CA2964834C - Antisense-oligonucleotides as inhibitors of tgf-r signaling - Google Patents

Antisense-oligonucleotides as inhibitors of tgf-r signaling Download PDF

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Publication number
CA2964834C
CA2964834C CA2964834A CA2964834A CA2964834C CA 2964834 C CA2964834 C CA 2964834C CA 2964834 A CA2964834 A CA 2964834A CA 2964834 A CA2964834 A CA 2964834A CA 2964834 C CA2964834 C CA 2964834C
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antisense
seq
lna
oligonucleotide
nucleotides
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French (fr)
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CA2964834A1 (en
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Markus Hossbach
Monika KRAMPERT
Hans-Lothar ARTH
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Neurovision Pharma GmbH
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Neurovision Pharma GmbH
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)

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CA2964834A 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling Active CA2964834C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3201845A CA3201845C (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193368.9 2014-11-16
EP14193368.9A EP3020813A1 (en) 2014-11-16 2014-11-16 Antisense-oligonucleotides as inhibitors of TGF-R signaling
PCT/EP2015/076730 WO2016075339A1 (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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CA3201845A Division CA3201845C (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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CA2964834A1 CA2964834A1 (en) 2016-05-19
CA2964834C true CA2964834C (en) 2023-08-08

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CA3201845A Active CA3201845C (en) 2014-11-16 2015-11-16 Antisense-oligonucleotides as inhibitors of tgf-r signaling

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US (4) US11213541B2 (enExample)
EP (3) EP3020813A1 (enExample)
JP (2) JP6832285B2 (enExample)
KR (2) KR102310899B1 (enExample)
CN (2) CN107002082B (enExample)
AU (3) AU2015345006B2 (enExample)
BR (1) BR112017006201B1 (enExample)
CA (2) CA2964834C (enExample)
CL (2) CL2017001233A1 (enExample)
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DK (1) DK3218488T3 (enExample)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3020813A1 (en) * 2014-11-16 2016-05-18 Neurovision Pharma GmbH Antisense-oligonucleotides as inhibitors of TGF-R signaling
WO2019010226A1 (en) * 2017-07-03 2019-01-10 The Regents Of The University Of California CHEMICALLY MODIFIED MICROARN-214 ANTISENS AND USE THEREOF FOR THE TREATMENT OF HEMORRHAGIC RECTOCOLITE AND PROCTITE
SG11202003862PA (en) * 2017-11-01 2020-05-28 Editas Medicine Inc Methods, compositions and components for crispr-cas9 editing of tgfbr2 in t cells for immunotherapy
CA3085406A1 (en) * 2017-12-22 2019-06-27 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorodithioate internucleoside linkage
MX2020005754A (es) * 2017-12-22 2020-08-20 Roche Innovation Ct Copenhagen As Oligonucleotidos gapmeros que comprenden un enlace internucleosido fosforoditioato.
EP4092118A1 (en) * 2017-12-22 2022-11-23 Roche Innovation Center Copenhagen A/S Novel thiophosphoramidites
IL316397A (en) 2018-05-22 2024-12-01 Ionis Pharmaceuticals Inc Modulators of APOL1 expression
WO2020025527A1 (en) * 2018-07-31 2020-02-06 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
EP4122943B1 (en) * 2018-07-31 2024-05-29 Roche Innovation Center Copenhagen A/S Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
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