RU2621725C2 - Способ получения 1-([1,3]диоксолан-4-илметил)-1н-пиразол-3-иламина - Google Patents
Способ получения 1-([1,3]диоксолан-4-илметил)-1н-пиразол-3-иламина Download PDFInfo
- Publication number
- RU2621725C2 RU2621725C2 RU2015126911A RU2015126911A RU2621725C2 RU 2621725 C2 RU2621725 C2 RU 2621725C2 RU 2015126911 A RU2015126911 A RU 2015126911A RU 2015126911 A RU2015126911 A RU 2015126911A RU 2621725 C2 RU2621725 C2 RU 2621725C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- phenyl
- alkyl
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/087380 | 2012-12-25 | ||
| CN2012087380 | 2012-12-25 | ||
| PCT/EP2013/077563 WO2014102164A1 (en) | 2012-12-25 | 2013-12-20 | Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015126911A RU2015126911A (ru) | 2017-01-31 |
| RU2621725C2 true RU2621725C2 (ru) | 2017-06-07 |
Family
ID=49876646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015126911A RU2621725C2 (ru) | 2012-12-25 | 2013-12-20 | Способ получения 1-([1,3]диоксолан-4-илметил)-1н-пиразол-3-иламина |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9388168B2 (enExample) |
| EP (1) | EP2938609B1 (enExample) |
| JP (1) | JP6297590B2 (enExample) |
| KR (1) | KR102122569B1 (enExample) |
| CN (1) | CN105051031B (enExample) |
| AU (1) | AU2013369473B2 (enExample) |
| BR (1) | BR112015015229B1 (enExample) |
| CA (1) | CA2896155C (enExample) |
| CY (1) | CY1119040T1 (enExample) |
| DK (1) | DK2938609T3 (enExample) |
| ES (1) | ES2629313T3 (enExample) |
| HR (1) | HRP20170653T1 (enExample) |
| HU (1) | HUE032621T2 (enExample) |
| IL (1) | IL239558A (enExample) |
| LT (1) | LT2938609T (enExample) |
| NZ (1) | NZ709362A (enExample) |
| PL (1) | PL2938609T3 (enExample) |
| PT (1) | PT2938609T (enExample) |
| RU (1) | RU2621725C2 (enExample) |
| SG (1) | SG11201504951TA (enExample) |
| SI (1) | SI2938609T1 (enExample) |
| WO (1) | WO2014102164A1 (enExample) |
| ZA (1) | ZA201504601B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3556354T3 (da) * | 2016-12-15 | 2025-08-04 | Hua Medicine Shanghai Ltd | Oral fremstilling af en glucokinaseaktivator og fremgangsmåde til fremstilling deraf |
| CN113493442B (zh) * | 2020-04-03 | 2024-11-08 | 天津药物研究院有限公司 | 作为葡萄糖激酶活化剂的吡咯烷酮衍生物及其制备方法和用途 |
| US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| WO2021212360A1 (en) * | 2020-04-22 | 2021-10-28 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| CN111732543A (zh) * | 2020-08-14 | 2020-10-02 | 浙江鼎龙科技有限公司 | 一种4,5-二氨基-1-（2-羟乙基）吡唑硫酸盐的制备方法 |
| CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
| AR127064A1 (es) * | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU703020A3 (ru) * | 1977-01-31 | 1979-12-05 | Жансен Фармасетика Н.В. (Фирма) | Способ получени гетероциклических производных 1-(1,3-диоксолан-2-илме-тил)-1н-имидазолов или -1н-1,2,4-триазолов или их кислотно-аддитивных солей,в виде смеси или отдельных стереоизомеров |
| WO2009127546A1 (en) * | 2008-04-16 | 2009-10-22 | F. Hoffmann-La Roche Ag | Pyrrolidinone glucokinase activators |
| EP2236498A1 (en) * | 2008-01-18 | 2010-10-06 | Astellas Pharma Inc. | Phenyl acetamide derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2748274B1 (fr) * | 1996-05-03 | 1998-06-12 | Oreal | Nouveaux diamino pyrazoles, leur synthese, compositions de teinture des fibres keratiniques les contenant, procede de teinture des fibres keratiniques |
| US8178689B2 (en) * | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
-
2013
- 2013-12-20 US US14/655,287 patent/US9388168B2/en active Active
- 2013-12-20 CN CN201380068179.8A patent/CN105051031B/zh active Active
- 2013-12-20 DK DK13811542.3T patent/DK2938609T3/en active
- 2013-12-20 PT PT138115423T patent/PT2938609T/pt unknown
- 2013-12-20 WO PCT/EP2013/077563 patent/WO2014102164A1/en not_active Ceased
- 2013-12-20 SG SG11201504951TA patent/SG11201504951TA/en unknown
- 2013-12-20 HU HUE13811542A patent/HUE032621T2/en unknown
- 2013-12-20 AU AU2013369473A patent/AU2013369473B2/en active Active
- 2013-12-20 LT LTEP13811542.3T patent/LT2938609T/lt unknown
- 2013-12-20 JP JP2015550041A patent/JP6297590B2/ja active Active
- 2013-12-20 HR HRP20170653TT patent/HRP20170653T1/hr unknown
- 2013-12-20 EP EP13811542.3A patent/EP2938609B1/en active Active
- 2013-12-20 NZ NZ709362A patent/NZ709362A/en unknown
- 2013-12-20 KR KR1020157019691A patent/KR102122569B1/ko active Active
- 2013-12-20 BR BR112015015229-5A patent/BR112015015229B1/pt active IP Right Grant
- 2013-12-20 CA CA2896155A patent/CA2896155C/en active Active
- 2013-12-20 ES ES13811542.3T patent/ES2629313T3/es active Active
- 2013-12-20 PL PL13811542T patent/PL2938609T3/pl unknown
- 2013-12-20 SI SI201330684A patent/SI2938609T1/sl unknown
- 2013-12-20 RU RU2015126911A patent/RU2621725C2/ru active
-
2015
- 2015-06-21 IL IL239558A patent/IL239558A/en active IP Right Grant
- 2015-06-25 ZA ZA2015/04601A patent/ZA201504601B/en unknown
-
2017
- 2017-07-10 CY CY20171100727T patent/CY1119040T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU703020A3 (ru) * | 1977-01-31 | 1979-12-05 | Жансен Фармасетика Н.В. (Фирма) | Способ получени гетероциклических производных 1-(1,3-диоксолан-2-илме-тил)-1н-имидазолов или -1н-1,2,4-триазолов или их кислотно-аддитивных солей,в виде смеси или отдельных стереоизомеров |
| EP2236498A1 (en) * | 2008-01-18 | 2010-10-06 | Astellas Pharma Inc. | Phenyl acetamide derivative |
| WO2009127546A1 (en) * | 2008-04-16 | 2009-10-22 | F. Hoffmann-La Roche Ag | Pyrrolidinone glucokinase activators |
| US20090264445A1 (en) * | 2008-04-16 | 2009-10-22 | Steven Joseph Berthel | Pyrrolidinone glucokinase activators |
Non-Patent Citations (1)
| Title |
|---|
| WO 2009127546 A1, 22/10.2009. * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20210910 |