MX384877B - Composiciones de éster de colina de ácido lipoico y métodos de uso. - Google Patents

Composiciones de éster de colina de ácido lipoico y métodos de uso.

Info

Publication number
MX384877B
MX384877B MX2016011290A MX2016011290A MX384877B MX 384877 B MX384877 B MX 384877B MX 2016011290 A MX2016011290 A MX 2016011290A MX 2016011290 A MX2016011290 A MX 2016011290A MX 384877 B MX384877 B MX 384877B
Authority
MX
Mexico
Prior art keywords
lipoic acid
choline ester
acid choline
methods
aqueous
Prior art date
Application number
MX2016011290A
Other languages
English (en)
Other versions
MX2016011290A (es
Inventor
Margaret H Garner
William H Garner
William R Burns
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2016011290A publication Critical patent/MX2016011290A/es
Publication of MX384877B publication Critical patent/MX384877B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con composiciones farmacéuticas que comprenden una cantidad terapéuticamente efectiva de éster de colina del ácido lipoico o derivados del mismo y un excipiente no acuoso mezclado en una solución acuosa. También se proporcionan en la presente composiciones no acuosas preparadas mezclando la cantidad terapéuticamente efectiva de éster de colina del ácido lipoico y el excipiente no acuoso. Las composiciones no acuosas además pueden mezclarse con la solución acuosa.
MX2016011290A 2014-03-03 2015-03-03 Composiciones de éster de colina de ácido lipoico y métodos de uso. MX384877B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461947378P 2014-03-03 2014-03-03
PCT/US2015/018505 WO2015134510A1 (en) 2014-03-03 2015-03-03 Lipoic acid choline ester compositions and methods of use

Publications (2)

Publication Number Publication Date
MX2016011290A MX2016011290A (es) 2017-04-27
MX384877B true MX384877B (es) 2025-03-14

Family

ID=54055796

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011290A MX384877B (es) 2014-03-03 2015-03-03 Composiciones de éster de colina de ácido lipoico y métodos de uso.

Country Status (12)

Country Link
US (2) US20160354340A1 (es)
EP (1) EP3113613A4 (es)
JP (1) JP6526066B2 (es)
KR (1) KR20160145558A (es)
CN (2) CN112641720A (es)
AU (2) AU2015227307A1 (es)
BR (1) BR112016020181A8 (es)
CA (1) CA2941518A1 (es)
IL (1) IL247529B (es)
MX (1) MX384877B (es)
RU (1) RU2735790C2 (es)
WO (1) WO2015134510A1 (es)

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CN106967044B (zh) * 2017-05-12 2019-02-22 苏州富士莱医药股份有限公司 制备r-硫辛酸胆碱酯卤化物的方法
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
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Also Published As

Publication number Publication date
CA2941518A1 (en) 2015-09-11
JP2017511816A (ja) 2017-04-27
EP3113613A1 (en) 2017-01-11
BR112016020181A2 (pt) 2017-08-15
AU2019240641B2 (en) 2020-10-29
AU2019240641A1 (en) 2019-10-24
KR20160145558A (ko) 2016-12-20
US20160354340A1 (en) 2016-12-08
RU2016137784A3 (es) 2018-10-18
IL247529B (en) 2020-10-29
EP3113613A4 (en) 2019-03-13
AU2015227307A1 (en) 2016-10-13
BR112016020181A8 (pt) 2021-06-29
CN106455563A (zh) 2017-02-22
MX2016011290A (es) 2017-04-27
CN112641720A (zh) 2021-04-13
RU2735790C2 (ru) 2020-11-09
IL247529A0 (en) 2016-11-30
US20200281891A1 (en) 2020-09-10
US11426381B2 (en) 2022-08-30
JP6526066B2 (ja) 2019-06-05
WO2015134510A1 (en) 2015-09-11
RU2016137784A (ru) 2018-04-03

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