RU2624041C2 - Конструкции гомодимерных белков - Google Patents
Конструкции гомодимерных белков Download PDFInfo
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- RU2624041C2 RU2624041C2 RU2013103335A RU2013103335A RU2624041C2 RU 2624041 C2 RU2624041 C2 RU 2624041C2 RU 2013103335 A RU2013103335 A RU 2013103335A RU 2013103335 A RU2013103335 A RU 2013103335A RU 2624041 C2 RU2624041 C2 RU 2624041C2
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- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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| EP10167291.3 | 2010-06-25 | ||
| EP10167291 | 2010-06-25 | ||
| PCT/EP2011/060628 WO2011161244A1 (en) | 2010-06-25 | 2011-06-24 | Homodimeric protein constructs |
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| AU2017205270B2 (en) * | 2016-01-08 | 2024-01-18 | Nykode Therapeutics ASA | Therapeutic anticancer neoepitope vaccine |
| KR102682118B1 (ko) * | 2016-04-29 | 2024-07-08 | 주식회사유한양행 | Ccl3 변이체를 포함하는 융합 단백질 및 이의 용도 |
| KR20190065318A (ko) | 2016-09-23 | 2019-06-11 | 메뤼스 엔.페. | 세포에 의해 발현되는 생물학적 활성을 조절하는 결합 분자 |
| WO2019048936A1 (en) | 2017-09-07 | 2019-03-14 | University Of Oslo | VACCINE MOLECULES |
| WO2021204911A1 (en) * | 2020-04-07 | 2021-10-14 | Evaxion Biotech A/S | Neoepitope immunotherapy with apc targeting unit |
| CN116096735A (zh) | 2020-05-01 | 2023-05-09 | 耐考德治疗股份有限公司 | 乙型冠状病毒的预防和治疗 |
| JP2023533871A (ja) * | 2020-07-14 | 2023-08-04 | エヴァクシオン・バイオテック・アクティエセルスカブ | 免疫療法のためのａｐｃ標的化単位 |
| KR20230164118A (ko) | 2021-03-26 | 2023-12-01 | 니코데 테라퓨틱스 에이에스에이 | 암 치료를 위한 치료 조합 |
| US20250339509A1 (en) | 2021-05-03 | 2025-11-06 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| EP4337251A1 (en) | 2021-05-10 | 2024-03-20 | Nykode Therapeutics ASA | Tolerance-inducing constructs and composition and their use for the treatment of immune disorders |
| WO2022238420A2 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Co-expression of constructs and immunostimulatory compounds |
| WO2022238363A1 (en) | 2021-05-10 | 2022-11-17 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases |
| JP2024518463A (ja) | 2021-05-10 | 2024-05-01 | ナイコード セラピューティクス アルメン アクスイェ セルスカプ | 構築物及び免疫阻害化合物の共発現 |
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| WO2023079001A1 (en) | 2021-11-03 | 2023-05-11 | Nykode Therapeutics ASA | Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of diseases caused by sars-cov-2 |
| WO2024092025A1 (en) | 2022-10-25 | 2024-05-02 | Nykode Therapeutics ASA | Constructs and their use |
| EP4615980A1 (en) | 2022-11-09 | 2025-09-17 | Nykode Therapeutics ASA | Co-expression of constructs and polypeptides |
| WO2025064470A1 (en) | 2023-09-19 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Viral peptides and uses thereof |
| WO2025064761A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Kras10-18 g12d off-target peptides and uses thereof |
| WO2025064738A1 (en) | 2023-09-22 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Dntt 250-258 off-target peptides and uses thereof |
| WO2025136809A2 (en) | 2023-12-19 | 2025-06-26 | Regeneron Pharmaceuticals, Inc. | Foxp3 peptides and uses thereof |
| WO2025178991A1 (en) | 2024-02-21 | 2025-08-28 | Regeneron Pharmaceuticals, Inc. | Splicing factor gene mutation-associated neoantigenic peptides and uses thereof |
| WO2026006734A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Off-target peptide-mhc complex conformation modeling systems and methods for antigen-recognition molecule development |
| WO2026006724A1 (en) | 2024-06-28 | 2026-01-02 | Regeneron Pharmaceuticals, Inc. | Prame off-target peptides and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| RU2343195C2 (ru) * | 2003-03-24 | 2009-01-10 | Дзе Скриппс Рисерч Инститьют | Днк-вакцины против опухолевого роста и способы их применения |
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| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| US6099846A (en) | 1992-10-14 | 2000-08-08 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates |
| EP0920522B1 (en) | 1996-08-14 | 2003-10-29 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | A vector for polynucleotide vaccines |
| GB9820014D0 (en) | 1998-09-14 | 1998-11-04 | Cancer Res Campaign Tech | Receptor antagonists and uses thereof |
| US20030125521A1 (en) | 2001-06-20 | 2003-07-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| DE60216287T2 (de) | 2001-07-13 | 2007-05-31 | Nanocarrier Co., Ltd. | Lyophilisierende zusammensetzung von wirkstoff-verkapselnder polymer-mizelle und verfahren zu ihrer herstellung |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| KR20040099264A (ko) | 2002-01-18 | 2004-11-26 | 이노비오 에이에스 | 근육내 투여를 위한 이중특이성 항체 ｄｎａ 작제물 |
| DE60312639T2 (de) | 2002-01-18 | 2007-11-29 | Pierre Fabre Médicament | Antikörper gegen igf-ir und ihre verwendungen |
| GB0222953D0 (en) * | 2002-10-03 | 2002-11-13 | Glaxo Group Ltd | Novel Compounds |
| EP2862878B1 (en) * | 2003-02-25 | 2022-11-02 | Nykode Therapeutics ASA | Modified antibody |
| US20070298051A1 (en) | 2003-11-19 | 2007-12-27 | Beth Israel Deaconess Medical Center | Adjuvants Of Immune Response |
| CN101517068B (zh) * | 2005-09-07 | 2017-02-08 | 安进弗里蒙特公司 | 活化素受体样激酶‑1的人单克隆抗体 |
| US20090010948A1 (en) * | 2006-12-15 | 2009-01-08 | The University Of Hong Kong | Anti-tumor vaccines delivered by dendritic cells devoid of interleukin-10 |
| SG163558A1 (en) * | 2006-12-29 | 2010-08-30 | Osprey Pharmaceuticals Usa Inc | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof |
| ES2595364T3 (es) | 2008-10-07 | 2016-12-29 | The Regents Of The University Of California | Producción de proteínas NELL recombinantes |
| DK2585107T3 (en) | 2010-06-25 | 2019-02-11 | Vaccibody As | Homodimeric protein constructs |
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- 2011-06-24 WO PCT/EP2011/060628 patent/WO2011161244A1/en not_active Ceased
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| US5646016A (en) * | 1991-02-06 | 1997-07-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules |
| RU2343195C2 (ru) * | 2003-03-24 | 2009-01-10 | Дзе Скриппс Рисерч Инститьют | Днк-вакцины против опухолевого роста и способы их применения |
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| DK2585107T3 (en) | 2019-02-11 |
| US20130336971A9 (en) | 2013-12-19 |
| CN102985109B (zh) | 2016-05-11 |
| EP2585107A1 (en) | 2013-05-01 |
| JP2013532971A (ja) | 2013-08-22 |
| EP2585107B1 (en) | 2018-10-24 |
| WO2011161244A1 (en) | 2011-12-29 |
| US11479605B2 (en) | 2022-10-25 |
| US20130171140A1 (en) | 2013-07-04 |
| CA2803058A1 (en) | 2011-12-29 |
| US20230065226A1 (en) | 2023-03-02 |
| KR20180099918A (ko) | 2018-09-05 |
| CN102985109A (zh) | 2013-03-20 |
| JP6538622B2 (ja) | 2019-07-03 |
| CA2803058C (en) | 2022-07-05 |
| AU2011268934B2 (en) | 2015-09-10 |
| JP2016202185A (ja) | 2016-12-08 |
| US20200239568A1 (en) | 2020-07-30 |
| RU2013103335A (ru) | 2014-07-27 |
| EP3441085A1 (en) | 2019-02-13 |
| US10590195B2 (en) | 2020-03-17 |
| KR102044948B1 (ko) | 2019-11-14 |
| KR20130087517A (ko) | 2013-08-06 |
| AU2011268934A1 (en) | 2013-01-10 |
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