MX355572B - Metodo para la preparacion de trigliceridos de acidos grasos de cadena media. - Google Patents

Metodo para la preparacion de trigliceridos de acidos grasos de cadena media.

Info

Publication number
MX355572B
MX355572B MX2014010446A MX2014010446A MX355572B MX 355572 B MX355572 B MX 355572B MX 2014010446 A MX2014010446 A MX 2014010446A MX 2014010446 A MX2014010446 A MX 2014010446A MX 355572 B MX355572 B MX 355572B
Authority
MX
Mexico
Prior art keywords
triglycerides
preparation
medium
fatty acids
chain length
Prior art date
Application number
MX2014010446A
Other languages
English (en)
Other versions
MX2014010446A (es
Inventor
Christopher Penney
Jean-Simon Duceppe
Boulos Zacharie
Original Assignee
Prometic Pharma Smt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Pharma Smt Ltd filed Critical Prometic Pharma Smt Ltd
Publication of MX2014010446A publication Critical patent/MX2014010446A/es
Publication of MX355572B publication Critical patent/MX355572B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
    • C11C3/025—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol with a stoechiometric excess of glycerol

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describe un método para la preparación de ésteres de glicerol (triglicéridos) de ácidos grasos monocarboxílicos de cadena media que consisten en la reacción del precursor del ácido graso libre y glicerol en presencia de un catalizador bajo vacío parcial; el procedimiento utiliza preferentemente un catalizador metálico tal como un óxido o un cloruro de tungsteno, molibdeno, calcio, cinc, cromo o magnesio; el método de la invención permite la preparación con alto rendimiento y pureza alta (>99.5%) del triglicérido final; el método de la presente permite la formación de triglicéridos sin solvente; también se contempla el triglicérido obtenido mediante el método y la composición farmacéutica que contiene el triglicérido como excipiente o como ingrediente activo.
MX2014010446A 2012-03-01 2013-02-28 Metodo para la preparacion de trigliceridos de acidos grasos de cadena media. MX355572B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261605489P 2012-03-01 2012-03-01
PCT/CA2013/000174 WO2013126990A1 (en) 2012-03-01 2013-02-28 Method for the preparation of triglycerides of medium-chain length fatty acids

Publications (2)

Publication Number Publication Date
MX2014010446A MX2014010446A (es) 2014-10-13
MX355572B true MX355572B (es) 2018-04-23

Family

ID=49081484

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014010446A MX355572B (es) 2012-03-01 2013-02-28 Metodo para la preparacion de trigliceridos de acidos grasos de cadena media.

Country Status (21)

Country Link
US (1) US9447016B2 (es)
EP (1) EP2819989B1 (es)
JP (1) JP6148690B2 (es)
KR (1) KR102098974B1 (es)
CN (1) CN104203896B (es)
AU (1) AU2013225572B2 (es)
CA (1) CA2865664C (es)
DK (1) DK2819989T3 (es)
ES (1) ES2719077T3 (es)
HK (1) HK1205096A1 (es)
IL (1) IL234104A (es)
MX (1) MX355572B (es)
NZ (1) NZ629227A (es)
PH (1) PH12014501863A1 (es)
PL (1) PL2819989T3 (es)
PT (1) PT2819989T (es)
RU (1) RU2641307C2 (es)
TR (1) TR201905237T4 (es)
TW (1) TWI572352B (es)
WO (1) WO2013126990A1 (es)
ZA (1) ZA201405956B (es)

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MX2016006329A (es) * 2013-11-14 2016-09-06 Ultragenyx Pharmaceutical Inc Composiciones solidas de trigliceridos y usos de estas.
PH12014000195A1 (en) 2014-07-10 2017-01-23 Lao Dean Jr Preparation and composition of medium chain triglycerides containing substantial amount of lauric acid
RU2017114438A (ru) * 2014-10-10 2018-10-26 Нестек Са Композиции и способы повышения подвижности или активности или лечения дряхлости
CN104689327B (zh) * 2015-03-23 2019-02-12 山东北大高科华泰制药有限公司 谷维素液体组合物
WO2017093449A1 (en) * 2015-12-04 2017-06-08 Nestec S.A. Medium chain triglyceride compositions
JP6847514B2 (ja) * 2017-01-20 2021-03-24 日清オイリオグループ株式会社 固化性又は結晶性トリグリセリド
CN107129430B (zh) * 2017-05-09 2020-08-21 辽宁新兴药业股份有限公司 一种原料药中链甘油三酸酯合成方法
JP7223744B2 (ja) 2017-07-26 2023-02-16 ティージーエックス ソフト チュー エルエルシー 獣医用途のためのデンプン不含のソフトチュー
KR102043442B1 (ko) * 2019-02-01 2019-11-11 주식회사 천강 지방산 및 유리지방산을 다량 함유한 유지를 촉매를 사용하지 않고 바이오디젤 원료용 저산가 글리세라이드를 제조하는 방법
CN109836328A (zh) * 2019-03-16 2019-06-04 广州隽沐生物科技股份有限公司 中链甘油三酸酯的合成方法
CN110204440A (zh) * 2019-04-30 2019-09-06 沈阳化工大学 一种乙酰丙酸基液体燃料的制备方法
CN110105203A (zh) * 2019-04-30 2019-08-09 沈阳化工大学 一种乙酰丙酸六碳酯的制备方法
FR3112344B1 (fr) 2020-07-10 2022-12-23 Arkema France Procédé de préparation d’un triglycéride d’acide heptanoïque
CN112321422B (zh) * 2020-10-27 2023-04-25 湖北葛店人福药用辅料有限责任公司 辛酸癸酸单双甘油酯的制备方法
KR20240011763A (ko) * 2021-05-21 2024-01-26 이오이 올레오 게엠베하 고 등급 지방산 폴리올 에스테르, 특히 지방산 글리세롤 에스테르의 제조 방법
AU2022375734A1 (en) * 2021-11-01 2024-05-16 Bioveritas, Llc Triglycerides and structured lipids from short- and medium-chain fatty acids
WO2024069590A1 (en) 2022-09-30 2024-04-04 Amyris Bio Products Portugal, Unipessoal, Ltda. Compositions and methods for preservation of food and cosmetic products
CN115536531B (zh) * 2022-11-02 2024-05-28 湖北葛店人福药用辅料有限责任公司 一种三辛酸甘油酯的制备方法
WO2024126775A1 (en) 2022-12-16 2024-06-20 Itf Research Pharma, S.L.U Melatonin liquid formulations

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Also Published As

Publication number Publication date
PH12014501863B1 (en) 2014-11-17
PH12014501863A1 (en) 2014-11-17
ES2719077T3 (es) 2019-07-08
US20150018295A1 (en) 2015-01-15
AU2013225572B2 (en) 2017-02-23
MX2014010446A (es) 2014-10-13
ZA201405956B (en) 2016-08-31
JP6148690B2 (ja) 2017-06-14
EP2819989A4 (en) 2016-03-09
CA2865664A1 (en) 2013-09-06
WO2013126990A8 (en) 2014-02-20
KR102098974B1 (ko) 2020-04-08
NZ629227A (en) 2016-09-30
AU2013225572A1 (en) 2014-10-02
IL234104A0 (en) 2014-09-30
US9447016B2 (en) 2016-09-20
RU2014139702A (ru) 2016-04-20
WO2013126990A1 (en) 2013-09-06
TW201343160A (zh) 2013-11-01
PL2819989T3 (pl) 2019-07-31
CN104203896A (zh) 2014-12-10
PT2819989T (pt) 2019-05-08
CA2865664C (en) 2020-11-03
JP2015510010A (ja) 2015-04-02
HK1205096A1 (en) 2015-12-11
TR201905237T4 (tr) 2019-05-21
CN104203896B (zh) 2018-05-15
IL234104A (en) 2017-07-31
RU2641307C2 (ru) 2018-01-17
EP2819989B1 (en) 2019-01-16
DK2819989T3 (en) 2019-04-23
KR20140131988A (ko) 2014-11-14
EP2819989A1 (en) 2015-01-07
TWI572352B (zh) 2017-03-01

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