RU2017120481A

RU2017120481A - Антисмысловые олигонуклеотиды в качестве ингибиторов сигнального пути tgf-r

Info

Publication number: RU2017120481A
Application number: RU2017120481A
Authority: RU
Inventors: Маркус Хоссбах; Моника КРАМПЕРТ; Ханс-Лотар АРТ
Original assignee: Ньюровижн Фарма Гмбх
Priority date: 2014-11-16
Filing date: 2015-11-16
Publication date: 2018-12-18
Also published as: JP6983343B2; IL269151B2; KR102417601B1; MX2020011476A; US20220143071A1; KR20210113697A; US10363266B2; CA3201845C; RU2017120481A3; EP3218488B1; CN107002082B; EP3218488A1; RU2717454C2; KR102310899B1; CY1121110T1; JP2018501816A; CA2964834C; DK3218488T3; IL269151A; AU2015345006A1

Claims

1. Антисмысловой олигонуклеотид, состоящий из 10-28 нуклеотидов, и, по меньшей мере, два из 10-28 нуклеотидов представляют LNA, и антисмысловой олигонуклеотид способен гибридизоваться с участком гена, кодирующего TGF-R_II, или с участком мРНК, кодирующей TGF-R_II, где участок гена, кодирующего TGF-R_II, или участок мРНК, кодирующей TGF-R_II, содержит последовательность TGGTCCATTC (SEQ. ID NO: 4)или последовательность CCCTAAACAC (SEQ. ID NO: 5), или последовательность ACTACCAAAT (SEQ. ID NO: 6), или последовательность GGACGCGTAT (SEQ. ID NO: 7), или последовательность GTCTATGACG (SEQ. ID NO: 8), или последовательность TTATTAATGC (SEQ. ID NO: 9),и антисмысловой олигонуклеотид содержит последовательность, способную гибридизоваться с указанной последовательностью TGGTCCATTC (SEQ. ID NO: 4) или последовательностью CCCTAAACAC (SEQ. ID NO: 5), или последовательностью ACTACCAAAT (SEQ. ID NO: 6), или последовательностью GGACGCGTAT (SEQ. ID NO: 7), или последовательностью GTCTATGACG (SEQ. ID NO: 8), или последовательностью TTATTAATGC (SEQ. ID NO: 9) соответственно, и соли и оптические изомеры указанного антисмыслового олигонуклеотида.

2. Антисмысловой олигонуклеотид по п.1, где антисмысловой олигонуклеотид гибридизуется избирательно только с последовательностью TGGTCCATTC (SEQ. ID NO: 4) или последовательностью CCCTAAACAC (SEQ. ID NO: 5), или последовательностью ACTACCAAAT (SEQ. ID NO: 6), или последовательностью GGACGCGTAT (SEQ. ID NO: 7), или последовательностью GTCTATGACG (SEQ. ID NO: 8), или последовательностью TTATTAATGC (SEQ. ID NO: 9) участка гена, кодирующего TGF-R_II, или участка мРНК, кодирующей TGF-R_II.

3. Антисмысловой олигонуклеотид по п.1 или 2, где антисмысловой олигонуклеотид имеет длину 12-20 нуклеотидов, и/или где антисмысловой олигонуклеотид имеет гапмерную структуру с 1-5 звеньями LNA на терминальном 3ʹ-конце и 1-5 звеньями LNA на терминальном 5ʹ-конце, и/или где антисмысловой олигонуклеотид содержит фосфат, фосфоротиоат и/или фосфородитиоат в качестве межнуклеотидных связей.

4. Антисмысловой олигонуклеотид по любому из пп.1-3, где антисмысловой олигонуклеотид представлен следующей последовательностью:

5ʹ-N¹-GTCATAGA-N²-3ʹ (SEQ. ID NO: 12) или

5ʹ-N³-ACGCGTCC-N⁴-3ʹ (SEQ. ID NO: 98) или

5ʹ-N⁵-TTTGGTAG-N⁶-3ʹ (SEQ. ID NO: 11) или

5ʹ-N ⁷ -AATGGACC-N ⁸-3ʹ (SEQ. ID NO: 100) или

5ʹ-N⁹-ATTAATAA-N¹⁰-3ʹ (SEQ. ID NO: 101) или

5ʹ-N¹¹-TGTTTAGG-N¹²-3ʹ (SEQ. ID NO: 10) или

где:

N¹ представляет: CATGGCAGACCCCGCTGCTC-, ATGGCAGACCCCGCTGCTC-, TGGCAGACCCCGCTGCTC-, GGCAGACCCCGCTGCTC-, GCAGACCCCGCTGCTC-, CAGACCCCGCTGCTC-, AGACCCCGCTGCTC-, GACCCCGCTGCTC-, ACCCCGCTGCTC-, CCCCGCTGCTC-, CCCGCTGCTC-, CCGCTGCTC-, CGCTGCTC-, GCTGCTC-, CTGCTC-, TGCTC-, GCTC-, CTC-, TC- или C-;

N² представляет: -C, -CC, -CCG, -CCGA, -CCGAG, -CCGAGCC, -CCGAGCCCCC, -CCGAGCCCCCC, -CCGAGCCCCCCAG, -CCGAGCCCCCAGC, -CCGAGCCCCCAGCG, -CCGAGCCCCCAGCGC, -CCGAGCCCCCAGCGCA, -CCGAGCCCCCAGCGCAG, -CCGAGCCCCCAGCGCAGC, -CCGAGCCCCCAGCGCAGCGG или -CCGAGCCCCCAGCGCAGCGG;

N³ представляет: GGTGGGATCGTGCTGGCGAT-, GTGGGATCGTGCTGGCGAT-, TGGGATCGTGCTGGCGAT-, GGGATCGTGCTGGCGAT-, GGATCGTGCTGGCGAT-, GATCGTGCTGGCGAT-, ATCGTGCTGGCGAT-, TCGTGCTGGCGAT-, CGTGCTGGCGAT-, GTGCTGGCGAT-, TGCTGGCGAT-, GCTGGCGAT-, CTGGCGAT-, TGGCGAT-, GGCGAT-, GCGAT-, CGAT-, GAT-, AT- или Т-;

N⁴ представляет: -ACAGGACGATGTGCAGCGGC, -ACAGGACGATGTGCAGCGG, -ACAGGACGATGTGCAGCG, -ACAGGACGATGTGCAGC, -ACAGGACGATGTGCAG, -ACAGGACGATGTGCA, -ACAGGACGATGTGC, -ACAGGACGATGTG, -ACAGGACGATGT, -ACAGGACGATG, -ACAGGACGAT, -ACAGGACGA, -ACAGGACG, -ACAGGAC, -ACAGGA, -ACAGG, -ACAG, -ACA, -AC или -A;

N⁵ представляет: GCCCAGCCTGCCCCAGAAGAGCTA-, CCCAGCCTGCCCCAGAAGAGCTA-, CCAGCCTGCCCCAGAAGAGCTA-, CAGCCTGCCCCAGAAGAGCTA-, AGCCTGCCCCAGAAGAGCTA-, GCCTGCCCCAGAAGAGCTA-, CCTGCCCCAGAAGAGCTA-, CTGCCCCAGAAGAGCTA-, TGCCCCAGAAGAGCTA-, GCCCCAGAAGAGCTA-, CCCCAGAAGAGCTA-, CCCAGAAGAGCTA-, CCAGAAGAGCTA-, CAGAAGAGCTA-, AGAAGAGCTA-, GAAGAGCTA-, AAGAGCTA-, AGAGCTA-, GAGCTA-, AGCTA-, GCTA-, CTA-, TA- или A-;

N⁶ представляет: -TGTTTAGGGAGCCGTCTTCAGGAA, -TGTTTAGGGAGCCGTCTTCAGGA, -TGTTTAGGGAGCCGTCTTCAGG, -TGTTTAGGGAGCCGTCTTCAG, -TGTTTAGGGAGCCGTCTTCA, -TGTTTAGGGAGCCGTCTTC, -TGTTTAGGGAGCCGTCTT, -TGTTTAGGGAGCCGTCT, -TGTTTAGGGAGCCGTC, -TGTTTAGGGAGCCGT, -TGTTTAGGGAGCCG, -TGTTTAGGGAGCC, -TGTTTAGGGAGC, -TGTTTAGGGAG, -TGTTTAGGGA, -TGTTTAGGG, -TGTTTAGG, -TGTTTAG, -TGTTTA, -TGTTT, -TGTT, -TGT, -TG или -T;

N⁷ представляет: TGAATCTTGAATATCTCATG-, GAATCTTGAATATCTCATG-, AATCTTGAATATCTCATG-, ATCTTGAATATCTCATG-, TCTTGAATATCTCATG-, CTTGAATATCTCATG-, TTGAATATCTCATG-, TGAATATCTCATG-, GAATATCTCATG-, AATATCTCATG-, ATATCTCATG-, TATCTCATG-, ATCTCATG-, TCTCATG-, CTCATG-, TCATG-, CATG-, ATG-, TG- или G-; и

N⁸ выбран из: -AGTATTCTAGAAACTCACCA, -AGTATTCTAGAAACTCACC, -AGTATTCTAGAAACTCAC, -AGTATTCTAGAAACTCA, -AGTATTCTAGAAACTC, -AGTATTCTAGAAACT, -AGTATTCTAGAAAC, -AGTATTCTAGAAA, -AGTATTCTAGAA, -AGTATTCTAGA, -AGTATTCTAG, -AGTATTCTA, -AGTATTCT, -AGTATTC, -AGTATT, -AGTAT, -AGTA, -AGT, -AG или -A;

N⁹ представляет: ATTCATATTTATATACAGGC-, TTCATATTTATATACAGGC-, TCATATTTATATACAGGC-, CATATTTATATACAGGC-, ATATTTATATACAGGC-, TATTTATATACAGGC-, ATTTATATACAGGC-, TTTATATACAGGC-, TTATATACAGGC-, TATATACAGGC-, ATATACAGGC-, TATACAGGC-, ATACAGGC-, TACAGGC-, ACAGGC-, CAGGC-, AGGC-, GGC-, GC- или C-;

N¹⁰ представляет: -AGTGCAAATGTTATTGGCTA, -AGTGCAAATGTTATTGGCT, -AGTGCAAATGTTATTGGC, -AGTGCAAATGTTATTGG, -AGTGCAAATGTTATTG, -AGTGCAAATGTTATT, -AGTGCAAATGTTAT, -AGTGCAAATGTTA, -AGTGCAAATGTT, -AGTGCAAATGT, -AGTGCAAATG, -AGTGCAAAT, -AGTGCAAA, -AGTGCAA, -AGTGCA, -AGTGC, -AGTG, -AGT, -AG или -A;

N¹¹ представляет: TGCCCCAGAAGAGCTATTTGGTAG-, GCCCCAGAAGAGCTATTTGGTAG-, CCCCAGAAGAGCTATTTGGTAG-, CCCAGAAGAGCTATTTGGTAG-, CCAGAAGAGCTATTTGGTAG-, CAGAAGAGCTATTTGGTAG-, AGAAGAGCTATTTGGTAG-, GAAGAGCTATTTGGTAG-, AAGAGCTATTTGGTAG-, AGAGCTATTTGGTAG-, GAGCTATTTGGTAG-, AGCTATTTGGTAG-, GCTATTTGGTAG-, CTATTTGGTAG-, TATTTGGTAG-, ATTTGGTAG-, TTTGGTAG-, TTGGTAG-, TGGTAG-, GGTAG-, GTAG-, TAG-, AG- или G-,

N¹² представляет: -GAGCCGTCTTCAGGAATCTTCTCC, -GAGCCGTCTTCAGGAATCTTCTC, -GAGCCGTCTTCAGGAATCTTCT, -GAGCCGTCTTCAGGAATCTTC, -GAGCCGTCTTCAGGAATCTT, -GAGCCGTCTTCAGGAATCT, -GAGCCGTCTTCAGGAATC,-GAGCCGTCTTCAGGAAT, -GAGCCGTCTTCAGGAA, -GAGCCGTCTTCAGGA,-GAGCCGTCTTCAGG, -GAGCCGTCTTCAG, -GAGCCGTCTTCA, -GAGCCGTCTTC, -GAGCCGTCTT, -GAGCCGTCT, -GAGCCGTC, -GAGCCGT,-GAGCCG, -GAGCC, -GAGC, -GAG, -GA или -G.

5. Антисмысловой олигонуклеотид по любому из пп.1-4, где последние 2-4 нуклеотида на терминальном 5ʹ-конце представляют нуклеотиды LNA, и последние 2-4 нуклеотида на терминальном 3ʹ-конце представляют нуклеотиды LNA, и между нуклеотидами LNA на терминальном 5ʹ-конце и нуклеотидами LNA на терминальном 3ʹ-конце находится, по меньшей мере, 6 последовательных нуклеотидов, представляющих нуклеотиды, которые не являются LNA, или которые представляют нуклеотиды ДНК.

6. Антисмысловой олигонуклеотид по любому из пп.1-5, где нуклеотиды LNA связаны друг с другом через фосфоротиоатную группу или фосфородитиоатную группу, или где все нуклеотиды связаны друг с другом через фосфатную группу или фосфоротиоатную группу, или фосфородитиоатную группу.

7. Антисмысловой олигонуклеотид по любому из пп.1-6, где нуклеотиды LNA выбраны из следующей группы:

где:

ILʹ представляет -Xʺ-P(=Xʹ)(X^-)-;

Xʹ представляет =O или =S;

X^- представляет -O^-, -OH, -OR^H, -NHR^H, -N(R^H)₂, -OCH₂CH₂OR^H, -OCH₂CH₂SR^H, -BH₃ ^-, -R^H, -SH, -SR^H или -S^-;

Xʺ представляет -O-, -NH-, -NR^H-, -CH₂- или –S-;

Y представляет -O-, -NH-, -NR^H-, -CH₂- или –S-;

R^C и R^H независимо друг от друг выбраны из атома водорода и C_1-4-алкила.

В представляет азотистое основание, выбранное из следующей группы:

аденин, тимин, гуанин, цитозин, урацил, 5-метилцитозин, 5-гидроксиметилцитозин, N⁴-метилцитозин, ксантин, гипоксантин, 7-деазаксантин, 2-аминоаденин, 6-метиладенин, 6-метилгуанин, 6-этиладенин, 6-этилгуанин, 2-пропиладенин, 2-пропилгуанин, 6-карбоксиурацил, 5,6-дигидроурацил, 5-пропинилурацил, 5-пропинилцитозин, 6-азаурацил, 6-азацитозин, 6-азатимин, 5-урацил, 4-тиоурацил, 8-фтораденин, 8-хлораденин, 8-бромаденин, 8-иодаденин, 8-аминоаденин, 8-тиоладенин, 8-тиоалкиладенин, 8-гидроксиладенин, 8-фторгуанин, 8-хлоргуанин, 8-бромгуанин, 8-иодгуанин, 8-аминогуанин, 8-тиолгуанин, 8-тиоалкилгуанин, 8-гидроксилгуанин, 5-фторурацил, 5-бромурацил, 5-хлорурацил, 5-иодурацил, 5-трифторметилурацил, 5-фторцитозин, 5-бромцитозин, 5-хлорцитозин, 5-иодцитозин, 5-трифторметилцитозин, 7-метилгуанин, 7-метиладенин, 8-азагуанин, 8-азааденин, 7-деазагуанин, 7-деазааденин, 7-деаза-8-азааденин, 3-деазагуанин, 3-деазааденин, 2-тиоурацил, 2-тиотимин и 2-тиоцитозин.

8. Антисмысловой олигонуклеотид по любому из пп.1-7, имеющий одну из следующих гапмерных структур: 3-8-3, 4-8-2, 2-8-4, 3-8-4, 4-8-3, 4-8-4, 3-9-3, 4-9-2, 2-9-4, 4-9-3, 3-9-4, 4-9-4, 3-10-3, 2-10-4, 4-10-2, 3-10-4, 4-10-3, 4-10-4, 2-11-4, 4-11-2, 3-11-4, 4-11-3.

9. Антисмысловой олигонуклеотид по любому из пп.1-8, где антисмысловые олигонуклеотиды связываются со 100% комплементарностью с мРНК, кодирующей TGF-R_II, и не связываются с каким-либо другим участком в транскриптоме человека.

10. Антисмысловой олигонуклеотид, выбранный из следующей группы:

SEQ ID No: Последовательность, 5'-3' 219a Gb ¹ sAb ¹ sdAsdTsdGsdGsdAsdCsC*b ¹ sAb ¹ 219b Gb ¹ Ab ¹dAdTdGdGdAdCC*b ¹ Ab ¹ 220a Tb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdAsdCsC*b ¹ sAb ¹ sGb ¹ 220b Tb ¹ Gb ¹ Ab ¹ dAdTdGdGdAdCC*b ¹ Ab ¹ Gb ¹ 220c Tb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdAsdCsdC*sAb ¹ sGb ¹ 220d Tb ¹ sdGsdA*sdAsdTsdGsdGsdAsdC*sdCsAb ¹ sGb ¹ 220e Tb ¹ sGb ¹ sdA*sdA*sdTsdGsdGsdA*sdC*sdC*sdAsGb ¹ 221a Tb ¹ sGb ¹ sAb ¹ sAb ¹ sdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ 221b Tb ¹ Gb ¹ Ab ¹ Ab ¹ dUdGdGdAdCdCAb ¹ Gb ¹ Tb ¹ 221c Tb ¹ sGb ¹ sAb ¹ sAb ¹ sdTsdGsdGsdAsdCsdC*sAb ¹ sGb ¹ sTb ¹ 221d Tb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdA*sdCsdC*sdAsGb ¹ sTb ¹ 221e Tb ¹ sGb ¹ sdA*sdAsdTsdGsdGsdAsdC*sdCsdAsdGsTb ¹ 221f Tb ¹ sdGsdAsdA*sdTsdGsdGsdAsdCsC*b ¹ sAb ¹ sGb ¹ sTb ¹ 222a Ab ¹ sTb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdAsdCsC*b ¹ sAb ¹ sGb ¹ sTb ¹ 222b Ab ¹ Tb ¹ Gb ¹ Ab ¹dAsdTsdGsdGsdAsdCsdC*sAb ¹ Gb ¹ Tb ¹ 222c Ab ¹ Tb ¹dGdA*dAdTdGdGdA*dCC*b ¹ Ab ¹ Gb ¹ Tb ¹ 222d Ab ⁴ sTb ⁴ sGb ⁴ sdA*sdAsdTsdGsdGsdAsdCsdC*sAbsGb ⁴ sTb ⁴ 222e Ab ¹ sdTsdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sdA*sdGsTb ¹ 222f Ab ² sTb ² sGb ² sdA*sdAsdUsdGsdGsdAsdCsdCsAb ² sGb ² sTb ² 222g Ab ⁴ ssTb ⁴ ssdGssdAssdAssdTssdGssdGssdAssdCssdCssAb ⁴ ssGb ⁴ ssTb ⁴ 223a Ab ¹ sTb ¹ sGb ¹ sAb ¹ sdAdTdGdGdAdCdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 223b Ab ¹ ssTb ¹ ssdGssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdTssAb ¹ 223c Ab ¹dTdGdAdAdTdGdGdAdCdCdAdGdTAb ¹ 223d Ab ¹ sTb ¹ sdGsdAsdAsdUsdGsdGsdA*sdCsdCsdAsGb ¹ sTb ¹ sAb ¹ 223e Ab ⁶ Tb ⁶ Gb ⁶dA*dAdTdGdGdAdCdC*dAGb ⁶ Tb ⁶ Ab ⁶ 223f Ab ¹ Tb ¹dGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb ¹ Gb ¹ Tb ¹ Ab ¹ 223g Ab ⁴ sTb ⁴ sGb ⁴ sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ⁴ sAb ⁴ 223h Ab ¹ sTb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdAsdC*sdC*sdAsdGsdTsAb ¹ 223i Ab ¹ ssTb ¹ ssdGssdAssdAssdUssdGssdGssdA*ssdCssdCssdAssdGssTb ¹ ssAb ¹ 218y C*b ² sAb ² sTb ² sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ² sGb ² sTb ² sAb ² 218z C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218aa C*b ¹ ssAb ¹ ssTb ¹ ssdGssdAssdAssdTssdGssdGssdAssdCssdCssAb ¹ ssGb ¹ ssTb ¹ ssAb ¹ 218ab C*b ¹ Ab ¹ Tb ¹dGsdAsdAsdUsdGsdGsdAsdC*sdC*sAb ¹ Gb ¹ Tb ¹ Ab ¹ 218ac C*b ¹ Ab ¹ Tb ¹dGsdA*sdA*sdTsdGsdGsdA*sdCsdCsAb ¹ Gb ¹ Tb ¹ Ab ¹ 218ad C*b ⁶ sAb ⁶ sTb ⁶ sdGdAdAdTdGdGdAdCdCAb ⁶ sGb ⁶ sTb ⁶ sAb ⁶ 218ae C*b ⁷ sAb ⁷ sTb ⁷ sGb ⁷ sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ⁷ sTb ⁷ sAb ⁷ 218af C*bs ¹ Ab ¹ sdUsdGsdAsdAsdUsdGsdGsdUsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218b C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218m C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218n C*b ¹ Ab ¹ Tb ¹dGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb ¹ Gb ¹ Tb ¹ Ab ¹ 218o C*b ¹ sAb ¹ sTb ¹ sdGsdA*sdA*sdTsdGsdGsdA*sdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218p C*b ¹ sAb ¹ sTb ¹ sdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218q C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdC*sdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218c C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218r C*b ¹ Ab ¹ Tb ¹dGdAdAdTdGdGdAdCdCAb ¹ Gb ¹ Tb ¹ Ab ¹ 218s C*b ¹ sAb ¹ sTb ¹ sdGdAdAdTdGdGdAdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218t /5SpC3s/C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218u C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ /3SpC3s/ 218v /5SpC3s/C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ /3SpC3s/ 218ag C*b ¹ sAb ¹ sTb ¹ sdGsdA*sdA*sdUsdGsdGsdA*sdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ 218ah C*b ⁴ ssAb ⁴ ssTb ⁴ ssdGssdA*ssdA*ssdTssdGssdGssdA*ssdCssdCssdAssdGssTb ⁴ ssAb ⁴ 218ai C*b ² ssAb ² ssTb ² ssGb ² ssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdTssAb ² 218aj C*b ¹ Ab ¹ Tb ¹ Gb ¹dAdAdUdGdGdAdCdCAb ¹ Gb ¹ Tb ¹ Ab ¹ 218ak C*b ¹ sAb ¹ sTb ¹ sGb ¹ sAb ¹ sdA*sdUsdGsdGsdAsdCsdCsdA*sGb ¹ sTb ¹ sAb ¹ 218am C*b ¹ sAb ¹ sdUsdGsdAsdAsdUsdGsdGsdAsdCsC*b ¹ sAb ¹ sGb ¹ sTb ¹ sAb ¹ 218an C*b ⁶ sAb ⁶ sTb ⁶ sGb ⁶ sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ⁶ sTb ⁶ sAb ⁶ 218ao C*b ⁷ sAb ⁷ sTb ⁷ sdGsdA*sdA*sdUsdGsdGsdAsdCsdCsdA*sGb ⁷ sTb ⁷ sAb ⁷ 218ap C*b ⁴ sAb ⁴ sTb ⁴ sGb ⁴ sdA*sdAsdTsdGsdGsdAsdCsdC*sdAsdGsTb ⁴ sAb ⁴ 218aq C*b ⁴ Ab ⁴ Tb ⁴ Gb ⁴ dAdAdTdGdGdAdCdCdAdGTb ⁴ Ab ⁴ 218ar C*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ 224a C*b ¹ sAb ¹ sTb ¹ sGb ¹ sAb ¹ sdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ sTb ¹ 224b C*b ² sAb ² sTb ² sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ² sGb ² sTb ² sAb ² sTb ² 224c C*b ¹ sAb ¹ sTb ¹ sGb ¹ sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ¹ sAb ¹ sTb ¹ 224d C*b ¹ sdAsdUsdGsdAsdAsdUsdGsdGsdAsdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ sTb ¹ 224e C*b ¹ sAb ¹ sTb ¹ sdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sAb ¹ sGb ¹ sTb ¹ sAb ¹ sTb ¹ 224f C*b ¹ Ab ¹dTdGdAdAdTdGdGdAdCdCdAGb ¹ Tb ¹ Ab ¹ Tb ¹ 224g C*b ¹ sdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ¹ sAb ¹ sTb ¹ 224h C*b ¹ Ab ¹ Tb ¹ Gb ¹ Ab ¹ dA*dTdGdGdA*dC*dC*dAdGdTAb ¹ Tb ¹ 224i C*b ¹ ssAb ¹ ssTb ¹ ssGb ¹ ssAb ¹ ssdAssdTssdGssdGssdAssdCssdCssdAssdGssTb ¹ ssAb ¹ ssTb ¹ 224j C*b ⁴ Ab ⁴ Tb ⁴dGdA*dA*dTdGdGdA*dCdCdAGb ⁴ Tb ⁴ Ab ⁴ Tb ⁴ 224k C*b ⁶ sAb ⁶ sTb ⁶ sdGsdA*sdA*sdUsdGsdGsdA*sdC*sdC*sdAsdGsTb ⁶ sAb ⁶ sTb ⁶ 224m C*b ⁷ sAb ⁷ sTb ⁷ sGb ⁷ sdAdAdTdGdGdAdC*dC*dAsGb ⁷ sTb ⁷ sAb ⁷ sTb ⁷ 225a Tb ¹ sC*b ¹ sAb ¹ sTb ¹ sGb ¹ sdAsdAsdTsdGsdGsdAsdCsdCsAb ¹ sGb ¹ sTb ¹ sAb ¹ sTb ¹ 225b Tb ⁷ sC*b ⁷ sAb ⁷ sTb ⁷ sGb ⁷ sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsdAsTb ⁷ 225c Tb ¹ sC*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ 225d Tb ¹ sC*b ¹ sAb ¹ sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ 225e Tb ¹ sC*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ¹ sAb ¹ sTb ¹ 225f Tb ¹ C*b ¹dA*dTdGdAdAdUdGdGdAdCdC*Ab ¹ Gb ¹ Tb ¹ Ab ¹ Tb ¹ 225g Tb ⁴ C*b ⁴ Ab ⁴ Tb ⁴ sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb ⁴ Gb ⁴ Tb ⁴ Ab ⁴ Tb ⁴ 225h Tb ¹ ssC*b ¹ ssAb ¹ ssdTssdGssdA*ssdA*ssdTssdGssdGssdAssdCssdC*ssdA*ssdGssTb ¹ ssAb ¹ ssTb ¹ 225i Tb ² C*b ² Ab ² dTdGdAdAdTdGdGdAdC*dC*Ab ² Gb ² Tb ² Ab ² Tb ² 226a Tb ¹ sC*b ¹ sAb ¹ sTb ¹ sGb ¹ sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ sTb ¹ 226b Tb ⁶ C*b ⁶ Ab ⁶ Tb ⁶ Gb ⁶dAdAdTdGdGdAdCdCdAGb ⁶ Tb ⁶ Ab ⁶ Tb ⁶ Tb ⁶ 226c Tb ¹ sC*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsAb ¹ sTb ¹ sTb ¹ 226d Tb ¹ sdCsdAsdTsdGsdAsdA*sdUsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ sTb ¹ 226e Tb ⁴ sC*b ⁴ sdAsdUsdGsdAsdAsdUsdGsdGsdAsdCsdC*sdAsdGsTb ⁴ sAb ⁴ sTb ⁴ sTb ⁴ 226f Tb ² ssC*b ² ssAb ² ssTb ² ssGb ² ssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdTssdAssTb ² ssTb ² 227a C*b ¹ sTb ¹ sC*b ¹ sAb ¹ sTb ¹ sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ sTb ¹ 227b C*b ² sTb ² sC*b ² sdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ² sTb ² sAb ² sTb ² sTb ² 227c C*b ¹ Tb ¹ C*b ¹dAdTdGdAdAdTdGdGdAdCdC*dAdGTb ¹ Ab ¹ Tb ¹ Tb ¹ 227d C*b ¹ sdUsdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb ¹ sTb ¹ sAb ¹ sTb ¹ sTb ¹ 227e C*b ⁴ sTb ⁴ sC*b ⁴ sAb ⁴ sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ⁴ sAb ⁴ sTb ⁴ sTb ⁴ 228a Tb ¹ sC*b ¹ sTb ¹ sC*b ¹ sAb ¹ sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb ¹ sAb ¹ sTb ¹ sTb ¹ sC*b ¹ 228b Tb ¹ C*b ¹ Tb ¹ C*b ¹ Ab ¹dTdGdAdAdTdGdGdAdC*dC*dAdGTb ¹ Ab ¹ Tb ¹ Tb ¹ C*b ¹ 228c Tb ⁶ sC*b ⁶ sTb ⁶ sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsAb ⁶ sTb ⁶ sTb ⁶ sC*b ⁶ 229a Ab ¹ sTb ¹ sC*b ¹ sTb ¹ sC*b ¹ sdAsdTsdGsdAsdAsdTsdGsdGsdAsdC*sdCsdAsdGsdTsAb ¹ sTb ¹ sTb ¹ sC*b ¹ sTb ¹ 229b Ab ¹ Tb ¹ C*b ¹ Tb ¹ C*b ¹AdTdGdAdAdTdGdGdAdCdCdAdGdTAb ¹ Tb ¹ Tb ¹ C*b ¹ Tb ¹ 230a Tb ¹ sAb ¹ sTb ¹ sC*b ¹ sTb ¹ sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsdAsTb ¹ sTb ¹ sC*b ¹ sTb ¹ sAb ¹ 230a Tb ¹ sAb ¹ sTb ¹ sC*b ¹ sTb ¹ sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsdAsTb ¹ sTb ¹ sC*b ¹ sTb ¹ sAb ¹ 230b Tb ¹ Ab ¹ Tb ¹ C*b ¹ Tb ¹dCdAdTdGdAdAdTdGdGdAdCdCdAdGdTdATb ¹ Tb ¹ C*b ¹ Tb ¹ Ab ¹ 231a Ab ¹ sTb ¹ sAb ¹ sTb ¹ sC*b ¹ sdTsdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsdAsdTsTb ¹ sC*b ¹ sTb ¹ sAb ¹ sGb ¹ 231b Ab ¹ Tb ¹ Ab ¹ Tb ¹ C*b ¹dTdCdAdTdGdAdAdTdGdGdAdCdCdAdGdTdAdTTb ¹ C*b ¹ Tb ¹ Ab ¹ Gb ¹ 232a C*b1sGb1sdTsdC*sdAsdTsdAsdGsAb1sC*b1 232b C*b1Gb1dTdC*dAdTdAdGAb1C*b1 233a Tb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsAb1sC*b1sC*b1 233b Tb1C*b1Gb1dTdC*dAdTdAdGAb1C*b1C*b1 233c Tb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1 233d Tb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1 233e Tb1sC*b1sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1 234a Tb1sC*b1sGb1sTb1sdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1 234b Tb1C*b1Gb1Tb1dCdAdUdAdGdAC*b1C*b1Gb1 234c Tb1sC*b1sGb1sTb1sdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1 234d Tb1sC*b1sGb1sdTsdC*sdA*sdTsdA*sdGsdA*sdC*sC*b1sGb1 234e Tb1sC*b1sdGsdTsdC*sdAsdTsdA*sdGsdA*sdC*sdCsGb1 234f Tb1sdCsdGsdTsdC*sdA*sdTsdAsdGsAb1sC*b1sC*b1sGb1 142c C*b1sGb1sTb1sdCsdAsdTsdAsdGsdAsdCsdCsGb1sAb1 143i C*b1sTb1sC*b1sGb1sdTsdCsdAsdTsdAsdGsAb1sC*b1sC*b1sGb1 143j C*b4ssTb4ssC*b4ssdGssdTssdCssdAssdTssdAssdGssdA*ssC*b4ssC*b4ssGb4 143h C*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1 143k C*b2ssTb2ssC*b2ssdGssdTssdCssdAssdTssdAssdGssdAssC*b2ssC*b2ssGb2 143m C*b1Tb1C*b1Gb1dUsdCsdAsdTsdAsdGsAb1C*b1C*b1Gb1 143n C*b1sTb1sC*b1sGb1sTb1sdCsdA*sdTsdA*sdGsdA*sC*b1sC*b1sGb1 143o C*b1sTb1sdCsdGsdUsdCsdAsdUsdAsGb1sAb1sC*b1sC*b1sGb1 143p C*b6sTb6sC*b6sGb6sdTsdCsdAsdTsdAsdGsdAsC*b6sC*b6sGb6 143q C*b7sTb7sC*b7sdGsdUsdCsdA*sdUsdA*sdGsdA*sC*b7sC*b7sGb7 143r C*b4sTb4sC*b4sGb4sdTsdC*sdA*sdTsdAsdGsdAsdC*sC*b4sGb4 143s C*b4Tb4C*b4Gb4dTdCdAdTdAdGdAdCC*b4Gb4 143t C*b1ssTb1ssC*b1ssdGssdTssdC*ssdAssdTssdAssdGssdAssC*b1ssC*b1ssGb1 143u C*b1Tb1sdCsdGsdUsdC*sdAsdUsdAsdGsdAsC*b1C*b1Gb1 143v C*b1Tb1sdC*sdGsdTsdC*sdA*sdTsdAsdGsdAsC*b1C*b1Gb1 143w C*b6sTb6sdC*dGdTdC*dAdTdAdGdAsC*b6sC*b6sGb6 143x C*b7sTb7sC*b7sGb7sdTsdC*sdAsdTsdAsdGsdAsC*b7sC*b7sGb7 143y C*b7sTb7sdC*sdGsdTsdCsdAsdUsdAsdGsAb7sC*b7sC*b7sGb7 143z C*b1sTb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1 143aa C*b1Tb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1C*b1Gb1 143ab C*b1sTb1sdC*sdGsdTsdC*sdA*sdTsdAsdGsdA*sC*b1sC*b1sGb1 143ac C*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1 143ad C*b1Tb1dC*dGdTdCdAdTdAdGdAC*b1C*b1Gb1 143ae C*b1sTb1sdC*dGdTdC*dAdTdAdGdAsC*b1sC*b1sGb1 143af /5SpC3s/C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1 143ag C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1/3SpC3s/ 143ah /5SpC3s/C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1/3SpC3s/ 143ai C*b1sTb1sdC*sdGsdUsdC*sdA*sdUsdA*sdGsdA*sC*b1sC*b1sGb1 143aj C*b1sTb1sC*b1sdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1 145c Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsAb1sC*b1sC*b1 235i C*b1sTb1sC*b1sGb1sdTdC*dAdTdAdGdAsC*b1sC*b1sGb1sAb1 235a C*b1ssTb1ssdCssdGssdTssdCssdAssdTssdAssdGssdAssdCssdCssdGssAb1 235b C*b1Tb1dCdGdTdCdAdTdAdGdAdCdCdGAb1 235c C*b1sTb1sdCsdGsdTsdCsdA*sdUsdAsdGsdAsdCsC*b1sGb1sAb1 235d C*b1Tb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1C*b1Gb1Ab1 235e C*b4sTb4sC*b4sdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsGb4sAb4 235f C*b6sTb6sC*b6sdGdTdCdA*dTdAdGdAdC*sC*b6sGb6sAb6 235g C*b1sTb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsdAsdC*sdC*sdGsAb1 235h C*b1ssTb1ssdCssdGssdUssdCssdAssdUssdAssdGssdAssdCssdCssGb1 ssAb1 144c Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1 141c Gb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1sAb1 141d Gb1C*b1Tb1C*b1sdGsdTsdC*sdAsdTsdAsdGsdAsdCsC*b1Gb1Ab1 141e Gb4sC*b4sTb4sC*b4sdGsdTsdC*sdAsdTsdAsdGsdA*sdC*sdC*sGb4sAb4 141f Gb1sdC*sdTsdCsdGsdTsdC*sdA*sdTsdAsdGsdA*sdC*sdC*sdGsAb1 141g Gb2sC*b2sTb2sdCsdGsdUsdCsdAsdTsdA*sdGsdAsdCsC*b2sGb2sAb2 141h Gb4ssC*b4ssTb4ssdCssdGssdTssdCssdAssdTssdAssdGssdAssC*b4ssC*b4ssGb4ssAb4 141i Gb1C*b1dTdCdGdTdCdA*dTdA*dGdA*dCC*b1Gb1Ab1 141j Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsdCsC*b1sGb1sAb1 139c C*b1sGb1sTb1sdCsdAsdTsdAsdGsdAsdCsdCsdGsdAsGb1sC*b1sC*b1 237a Tb1sGb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsAb1sC*b1sC*b1sGb1sAb1 237b Tb2sGb2sC*b2sdTsdGsdTsdC*sdAsdTsdAsdGsAb2sC*b2sC*b2sGb2sAb2 237c Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1 237d Tb1sdGsdCsdUsdC*sdGsdTsdC*sdAsdUsdAsdGsAb1sC*b1sC*b1sGb1sAb1 237e Tb1sGb1sC*b1sdTsdGsdTsdC*sdA*sdTsdA*sdGsAb1sC*b1sC*b1sGb1sAb1 237f Tb1Gb1dC*dTdGdTdC*dAdTdAdGdAC*b1C*b1Gb1Ab1 237g Tb1sdGsdC*sdTsdGsdTsdC*sdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1 237h Tb1Gb1C*b1Tb1C*b1dGdTdC*dA*dTdA*dGdA*dC*dC*Gb1Ab1 237i Tb1ssGb1ssC*b1ssTb1ssC*b1ssdGssdTssdCssdAssdTssdAssdGssdAssdCssC*b1ssGb1ssAb1 237j Tb4sGb4sC*b4sdTdGdTdCdA*dTdA*dGdA*sC*b4sC*b4sGb4sAb4 237k Tb6sGb6sC*b6sdUsdGsdUsdC*sdA*sdUsdA*sdGsdA*sdC*sC*b6sGb6sAb6 237m Tb7sGb7sC*b7sTb7sdC*dGdTdC*dAdTdAdGdAsC*b7sC*b7sGb7sAb7 238a Tb1sGb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1sAb1sGb1 238b Tb7sGb7sC*b7sTb7sC*b7sdGsdTsdC*sdAsdTsdAsdGsdAsdC*sdC*sdGsdAsGb7 238c Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1sGb1 238d Tb1sGb1sdC*sdTsdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sdC*sGb1sAb1sGb1 238e Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sdC*sGb1sAb1sGb1 238f Tb1Gb1dC*dUdC*dGdTdC*dAdTdAdGdA*C*b1C*b1Gb1Ab1Gb1 238g Tb4Gb4C*b4Tb4sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b4C*b4Gb4Ab4Gb4 238h Tb1ssGb1ssC*b1ssdTssdC*ssdGssdTssdC*ssdAssdTssdA*ssdGssdAssdC*ssdC*ssGb1ssAb1ssGb1 238i Tb2Gb2C*b2dTdCdGdTdC*dAdTdAdGdAC*b2C*b2Gb2Ab2Gb2 239a Tb1sGb1sC*b1sTb1sC*b1sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1sGb1sC*b1 239b Tb6Gb6C*b6Tb6C*b6dGdTdC*dAdTdAdGdAdC*C*b6Gb6Ab6Gb6C*b6 239c Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsdGsAb1sGb1sC*b1 239d Tb1sdGsdCsdTsdCsdGsdTsdCsdAsdTsdAsdGsdA*sdC*sC*b1sGb1sAb1sGb1sC*b1 239e Tb4sGb4sdCsdUsdCsdGsdUsdCsdAsdTsdAsdGsdA*sdC*sdC*sGb4sAb4sGb4sC*b4 239f Tb2ssGb2ssC*b2ssTb2ssC*b2ssdGssdTssdCssdAssdTssdAssdGssdAssdCssdCssdGssdAssGb2ssC*b2 240a C*b1sTb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1sGb1sC*b1 240b C*b2sTb2sGb2sdC*sdTsdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b2sGb2 sAb2sGb2sC*b2 240c C*b1Tb1Gb1dC*dTdC*dGdTdCdAdTdAdGdAdC*dC*Gb1Ab1Gb1C*b1 240d C*b1sdUsdGsdCsdUsdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1sGb1sC*b1 240e C*b4sTb4sGb4sC*b4sdTsdCsdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsGb4sAb4sGb4sC*b4 241a Gb1sC*b1sTb1sGb1sC*b1sdTsdC*sdGsdTsdCsdAsdTsdAsdGsdAsdCsdC*sGb1sAb1sGb1sC*b1sC*b1 241b Gb1C*b1Tb1Gb1C*b1dTdC*dGdTdC*dAdTdAdGdAdC*dC*Gb1Ab1Gb1C*b1C*b1 241c Gb1sC*b1sTb1sGb1sC*b1sdTsdCsdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsGb1sAb1sGb1sC*b1sC*b1 242a C*b1sGb1sC*b1sTb1sGb1sdCsdTsdCsdGsdTsdCsdAsdTsdAsdGsdAsdCsdC*sdGsAb1sGb1sC*b1sC*b1sC*b1 242b C*b1Gb1C*b1Tb1Gb1dC*dTdCdGdTdCdAdTdAdGdAdCdC*dGAb1Gb1C*b1C*b1C*b1 243a 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C*b1sGb1sAb1sdTsdAsdCsdGsdCsdGsdTsdCsC*b1sAb1 248a Gb1sAb1sTb1sAb1sdC*sdGsdC*sdGsdTsdC*sC*b1sAb1sC*b1sAb1 248b Gb1Ab1Tb1Ab1sdC*sdGsdCsdGsdTsdC*sdC*sAb1C*b1Ab1 248c Gb4sAb4sTb4sAb4sdC*sdGsdCsdGsdTsdC*sdC*sdA*sC*b4sAb4 248d Gb1sdA*sdTsdAsdCsdGsdCsdGsdTsdCsdC*sdA*sdCsAb1 248e Gb2sAb2sTb2sdA*sdCsdGsdCsdGsdUsdCsdCsAb2sC*b2sAb2 248f Gb4ssAb4ssdTssdAssdCssdGssdCssdGssdTssdCssdCssAb4ssC*b4ssAb4 248g Gb1Ab1dTdA*dCdGdCdGdTdCC*b1Ab1C*b1Ab1 152h C*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdCsdCsAb1sC*b1sAb1 152i C*b1Gb1Ab1Tb1sdAsdCsdGsdCsdGsdUsdCsdC*sAb1C*b1Ab1 152j C*b1Gb1Ab1Tb1sdA*sdCsdGsdCsdGsdUsdCsdCsAb1C*b1Ab1 152k C*b6sGb6sAb6sTb6sdAdC*dGdCdGdTdCdC*sAb6sC*b6sAb6 152m C*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdC*sdC*sAb1sC*b1sAb1 152n C*b1Gb1Ab1Tb1sdAsdC*sdGsdC*sdGsdTsdC*sdC*sAb1C*b1Ab1 152o C*b1sGb1sAb1sTb1sdA*sdCsdGsdCsdGsdTsdCsdC*sAb1sC*b1sAb1 152p C*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdCsdC*sAb1sC*b1sAb1 152q C*b1Gb1Ab1Tb1dAdCdGdC*dGdTdCdC*Ab1C*b1Ab1 152r C*b1sGb1sAb1sTb1sdAdC*dGdC*dGdTdC*dC*sAb1sC*b1sAb1 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C*b4Gb4Ab4Tb4dAdCdGdCdGdTdCdCdAC*b4Ab4 152ak C*b1sGb1sAb1sdTsdAsdCsdGsdCsdGsdTsdCsdCsAb1sC*b1sAb1 249a C*b1sGb1sAb1sTb1sdAdCdGdCdGdTdCdC*sAb1sC*b1sAb1sGb1 249b C*b1ssGb1ssdAssdTssdAssdCssdGssdCssdGssdTssdCssdCssdAssdCssdAssGb1 249c C*b1Gb1dAdTdAdCdGdCdGdTdCdCdAdCdAGb1 249d C*b1sGb1sdAsdUsdAsdC*sdGsdCsdGsdUsdCsdC*sdAsC*b1sAb1sGb1 249e C*b1Gb1sdAsdTsdAsdC*sdGsdC*sdGsdTsdCsdC*sAb1C*b1Ab1Gb1 249f C*b4sGb4sAb4sdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsAb4sGb4 249g C*b6Gb6Ab6dTdA*dCdGdCdGdTdC*dCdA*C*b6Ab6Gb6 249h C*b1sGb1sAb1sTb1sdAsdC*sdGsdCsdGsdTsdCsdC*sdAsdC*sdAsGb1 249i C*b1ssGb1ssdAssdUssdAssdCssdGssdCssdGssdUssdCssdCssdAssdCssAb1ssGb1 250a Gb1sC*b1sGb1sAb1sTb1sdAsdCsdGsdC*sdGsdTsdCsC*b1sAb1sC*b1sAb1sGb1 250b Gb1sC*b1sGb1sAb1sdTsdAsdC*sdGsdC*sdGsdTsdC*sdC*sdAsC*b1sAb1sGb1 250c Gb1sdC*sdGsdAsdUsdAsdCsdGsdC*sdGsdUsdCsC*b1sAb1sC*b1sAb1sGb1 250d Gb1sC*b1sGb1sdA*sdTsdA*sdC*sdGsdC*sdGsdTsdC*sC*b1sAb1sC*b1sAb1sGb1 250e Gb1C*b1dGdAdTdAdCdGdC*dGdTdCdC*Ab1C*b1Ab1Gb1 250f 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Gb1ssC*b1ssGb1ssdA*ssdTssdA*ssdCssdGssdCssdGssdTssdCssdCssdA*ssdC*ssAb1ssGb1ssGb1 251i Gb2C*b2Gb2dAdTdAdCdGdC*dGdTdCdC*Ab2C*b2Ab2Gb2Gb2 252a Gb1sC*b1sGb1sAb1sTb1sdAsdC*sdGsdCsdGsdTsdCsdCsdAsC*b1sAb1sGb1sGb1sAb1 252b Gb6C*b6Gb6Ab6Tb6dAdC*dGdCdGdTdCdC*dAC*b6Ab6Gb6Gb6Ab6 252c Gb1sC*b1sGb1sdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdC*sAb1sGb1sGb1sAb1 252d Gb1sdC*sdGsdA*sdTsdA*sdC*sdGsdCsdGsdTsdCsdCsdA*sC*b1sAb1sGb1sGb1sAb1 252e Gb4sC*b4sdGsdAsdUsdAsdCsdGsdCsdGsdUsdCsdCsdAsdC*sAb4sGb4sGb4sAb4 252f Gb2ssC*b2ssGb2ssAb2ssTb2ssdAssdCssdGssdCssdGssdTssdCssdCssdAssdCssdAssdGssGb2ssAb2 253a Gb1sGb1sC*b1sGb1sAb1sdTsdAsdCsdGsdCsdGsdTsdC*sdC*sdAsC*b1sAb1sGb1sGb1sAb1 253b Gb2sGb2sC*b2sdGsdAsdTsdAsdC*sdGsdCsdGsdTsdC*sdC*sdAsC*b2sAb2sGb2sGb2sAb2 253c Gb1Gb1C*b1dGdAdTdAdCdGdCdGdTdCdCdAdC*Ab1Gb1Gb1Ab1 253d Gb1sdGsdCsdGsdAsdTsdAsdCsdGsdC*sdGsdUsdCsdCsdAsC*b1sAb1sGb1sGb1sAb1 253e Gb4sGb4sC*b4sGb4sdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsAb4sGb4sGb4sAb4 254a Tb1sGb1sGb1sC*Gb1sdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdC*sAb1sGb1sGb1sAb1sC*b1 254b Tb1Gb1Gb1C*b1Gb1dAdTdAdC*dGdCdGdTdCdC*dAdCAb1Gb1Gb1Ab1C*b1 254c Tb6sGb6sGb6sC*b6sdGsdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsdAsdGsGb6sAb6sC*b6 255a C*b1sTb1sGb1sGb1sC*b1sdGsdAsdTsdAsdCsdGsdC*sdGsdTsdCsdC*sdAsdCsdAsGb1sGb1sAb1sC*b1sGb1 255b C*b1Tb1Gb1Gb1C*b1dGdAdTdAdCdGdC*dGdTdCdC*dAdC*dAGb1Gb1Ab1C*b1Gb1 256a Gb1sC*b1sTb1sGb1sGb1sdC*sdGsdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsdAsdGsGb1sAb1sC*b1sGb1sAb1 256b Gb1C*b1Tb1Gb1Gb1dC*dGdAdTdAdCdGdCdGdTdCdCdAdC*dAdGGb1Ab1C*b1Gb1Ab1 257a Tb1sGb1sC*b1sTb1sGb1sdGsdCsdGsdAsdTsdAsdC*sdGsdC*sdGsdTsdCsdCsdAsdCsdAsdGsGb1sAb1sC*b1sGb1sAb1 257b Tb1Gb1C*b1Tb1Gb1dGdCdGdAdTdAdCdGdCdGdTdCdC*dAdC*dAdGGb1Ab1C*b1Gb1Ab1 258a Gb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1 258b Gb1sTb1sdGsdUsdTsdTsdA*sdGsGb1sGb1 259a Ab1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1 259b Ab1Gb1Tb1dGdUdUdUdA*dGGb1Gb1Ab1 259c Ab1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsGb1sAb1 259d Ab1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1 259e Ab1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1 260a Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdAsdGsGb1sGb1sAb1 260b Tb1Ab1Gb1Tb1dGdUdUdUdAdGGb1Gb1Ab1 260c Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1 260d Tb1sAb1sGb1sdUsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1 260e Tb1sAb1sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1 260f Tb1sdA*sdGsdTsdGsdTsdTsdUsdA*sGb1sGb1sGb1sAb1 261a Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1sGb1 261b Tb1Ab1Gb1Tb1sdGsdTsdTsdTsdA*sdGsdGGb1Ab1Gb1 261c Tb4sAb4sGb4sTb4sdGsdUsdTsdUsdA*sdGsdGsdGsAb4sGb4 261d Tb1sdA*sdGsdUsdGsdTsdTsdUsdA*sdGsdGsdGsdA*sGb1 261e Tb2sAb2sGb2sdUsdGsdUsdUsdTsdAsdGsdGsGb2sAb2sGb2 261f Tb4sAb4sdGsdTsdGsdTsdTsdTsdAsdGsdGsGb4sAb4sGb4 261g Tb1Ab1dGdTdGdTdTdTdA*dGGb1Gb1Ab1Gb1 262a Tb1sAb1sGb1sTb1sdGdTdTdTdA*dGdGsGb1sAb1sGb1sC*b1 262b Tb1ssAb1ssdGssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssdGssC*b1 262c Tb1sAb1sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1sGb1sC*b1 262d Tb1dAdGdTdGdTdTdTdAdGdGdGdAdGC*b1 262e Tb1Ab1sdGsdUsdGsdUsdTsdUsdAsdGsdGsGb1Ab1Gb1C*b1 262f Tb4sAb4sGb4sdTsdGsdTsdTsdTsdAsdGsdGsdsdGsdAsGb4sC*b4 262g Tb6Ab6Gb6dUdGdTdTdUdAdGdGdGAb6Gb6C*b6 262h Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsC*b1 262i Tb1ssAb1ssdGssdTssdGssdUssdUssdUssdAssdGssdGssdGssdAssGb1ssC*b1 209s Gb1Tb1dAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1Gb1C*b1 209t Gb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1 209u Gb1Tb1dAdGdTdGdTdTdTdAdGdGdGAb1Gb1C*b1 209v /5SpC3s/Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1 209w Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1/s3SpC3/ 209x /5SpC3s/Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1/3SpC3s/ 209y Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1 209aa Gb1Tb1dA*sdGsdUsdGsdUsdUsdUsdAsdGsdGsdGsAb1Gb1C*b1 209ab Gb1Tb1dA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1Gb1C*b1 209ac Gb6sTb6sdA*dGdTdGdTdTdTdA*dGdGdGAb6sGb6sC*b6 209ad Gb1sTb1sdA*sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1sGb1sC*b1 209ae Gb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1 209af Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1 209ag Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1 209ah Gb1Tb1dAdGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1 209ai Gb6sTb6sdA*dGdTdGdTdTdTdAdGdGdGAb6sGb6sC*b6 209aj Gb1sTb1sdA*sdGsdUsdGsdTsdTsdUsdA*sdGsdGsdGsAb1sGb1sC*b1 209ak Gb7sTb7sAb7sGb7sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb7sGb7sC*b7 209am Gb7sTb7sdAsdGsdTsdGsdTsdTsdUsdA*sdGsdGsGb7sAb7sGb7sC*b7 209an Gb1ssTb1ssAb1ssdGssdTssdGssdTssdTssdTssdA*ssdGssdGssdGssAb1ssGb1ssC*b1 209ao Gb4ssTb4ssAb4ssdGssdTssdGssdTssdTssdTssdAssdGssdGssdGssdA*ssGb4ssC*b4 209ap Gb2ssTb2ssAb2ssGb2ssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssdGssC*b2 209aq Gb1Tb1Ab1Gb1dUdGdUdUdUdAdGdGGb1Ab1Gb1C*b1 209ar Gb1sTb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1 209as Gb1sTb1sdAsdGsdTsdGsdTsdTsdUsdAsdGsGb1sGb1sAb1sGb1sC*b1 209at Gb6sTb6sAb6sGb6sdTsdGsdTsdTsdTsdAsdGsdGsdGsAb6sGb6sC*b6 209au Gb7sTb7sAb7sdGsdUsdGsdTsdTsdTsdA*sdGsdGsdGsAb7sGb7sC*b7 209av Gb4sTb4sAb4sGb4sdUsdGsdTsdUsdTsdA*sdGsdGsdGsdA*sGb4sC*b4 209aw Gb4Tb4Ab4Gb4dTdGdTdTdTdAdGdGdGdAGb4C*b4 209ax Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1 209az Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsGb1sAb1sGb1sC*b1 209ba Gb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdAsdGsdGsGb1sAb1sGb1sC*b1 209bb Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb1sC*b1 263a Gb1sTb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1 263b Gb2sTb2sAb2sdGsdTsdGsdTsdTsdTsdA*sdGsdGsGb2sAb2sGb2sC*b2sC*b2 263c Gb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1 263d Gb1sdUsdA*sdGsdUsdGsdUsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1 263e Gb1sTb1sAb1sdGsdTsdGsdUsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1 263f Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1C*b1 263g Gb1sdTsdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sGb1sC*b1sC*b1 263h Gb1Tb1Ab1Gb1Tb1dGdTdUdTdAdGdGdGdA*dGC*b1C*b1 263i Gb1ssTb1ssAb1ssGb1ssTb1ssdGssdTssdTssdTssdAssdGssdGssdGssdAssGb1ssC*b1ssC*b1 263j Gb4Tb4dA*dGdTdGdTdTdTdAdGdGdGdA*Gb4C*b4C*b4 263k Gb6sTb6sAb6sdGsdTsdGsdUsdUsdTsdAsdGsdGsdGsdA*sGb6sC*b6sC*b6 263m Gb7sTb7sAb7sGb7sdTdGdTdTdTdA*dGdGdGsAb7sGb7sC*b7sC*b7 264a Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1 264b Gb7sGb7sTb7sAb7sGb7sdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsdC*sC*b7 264c Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sdGsdC*sC*b1 264d Gb1sGb1sTb1sAb1sGb1sdUsdGsdTsdTsdTsdAsdGsdGsdGsdA*sdGsdC*sC*b1 264e Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1 264f Gb1sGb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1 264g Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sGb1sC*b1sC*b1 264h Gb1Gb1dUdA*dGdTdGdTdTdTdAdGdGGb1Ab1Gb1C*b1C*b1 264i Gb4Gb4Tb4Ab4dGsdTsdGsdTsdTsdTsdAsdGsdGsGb4Ab4Gb4C*b4C*b4 264j Gb1ssGb1ssTb1ssdA*ssdGssdTssdGssdUssdTssdTssdA*ssdGssdGssdGssdA*ssGb1ssC*b1ssC*b1 264k Gb2Gb2Tb2dA*dGdTdGdTdTdTdAdGdGGb2Ab2Gb2C*b2C*b2 265a Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1sGb1 265b Gb6Gb6Tb6Ab6Gb6dTdGdTdTdTdA*dGdGdGAb6Gb6C*b6C*b6Gb6 265c Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sdGsC*b1sC*b1sGb1 265d Gb1sdGsdTsdA*sdGsdUsdGsdTsdUsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1sGb1 265e Gb4sGb4sdUsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sGb4sC*b4sC*b4sGb4 265f Gb2ssGb2ssTb2ssAb2ssGb2ssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssdGssdCssC*b2ssGb2 266a Tb1sGb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1sGb1 266b Tb2sGb2sGb2sdTsdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb2sGb2sC*b2sC*b2sGb2 266c Gb1Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGdA*Gb1C*b1C*b1Gb1 266d Tb1sdGsdGsdUsdA*sdGsdTsdGsdTsdUsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1sGb1 266e Tb4sGb4sGb4sTb4sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb4sC*b4sC*b4sGb4 267a Tb1sTb1sGb1sGb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sGb1sC*b1sC*b1sGb1sTb1 267b Tb1Tb1Gb1Gb1Tb1dA*dGdTdGdTdTdTdAdGdGdGdA*Gb1C*b1C*b1Gb1Tb1 267c Tb6sTb6sGb6sdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb6sC*b6sC*b6sGb6sTb6 268a Tb1sTb1sTb1sGb1sGb1sdTsdA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsdGC*b1sC*b1sGb1sTb1sC*b1 268b Tb1Tb1Tb1Gb1Gb1dTdA*dGdTdGdTdTdTdAdGdGdGdA*dGC*b1C*b1Gb1Tb1C*b1 269a Ab1sTb1sTb1sTb1sGb1sdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsdC*sC*b1sGb1sTb1sC*b1sTb1 269b Ab1Tb1Tb1Tb1Gb1dGdTdAdGdTdGdTdTdTdAdGdGdGdAdGdC*C*b1Gb1Tb1C*b1Tb1 270a Tb1sAb1sTb1sTb1sTb1sdGsdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsdC*sdCsGb1sTb1sC*b1sTb1sTb1 270b Tb1Ab1Tb1Tb1Tb1dGdGdTdAdGdTdGdTdTdTdAdGdGdGdAdGdC*dC*Gb1Tb1C*b1Tb1Tb1 271a Ab1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1 271b Ab1Tb1dTdTdGdGdTdA*Gb1Tb1 272a Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1 272b Tb1Ab1Tb1dTdTdGdGdTdA*Gb1Tb1Gb1 272c Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsTb1sGb1 272d Tb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdUsGb1 272e Tb1sdAsdTsdUsdTsdGsdGsdUsdA*sdGsTb1sGb1 273a Tb1sAb1sTb1sdTsdTsdGsdGsdTsdAsGb1sTb1sGb1sTb1 273b Tb1Ab1Tb1dUdUdGdGdUdAGb1Tb1Gb1Tb1 273c Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1sTb1 273d Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdUsGb1sTb1 273e Tb1sAb1sdUsdUsdUsdGsdGsdUsdA*sdGsdUsdGsTb1 273f Tb1sdA*sdTsdTsdUsdGsdGsdTsdA*sGb1sTb1sGb1sTb1 274a C*b1Tb1Ab1sdUsdTsdTsdGsdGsdTsdA*sGb1Tb1Gb1Tb1 274b C*b4sTb4sAb4sTb4sdTsdTsdGsdGsdTsdA*sdGsdUsGb4sTb4 274c C*b1sdUsdA*sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1 274d C*b2sTb2sAb2sdTsdTsdUsdGsdGsdTsdA*sdGsTb2sGb2sTb2 274e C*b4ssTb4ssdAssdTssdTssdTssdGssdGssdTssdAssdGssTb4ssGb4ssTb4 274f C*b1Tb1Ab1dTdTdTdGdGdTdA*Gb1Tb1Gb1Tb1 274g C*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1sTb1 275a C*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsTb1 275b C*b1sTb1sdA*sdUsdTsdUsdGsdGsdTsdAsdGsdUsGb1sTb1sTb1 275c C*b4sTb4sAb4sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4 275d C*b1ssTb1ssdAssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssdTssTb1 275e C*b1ssTb1ssdAssdUssdTssdTssdGssdGssdTssdAssdGssdUssdGssTb1ssTb1 275f C*b1sTb1sAb1sTb1sdTdTdGdGdTdA*dGsTb1sGb1sTb1sTb1 275g C*b1Tb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb1Gb1Tb1Tb1 275h C*b6Tb6Ab6dUdTdTdGdGdTdA*dGdUGb6Tb6Tb6 275i C*b1dTdAdTdTdTdGdGdTdAdGdTdGdTTb1 210o Gb1C*b1Tb1Ab1dTsdTsdTsdGsdGsdTsdAsdGsdTsGb1Tb1Tb1 210p Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1 210q Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1 210r Gb1C*b1Tb1Ab1dTdTdTdGdGdTdA*dGdTGb1Tb1Tb1 210s Gb1sC*b1sTb1sAb1sdUsdUsdTdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1 210t Gb1sC*b1sTb1sAb1sdUsdTsdTsdGsdGsdTsdAsdGsdUsGb1sTb1sTb1 210u Gb1sC*b1sTb1sAb1sdUsdUsdUsdGsdGsdUsdA*sdGsdUsGb1sTb1sTb1 210v /5SpC3s/Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1 210w Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1/3SpC3s/ 210x /5SpC3s/Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1/3SpC3s/ 210y Gb1C*b1Tb1Ab1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1Tb1Tb1 210z Gb1C*b1Tb1Ab1sdUsdTsdTsdGsdGsdUsdA*sdGsdTsGb1Tb1Tb1 210aa Gb1sC*b1sTb1sAb1sdTdTdTdGdGdTdA*dGdTsGb1sTb1sTb1 210ab Gb6sC*b6sTb6sAb6sdTdTdTdGdGdTdA*dGdTsGb6sTb6sTb6 210ac Gb6sC*b6sTb6sdAsdTsdTsdTsdGsdGsdTsdAsdGsTb6sGb6sTb6sTb6 210ad Gb7sC*b7sTb7sdA*sdTsdTsdTsdGsdGsdTsdA*sdGsTb7sGb7sTb7sTb7 210ae Gb7sC*b7sdUsdAsdTsdTsdUsdGsdGsdUsdA*sdGsTb7sGb7sTb7sTb7 210af Gb1ssC*b1ssTb1ssdAssdTssdTssdTssdGssdGssdTssdA*ssdGssdTssGb1ssTb1ssTb1 210ag Gb4ssC*b4ssTb4ssdA*ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssTb4ssTb4 210ah Gb2ssC*b2ssTb2ssAb2ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssdTssTb2 210ai Gb1C*b1Tb1Ab1dUsdTsdTsdGsdGsdTsdAsdGsTb1Gb1Tb1Tb1 210aj Gb4C*b4Tb4Ab4dTsdTsdTsdGsdGsdTsdAsdGsdTdGTb4Tb4 210ak Gb1sC*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1 210am Gb4sC*b4sTb4sAb4sdTsdTsdUsdGsdGsdTsdA*sdGsdTsdGsTb4sTb4 210an Gb7sC*b7sTb7sdA*sdTsdTsdUsdGsdGsdTsdA*sdGsdTsGb7sTb7sTb7 210ao Gb1sC*b1sdUsdAsdUsdUsdTsdGsdGsdUsdAsGb1sTb1sGb1sTb1sTb1 210ap Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1 210aq Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1 276a Gb1sC*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1sTb1 276b Gb2sC*b2sTb2sdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb2sGb2sTb2sTb2sTb2 276c Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1 276d Gb2sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsTb2sGb2sTb2sTb2sTb2 276e Gb6sC*b6sTb6sdA*sdUsdUsdUsdGsdGsdUsdA*sdGsdUsdGsTb6sTb6sTb6 276f Gb1sdC*sdTsdA*sdUsdUsdUsdGsdGsdUsdAsdGsdUsdGsTb1sTb1sTb1 276g Gb1C*b1dTdA*dTdTdTdGdGdTdA*dGdTGb1Tb1Tb1Tb1 276h Gb4C*b4Tb4Ab4dTdTdTdGdGdTdA*dGdTdGTb4Tb4Tb4 276i Gb1C*b1Tb1Ab1Tb1dUdTdGdGdTdA*dGdTdGdUTb1Tb1 276j Gb1ssC*b1ssTb1ssAb1ssTb1ssdTssdTssdGssdGssdTssdAssdGssdTssdGssTb1ssTb1ssTb1 276k Gb7sC*b7sTb7sAb7sdTdTdTdGdGdTdA*dGdTsGb7sTb7sTb7sTb7 277a Ab1sGb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1sTb1 277b Ab7sGb7sC*b7sTb7sAb7sdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsdTsTb7 277c Ab1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsTb1sGb1sTb1sTb1sTb1 277d Ab1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1sTb1 277e Ab1Gb1dC*dTdAdUdTdTdGdGdTdA*dGTb1Gb1Tb1Tb1Tb1 277f Ab2Gb2C*b2dTdAdTdTdTdGdGdTdA*dGTb2Gb2Tb2Tb2Tb2 277g Ab1sGb1sC*b1sTb1sdA*sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1 277h Ab1sGb1sC*b1sTb1sdA*sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1sTb1 277i Ab1sGb1sC*b1sdTsdA*sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1 277j Ab4Gb4C*b4Tb4sdAsdTsdTsdTsdGsdGsdTsdAsdGsTb4Gb4Tb4Tb4Tb4 277k Ab1ssGb1ssC*b1ssdTssdA*ssdTssdTssdTssdGssdGssdTssdA*ssdGssdUssdGssTb1ssTb1ssTb1 278a Ab1sGb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1sAb1 278b Ab2ssGb2ssC*b2ssTb2ssAb2ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssdTssdTssTb2ssAb2 278c Ab1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1sAb1 278d Ab1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdUsdA*sdGsdUsGb1sTb1sTb1sTb1sAb1 278e Ab1sGb1sC*b1sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsTb1sTb1sTb1sAb1 278f Ab4sGb4sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4sTb4sAb4 278g Ab6Gb6C*b6Tb6Ab6dTdTdTdGdGdTdA*dGdTGb6Tb6Tb6Tb6Ab6 279a Gb1sAb1sGb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1sAb1 279b Gb2sAb2sGb2sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsGb2sTb2sTb2sTb2sAb2 279c Gb1sdAsdGsdC*sdUsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1sAb1 279d Gb4sAb4sGb4sC*b4sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4sTb4sAb4 279e Gb1Ab1Gb1dC*dTdAdTdTdTdGdGdTdAdGdTdGTb1Tb1Tb1Ab1 280a Ab1sGb1sAb1sGb1sC*b1sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1sTb1sAb1sGb1 280b Ab1Gb1Ab1Gb1C*b1dTdAdTdTdTdGdGdTdAdGdTdGTb1Tb1Tb1Ab1Gb1 280c Ab1sGb1sAb1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1sTb1sAb1sGb1 280d Ab6sGb6sAb6sGb6sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsdTsTb6sAb6sGb6 281a Ab1sAb1sGb1sAb1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsdTsTb1sTb1sAb1sGb1sGb1 281b Ab1Ab1Gb1Ab1Gb1dC*dTdAdTdTdTdGdGdTdAdGdTdGdTTb1Tb1Ab1Gb1Gb1 282a Gb1sAb1sAb1sGb1sAb1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsdTsdTsTb1sAb1sGb1sGb1sGb1 282b Gb1Ab1Ab1Gb1Ab1dGdC*dTdAdTdTdTdGdGdTdAdGdTdGdTdTTb1Ab1Gb1Gb1Gb1 283a Ab1sGb1sAb1sAb1sGb1sdAsdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsdTsdTsdTsAb1sGb1sGb1sGb1sAb1 283b Ab1Gb1Ab1Ab1Gb1dAdGdC*dTdAdTdTdTdGdGdTdAdGdTdGdTdTdTAb1Gb1Gb1Gb1Ab1 284a C*b1sAb1sdTsdTsdAsdAsdTsdA*sAb1sAb1 284b C*b1Ab1dTdTdA*dAdTdA*Ab1Ab1 285a Gb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsAb1sAb1sGb1 285b Gb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsdA*sAb1sGb1 285c 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Gb4ssGb4ssdCssdAssdTssdTssdAssdAssdTssdAssAb4ssAb4ssGb4ssTb4 287j Gb4ssGb4ssdC*ssdAssdTssdTssdAssdAssdTssdAssAb4ssAb4ssGb4ssTb4 288a Gb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1 288b Gb1sGb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsdAsdAsdGsdTsGb1 288c Gb4sGb4sC*b4sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb4sGb4 288d Gb1sGb1sC*b1sAb1sdTdTdAdAdTdAdAsAb1sGb1sTb1sGb1 288e Gb1Gb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1Gb1Tb1Gb1 288f Gb1ssGb1ssdCssdAssdUssdUssdAssdAssdUssdAssdAssdAssdGssTb1ssGb1 288g Gb1ssGb1ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAssdGssdTssGb1 288h Gb6Gb6C*b6dA*dTdTdAdAdUdA*dA*dAGb6Tb6Gb6 288i Gb1Gb1C*b1dAdTdTdAdAdUdAdAdAGb1Tb1Gb1 289a Ab1sGb1sGb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdA*sAb1sAb1sGb1sTb1sGb1 289b Ab1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1sGb1 289c Ab1sGb1sGb1sdC*sdA*sdTsdTsdA*sdA*sdTsdA*sAb1sAb1sGb1sTb1sGb1 289d Ab2sGb2sGb2sdC*sdAsdTsdTsdAsdAsdTsdAsAb2sAb2sGb2sTb2sGb2 289e Ab1sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1sGb1 289f 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C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1/3SpC3s/ 213q /5SpC3s/C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1/3SpC3s/ 213r C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsdA*sGb1sTb1sGb1 213s C*b6sAb6sGb6sdGdC*dAdTdTdAdAdTdAdAdAsGb6sTb6sGb6 213t C*b1sAb1sGb1sdGdC*dAdTdTdAdAdTdAdAdAsGb1sTb1sGb1 213u C*b1Ab1Gb1sdGsdC*sdAsdUsdUsdAsdAsdUsdAsdAsdAsGb1Tb1Gb1 213v C*b1Ab1Gb1sdGsdC*sdAsdTsdTsdAsdA*sdTsdAsdAsdA*sGb1Tb1Gb1 213w C*b1Ab1Gb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1Tb1Gb1 213x C*b7sAb7sGb7sGb7sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb7sTb7sGb7 213y C*b6sAb6sGb6sGb6sdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsGb6sTb6sGb6 213z C*b7sAb7sGb7sdGsdCsdA*sdUsdTsdAsdAsdTsdAsdAsAb7sGb7sTb7sGb7 213aa C*b4sAb4sGb4sGb4sdC*sdA*sdTsdTsdAsdAsdTsdAsdA*sdAsdGsTb4sGb4 213ab C*b1sAb1sGb1sGb1sC*b1sdA*sdTsdTsdA*sdA*sdTsdAsdA*sdA*sGb1sTb1sGb1 213ac C*b1sAb1sGb1sdGsdCsdAsdTsdTsdA*sdA*sdTsdAsAb1sAb1sGb1sTb1sGb1 213ad C*b1sAb1sdGsdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsAb1sGb1sTb1sGb1 213ae C*b1ssAb1ssGb1ssdGssdC*ssdAssdTssdTssdAssdAssdTssdAssdAssAb1ssGb1ssTb1ssGb1 213af C*b4ssAb4ssGb4ssdGssdCssdAssdTssdTssdA*ssdAssdTssdAssdAssdAssdGssTb4ssGb4 213ag C*b2ssAb2ssGb2ssGb2ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAssdGssdTssGb2 213ah C*b1Ab1Gb1Gb1dCdAdTdTdAdAdUdAdAAb1Gb1Tb1Gb1 213ai C*b4Ab4Gb4Gb4dCdAdTdTdAdAdTdAdAdAdGTb4Gb4 213aj C*b1Ab1Gb1dGdCdAdTdTdAdAdUdAdAdAGb1Tb1Gb1 213ak C*b1sAb1sGb1sGb1sdCsdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1 290a C*b1sAb1sGb1sGb1sC*b1sdAsdTsdTsdAsdAsdTsdA*sdAsAb1sGb1sTb1sGb1sC*b1 290b C*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1sC*b1 290c C*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1sGb1sC*b1 290d C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1sC*b1 290e C*b7sAb7sGb7sGb7sC*b7sdA*sdTsdTsdAsdAsdTsdAsdAsdAsdGsdTsdGsC*b7 290f C*b4Ab4Gb4Gb4sdCsdAsdTsdTsdAsdAsdTsdA*sdAsAb4Gb4Tb4Gb4C*b4 290g C*b1ssAb1ssGb1ssdGssdC*ssdAssdTssdTssdA*ssdAssdTssdA*ssdAssdA*ssdGssTb1ssGb1ssC*b1 290h C*b2Ab2Gb2dGdC*dAdTdTdAdAdTdAdAAb2Gb2Tb2Gb2C*b2 290i C*b1Ab1dGdGdC*dA*dUdUdAdAdUdA*dA*Ab1Gb1Tb1Gb1C*b1 291a Ab1sC*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1sC*b1 291b Ab1sC*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1sGb1sC*b1 291c Ab4sC*b4sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsdAsGb4sTb4sGb4sC*b4 291d Ab1sdC*sdAsdGsdGsdC*sdA*sdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1sC*b1 291e Ab2ssC*b2ssAb2ssGb2ssGb2ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAssdGssdTssGb2ssC*b2 291f Ab6C*b6Ab6Gb6Gb6dC*dAdTdTdAdAdTdAdAAb6Gb6Tb6Gb6C*b6 292a Ab1sC*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1sC*b1sAb1 292b Ab2sC*b2sAb2sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb2sTb2sGb2sC*b2sAb2 292c Ab1sdC*sdAsdGsdGsdC*sdAsdUsdUsdAsdAsdUsdAsdAsdAsGb1sTb1sGb1sC*b1sAb1 292d Ab4sC*b4sAb4sGb4sdGsdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb4sGb4sC*b4sAb4 292e Ab1C*b1Ab1dGdGdC*dAdTdTdAdAdTdAdAdAdGTb1Gb1C*b1Ab1 293a Tb1sAb1sC*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1sGb1sC*b1sAb1sAb1 293b Tb1Ab1C*b1Ab1Gb1dGdC*dAdTdTdAdAdTdAdAdAdGTb1Gb1C*b1Ab1Ab1 293c Tb6sAb6sC*b6sdAsdGsdGsdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb6sGb6sC*b6sAb6sAb6 294a Ab1sTb1sAb1sC*b1sAb1sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsdTsGb1sC*b1sAb1sAb1sAb1 294b Ab1Tb1Ab1C*b1Ab1dGdGdC*dAdTdTdAdAdTdAdAdAdGdTGb1C*b1Ab1Ab1Ab1 295a Tb1sAb1sTb1sAb1sC*b1sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsdTsdGsC*b1sAb1sAb1sAb1sTb1 295b Tb1Ab1Tb1Ab1C*b1dAdGdGdC*dAdTdTdAdAdTdAdAdAdGdTdGC*b1Ab1Ab1Ab1Tb1 236a Ab1sTb1sAb1sTb1sAb1sdC*sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsdTsdGsdC*sAb1sAb1sAb1sTb1sGb1 236b Ab1Tb1Ab1Tb1Ab1dC*dAdGdGdCdAdTdTdAdAdTdAdAdAdGdTdGdC*Ab1Ab1Ab1Tb1Gb1

11. Антисмысловой олигонуклеотид по любому из пп.1-10 для стимуляции регенерации и функционального восстановления поврежденных нервных путей и/или для лечения и компенсации индуцированного возрастом снижения обновления нейрональных стволовых клеток.

12. Антисмысловой олигонуклеотид по любому из пп.1-10 для применения в профилактике и лечении нейродегенеративных заболеваний, нейровоспалительных расстройств, травматических или посттравматических расстройств, нейрососудистых расстройств, гипоксических расстройств, постинфекционных расстройств центральной нервной системы, фиброзных болезней, гиперпролиферативных заболеваний, рака, опухолей, пресбиакузиса и пресбиопии.

13. Антисмысловой олигонуклеотид для применения по п.12, где нейродегенеративные заболевания и нейровоспалительные расстройства выбраны из группы, состоящей из: болезни Альцгеймера, болезни Паркинсона, болезни Крейтцфельдта-Якоба, нового варианта болезни Крейтцфельдта-Якоба, болезни Галлервордена-Шпатца, болезни Гентингтона, мультисистемной атрофии, деменции, лобно-височной деменции, расстройств двигательного нейрона, бокового амиотрофического склероза, спинномозговой мышечной атрофии, спиноцеребеллярных атрофий, шизофрении, аффективных расстройств, большого депрессивного расстройства, менингоэнцефалита, бактериального менингоэнцефалита, вирусного менингоэнцефалита, аутоиммунных расстройств ЦНС, рассеянного склероза, острых ишемических/гипоксических поражений, травмы центральной нервной системы и спинного мозга, травмы головы и позвоночника, черепно-мозговых травм, артериосклероза, атеросклероза, микроангиопатической деменции, болезни Бинсвангера, дегенерации сетчатки, улитковой дегенерации, дегенерации желтого пятна, улитковой глухоты, деменции, связанной со СПИДом, пигментного ретинита, Х-сцепленного рецессивного синдрома тремора/атаксии, прогрессирующего супрануклеарного паралича, стриатонигральной дегенерации, оливопонтомозжечковой дегенерации, синдрома Шая-Дрейджера, зависящего от возраста дефицита памяти, неврологических расстройств развития, связанных с деменцией, синдрома Дауна, синуклеинопатий, мутаций супероксиддисмутазы, расстройств повторов тринуклеотида, травмы, гипоксии, сосудистых заболеваний, сосудистых воспалений и старения ЦНС, и где фиброзные болезни выбраны из группы, состоящей из: фиброза легких, кистозного фиброза, цирроза печени, эндомиокардиального фиброза, «старого» инфаркта миокарда, фиброза предсердий, фиброза средостения, миелофиброза, забрюшинного фиброза, прогрессирующего массивного фиброза, нефрогенного системного фиброза, болезни Крона, келоида, системного склероза, артрофиброза, болезни Пейрони, контрактуры Дюпюитрена и остаточных явлений после красной волчанки.

14. Фармацевтическая композиция, содержащая, по меньшей мере, один антисмысловой олигонуклеотид по любому из пп.1-10 вместе, по меньшей мере, с одним фармацевтически приемлемым носителем, эксципиентом, адъювантом, растворителем или разбавителем.