SG11201703127SA - Antisense-oligonucleotides as inhibitors of tgf-r signaling - Google Patents

Antisense-oligonucleotides as inhibitors of tgf-r signaling

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Publication number
SG11201703127SA
SG11201703127SA SG11201703127SA SG11201703127SA SG11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA SG 11201703127S A SG11201703127S A SG 11201703127SA
Authority
SG
Singapore
Prior art keywords
tgf
antisense
oligonucleotides
inhibitors
signaling
Prior art date
Application number
SG11201703127SA
Other languages
English (en)
Inventor
Markus Hossbach
Monika Krampert
Hans-Lothar Arth
Original Assignee
Neurovision Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurovision Pharma GmbH filed Critical Neurovision Pharma GmbH
Publication of SG11201703127SA publication Critical patent/SG11201703127SA/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)

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SG11201703127SA 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling SG11201703127SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Publications (1)

Publication Number Publication Date
SG11201703127SA true SG11201703127SA (en) 2017-06-29

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SG11201703127SA SG11201703127SA (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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US (4) US11213541B2 (ru)
EP (3) EP3020813A1 (ru)
JP (2) JP6832285B2 (ru)
KR (2) KR102310899B1 (ru)
CN (2) CN107002082B (ru)
AU (3) AU2015345006B2 (ru)
BR (1) BR112017006201B1 (ru)
CA (2) CA3201845C (ru)
CL (2) CL2017001233A1 (ru)
CY (1) CY1121110T1 (ru)
DK (1) DK3218488T3 (ru)
ES (1) ES2705066T3 (ru)
HU (1) HUE041793T2 (ru)
IL (2) IL251565B (ru)
MX (2) MX2017006369A (ru)
MY (1) MY181404A (ru)
PL (1) PL3218488T3 (ru)
PT (1) PT3218488T (ru)
RU (1) RU2717454C2 (ru)
SG (1) SG11201703127SA (ru)
TR (1) TR201900844T4 (ru)
WO (1) WO2016075339A1 (ru)

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EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
EP3728590A1 (en) * 2017-12-22 2020-10-28 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
US20200339982A1 (en) * 2017-12-22 2020-10-29 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
KR20200104347A (ko) * 2017-12-22 2020-09-03 로슈 이노베이션 센터 코펜하겐 에이/에스 포스포로디티오에이트 인터뉴클레오시드 연결을 포함하는 갭머 올리고뉴클레오티드
ES2924362T3 (es) * 2018-07-31 2022-10-06 Roche Innovation Ct Copenhagen As Oligonucleótidos que comprenden un enlace internucleosídico fosforotritioato
EP4237436A2 (en) * 2020-10-29 2023-09-06 Mariano A. Garcia-Blanco Soluble interleukin-7 receptor (sil7r) modulating therapy to treat cancer
CN114588160A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有抗肺纤维化作用的次黄碱衍生物
CN113992687B (zh) * 2021-12-28 2022-04-08 浙江宇视科技有限公司 智能业务集群调度方法、装置、电子设备及存储介质

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