CN105051031B - 1‑([1,3]二氧戊环‑4‑基甲基)‑1h‑吡唑‑3‑胺的制备方法 - Google Patents
1‑([1,3]二氧戊环‑4‑基甲基)‑1h‑吡唑‑3‑胺的制备方法 Download PDFInfo
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- CN105051031B CN105051031B CN201380068179.8A CN201380068179A CN105051031B CN 105051031 B CN105051031 B CN 105051031B CN 201380068179 A CN201380068179 A CN 201380068179A CN 105051031 B CN105051031 B CN 105051031B
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- 0 *C[C@](CO1)*C1(*)I Chemical compound *C[C@](CO1)*C1(*)I 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201380068179.8A CN105051031B (zh) | 2012-12-25 | 2013-12-20 | 1‑([1,3]二氧戊环‑4‑基甲基)‑1h‑吡唑‑3‑胺的制备方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/087380 | 2012-12-25 | ||
| CN2012087380 | 2012-12-25 | ||
| CN201380068179.8A CN105051031B (zh) | 2012-12-25 | 2013-12-20 | 1‑([1,3]二氧戊环‑4‑基甲基)‑1h‑吡唑‑3‑胺的制备方法 |
| PCT/EP2013/077563 WO2014102164A1 (en) | 2012-12-25 | 2013-12-20 | Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105051031A CN105051031A (zh) | 2015-11-11 |
| CN105051031B true CN105051031B (zh) | 2017-10-10 |
Family
ID=49876646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068179.8A Active CN105051031B (zh) | 2012-12-25 | 2013-12-20 | 1‑([1,3]二氧戊环‑4‑基甲基)‑1h‑吡唑‑3‑胺的制备方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9388168B2 (enExample) |
| EP (1) | EP2938609B1 (enExample) |
| JP (1) | JP6297590B2 (enExample) |
| KR (1) | KR102122569B1 (enExample) |
| CN (1) | CN105051031B (enExample) |
| AU (1) | AU2013369473B2 (enExample) |
| BR (1) | BR112015015229B1 (enExample) |
| CA (1) | CA2896155C (enExample) |
| CY (1) | CY1119040T1 (enExample) |
| DK (1) | DK2938609T3 (enExample) |
| ES (1) | ES2629313T3 (enExample) |
| HR (1) | HRP20170653T1 (enExample) |
| HU (1) | HUE032621T2 (enExample) |
| IL (1) | IL239558A (enExample) |
| LT (1) | LT2938609T (enExample) |
| NZ (1) | NZ709362A (enExample) |
| PL (1) | PL2938609T3 (enExample) |
| PT (1) | PT2938609T (enExample) |
| RU (1) | RU2621725C2 (enExample) |
| SG (1) | SG11201504951TA (enExample) |
| SI (1) | SI2938609T1 (enExample) |
| WO (1) | WO2014102164A1 (enExample) |
| ZA (1) | ZA201504601B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI3556354T3 (fi) * | 2016-12-15 | 2025-07-30 | Hua Medicine Shanghai Ltd | Glukokinaasiaktivaattorin suun kautta otettava valmiste ja sen valmistusmenetelmä |
| CN113493442B (zh) * | 2020-04-03 | 2024-11-08 | 天津药物研究院有限公司 | 作为葡萄糖激酶活化剂的吡咯烷酮衍生物及其制备方法和用途 |
| US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| CA3181882A1 (en) * | 2020-04-22 | 2021-10-28 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
| CN111732543A (zh) * | 2020-08-14 | 2020-10-02 | 浙江鼎龙科技有限公司 | 一种4,5-二氨基-1-（2-羟乙基）吡唑硫酸盐的制备方法 |
| CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
| AR127064A1 (es) * | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101918363A (zh) * | 2008-01-18 | 2010-12-15 | 安斯泰来制药株式会社 | 苯乙酰胺衍生物 |
| CN102007118A (zh) * | 2008-04-16 | 2011-04-06 | 霍夫曼-拉罗奇有限公司 | 吡咯烷酮葡糖激酶激活剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4160841A (en) * | 1977-01-31 | 1979-07-10 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles |
| FR2748274B1 (fr) * | 1996-05-03 | 1998-06-12 | Oreal | Nouveaux diamino pyrazoles, leur synthese, compositions de teinture des fibres keratiniques les contenant, procede de teinture des fibres keratiniques |
| US8178689B2 (en) * | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
-
2013
- 2013-12-20 CN CN201380068179.8A patent/CN105051031B/zh active Active
- 2013-12-20 JP JP2015550041A patent/JP6297590B2/ja active Active
- 2013-12-20 DK DK13811542.3T patent/DK2938609T3/en active
- 2013-12-20 LT LTEP13811542.3T patent/LT2938609T/lt unknown
- 2013-12-20 BR BR112015015229-5A patent/BR112015015229B1/pt active IP Right Grant
- 2013-12-20 KR KR1020157019691A patent/KR102122569B1/ko active Active
- 2013-12-20 HU HUE13811542A patent/HUE032621T2/en unknown
- 2013-12-20 SG SG11201504951TA patent/SG11201504951TA/en unknown
- 2013-12-20 PT PT138115423T patent/PT2938609T/pt unknown
- 2013-12-20 ES ES13811542.3T patent/ES2629313T3/es active Active
- 2013-12-20 RU RU2015126911A patent/RU2621725C2/ru active
- 2013-12-20 US US14/655,287 patent/US9388168B2/en active Active
- 2013-12-20 CA CA2896155A patent/CA2896155C/en active Active
- 2013-12-20 EP EP13811542.3A patent/EP2938609B1/en active Active
- 2013-12-20 HR HRP20170653TT patent/HRP20170653T1/hr unknown
- 2013-12-20 SI SI201330684A patent/SI2938609T1/sl unknown
- 2013-12-20 PL PL13811542T patent/PL2938609T3/pl unknown
- 2013-12-20 WO PCT/EP2013/077563 patent/WO2014102164A1/en not_active Ceased
- 2013-12-20 AU AU2013369473A patent/AU2013369473B2/en active Active
- 2013-12-20 NZ NZ709362A patent/NZ709362A/en unknown
-
2015
- 2015-06-21 IL IL239558A patent/IL239558A/en active IP Right Grant
- 2015-06-25 ZA ZA2015/04601A patent/ZA201504601B/en unknown
-
2017
- 2017-07-10 CY CY20171100727T patent/CY1119040T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101918363A (zh) * | 2008-01-18 | 2010-12-15 | 安斯泰来制药株式会社 | 苯乙酰胺衍生物 |
| CN102007118A (zh) * | 2008-04-16 | 2011-04-06 | 霍夫曼-拉罗奇有限公司 | 吡咯烷酮葡糖激酶激活剂 |
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Application publication date: 20151111 Assignee: Sino leader medical technology (Shanghai) Co., Ltd. Assignor: Hua Yiyao Contract record no.: 2018990000185 Denomination of invention: Method for preparing 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-amine Granted publication date: 20171010 License type: Exclusive License Record date: 20180720 |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210805 Address after: 275 Edison Road, Pudong New Area, Shanghai Patentee after: Hua Medicine (Shanghai) Ltd. Address before: Greater Cayman, Cayman Islands Patentee before: Hua Yiyao |
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| EC01 | Cancellation of recordation of patent licensing contract | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: HUA MEDICINE (SHANGHAI) Ltd. Assignor: Hua Yiyao Contract record no.: 2018990000185 Date of cancellation: 20210908 |