RU2643146C2 - Способ получения аминокислотных соединений - Google Patents

Способ получения аминокислотных соединений Download PDF

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Publication number
RU2643146C2
RU2643146C2 RU2014150991A RU2014150991A RU2643146C2 RU 2643146 C2 RU2643146 C2 RU 2643146C2 RU 2014150991 A RU2014150991 A RU 2014150991A RU 2014150991 A RU2014150991 A RU 2014150991A RU 2643146 C2 RU2643146 C2 RU 2643146C2
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Russia
Prior art keywords
compound
formula
salt
hydrogen
alkyl
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RU2014150991A
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English (en)
Russian (ru)
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RU2014150991A (ru
Inventor
Трэвис РЕМАРЧУК
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Дженентек, Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
RU2014150991A 2012-05-17 2013-05-17 Способ получения аминокислотных соединений RU2643146C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648534P 2012-05-17 2012-05-17
US61/648,534 2012-05-17
PCT/US2013/041687 WO2013173779A1 (en) 2012-05-17 2013-05-17 Process for making amino acid compounds

Publications (2)

Publication Number Publication Date
RU2014150991A RU2014150991A (ru) 2016-07-10
RU2643146C2 true RU2643146C2 (ru) 2018-01-31

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RU2014150991A RU2643146C2 (ru) 2012-05-17 2013-05-17 Способ получения аминокислотных соединений

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US (1) US9278917B2 (enExample)
EP (1) EP2850054B1 (enExample)
JP (1) JP6196294B2 (enExample)
KR (1) KR102074535B1 (enExample)
CN (1) CN104520263B (enExample)
AU (1) AU2013262516B2 (enExample)
BR (1) BR112014028585B1 (enExample)
CA (1) CA2873658C (enExample)
ES (1) ES2668477T3 (enExample)
HR (1) HRP20180948T1 (enExample)
IL (1) IL235630A (enExample)
MA (1) MA37751B1 (enExample)
MX (1) MX350443B (enExample)
MY (1) MY171538A (enExample)
NZ (1) NZ702939A (enExample)
PL (1) PL2850054T3 (enExample)
RU (1) RU2643146C2 (enExample)
SG (1) SG11201407625WA (enExample)
SI (1) SI2850054T1 (enExample)
TR (1) TR201807444T4 (enExample)
WO (1) WO2013173779A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2712224C2 (ru) * 2014-09-26 2020-01-27 Ф. Хоффманн-Ля Рош Аг Способы получения (циклопентил[d]пиримидин-4-ил)пиперазиновых соединений

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Publication number Priority date Publication date Assignee Title
LT2858989T (lt) 2012-05-17 2020-08-10 Genentech, Inc. Akt inhibuojančio pirimidinil-ciklopentano junginio amorfinė forma, jo kompozicijos ir būdai
ES2582557T3 (es) 2012-05-17 2016-09-13 Array Biopharma, Inc. Proceso para la preparación de compuestos hidroxilados de ciclopentilpirimidina
ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
EP2850200A1 (en) 2012-05-17 2015-03-25 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
CN112898210B (zh) 2013-11-15 2025-02-21 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法

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US4663327A (en) * 1984-05-23 1987-05-05 Bayer Aktiengesellschaft 1-heteroaryl-4-aryl-pyrazolin-5-ones
US20080262020A1 (en) * 2005-10-20 2008-10-23 Sanofi-Aventis 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof
RU2009103900A (ru) * 2006-07-06 2010-08-20 Эррэй Биофарма Инк. (Us) Гидроксилированные и метоксилированные циклопента[d]пиримидины в качестве ингибиторов акт протеинкиназ

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EP2850200A1 (en) 2012-05-17 2015-03-25 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
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US20080262020A1 (en) * 2005-10-20 2008-10-23 Sanofi-Aventis 6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof
RU2009103900A (ru) * 2006-07-06 2010-08-20 Эррэй Биофарма Инк. (Us) Гидроксилированные и метоксилированные циклопента[d]пиримидины в качестве ингибиторов акт протеинкиназ

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Publication number Priority date Publication date Assignee Title
RU2712224C2 (ru) * 2014-09-26 2020-01-27 Ф. Хоффманн-Ля Рош Аг Способы получения (циклопентил[d]пиримидин-4-ил)пиперазиновых соединений

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Publication number Publication date
CA2873658C (en) 2021-01-26
MY171538A (en) 2019-10-17
EP2850054B1 (en) 2018-03-21
SI2850054T1 (en) 2018-06-29
HRP20180948T1 (hr) 2018-08-10
AU2013262516A1 (en) 2015-01-22
MA37751B1 (fr) 2018-08-31
TR201807444T4 (tr) 2018-06-21
RU2014150991A (ru) 2016-07-10
MA37751A1 (fr) 2018-01-31
WO2013173779A1 (en) 2013-11-21
IL235630A (en) 2017-03-30
CN104520263B (zh) 2016-11-09
PL2850054T3 (pl) 2018-08-31
NZ702939A (en) 2016-08-26
US20150148559A1 (en) 2015-05-28
BR112014028585B1 (pt) 2020-12-22
US9278917B2 (en) 2016-03-08
IL235630A0 (en) 2015-02-01
KR102074535B1 (ko) 2020-02-06
MX350443B (es) 2017-09-06
HK1208857A1 (en) 2016-03-18
EP2850054A1 (en) 2015-03-25
JP6196294B2 (ja) 2017-09-13
CN104520263A (zh) 2015-04-15
AU2013262516B2 (en) 2017-10-19
ES2668477T3 (es) 2018-05-18
MX2014013863A (es) 2015-05-07
BR112014028585A8 (pt) 2020-09-24
JP2015520165A (ja) 2015-07-16
CA2873658A1 (en) 2013-11-21
SG11201407625WA (en) 2014-12-30
BR112014028585A2 (pt) 2017-06-27
KR20150013808A (ko) 2015-02-05

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