RU2641307C2 - Способ получения триглицеридов среднецепочечных жирных кислот - Google Patents

Способ получения триглицеридов среднецепочечных жирных кислот Download PDF

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Publication number
RU2641307C2
RU2641307C2 RU2014139702A RU2014139702A RU2641307C2 RU 2641307 C2 RU2641307 C2 RU 2641307C2 RU 2014139702 A RU2014139702 A RU 2014139702A RU 2014139702 A RU2014139702 A RU 2014139702A RU 2641307 C2 RU2641307 C2 RU 2641307C2
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Prior art keywords
fatty acids
chain fatty
medium
chain
temperature
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RU2014139702A
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English (en)
Russian (ru)
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RU2014139702A (ru
Inventor
Було Зашари
Жан-Симон Дюсепп
Кристофер Пенни
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Прометик Фарма Смт Лимитед
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
    • C11C3/025—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol with a stoechiometric excess of glycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
RU2014139702A 2012-03-01 2013-02-28 Способ получения триглицеридов среднецепочечных жирных кислот RU2641307C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261605489P 2012-03-01 2012-03-01
US61/605,489 2012-03-01
PCT/CA2013/000174 WO2013126990A1 (en) 2012-03-01 2013-02-28 Method for the preparation of triglycerides of medium-chain length fatty acids

Publications (2)

Publication Number Publication Date
RU2014139702A RU2014139702A (ru) 2016-04-20
RU2641307C2 true RU2641307C2 (ru) 2018-01-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2014139702A RU2641307C2 (ru) 2012-03-01 2013-02-28 Способ получения триглицеридов среднецепочечных жирных кислот

Country Status (20)

Country Link
US (1) US9447016B2 (enExample)
EP (1) EP2819989B1 (enExample)
JP (1) JP6148690B2 (enExample)
KR (1) KR102098974B1 (enExample)
CN (1) CN104203896B (enExample)
AU (1) AU2013225572B2 (enExample)
CA (1) CA2865664C (enExample)
DK (1) DK2819989T3 (enExample)
ES (1) ES2719077T3 (enExample)
IL (1) IL234104A (enExample)
MX (1) MX355572B (enExample)
NZ (1) NZ629227A (enExample)
PH (1) PH12014501863B1 (enExample)
PL (1) PL2819989T3 (enExample)
PT (1) PT2819989T (enExample)
RU (1) RU2641307C2 (enExample)
TR (1) TR201905237T4 (enExample)
TW (1) TWI572352B (enExample)
WO (1) WO2013126990A1 (enExample)
ZA (1) ZA201405956B (enExample)

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PH12014000195B1 (en) 2014-07-10 2023-06-30 D&L Ind Inc Composition of medium chain triglycerides containing substantial amount of lauric acid
MX2017004662A (es) * 2014-10-10 2017-07-26 Nestec Sa Composiciones y metodos para mejorar la movilidad o actividad o tratar la fragilidad.
CN104689327B (zh) * 2015-03-23 2019-02-12 山东北大高科华泰制药有限公司 谷维素液体组合物
EP4406603B1 (en) * 2015-12-04 2026-08-19 Société des Produits Nestlé S.A. Medium chain triglyceride compositions for use in the treatment or prevention of conditions associated with brain energy deficiency condition or disease and neurological conditions
JP6847514B2 (ja) * 2017-01-20 2021-03-24 日清オイリオグループ株式会社 固化性又は結晶性トリグリセリド
CN107129430B (zh) * 2017-05-09 2020-08-21 辽宁新兴药业股份有限公司 一种原料药中链甘油三酸酯合成方法
CN110996920A (zh) 2017-07-26 2020-04-10 太杰先软嚼有限责任公司 用于兽医应用的无淀粉软咀嚼物
MA53188A1 (fr) 2018-10-11 2021-12-31 Basf As Composés aromatiques et leurs utilisations pharmaceutiques
KR102043442B1 (ko) * 2019-02-01 2019-11-11 주식회사 천강 지방산 및 유리지방산을 다량 함유한 유지를 촉매를 사용하지 않고 바이오디젤 원료용 저산가 글리세라이드를 제조하는 방법
CN109836328A (zh) * 2019-03-16 2019-06-04 广州隽沐生物科技股份有限公司 中链甘油三酸酯的合成方法
CN110204440A (zh) * 2019-04-30 2019-09-06 沈阳化工大学 一种乙酰丙酸基液体燃料的制备方法
CN110105203A (zh) * 2019-04-30 2019-08-09 沈阳化工大学 一种乙酰丙酸六碳酯的制备方法
FR3112344B1 (fr) 2020-07-10 2022-12-23 Arkema France Procédé de préparation d’un triglycéride d’acide heptanoïque
CN112321422B (zh) * 2020-10-27 2023-04-25 湖北葛店人福药用辅料有限责任公司 辛酸癸酸单双甘油酯的制备方法
CN117412948A (zh) * 2021-05-21 2024-01-16 Ioi油脂化学品有限责任公司 生产高级脂肪酸多元醇酯，特别是脂肪酸甘油酯的方法
ES2995469T3 (en) * 2021-05-21 2025-02-10 Ioi Oleo Gmbh Process for producing high-grade tricaprylin
US12415772B1 (en) * 2021-05-26 2025-09-16 Savor Foods Limited System and method for production of synthetic fatty acids
MX2024005263A (es) 2021-11-01 2024-08-19 Bioveritas Llc Triglicéridos y lípidos estructurados a partir de ácidos grasos de cadena corta y media.
WO2024069590A1 (en) 2022-09-30 2024-04-04 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for preservation of food and cosmetic products
CN115536531B (zh) * 2022-11-02 2024-05-28 湖北葛店人福药用辅料有限责任公司 一种三辛酸甘油酯的制备方法
US20260207552A1 (en) 2022-12-16 2026-07-23 Itf Research Pharma, S.L.U. Melatonin liquid formulations
US20250026708A1 (en) 2023-07-12 2025-01-23 Navinta, Llc Process for preparation of triheptanoin
CN117229145B (zh) * 2023-07-21 2026-05-26 广州白云山汉方现代药业股份有限公司 一种1,2-二脂肪酸甘油酯的产业化化学制备方法
WO2025038940A1 (en) 2023-08-16 2025-02-20 Savor Foods Limited System and method for triglyceride manufacture

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EP1269859A2 (de) * 2001-06-25 2003-01-02 HEIRLER, Horst Verwendung von mittelkettigen Triglyceriden zur Prävention und Therapie von Adipositas
US6835750B1 (en) * 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
CN1594274A (zh) * 2004-07-01 2005-03-16 江南大学 一种中碳链甘三酯的合成和纯化方法
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EP1592416B1 (en) * 2003-02-07 2009-01-07 ProMetic BioSciences Inc. Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis
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US7745488B2 (en) * 2001-04-18 2010-06-29 Prometic Biosciences, Inc. Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors
EP1269859A2 (de) * 2001-06-25 2003-01-02 HEIRLER, Horst Verwendung von mittelkettigen Triglyceriden zur Prävention und Therapie von Adipositas
EP1592416B1 (en) * 2003-02-07 2009-01-07 ProMetic BioSciences Inc. Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis
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Also Published As

Publication number Publication date
HK1205096A1 (en) 2015-12-11
RU2014139702A (ru) 2016-04-20
ES2719077T3 (es) 2019-07-08
TR201905237T4 (tr) 2019-05-21
PH12014501863A1 (en) 2014-11-17
KR102098974B1 (ko) 2020-04-08
PL2819989T3 (pl) 2019-07-31
EP2819989A1 (en) 2015-01-07
ZA201405956B (en) 2016-08-31
EP2819989B1 (en) 2019-01-16
AU2013225572B2 (en) 2017-02-23
NZ629227A (en) 2016-09-30
CN104203896B (zh) 2018-05-15
TW201343160A (zh) 2013-11-01
JP6148690B2 (ja) 2017-06-14
DK2819989T3 (en) 2019-04-23
PH12014501863B1 (en) 2014-11-17
PT2819989T (pt) 2019-05-08
MX2014010446A (es) 2014-10-13
TWI572352B (zh) 2017-03-01
IL234104A0 (en) 2014-09-30
AU2013225572A1 (en) 2014-10-02
US20150018295A1 (en) 2015-01-15
IL234104A (en) 2017-07-31
EP2819989A4 (en) 2016-03-09
MX355572B (es) 2018-04-23
WO2013126990A8 (en) 2014-02-20
KR20140131988A (ko) 2014-11-14
US9447016B2 (en) 2016-09-20
CN104203896A (zh) 2014-12-10
WO2013126990A1 (en) 2013-09-06
JP2015510010A (ja) 2015-04-02
CA2865664C (en) 2020-11-03
CA2865664A1 (en) 2013-09-06

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