RU2717454C2 - Антисмысловые олигонуклеотиды в качестве ингибиторов сигнального пути tgf-r - Google Patents

Антисмысловые олигонуклеотиды в качестве ингибиторов сигнального пути tgf-r Download PDF

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RU2717454C2
RU2717454C2 RU2017120481A RU2017120481A RU2717454C2 RU 2717454 C2 RU2717454 C2 RU 2717454C2 RU 2017120481 A RU2017120481 A RU 2017120481A RU 2017120481 A RU2017120481 A RU 2017120481A RU 2717454 C2 RU2717454 C2 RU 2717454C2
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sgb
stb
sab
seq
lna
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RU2017120481A3 (enExample
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Маркус Хоссбах
Моника КРАМПЕРТ
Ханс-Лотар АРТ
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Ньюровижн Фарма Гмбх
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RU2017120481A 2014-11-16 2015-11-16 Антисмысловые олигонуклеотиды в качестве ингибиторов сигнального пути tgf-r RU2717454C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
EP14193368.9 2014-11-16
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Publications (3)

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RU2017120481A RU2017120481A (ru) 2018-12-18
RU2017120481A3 RU2017120481A3 (enExample) 2019-05-27
RU2717454C2 true RU2717454C2 (ru) 2020-03-23

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US (4) US11213541B2 (enExample)
EP (3) EP3020813A1 (enExample)
JP (2) JP6832285B2 (enExample)
KR (2) KR102310899B1 (enExample)
CN (2) CN107002082B (enExample)
AU (3) AU2015345006B2 (enExample)
BR (1) BR112017006201B1 (enExample)
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PT (1) PT3218488T (enExample)
RU (1) RU2717454C2 (enExample)
SG (1) SG11201703127SA (enExample)
TR (1) TR201900844T4 (enExample)
WO (1) WO2016075339A1 (enExample)

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EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
US20230061455A1 (en) * 2017-11-01 2023-03-02 Editas Medicine, Inc. Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy
CN111757936B (zh) * 2017-12-22 2025-07-04 罗氏创新中心哥本哈根有限公司 包含二硫代磷酸酯核苷间连接的寡核苷酸
US20200332289A1 (en) * 2017-12-22 2020-10-22 Roche Innovation Center Copenhagen A/S Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
US11597926B2 (en) * 2017-12-22 2023-03-07 Roche Innovation Center Copenhagen A/S Thiophosphoramidites
MY200352A (en) 2018-05-22 2023-12-21 Ionis Pharmaceuticals Inc Modulators of apol1 expression
CN112513060B (zh) * 2018-07-31 2024-08-06 罗氏创新中心哥本哈根有限公司 包含三硫代磷酸酯核苷间键的寡核苷酸
US20210221837A1 (en) * 2018-07-31 2021-07-22 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
CN113490742A (zh) * 2019-02-20 2021-10-08 罗氏创新中心哥本哈根有限公司 膦酰基乙酸酯缺口聚物寡核苷酸
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CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
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