RU2745601C2 - Составы, содержащие антитела - Google Patents

Составы, содержащие антитела Download PDF

Info

Publication number
RU2745601C2
RU2745601C2 RU2015132431A RU2015132431A RU2745601C2 RU 2745601 C2 RU2745601 C2 RU 2745601C2 RU 2015132431 A RU2015132431 A RU 2015132431A RU 2015132431 A RU2015132431 A RU 2015132431A RU 2745601 C2 RU2745601 C2 RU 2745601C2
Authority
RU
Russia
Prior art keywords
composition
formulation
present
acz885
antibodies
Prior art date
Application number
RU2015132431A
Other languages
English (en)
Russian (ru)
Other versions
RU2015132431A (ru
RU2015132431A3 (show.php
Inventor
Йоахим МОММ
Ханс-Йоахим ВАЛЛЬНИ
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40637230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2745601(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2015132431A publication Critical patent/RU2015132431A/ru
Publication of RU2015132431A3 publication Critical patent/RU2015132431A3/ru
Application granted granted Critical
Publication of RU2745601C2 publication Critical patent/RU2745601C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/245IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
RU2015132431A 2008-12-10 2009-12-09 Составы, содержащие антитела RU2745601C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08170884A EP2196476A1 (en) 2008-12-10 2008-12-10 Antibody formulation
EP08170884.4 2008-12-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2011127913/15A Division RU2563179C2 (ru) 2008-12-10 2009-12-09 Составы, содержащие антитела

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2021107534A Division RU2021107534A (ru) 2008-12-10 2021-03-23 Составы, содержащие антитела

Publications (3)

Publication Number Publication Date
RU2015132431A RU2015132431A (ru) 2018-12-24
RU2015132431A3 RU2015132431A3 (show.php) 2018-12-24
RU2745601C2 true RU2745601C2 (ru) 2021-03-29

Family

ID=40637230

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2015132431A RU2745601C2 (ru) 2008-12-10 2009-12-09 Составы, содержащие антитела
RU2011127913/15A RU2563179C2 (ru) 2008-12-10 2009-12-09 Составы, содержащие антитела

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2011127913/15A RU2563179C2 (ru) 2008-12-10 2009-12-09 Составы, содержащие антитела

Country Status (31)

Country Link
US (3) US20110236398A1 (show.php)
EP (4) EP2196476A1 (show.php)
JP (6) JP6143416B2 (show.php)
KR (2) KR20170044211A (show.php)
CN (3) CN104399076B (show.php)
AU (1) AU2009324371B2 (show.php)
BR (1) BRPI0922730A2 (show.php)
CA (1) CA2745938C (show.php)
CL (1) CL2011001406A1 (show.php)
CO (1) CO6361952A2 (show.php)
CY (2) CY1117735T1 (show.php)
DK (2) DK3072906T3 (show.php)
EC (1) ECSP11011192A (show.php)
ES (2) ES2900624T3 (show.php)
HR (2) HRP20160754T1 (show.php)
HU (2) HUE028408T2 (show.php)
IL (3) IL264316B2 (show.php)
LT (1) LT3072906T (show.php)
MA (1) MA33023B1 (show.php)
MX (1) MX2011006242A (show.php)
MY (2) MY157772A (show.php)
NZ (1) NZ592918A (show.php)
PE (1) PE20120342A1 (show.php)
PL (2) PL3072906T3 (show.php)
PT (2) PT2376533T (show.php)
RU (2) RU2745601C2 (show.php)
SI (2) SI2376533T1 (show.php)
SM (1) SMT201600222B (show.php)
TN (1) TN2011000229A1 (show.php)
WO (1) WO2010066762A1 (show.php)
ZA (1) ZA201103362B (show.php)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
US8221753B2 (en) 2009-09-30 2012-07-17 Tracon Pharmaceuticals, Inc. Endoglin antibodies
SI3409289T1 (sl) 2010-02-26 2020-12-31 Novo Nordisk A/S Stabilni sestavki, ki vsebujejo protitelo
SMT201700454T1 (it) 2010-03-01 2018-01-11 Bayer Healthcare Llc Anticorpi monoclonali ottimizzati contro inibitore della via di fattore tissutale (tfpi)
HRP20241526T1 (hr) 2010-05-28 2025-01-03 Novo Nordisk A/S Stabilni višedozni pripravci, koji sadrže protutijelo i konzervans
AR082319A1 (es) * 2010-07-22 2012-11-28 Biomarin Pharm Inc Produccion de una n-acetilgalactosamina-6-sulfatasa humana activa altamente fosforilada y sus usos
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EA027353B1 (ru) 2010-09-17 2017-07-31 Баксалта Инкорпорейтид СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО
SMT202200321T1 (it) 2010-10-01 2022-09-14 Modernatx Inc Acidi ribonucleici contenenti n1-metil-pseudouracili e loro usi
TWI700093B (zh) 2011-03-16 2020-08-01 法商賽諾菲公司 雙重v區類抗體蛋白質之用途
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP6113737B2 (ja) 2011-10-03 2017-04-12 モデルナティエックス インコーポレイテッドModernaTX,Inc. 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法
FI123630B (fi) 2011-10-24 2013-08-30 Teknologian Tutkimuskeskus Vtt Menetelmä NFC-kalvojen valmistamiseksi alustoille
US20140348848A1 (en) 2011-12-02 2014-11-27 Dhananjay Kaul Anti-il-1beta (interleukin-1beta) antibody-based prophylactic therapy to prevent complications leading to vaso-occlusion in sickle cell disease
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
CA2864539C (en) * 2012-02-16 2022-06-07 Santarus, Inc. Antibody formulations
CN104302171B (zh) * 2012-03-16 2017-05-03 瑞泽恩制药公司 表达ph敏感性免疫球蛋白序列的非人动物
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
JP2015513913A (ja) 2012-04-02 2015-05-18 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 修飾ポリヌクレオチド
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US8613919B1 (en) 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations
US8883979B2 (en) * 2012-08-31 2014-11-11 Bayer Healthcare Llc Anti-prolactin receptor antibody formulations
UA115789C2 (uk) 2012-09-05 2017-12-26 Трейкон Фармасутікалз, Інк. Композиція антитіла до cd105 та її застосування
CN104995210A (zh) 2012-09-20 2015-10-21 莫弗系统股份公司 类风湿关节炎的治疗
WO2014078502A1 (en) * 2012-11-16 2014-05-22 Novartis Ag Use of il-1 beta binding antibodies for treating peripheral arterial disease
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
AR095496A1 (es) 2013-03-15 2015-10-21 Bayer Healthcare Llc Formulaciones de anticuerpos anti-receptor de prolactina
TWI679019B (zh) 2013-04-29 2019-12-11 法商賽諾菲公司 抗il-4/抗il-13之雙特異性抗體調配物
NL1040254C2 (en) * 2013-05-17 2014-11-24 Ablynx Nv Stable formulations of immunoglobulin single variable domains and uses thereof.
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
MX2016004249A (es) 2013-10-03 2016-11-08 Moderna Therapeutics Inc Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad.
US10206878B2 (en) * 2014-05-28 2019-02-19 Nono Inc. Lyophilized formulation of TAT-NR2B9C with acetylation scavenger
CN106604744A (zh) * 2014-09-03 2017-04-26 免疫医疗有限公司 稳定的抗IL‑4R‑α抗体配制品
US9926375B2 (en) 2014-11-12 2018-03-27 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
US10155820B2 (en) 2014-11-12 2018-12-18 Tracon Pharmaceuticals, Inc. Anti-endoglin antibodies and uses thereof
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
AR104847A1 (es) 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
EA201891339A1 (ru) 2015-12-07 2019-01-31 Мерк Патент Гмбх Водный фармацевтический препарат, который содержит антитело к pd-l1 авелумаб
HRP20210945T1 (hr) * 2016-06-27 2021-09-17 Morphosys Ag Formulacije protutijela anti-cd19
KR20190032436A (ko) * 2016-07-21 2019-03-27 노파르티스 아게 폐 유육종증의 증상을 치료하거나 완화하기 위한 il-1beta 결합 항체 카나키누맙의 용도
EP3518891A1 (en) * 2016-09-27 2019-08-07 Fresenius Kabi Deutschland GmbH Liquid pharmaceutical composition
US10517966B2 (en) 2016-11-18 2019-12-31 Astellas Pharma Inc. Anti-human MUC1 antibody Fab fragment
US20190048072A1 (en) * 2017-06-22 2019-02-14 Novartis Ag USE OF IL-1beta BINDING ANTIBODIES
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類CEACAM5抗體Fab片段
AU2018333106A1 (en) * 2017-09-13 2020-04-02 Novartis Ag Use of il-1b binding antibodies for the treatment of alcoholic hepatitis
CN112004827A (zh) * 2018-03-23 2020-11-27 艾伯维德国有限责任两合公司 稳定的水性抗tau抗体调配物
BR112020023420A8 (pt) 2018-05-17 2022-07-05 Astellas Pharma Inc Complexo tendo fragmento fab de anticorpo anti-muc1 humano, peptídeo ligador e/ou ligante
SG11202103670XA (en) 2018-10-10 2021-05-28 Astellas Pharma Inc Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
UA128098C2 (uk) 2019-02-18 2024-04-03 Елі Ліллі Енд Компані Водна фармацевтична композиція антитіла проти il-17a
CN113967195A (zh) * 2020-07-22 2022-01-25 三生国健药业(上海)股份有限公司 抗her2/pd1双特异性抗体冻干制剂及其制备方法
WO2022135395A1 (zh) * 2020-12-22 2022-06-30 百奥泰生物制药股份有限公司 稳定的抗体制剂及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016436A2 (en) * 2000-08-22 2002-02-28 Novartis Ag ANTIBODIES TO HUMAN IL-1$g(b)
WO2003039485A2 (en) * 2001-11-08 2003-05-15 Protein Design Labs Stable liquid pharmaceutical formulation of igg antibodies
US20060210557A1 (en) * 2005-01-28 2006-09-21 Donna Luisi Stabilized liquid polypeptide formulations
US20070053900A1 (en) * 2003-04-04 2007-03-08 Genentech, Inc. High concentration antibody and protein formulations

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001997A1 (en) 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
PE64396A1 (es) 1995-01-23 1997-01-28 Hoffmann La Roche Proteina accesoria del receptor de la interleucina 1
EP2275119B1 (en) 1995-07-27 2013-09-25 Genentech, Inc. Stable isotonic lyophilized protein formulation
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
GB0001662D0 (en) 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
TWI260321B (en) 1999-09-22 2006-08-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
WO2002002773A2 (en) * 2000-06-29 2002-01-10 Abbott Laboratories Dual specificity antibodies and methods of making and using
US20040038878A1 (en) * 2000-08-04 2004-02-26 Masahiko Tanikawa Injectable protein formulations
US7132100B2 (en) * 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
GT200600031A (es) * 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
AR062247A1 (es) * 2005-03-08 2008-10-29 Pharmacia & Upjohn Co Llc Composiciones de anticuerpos anti-ctla-4
WO2006125207A2 (en) * 2005-05-19 2006-11-23 Amgen Inc. Compositions and methods for increasing the stability of antibodies
KR20170038131A (ko) 2005-10-26 2017-04-05 노파르티스 아게 Il-1베타 화합물의 신규 용도
CN201044845Y (zh) * 2006-10-28 2008-04-09 李开元 自动注射器
RU2009126420A (ru) * 2006-12-11 2011-01-20 Ф.Хоффманн-Ля Рош Аг (Ch) Парентеральная лекарственная форма антитела к абета
EP2136839A4 (en) * 2007-03-22 2010-04-07 Imclone Llc STABLE ANTIBODY FORMULATIONS
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
WO2010100179A2 (en) 2009-03-05 2010-09-10 Novartis Ag Self-forming gel system for sustained drug delivery
WO2012028683A1 (en) 2010-09-02 2012-03-08 Novartis Ag Antibody gel system for sustained drug delivery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002016436A2 (en) * 2000-08-22 2002-02-28 Novartis Ag ANTIBODIES TO HUMAN IL-1$g(b)
WO2003039485A2 (en) * 2001-11-08 2003-05-15 Protein Design Labs Stable liquid pharmaceutical formulation of igg antibodies
US20070053900A1 (en) * 2003-04-04 2007-03-08 Genentech, Inc. High concentration antibody and protein formulations
US20060210557A1 (en) * 2005-01-28 2006-09-21 Donna Luisi Stabilized liquid polypeptide formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALTEN RIEKE ET AL., The human anti-IL-1? monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol.10, no. 3, 5 June 2008, p.R67. *

Also Published As

Publication number Publication date
KR101762966B1 (ko) 2017-07-31
JP2012511540A (ja) 2012-05-24
JP7286595B2 (ja) 2023-06-05
MA33023B1 (fr) 2012-02-01
CN114225022A (zh) 2022-03-25
LT3072906T (lt) 2021-12-27
CY1124844T1 (el) 2022-11-25
MY157772A (en) 2016-07-29
NZ592918A (en) 2012-12-21
CN104399076B (zh) 2021-09-14
MX2011006242A (es) 2011-06-24
WO2010066762A1 (en) 2010-06-17
CY1117735T1 (el) 2017-05-17
TN2011000229A1 (en) 2012-12-17
DK3072906T3 (da) 2021-12-13
US20110236398A1 (en) 2011-09-29
DK2376533T3 (en) 2016-06-27
PE20120342A1 (es) 2012-04-24
IL264316B2 (en) 2024-01-01
IL212922A0 (en) 2011-07-31
ES2900624T3 (es) 2022-03-17
SMT201600222B (it) 2016-08-31
EP3792282A1 (en) 2021-03-17
CO6361952A2 (es) 2012-01-20
EP3072906A1 (en) 2016-09-28
IL264316B1 (en) 2023-09-01
EP3072906B1 (en) 2021-09-08
IL212922B (en) 2019-02-28
AU2009324371B2 (en) 2013-10-10
US20200384108A1 (en) 2020-12-10
BRPI0922730A2 (en) 2018-11-06
HRP20211899T1 (hr) 2022-03-04
JP2015231997A (ja) 2015-12-24
RU2563179C2 (ru) 2015-09-20
ECSP11011192A (es) 2011-08-31
PT2376533T (pt) 2016-07-13
JP2018168158A (ja) 2018-11-01
SI2376533T1 (sl) 2016-07-29
PT3072906T (pt) 2021-12-14
IL264316A (en) 2019-02-28
MY166050A (en) 2018-05-22
CN104399076A (zh) 2015-03-11
EP2376533A1 (en) 2011-10-19
HK1159130A1 (zh) 2012-07-27
PL2376533T3 (pl) 2016-09-30
RU2011127913A (ru) 2013-01-20
PL3072906T3 (pl) 2022-01-24
HRP20160754T1 (hr) 2016-08-12
KR20170044211A (ko) 2017-04-24
HUE028408T2 (en) 2016-12-28
ES2579835T3 (es) 2016-08-17
CN102245639A (zh) 2011-11-16
RU2015132431A (ru) 2018-12-24
CA2745938C (en) 2018-04-24
CN102245639B (zh) 2014-12-24
US8623367B2 (en) 2014-01-07
US20120315285A1 (en) 2012-12-13
CA2745938A1 (en) 2010-06-17
JP6143416B2 (ja) 2017-06-07
JP2026021446A (ja) 2026-02-10
AU2009324371A1 (en) 2011-06-23
ZA201103362B (en) 2012-01-25
IL276622A (en) 2020-09-30
HUE056626T2 (hu) 2022-02-28
CL2011001406A1 (es) 2012-03-30
SI3072906T1 (sl) 2022-01-31
EP2196476A1 (en) 2010-06-16
EP2376533B1 (en) 2016-03-30
KR20120009421A (ko) 2012-01-31
JP2020203889A (ja) 2020-12-24
RU2015132431A3 (show.php) 2018-12-24
JP2023109938A (ja) 2023-08-08

Similar Documents

Publication Publication Date Title
RU2745601C2 (ru) Составы, содержащие антитела
US20230047111A1 (en) Pharmaceutical formulations of tnf-alpha antibodies
US7740842B2 (en) Stable liquid formulations of antibodies
US20230115267A1 (en) Pharmaceutical liquid composition having increased stability
US20210347877A1 (en) Pharmaceutical composition comprising antibody, device comprising same, and use thereof
HK40041917A (en) Antibody formulation
HK1159130B (en) Antibody formulation

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20191209

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20201203