) |
ZA (1) | ZA9110009B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5157027A (en) * | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
US5591730A (en) * | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
FI104901B (fi) | 1997-10-20 | 2000-04-28 | Leiras Oy | Uudet metyleenibisfosfonihappojohdannaiset |
EP1200451A1 (en) | 1999-08-03 | 2002-05-02 | Amersham plc | Radiolabelled bisphosphonates and method |
PL196485B1 (pl) * | 2000-05-11 | 2008-01-31 | Inst Farmaceutyczny | Stała doustna kompozycja farmaceutyczna zawierająca aminową pochodną kwasu bisfosfonowego i sposób jej wytwarzania |
ATE353656T1 (de) * | 2000-10-27 | 2007-03-15 | Schering Ag | Bisphosphonsäurederivate zur stärkung von kortikalknochen |
ES2243457T3 (es) * | 2001-01-23 | 2005-12-01 | Gador S.A. | Composicion que comprende bifosfonatos para la prevencion y/o tratamiento de trastornos metabolicos de huesos, procedimiento de preparacion de dicha composicion y usos de la misma. |
SK13512003A3 (sk) * | 2001-05-02 | 2004-08-03 | Novartis Ag | Použitie N-bisfosfonátu na prípravu liečiva na liečenie kostných metastáz spojených s karcinómom prostaty |
WO2003008425A1 (fr) * | 2001-07-16 | 2003-01-30 | Universite Paris 13 | Nouveaux derives de bisphosphonates, leurs preparations et utilisations |
US20030036537A1 (en) * | 2001-07-16 | 2003-02-20 | Marc Lecouvey | Bisphosphonate derivatives, their preparations and uses |
FR2837490B1 (fr) * | 2002-03-21 | 2009-04-17 | Univ Paris 13 | Nouveaux derives de bisphosphonates, leurs preparations et utilisations |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
US20080286359A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US20080287400A1 (en) * | 2004-05-24 | 2008-11-20 | Richard John Dansereau | Low Dosage Forms Of Risedronate Or Its Salts |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
WO2010035664A1 (ja) * | 2008-09-24 | 2010-04-01 | 田辺三菱製薬株式会社 | ビスホスホン酸誘導体の製法 |
CN107011380A (zh) * | 2016-01-28 | 2017-08-04 | 臧伟 | 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用 |
TWI730039B (zh) | 2016-01-29 | 2021-06-11 | 日商富士藥品股份有限公司 | 新穎雙膦酸化合物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3303139A (en) * | 1962-01-27 | 1967-02-07 | Henkel & Cie Gmbh | Aminophosphonic acids and their derivatives as complex formers for metal ions |
DE1202441B (de) * | 1963-03-02 | 1965-10-07 | Therachemie Chem Therapeut | Mittel zur Verminderung der Schaedigung von Haaren beim Bleichen und Faerben |
DE1617118C3 (de) * | 1966-08-26 | 1975-04-03 | Henkel & Cie Gmbh, 4000 Duesseldorf | Verfahren zur Reinigung von etikettierten starren Gegenständen |
US3957858A (en) * | 1970-04-13 | 1976-05-18 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
US3962318A (en) * | 1970-04-13 | 1976-06-08 | Monsanto Company | Substituted ethane diphosphonic acids and salts and esters thereof |
US3683080A (en) * | 1970-08-28 | 1972-08-08 | Procter & Gamble | Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue |
CH555894A (fr) * | 1972-08-10 | 1974-11-15 | Oxy Metal Industries Corp | Utilisation de derives organophosphores dans les bains sulfitiques pour l'electrodeposition de l'or et des alliages d'or. |
US4113861A (en) * | 1977-05-02 | 1978-09-12 | The Procter & Gamble Company | Phosphonate pharmaceutical composition |
GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
US4634691A (en) * | 1980-10-07 | 1987-01-06 | The Procter & Gamble Company | Method for inhibiting tumor metastasis |
DE3225469A1 (de) * | 1982-07-05 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
US4818774A (en) * | 1986-03-10 | 1989-04-04 | Occidental Chemical Corporation | Organophosphorus compounds |
DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
-
1990
- 1990-12-20 FI FI906294A patent/FI89364C/fi not_active IP Right Cessation
-
1991
- 1991-12-11 IL IL100338A patent/IL100338A/en not_active IP Right Cessation
- 1991-12-17 IE IE438891A patent/IE914388A1/en not_active Application Discontinuation
- 1991-12-18 CA CA002098732A patent/CA2098732C/en not_active Expired - Fee Related
- 1991-12-18 WO PCT/FI1991/000394 patent/WO1992011267A1/en active IP Right Grant
- 1991-12-18 NZ NZ241041A patent/NZ241041A/en unknown
- 1991-12-18 JP JP50168492A patent/JP3347324B2/ja not_active Expired - Fee Related
- 1991-12-18 US US08/078,157 patent/US5438048A/en not_active Expired - Lifetime
- 1991-12-18 AT AT92900615T patent/ATE192451T1/de not_active IP Right Cessation
- 1991-12-18 RU RU9193044225A patent/RU2079504C1/ru not_active IP Right Cessation
- 1991-12-18 EP EP92900615A patent/EP0563096B1/en not_active Expired - Lifetime
- 1991-12-18 CZ CZ19931198A patent/CZ287453B6/cs not_active IP Right Cessation
- 1991-12-18 DE DE69132163T patent/DE69132163T2/de not_active Expired - Fee Related
- 1991-12-18 AU AU90749/91A patent/AU665342B2/en not_active Ceased
- 1991-12-18 DK DK92900615T patent/DK0563096T3/da active
- 1991-12-18 HU HU9301779A patent/HUT64546A/hu unknown
- 1991-12-18 PL PL91299979A patent/PL169772B1/pl not_active IP Right Cessation
- 1991-12-18 SK SK629-93A patent/SK281788B6/sk unknown
- 1991-12-18 KR KR1019930701877A patent/KR100233986B1/ko not_active IP Right Cessation
- 1991-12-18 ES ES92900615T patent/ES2147183T3/es not_active Expired - Lifetime
- 1991-12-19 ZA ZA9110009A patent/ZA9110009B/xx unknown
- 1991-12-20 CN CN91111086A patent/CN1030609C/zh not_active Expired - Fee Related
- 1991-12-31 TW TW080110322A patent/TW203054B/zh active
-
1993
- 1993-06-18 NO NO932254A patent/NO301590B1/no not_active IP Right Cessation
-
1994
- 1994-11-14 EE EE9400229A patent/EE02948B1/xx not_active IP Right Cessation
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