RU2624041C2 - Конструкции гомодимерных белков - Google Patents
Конструкции гомодимерных белков Download PDFInfo
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- RU2624041C2 RU2624041C2 RU2013103335A RU2013103335A RU2624041C2 RU 2624041 C2 RU2624041 C2 RU 2624041C2 RU 2013103335 A RU2013103335 A RU 2013103335A RU 2013103335 A RU2013103335 A RU 2013103335A RU 2624041 C2 RU2624041 C2 RU 2624041C2
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- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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| EP10167291.3 | 2010-06-25 | ||
| EP10167291 | 2010-06-25 | ||
| PCT/EP2011/060628 WO2011161244A1 (en) | 2010-06-25 | 2011-06-24 | Homodimeric protein constructs |
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| RU2624041C2 true RU2624041C2 (ru) | 2017-06-30 |
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| AU2004215489B2 (en) * | 2003-02-25 | 2010-07-15 | Nykode Therapeutics ASA | Modified antibody |
| AU2011268934B2 (en) | 2010-06-25 | 2015-09-10 | Nykode Therapeutics ASA | Homodimeric protein constructs |
| RU2644201C2 (ru) * | 2011-12-21 | 2018-02-08 | Вэксибоди Ас | Вакцины против hpv |
| CA3008437A1 (en) | 2016-01-08 | 2017-07-13 | Vaccibody As | Therapeutic anticancer neoepitope vaccine |
| KR102682118B1 (ko) * | 2016-04-29 | 2024-07-08 | 주식회사유한양행 | Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도 |
| CN117510643A (zh) | 2016-09-23 | 2024-02-06 | 美勒斯公司 | 调节细胞表达的生物活性的结合分子 |
| WO2019048936A1 (en) * | 2017-09-07 | 2019-03-14 | University Of Oslo | VACCINE MOLECULES |
| AU2021253641A1 (en) * | 2020-04-07 | 2022-10-27 | Evaxion Biotech A/S | Neoepitope immunotherapy with APC targeting unit |
| US20230165952A1 (en) | 2020-05-01 | 2023-06-01 | Nykode Therapeutics ASA | Betacoronavirus prophylaxis and therapy |
| AU2021307553A1 (en) * | 2020-07-14 | 2023-02-16 | Evaxion Biotech A/S | APC targeting units for immunotherapy |
| US20240173391A1 (en) | 2021-03-26 | 2024-05-30 | Nykode Therapeutics ASA | Therapeutic combination for treating cancer |
| EP4333881A1 (en) | 2021-05-03 | 2024-03-13 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| MX2023013309A (es) | 2021-05-10 | 2024-02-14 | Nykode Therapeutics ASA | Coexpresion de construcciones y compuestos inmunoestimuladores. |
| CA3212784A1 (en) | 2021-05-10 | 2022-11-17 | Agnete Brunsvik Fredriksen | Tolerance-inducing constructs and compositions and their use for the treatment of immune disorders |
| KR20240019136A (ko) | 2021-05-10 | 2024-02-14 | 니코데 테라퓨틱스 에이에스에이 | 작제물과 면역억제 화합물의 공동발현 |
| US20250195632A1 (en) | 2021-05-10 | 2025-06-19 | Nykode Therapeutics ASA | Tolerance-inducing constructs and composition and their use for the treatment of immune disorders |
| WO2022238363A1 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| KR20240110821A (ko) | 2021-11-03 | 2024-07-16 | 니코데 테라퓨틱스 에이에스에이 | SARS-CoV-2로 인한 질병의 예방적 및 치료적 처치에 사용하기 위한 면역원성 작제물 및 백신 |
| EP4608436A1 (en) | 2022-10-25 | 2025-09-03 | Nykode Therapeutics ASA | Constructs and their use |
| EP4615980A1 (en) | 2022-11-09 | 2025-09-17 | Nykode Therapeutics ASA | Co-expression of constructs and polypeptides |
| WO2025064470A1 (en) | 2023-09-19 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Viral peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025136809A2 (en) | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
Citations (2)
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| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| RU2343195C2 (ru) * | 2003-03-24 | 2009-01-10 | Дзе Скриппс Рисерч Инститьют | Днк-вакцины против опухолевого роста и способы их применения |
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| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| AU5361794A (en) | 1992-10-14 | 1994-05-09 | Board Of Trustees Of The Leland Stanford Junior University | Enhancement of b cell lymphoma tumor resistance using idiotype/cytokine conjugates |
| AU3980497A (en) | 1996-08-14 | 1998-03-06 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | A vector for polynucleotide vaccines |
| GB9820014D0 (en) | 1998-09-14 | 1998-11-04 | Cancer Res Campaign Tech | Receptor antagonists and uses thereof |
| US20030119112A1 (en) | 2001-06-20 | 2003-06-26 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| EP1415648B1 (en) | 2001-07-13 | 2006-11-22 | NanoCarrier Co., Ltd. | Lyophilizing composition of drug-encapsulating polymer micelle and method for preparation thereof |
| EP2075256A2 (en) | 2002-01-14 | 2009-07-01 | William Herman | Multispecific binding molecules |
| US20040052773A1 (en) | 2002-01-18 | 2004-03-18 | Inovio As | Production of multi-chain protein from muscle |
| DK1461359T3 (da) | 2002-01-18 | 2007-07-09 | Pf Medicament | Hidtil ukendte anti-IGF-IR-antistoffer og anvendelser deraf |
| GB0222953D0 (en) * | 2002-10-03 | 2002-11-13 | Glaxo Group Ltd | Novel Compounds |
| AU2004215489B2 (en) * | 2003-02-25 | 2010-07-15 | Nykode Therapeutics ASA | Modified antibody |
| US20070298051A1 (en) | 2003-11-19 | 2007-12-27 | Beth Israel Deaconess Medical Center | Adjuvants Of Immune Response |
| DK1933871T3 (da) * | 2005-09-07 | 2013-07-08 | Amgen Fremont Inc | Humane monoklonale antistoffer mod activin-receptor-lignende kinase-1 |
| US20090010948A1 (en) * | 2006-12-15 | 2009-01-08 | The University Of Hong Kong | Anti-tumor vaccines delivered by dendritic cells devoid of interleukin-10 |
| EP2097529A4 (en) * | 2006-12-29 | 2010-03-24 | Osprey Pharmaceuticals Usa Inc | METHOD FOR SELECTION AND PRODUCTION OF MODIFIED TOXINS, MODIFIED TOXINE CONJUGATES AND USES THEREOF |
| ES2595364T3 (es) | 2008-10-07 | 2016-12-29 | The Regents Of The University Of California | Producción de proteínas NELL recombinantes |
| AU2011268934B2 (en) | 2010-06-25 | 2015-09-10 | Nykode Therapeutics ASA | Homodimeric protein constructs |
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| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| RU2343195C2 (ru) * | 2003-03-24 | 2009-01-10 | Дзе Скриппс Рисерч Инститьют | Днк-вакцины против опухолевого роста и способы их применения |
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| AU2011268934B2 (en) | 2015-09-10 |
| EP2585107A1 (en) | 2013-05-01 |
| EP2585107B1 (en) | 2018-10-24 |
| CN102985109A (zh) | 2013-03-20 |
| US20200239568A1 (en) | 2020-07-30 |
| RU2013103335A (ru) | 2014-07-27 |
| CA2803058A1 (en) | 2011-12-29 |
| KR20130087517A (ko) | 2013-08-06 |
| WO2011161244A1 (en) | 2011-12-29 |
| EP3441085A1 (en) | 2019-02-13 |
| JP2016202185A (ja) | 2016-12-08 |
| US10590195B2 (en) | 2020-03-17 |
| DK2585107T3 (en) | 2019-02-11 |
| US20230065226A1 (en) | 2023-03-02 |
| US11479605B2 (en) | 2022-10-25 |
| JP2013532971A (ja) | 2013-08-22 |
| AU2011268934A1 (en) | 2013-01-10 |
| KR20180099918A (ko) | 2018-09-05 |
| CN102985109B (zh) | 2016-05-11 |
| CA2803058C (en) | 2022-07-05 |
| US20130171140A1 (en) | 2013-07-04 |
| KR102044948B1 (ko) | 2019-11-14 |
| JP6538622B2 (ja) | 2019-07-03 |
| US20130336971A9 (en) | 2013-12-19 |
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