RU2701156C9 - Азотсодержащие гетероциклические производные и их применение в фармацевтических препаратах - Google Patents

Азотсодержащие гетероциклические производные и их применение в фармацевтических препаратах Download PDF

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RU2701156C9
RU2701156C9 RU2015105262A RU2015105262A RU2701156C9 RU 2701156 C9 RU2701156 C9 RU 2701156C9 RU 2015105262 A RU2015105262 A RU 2015105262A RU 2015105262 A RU2015105262 A RU 2015105262A RU 2701156 C9 RU2701156 C9 RU 2701156C9
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alkyl
alkoxy
aryl
spiro
fused
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RU2015105262A
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RU2701156C2 (ru
RU2015105262A (ru
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Инжунь ЧЖАН
Цзяньцунь Чжан
Сяоцзюнь ВАН
Жуньфэн ЛИНЬ
Шентянь ЦАО
Чжаохэ ВАН
Цзин Ли
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Саншайн Лейк Фарма Ко., Лтд.
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    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2635581C (en) 2005-12-28 2017-02-28 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP3083584B1 (en) 2013-12-19 2018-02-21 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in the treatment of tissue fibrosis
JP6525437B2 (ja) 2014-04-02 2019-06-05 インターミューン， インコーポレイテッド 抗線維性ピリジノン
KR20170063954A (ko) 2014-10-07 2017-06-08 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정
CN106397408B (zh) * 2015-07-30 2019-04-02 四川大学 5-甲基-2(1h)吡啶酮衍生物及其制备方法和用途
FR3046793B1 (fr) * 2016-01-14 2018-01-05 Les Laboratoires Servier Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN106083817B (zh) * 2016-06-14 2019-01-18 四川大学 吡非尼酮衍生物及其制备方法
CN106045971B (zh) * 2016-06-16 2018-12-21 杨若一 吡非尼酮衍生物及其制备方法
WO2018019244A1 (zh) * 2016-07-27 2018-02-01 广东东阳光药业有限公司 2,6-二甲基嘧啶酮衍生物的盐及其用途
CN107663177B (zh) * 2016-07-27 2022-07-08 广东东阳光药业有限公司 2,6-二甲基嘧啶酮衍生物的盐及其用途
EP3652158B1 (en) * 2017-07-14 2024-05-29 Sunshine Lake Pharma Co., Ltd. Method for preparing pyrimidone compound
WO2020078445A1 (zh) * 2018-10-19 2020-04-23 广东东阳光药业有限公司 一种治疗纤维化疾病的药物组合或药物组合物
EP3902805A4 (en) 2018-12-28 2023-03-01 SPV Therapeutics Inc. CYCLINE-DEPENDENT KINASE INHIBITORS
US11603523B2 (en) 2019-01-18 2023-03-14 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
CN109734618B (zh) * 2019-02-27 2021-08-17 宜春学院 一种苯氧乙酰胺类化合物的制备方法和苯氧乙酰胺类化合物
CN109942497A (zh) * 2019-05-06 2019-06-28 南京工业大学 一种多取代嘧啶酮化合物及其制备方法
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
IL307258A (en) 2021-04-05 2023-11-01 Halia Therapeutics Inc NEK7 inhibitors
US20250177382A1 (en) 2021-04-22 2025-06-05 Halia Therapeutics, Inc. Nek7 inhibitors
EP4413987A4 (en) 2021-10-09 2025-10-29 Sunshine Lake Pharma Co Ltd ANTIFIBROTIC COMPOSITION
KR102762725B1 (ko) * 2022-03-24 2025-02-06 주식회사 케이에스비튜젠 레보드로프로피진을 유효성분으로 포함하는 근육질환의 예방, 치료 또는 개선용 조성물

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1300396A1 (en) * 2000-06-12 2003-04-09 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
WO2008011109A2 (en) * 2006-07-20 2008-01-24 Amgen Inc. Substituted pyridone compounds and methods of use
WO2009149188A1 (en) * 2008-06-03 2009-12-10 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
EP2436670A1 (en) * 2009-05-25 2012-04-04 Central South University Preparation methods and uses of 1-(substituted aryl)-5-trifluoromethyl-2-(1h)-pyridone compounds and their salts
US20120178733A1 (en) * 2004-06-18 2012-07-12 Millennium Pharmaceuticals, Inc. Factor xa inhibitors

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185689A (en) * 1965-05-25 Tolyl-x-(jh)-pyrimidones
DE2808193A1 (de) 1978-02-25 1979-09-06 Basf Ag Pyridazon-verbindungen
DE3202678A1 (de) 1982-01-28 1983-08-04 Basf Ag, 6700 Ludwigshafen Substituierte 4,5-dimethoxy-pyridazone, verfahren zu ihrer herstellung, diese enthaltende herbizide und ihre anwendung als herbizide
US5149810A (en) 1988-04-22 1992-09-22 Imperial Chemical Industries Plc Pyrimidine compounds
GB8818560D0 (en) 1988-08-04 1988-09-07 Ici Plc Novel compounds
JPH02215719A (ja) 1989-02-15 1990-08-28 Yamauchi Akitomo 線維化病変組織の修復並びに線維化病変の阻止剤
GB8908638D0 (en) 1989-04-17 1989-06-01 Ici Plc Novel compounds
GB8915962D0 (en) 1989-07-12 1989-08-31 Ici Plc Novel compounds
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
IE912114A1 (en) 1990-07-02 1992-01-15 Union Pharma Scient Appl Novel pyrimidine derivatives which are angiotensin ii¹receptor antagonists, their methods of preparation and¹pharmaceutical compositions in which they are present
US5470975A (en) 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
GB9022445D0 (en) 1990-10-16 1990-11-28 Ici Plc Heterocyclic compounds
TW229142B (OSRAM) 1992-04-15 1994-09-01 Nissan Detrochem Corp
CA2094949A1 (en) 1992-04-28 1993-10-29 Eiki Nagano Pyrimidone derivatives and their use
EP0724573A1 (en) 1993-10-20 1996-08-07 PHARMACIA & UPJOHN COMPANY Pyrimidinones as antiarthritic and anti-inflammatories
DE4343528A1 (de) 1993-12-16 1995-06-22 Schering Ag Zweifach heterocyclisch substituierte Benzole und Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
DE4431218A1 (de) 1994-09-02 1996-03-07 Bayer Ag Substituierte Pyrimidin(thi)one
DE4432888A1 (de) 1994-09-15 1996-03-21 Bayer Ag Verwendung von Aryluracilen im semi- und nicht-selektiven Bereich der Unkrautbekämpfung
KR100300566B1 (ko) 1994-09-17 2001-11-22 조생현 피리미디논유도체와그의제조방법및용도
DE19520613A1 (de) 1995-06-06 1996-12-12 Bayer Ag Phenylpyridazinone
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
EP1070055A1 (de) 1998-04-09 2001-01-24 Bayer Aktiengesellschaft Substituierte phenylpyridazinone
WO2002053156A1 (en) 2000-12-29 2002-07-11 Alteon, Inc. Method for treating glaucoma ii b
EP1441732A2 (en) 2001-11-08 2004-08-04 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivative and pharmaceutical use thereof
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
CA2474239A1 (en) 2002-01-18 2003-07-24 Pharmacia Corporation Substituted pyridazinones as inhibitors of p38
AP1822A (en) 2002-02-14 2008-01-30 Pharmacia Corp Substituted pyridinones as modulators of P38 MAP kinase.
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
CN1218942C (zh) 2002-06-11 2005-09-14 中南大学湘雅医学院 抗纤维化吡啶酮化合物及其生产工艺方法
US7183287B2 (en) 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
CN1812981A (zh) * 2003-06-27 2006-08-02 万有制药株式会社 杂芳氧基含氮饱和杂环衍生物
KR20060041309A (ko) 2003-08-13 2006-05-11 다케다 야쿠힌 고교 가부시키가이샤 ４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
NL1026826C2 (nl) 2003-08-13 2007-01-04 Pharmacia Corp Gesubstitueerde pyridinonen.
US7790734B2 (en) 2003-09-08 2010-09-07 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1683788B1 (en) 2003-11-14 2012-03-21 Shanghai Genomics, Inc. Derivatives of pyridone and use thereof
WO2005085200A1 (ja) 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. ピリドン誘導体
CN1308028C (zh) 2004-09-10 2007-04-04 石药集团中奇制药技术（石家庄）有限公司 一种治疗肝纤维化的药物及其制备方法
JP2008515902A (ja) * 2004-10-06 2008-05-15 エヌピーエス ファーマシューティカルズ インコーポレイテッド カルシウム拮抗化合物としての相補ピリミジノン化合物
US8324230B2 (en) 2004-10-13 2012-12-04 Pfizer Inc. Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-Yl]-N-(2-hydroxyethyl)-4-methylbenzamide
WO2006047415A2 (en) * 2004-10-26 2006-05-04 Janssen Pharmaceutica, N.V. Factor xa compounds
CN1846699A (zh) * 2005-04-13 2006-10-18 中南大学湘雅医院 1－(取代苯基)－5－甲基－2－(1h) 吡啶酮(i)化合物用于制备抗除肾间质纤维化外其他器官纤维化或组织纤维化药物的应用
US20090137557A1 (en) 2005-11-22 2009-05-28 Thomas Wen Fu Ku Calcilytic Compounds
US20070129379A1 (en) 2005-12-01 2007-06-07 Bristol-Myers Squibb Company Hiv integrase inhibitors
EP2016072B1 (en) * 2006-05-05 2014-07-16 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
PE20080150A1 (es) 2006-06-02 2008-04-11 Janssen Pharmaceutica Nv Derivados de piridinona n-aril y n-heteroaril sustituidos como antagonistas del receptor de la hormona concentradora de melanina (mch)
WO2007142217A1 (ja) 2006-06-07 2007-12-13 Banyu Pharmaceutical Co., Ltd. １－フェニルピリドン誘導体
CA2657183A1 (en) 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds
WO2008041090A1 (en) 2006-10-06 2008-04-10 Pfizer Limited Malanin concentrating hormone receptor-1 antagonist pyridinones
ES2483866T3 (es) 2006-12-05 2014-08-08 Janssen Pharmaceutica Nv Derivados de diaza-espiro-piridinona sustituidos novedosos para uso en enfermedades mediadas por MCH-1
JP2010515691A (ja) 2007-01-05 2010-05-13 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 第Ｘａ因子阻害剤
JP2010529129A (ja) 2007-06-06 2010-08-26 タイロジェネックス，インコーポレイテッド キナーゼ阻害剤化合物
WO2008156607A1 (en) 2007-06-12 2008-12-24 Neurogen Corporation Substituted pyrimidinones
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
CN101842361B (zh) 2007-06-27 2013-06-05 阿斯利康(瑞典)有限公司 吡嗪酮衍生物及其在治疗肺病中的用途
RU2486187C2 (ru) * 2007-09-11 2013-06-27 Эбботт Лэборетриз N-ОКСИДЫ ОКТАГИДРО-ПИРРОЛО[3,4-b]ПИРРОЛА
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
GB0724342D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
US8153813B2 (en) * 2007-12-20 2012-04-10 Abbott Laboratories Benzothiazole and benzooxazole derivatives and methods of use
ES2556353T3 (es) 2008-02-21 2016-01-15 Merck Sharp & Dohme Corp. Compuestos que son inhibidores de las ERK
CN101235013A (zh) * 2008-03-10 2008-08-06 广东东阳光药业有限公司 结晶型1-（3-氟苯基）-5-甲基-2-（1h）吡啶酮、其制备方法、及其组合物和应用
BRPI1006979A2 (pt) * 2009-01-26 2016-04-12 Intermune Inc métodos para tratar infartos agudos do miocárdio e distúrbios associados
SG10201401169QA (en) * 2009-04-02 2014-05-29 Merck Serono Sa Dihydroorotate dehydrogenase inhibitors
US8377932B2 (en) 2009-05-25 2013-02-19 Central South University Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2(1H)pyridone compounds and salts thereof and their applications
CN101921225B (zh) 2009-06-11 2013-04-03 北京凯得尔森生物技术有限公司 吡啡尼酮类化合物、其制备方法和应用
HUE036431T2 (hu) 2010-03-04 2018-07-30 Merck Sharp & Dohme Katechin o-metil transzferáz gátlók és alkalmazásuk pszichotikus betegségek kezelésében
JPWO2012011592A1 (ja) 2010-07-23 2013-09-09 武田薬品工業株式会社 複素環化合物およびその用途
WO2012096928A2 (en) 2011-01-10 2012-07-19 Glaxosmithkline Llc Pyrimidinone derivatives as fatty acid synthase inhibitors
WO2013086208A1 (en) 2011-12-06 2013-06-13 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
US8859559B2 (en) * 2011-12-20 2014-10-14 Boehringer Ingelheim International Gmbh Substituted pyrazines and their use in the treatment of disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1300396A1 (en) * 2000-06-12 2003-04-09 Eisai Co., Ltd. 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
US20120178733A1 (en) * 2004-06-18 2012-07-12 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
WO2008011109A2 (en) * 2006-07-20 2008-01-24 Amgen Inc. Substituted pyridone compounds and methods of use
WO2009149188A1 (en) * 2008-06-03 2009-12-10 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
EP2436670A1 (en) * 2009-05-25 2012-04-04 Central South University Preparation methods and uses of 1-(substituted aryl)-5-trifluoromethyl-2-(1h)-pyridone compounds and their salts

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EP2875001A4 (en) 2016-06-01
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CN103570630B (zh) 2016-04-20
RU2701156C2 (ru) 2019-09-25
BR112014030284A2 (pt) 2017-06-27
EP2875001B1 (en) 2019-01-09
AU2013292950C1 (en) 2016-01-21
RU2015105262A (ru) 2016-09-10
US9434695B2 (en) 2016-09-06
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BR112014030284B1 (pt) 2021-11-30
JP6186434B2 (ja) 2017-08-23
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