RU2735790C2 - Композиции и способы применения холинового эфира липоевой кислоты - Google Patents

Композиции и способы применения холинового эфира липоевой кислоты Download PDF

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RU2735790C2
RU2735790C2 RU2016137784A RU2016137784A RU2735790C2 RU 2735790 C2 RU2735790 C2 RU 2735790C2 RU 2016137784 A RU2016137784 A RU 2016137784A RU 2016137784 A RU2016137784 A RU 2016137784A RU 2735790 C2 RU2735790 C2 RU 2735790C2
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composition
lipoic acid
choline ester
pharmaceutical composition
aqueous
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RU2016137784A
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Russian (ru)
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RU2016137784A (ru
RU2016137784A3 (cg-RX-API-DMAC7.html
Inventor
Уилльям Х. ГАРНЕР
Маргарет Х. ГАРНЕР
Уилльям Р. БЕРНС
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Энкор Вижн, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2016137784A 2014-03-03 2015-03-03 Композиции и способы применения холинового эфира липоевой кислоты RU2735790C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461947378P 2014-03-03 2014-03-03
US61/947,378 2014-03-03
PCT/US2015/018505 WO2015134510A1 (en) 2014-03-03 2015-03-03 Lipoic acid choline ester compositions and methods of use

Publications (3)

Publication Number Publication Date
RU2016137784A RU2016137784A (ru) 2018-04-03
RU2016137784A3 RU2016137784A3 (cg-RX-API-DMAC7.html) 2018-10-18
RU2735790C2 true RU2735790C2 (ru) 2020-11-09

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US (2) US20160354340A1 (cg-RX-API-DMAC7.html)
EP (1) EP3113613A4 (cg-RX-API-DMAC7.html)
JP (1) JP6526066B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160145558A (cg-RX-API-DMAC7.html)
CN (2) CN112641720A (cg-RX-API-DMAC7.html)
AU (2) AU2015227307A1 (cg-RX-API-DMAC7.html)
BR (1) BR112016020181A8 (cg-RX-API-DMAC7.html)
CA (1) CA2941518A1 (cg-RX-API-DMAC7.html)
IL (1) IL247529B (cg-RX-API-DMAC7.html)
MX (1) MX384877B (cg-RX-API-DMAC7.html)
RU (1) RU2735790C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015134510A1 (cg-RX-API-DMAC7.html)

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US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
CN106967044B (zh) * 2017-05-12 2019-02-22 苏州富士莱医药股份有限公司 制备r-硫辛酸胆碱酯卤化物的方法
CN107089967A (zh) * 2017-05-12 2017-08-25 苏州富士莱医药股份有限公司 一种r‑硫辛酸胆碱酯卤化物的制备方法
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
CA3136938A1 (en) * 2019-04-17 2020-10-22 Santen Pharmaceutical Co., Ltd. Lipoic acid prodrug
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CN113387923A (zh) 2020-03-13 2021-09-14 诺华股份有限公司 硫辛酸胆碱酯盐的药物组合物及使用其的治疗方法
CN113717770B (zh) * 2020-05-25 2022-06-03 中国石油天然气股份有限公司 一种金属加工油
GB202305212D0 (en) 2023-04-06 2023-05-24 Elixa Mediscience Ltd Compounds

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CN106455563A (zh) 2017-02-22
CA2941518A1 (en) 2015-09-11
EP3113613A4 (en) 2019-03-13
CN112641720A (zh) 2021-04-13
IL247529B (en) 2020-10-29
AU2019240641A1 (en) 2019-10-24
WO2015134510A1 (en) 2015-09-11
AU2015227307A1 (en) 2016-10-13
EP3113613A1 (en) 2017-01-11
US11426381B2 (en) 2022-08-30
US20160354340A1 (en) 2016-12-08
KR20160145558A (ko) 2016-12-20
BR112016020181A2 (pt) 2017-08-15
IL247529A0 (en) 2016-11-30
RU2016137784A (ru) 2018-04-03
JP2017511816A (ja) 2017-04-27
AU2019240641B2 (en) 2020-10-29
MX2016011290A (es) 2017-04-27
BR112016020181A8 (pt) 2021-06-29
RU2016137784A3 (cg-RX-API-DMAC7.html) 2018-10-18
JP6526066B2 (ja) 2019-06-05
US20200281891A1 (en) 2020-09-10
MX384877B (es) 2025-03-14

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