RU2619869C2 - Композиция гидрокортизона с контролируемым высвобождением - Google Patents

Композиция гидрокортизона с контролируемым высвобождением Download PDF

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RU2619869C2
RU2619869C2 RU2014130866A RU2014130866A RU2619869C2 RU 2619869 C2 RU2619869 C2 RU 2619869C2 RU 2014130866 A RU2014130866 A RU 2014130866A RU 2014130866 A RU2014130866 A RU 2014130866A RU 2619869 C2 RU2619869 C2 RU 2619869C2
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composition
hydrocortisone
adrenal
delayed release
mass
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RU2014130866A
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Russian (ru)
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RU2014130866A (ru
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Хип ХЬЮТАН
Ричард Росс
Мартин УИТАКЕР
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Дайэрнал Лимитед
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
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    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2014130866A 2012-02-13 2013-02-12 Композиция гидрокортизона с контролируемым высвобождением RU2619869C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1202433.7 2012-02-13
GBGB1202433.7A GB201202433D0 (en) 2012-02-13 2012-02-13 Controlled drug release
US201261599704P 2012-02-16 2012-02-16
US61/599,704 2012-02-16
US201261600958P 2012-02-20 2012-02-20
US61/600,958 2012-02-20
PCT/GB2013/050311 WO2013121184A1 (en) 2012-02-13 2013-02-12 Hydrocortisone controlled release formulation

Publications (2)

Publication Number Publication Date
RU2014130866A RU2014130866A (ru) 2016-04-10
RU2619869C2 true RU2619869C2 (ru) 2017-05-18

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EP (1) EP2814469B1 (enExample)
JP (1) JP6293678B2 (enExample)
KR (1) KR102023559B1 (enExample)
CN (2) CN104105481A (enExample)
AU (1) AU2013220139B2 (enExample)
BR (1) BR112014020008B1 (enExample)
CA (1) CA2864031C (enExample)
CY (1) CY1123202T1 (enExample)
DK (1) DK2814469T3 (enExample)
ES (1) ES2792069T3 (enExample)
GB (2) GB201202433D0 (enExample)
HK (1) HK1203824A1 (enExample)
HR (1) HRP20200780T1 (enExample)
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IL (2) IL234061B (enExample)
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NZ (2) NZ715616A (enExample)
PL (1) PL2814469T3 (enExample)
PT (1) PT2814469T (enExample)
RS (1) RS60346B1 (enExample)
RU (1) RU2619869C2 (enExample)
SI (1) SI2814469T1 (enExample)
SM (1) SMT202000286T1 (enExample)
WO (1) WO2013121184A1 (enExample)
ZA (1) ZA201508728B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release
WO2016196687A1 (en) * 2015-06-01 2016-12-08 Massachusetts Institute Of Technology System and method for neuroendocrine control
FR3057775B1 (fr) * 2016-10-26 2018-11-02 Crossject Solution pharmaceutique d’hydrocortisone pour dispositif d’injection
KR101982287B1 (ko) * 2019-01-04 2019-05-24 (주)청아굿푸드 천연 추출물 함유 서방성 제제 및 그 제조방법
KR20230131916A (ko) 2021-01-15 2023-09-14 갈벤타 아게 박동성 방출 카페인 제제
US11904046B1 (en) 2022-11-14 2024-02-20 Eton Pharmaceuticals, Inc. Hydrocortisone oral liquid formulations
WO2025240605A1 (en) 2024-05-15 2025-11-20 Neurocrine Biosciences, Inc. Combination treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005065692A1 (en) * 2004-01-03 2005-07-21 University Of Sheffield Treatment
EA008224B1 (ru) * 2001-03-13 2007-04-27 Пенвест Фармасьютикалз Ко. Хронотерапевтические дозированные формы
EA200900259A1 (ru) * 2006-08-03 2009-06-30 Нитек Фарма Аг Лечение ревматоидного заболевания глюкокортикоидами с отсроченным высвобождением
WO2010032006A2 (en) * 2008-09-19 2010-03-25 Diurnal Limited Treatment of adrenal insufficiency
US20110189293A1 (en) * 2007-12-17 2011-08-04 CombinatoRx, Incoporated Therapeutic regimens for the treatment of immunoinflammatory disorders

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552872A (en) 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
JPS6013711A (ja) * 1983-06-21 1985-01-24 ザ、プロクタ−、エンド、ギヤンブル、カンパニ− コルチコステロイドを含有する浸透局所製薬組成物
GB2292079B (en) 1994-08-12 1998-07-15 Flexpharm Ltd Coated prednisolone preparation for the treatment of inflamatory bowel disease
IL139728A (en) * 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
US5686106A (en) 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery
ES2163000T3 (es) 1996-01-16 2002-01-16 Advanced Polymer Systems Inc Suministro topico de farmacos al tracto gastrointestinal inferior.
DE19718012C1 (de) 1997-04-29 1998-10-08 Jenapharm Gmbh Verfahren zur Herstellung peroral anwendbarer fester Arzneiformen mit gesteuerter Wirkstoffabgabe
US6066339A (en) 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
AU2000265525A1 (en) 2000-08-29 2002-03-13 Mepha Ag Medicament for treating intestinal diseases
IL160217A0 (en) 2001-08-06 2004-07-25 Euro Celtique Sa Compositions and methods to prevent abuse of opioids
GB0119848D0 (en) 2001-08-15 2001-10-10 Univ Sheffield Delayed and sustained drug release
AU2002226955B2 (en) 2001-11-23 2006-04-27 Allergan Pharmaceuticals International Limited Pharmaceutical dosage form with multiple coatings
DE602004028497D1 (de) 2003-09-15 2010-09-16 Nycomed Gmbh Verwendung von ciclesonid zur behandlung von entzündlichen darmerkrankungen
SE0401031D0 (sv) * 2004-04-22 2004-04-22 Duocort Ab A new glucocorticoid replacement therapy
AU2007321111A1 (en) 2006-11-17 2008-05-22 Da Volterra Colonic delivery using Zn/pectin beads with a Eudragit coating.
EP2143424A4 (en) 2007-03-26 2013-07-31 Teikoku Seiyaku Kk ORAL PHARMACEUTICAL PREPARATION FOR SPECIFIC DELIVERY TO THE COLON
NZ582836A (en) 2009-01-30 2011-06-30 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage
WO2010113177A2 (en) * 2009-03-31 2010-10-07 Reliance Life Sciences Pvt. Ltd. Oral insulin delivery systems for controlling diabetes
JP2012522816A (ja) * 2009-04-07 2012-09-27 デュオコート ファーマ エービー 改良されたグルココルチコイド療法
KR20120110098A (ko) 2009-11-16 2012-10-09 에보니크 룀 게엠베하 고형 (메트)아크릴레이트 공중합체를 분산제에 의해 분산된 형태로 전환시키는 방법
IT1405012B1 (it) 2010-08-06 2013-12-16 Sofar Spa Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008224B1 (ru) * 2001-03-13 2007-04-27 Пенвест Фармасьютикалз Ко. Хронотерапевтические дозированные формы
WO2005065692A1 (en) * 2004-01-03 2005-07-21 University Of Sheffield Treatment
US20070149493A1 (en) * 2004-01-03 2007-06-28 Richard Ross Sustained release hydrocortisone treatment
EA200900259A1 (ru) * 2006-08-03 2009-06-30 Нитек Фарма Аг Лечение ревматоидного заболевания глюкокортикоидами с отсроченным высвобождением
US20110189293A1 (en) * 2007-12-17 2011-08-04 CombinatoRx, Incoporated Therapeutic regimens for the treatment of immunoinflammatory disorders
WO2010032006A2 (en) * 2008-09-19 2010-03-25 Diurnal Limited Treatment of adrenal insufficiency

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HUE048904T2 (hu) 2020-08-28
CN110141557A (zh) 2019-08-20
IL234061A0 (en) 2014-09-30
MX2014009716A (es) 2015-01-14
CN104105481A (zh) 2014-10-15
CA2864031C (en) 2019-11-12
IL245546A0 (en) 2016-06-30
GB201302406D0 (en) 2013-03-27
SMT202000286T1 (it) 2020-07-08
JP2015506972A (ja) 2015-03-05
AU2013220139A1 (en) 2014-08-07
ME03742B (me) 2021-04-20
MX361407B (es) 2018-12-04
WO2013121184A1 (en) 2013-08-22
NZ627468A (en) 2016-02-26
RS60346B1 (sr) 2020-07-31
AU2013220139B2 (en) 2017-08-31
GB2502402A (en) 2013-11-27
BR112014020008A8 (pt) 2018-01-23
GB201202433D0 (en) 2012-03-28
ES2792069T3 (es) 2020-11-06
CY1123202T1 (el) 2021-10-29
HK1203824A1 (en) 2015-11-06
IN2014DN06808A (enExample) 2015-05-22
PL2814469T3 (pl) 2020-07-13
EP2814469B1 (en) 2020-04-08
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ZA201508728B (en) 2017-09-27
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IL234061B (en) 2018-03-29
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