MX2017006369A - Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r. - Google Patents
Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r.Info
- Publication number
- MX2017006369A MX2017006369A MX2017006369A MX2017006369A MX2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A MX 2017006369 A MX2017006369 A MX 2017006369A
- Authority
- MX
- Mexico
- Prior art keywords
- antisense
- oligonucleotides
- tgf
- inhibitors
- signaling
- Prior art date
Links
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 3
- 239000000074 antisense oligonucleotide Substances 0.000 title abstract 3
- 238000012230 antisense oligonucleotides Methods 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000011664 signaling Effects 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract
La presente invención se refiere a oligonucleótidos antisentido que tienen una longitud de al menos 10 nucleótidos, en donde al menos dos de los nucleótidos son LNAs, su uso como inhibidores de la señalización de TGF-R, composiciones farmacéuticas que contienen tales oligonucleótidos antisentido y el uso para profilaxis y tratamiento de enfermedades neurológicas, neurodegenerativas, fibróticas e hiperproliferativas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14193368.9A EP3020813A1 (en) | 2014-11-16 | 2014-11-16 | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
| PCT/EP2015/076730 WO2016075339A1 (en) | 2014-11-16 | 2015-11-16 | Antisense-oligonucleotides as inhibitors of tgf-r signaling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2017006369A true MX2017006369A (es) | 2018-02-16 |
Family
ID=51900289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017006369A MX2017006369A (es) | 2014-11-16 | 2015-11-16 | Oligonucleotidos antisentido como inhibidores de la señalizacion del tgf-r. |
| MX2020011476A MX2020011476A (es) | 2014-11-16 | 2017-05-16 | Oligonucleótidos antisentido como inhibidores de la señalización del tgf-r. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020011476A MX2020011476A (es) | 2014-11-16 | 2017-05-16 | Oligonucleótidos antisentido como inhibidores de la señalización del tgf-r. |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10363266B2 (es) |
| EP (3) | EP3020813A1 (es) |
| JP (2) | JP6832285B2 (es) |
| KR (2) | KR102417601B1 (es) |
| CN (2) | CN113151261A (es) |
| AU (3) | AU2015345006B2 (es) |
| BR (1) | BR112017006201B1 (es) |
| CA (2) | CA3201845C (es) |
| CL (2) | CL2017001233A1 (es) |
| CY (1) | CY1121110T1 (es) |
| DK (1) | DK3218488T3 (es) |
| ES (1) | ES2705066T3 (es) |
| HU (1) | HUE041793T2 (es) |
| IL (2) | IL251565B (es) |
| MX (2) | MX2017006369A (es) |
| MY (1) | MY181404A (es) |
| PL (1) | PL3218488T3 (es) |
| PT (1) | PT3218488T (es) |
| RU (1) | RU2717454C2 (es) |
| SG (1) | SG11201703127SA (es) |
| TR (1) | TR201900844T4 (es) |
| WO (1) | WO2016075339A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3020813A1 (en) * | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
| WO2019010226A1 (en) * | 2017-07-03 | 2019-01-10 | The Regents Of The University Of California | CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE |
| MX2020006430A (es) * | 2017-12-22 | 2020-09-17 | Roche Innovation Ct Copenhagen As | Oligonucleotidos que comprenden un enlace internucleosidico de fosforoditioato. |
| WO2019122277A1 (en) * | 2017-12-22 | 2019-06-27 | Roche Innovation Center Copenhagen A/S | Novel thiophosphoramidites |
| TW201934750A (zh) * | 2017-12-22 | 2019-09-01 | 丹麥商羅氏創新中心哥本哈根有限公司 | 包含二硫代磷酸酯核苷間連結之間隙子(gapmer)寡核苷酸 |
| JP2023548597A (ja) * | 2020-10-29 | 2023-11-17 | エー． ガルシア－ブランコ，マリアーノ | がんを処置するための可溶性インターロイキン－７受容体（ｓＩＬ７Ｒ）変調療法 |
| CN114588160A (zh) * | 2020-12-07 | 2022-06-07 | 四川大学华西医院 | 具有抗肺纤维化作用的次黄碱衍生物 |
| CN113992687B (zh) * | 2021-12-28 | 2022-04-08 | 浙江宇视科技有限公司 | 智能业务集群调度方法、装置、电子设备及存储介质 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0885016B1 (en) | 1996-02-19 | 2003-04-16 | Amersham Health AS | Thermally stabilized contrast agent |
| US20030064944A1 (en) | 2001-06-21 | 2003-04-03 | Isis Pharmaceuticals Inc. | Antisense modulation of transforming growth factor beta receptor II expression |
| EP2141233B1 (en) | 2002-11-18 | 2016-10-19 | Roche Innovation Center Copenhagen A/S | Antisense design |
| WO2005019422A2 (en) * | 2003-08-13 | 2005-03-03 | The Board Of Trustees Of The University Of Illinois | Silencing of tgf-beta receptor type ii expression by sirna |
| BRPI0507528A (pt) * | 2004-02-09 | 2007-07-03 | Regenion Gmbh | oligonucleotìdeos, preparação farmacêutica, uso de pelo menos um oligonucleotìdeo e método para identificar um composto |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| KR20130042043A (ko) | 2006-01-27 | 2013-04-25 | 아이시스 파마수티컬즈 인코포레이티드 | 6-변형된 바이시클릭 핵산 유사체 |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| WO2007134181A2 (en) | 2006-05-11 | 2007-11-22 | Isis Pharmaceuticals, Inc. | 5'-modified bicyclic nucleic acid analogs |
| CN101554074B (zh) | 2006-10-30 | 2012-08-22 | 诺基亚公司 | 为用户设备提供运营商控制的移动性的方法、设备和系统 |
| WO2008109546A2 (en) | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tgfbr gene expression and uses thereof |
| US8278425B2 (en) | 2007-05-30 | 2012-10-02 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| ES2386492T3 (es) | 2007-06-08 | 2012-08-21 | Isis Pharmaceuticals, Inc. | Análogos de ácidos nucleicos bicíclicos carbocíclicos |
| AU2008272918B2 (en) | 2007-07-05 | 2012-09-13 | Isis Pharmaceuticals, Inc. | 6-disubstituted bicyclic nucleic acid analogs |
| WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
| US20110119781A1 (en) * | 2008-07-15 | 2011-05-19 | Birgit Bramlage | Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes |
| CN102762215A (zh) * | 2009-10-16 | 2012-10-31 | 葛兰素集团有限公司 | Hbv反义抑制剂 |
| WO2011154542A1 (en) * | 2010-06-11 | 2011-12-15 | Artisense Pharma Gmbh | Method for selective oligonucleotide modification |
| US9115371B2 (en) * | 2011-08-18 | 2015-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Reduction of TGF beta signaling in myeloid cells in the treatment of cancer |
| CN104004762B (zh) * | 2014-05-20 | 2016-03-30 | 南京医科大学附属南京儿童医院 | Tgf-r反义序列及其在制备抗气道炎症反应药物中的应用 |
| EP3020813A1 (en) * | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
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