DK2814469T3 - Hydrocortisonformulering med controlled release - Google Patents
Hydrocortisonformulering med controlled release Download PDFInfo
- Publication number
- DK2814469T3 DK2814469T3 DK13709499.1T DK13709499T DK2814469T3 DK 2814469 T3 DK2814469 T3 DK 2814469T3 DK 13709499 T DK13709499 T DK 13709499T DK 2814469 T3 DK2814469 T3 DK 2814469T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrocortison
- formulation
- controlled release
- release
- controlled
- Prior art date
Links
- JYGXADMDTFJGBT-VWUMJDOOSA-N Hydrocortisone Natural products O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
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-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1202433.7A GB201202433D0 (en) | 2012-02-13 | 2012-02-13 | Controlled drug release |
| US201261599704P | 2012-02-16 | 2012-02-16 | |
| US201261600958P | 2012-02-20 | 2012-02-20 | |
| PCT/GB2013/050311 WO2013121184A1 (en) | 2012-02-13 | 2013-02-12 | Hydrocortisone controlled release formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2814469T3 true DK2814469T3 (da) | 2020-05-04 |
Family
ID=45930017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13709499.1T DK2814469T3 (da) | 2012-02-13 | 2013-02-12 | Hydrocortisonformulering med controlled release |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US9750704B2 (da) |
| EP (1) | EP2814469B1 (da) |
| JP (1) | JP6293678B2 (da) |
| KR (1) | KR102023559B1 (da) |
| CN (2) | CN110141557A (da) |
| AU (1) | AU2013220139B2 (da) |
| BR (1) | BR112014020008B1 (da) |
| CA (1) | CA2864031C (da) |
| CY (1) | CY1123202T1 (da) |
| DK (1) | DK2814469T3 (da) |
| ES (1) | ES2792069T3 (da) |
| GB (2) | GB201202433D0 (da) |
| HK (1) | HK1203824A1 (da) |
| HR (1) | HRP20200780T1 (da) |
| HU (1) | HUE048904T2 (da) |
| IL (2) | IL234061B (da) |
| IN (1) | IN2014DN06808A (da) |
| LT (1) | LT2814469T (da) |
| ME (1) | ME03742B (da) |
| MX (1) | MX361407B (da) |
| NZ (2) | NZ627468A (da) |
| PL (1) | PL2814469T3 (da) |
| PT (1) | PT2814469T (da) |
| RS (1) | RS60346B1 (da) |
| RU (1) | RU2619869C2 (da) |
| SI (1) | SI2814469T1 (da) |
| WO (1) | WO2013121184A1 (da) |
| ZA (1) | ZA201508728B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201202433D0 (en) | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
| WO2016196687A1 (en) * | 2015-06-01 | 2016-12-08 | Massachusetts Institute Of Technology | System and method for neuroendocrine control |
| FR3057775B1 (fr) * | 2016-10-26 | 2018-11-02 | Crossject | Solution pharmaceutique d’hydrocortisone pour dispositif d’injection |
| KR101982287B1 (ko) * | 2019-01-04 | 2019-05-24 | (주)청아굿푸드 | 천연 추출물 함유 서방성 제제 및 그 제조방법 |
| US20240316057A1 (en) | 2021-01-15 | 2024-09-26 | Galventa Ag | Pulsatile release caffeine formulation |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4552872A (en) | 1983-06-21 | 1985-11-12 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing corticosteroids |
| JPS6013711A (ja) * | 1983-06-21 | 1985-01-24 | ザ、プロクタ−、エンド、ギヤンブル、カンパニ− | コルチコステロイドを含有する浸透局所製薬組成物 |
| GB2292079B (en) | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
| IL139728A (en) * | 1995-01-09 | 2003-06-24 | Penwest Pharmaceuticals Compan | Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient |
| US5686106A (en) | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
| AU710109B2 (en) | 1996-01-16 | 1999-09-16 | Ap Pharma, Inc. | Topical delivery of drugs to the lower gastrointestinal tract |
| DE19718012C1 (de) | 1997-04-29 | 1998-10-08 | Jenapharm Gmbh | Verfahren zur Herstellung peroral anwendbarer fester Arzneiformen mit gesteuerter Wirkstoffabgabe |
| US6066339A (en) * | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
| DE50013843D1 (de) * | 2000-08-29 | 2007-01-18 | Mepha Ag | Arzneimittel zur behandlung von darmerkrankungen |
| US20030190360A1 (en) * | 2001-03-13 | 2003-10-09 | Baichwal Anand R. | Chronotherapeutic dosage forms containing glucocorticosteroid and methods of treatment |
| KR20040025741A (ko) | 2001-08-06 | 2004-03-25 | 유로-셀티크 소시에떼 아노뉨 | 오피오이드 남용을 방지하기 위한 조성물 및 방법 |
| GB0119848D0 (en) | 2001-08-15 | 2001-10-10 | Univ Sheffield | Delayed and sustained drug release |
| HU231030B1 (hu) | 2001-11-23 | 2019-12-30 | Warner Chilcott Company, Llc | Többszörös bevonattal ellátott gyógyszer dózisforma |
| CA2538202C (en) | 2003-09-15 | 2013-01-15 | Altana Pharma Ag | Use of ciclesonide for the treatment of inflammatory bowel diseases |
| GB0400031D0 (en) * | 2004-01-03 | 2004-02-04 | Univ Sheffield | Depression treatment |
| SE0401031D0 (sv) | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
| PT2049123E (pt) * | 2006-08-03 | 2013-03-06 | Horizon Pharma Ag | Tratamento de doença reumatóide com glucocorticóide de libertação retardada |
| BRPI0719319A2 (pt) | 2006-11-17 | 2014-02-04 | Da Volterra | Liberação colônica usando contas de zn/pectina com um revestimento de eudragit |
| US20100209520A1 (en) | 2007-03-26 | 2010-08-19 | Hiroyuki Kubo | Oral pharmaceutical preparation for colon-specific delivery |
| NZ586332A (en) * | 2007-12-17 | 2012-07-27 | Zalicus Inc | Therapeutic regimens for the treatment of immunoinflammatory disorders using dipyridamole and prednisolone |
| GB0817120D0 (en) | 2008-09-19 | 2008-10-29 | Diurnal Ltd | Treatment of adrenal insufficiency |
| NZ582836A (en) * | 2009-01-30 | 2011-06-30 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage |
| WO2010113177A2 (en) | 2009-03-31 | 2010-10-07 | Reliance Life Sciences Pvt. Ltd. | Oral insulin delivery systems for controlling diabetes |
| SG174583A1 (en) * | 2009-04-07 | 2011-10-28 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| EP2501368B1 (en) | 2009-11-16 | 2018-04-18 | Evonik Röhm GmbH | A process for converting a solid (meth)acrylate copolymer into a dispersed form by means of a dispersing agent |
| IT1405012B1 (it) * | 2010-08-06 | 2013-12-16 | Sofar Spa | Composizioni di beclometasone dipropionato in microsfere gastroresistenti a rilascio modificato e processo per il loro ottenimento |
| GB201202433D0 (en) | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
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2012
- 2012-02-13 GB GBGB1202433.7A patent/GB201202433D0/en not_active Ceased
-
2013
- 2013-02-12 CA CA2864031A patent/CA2864031C/en active Active
- 2013-02-12 ES ES13709499T patent/ES2792069T3/es active Active
- 2013-02-12 WO PCT/GB2013/050311 patent/WO2013121184A1/en active Application Filing
- 2013-02-12 MX MX2014009716A patent/MX361407B/es active IP Right Grant
- 2013-02-12 GB GB1302406.2A patent/GB2502402B/en active Active
- 2013-02-12 US US14/374,179 patent/US9750704B2/en active Active
- 2013-02-12 PT PT137094991T patent/PT2814469T/pt unknown
- 2013-02-12 HU HUE13709499A patent/HUE048904T2/hu unknown
- 2013-02-12 IN IN6808DEN2014 patent/IN2014DN06808A/en unknown
- 2013-02-12 BR BR112014020008-4A patent/BR112014020008B1/pt active IP Right Grant
- 2013-02-12 SI SI201331723T patent/SI2814469T1/sl unknown
- 2013-02-12 KR KR1020147025024A patent/KR102023559B1/ko active IP Right Grant
- 2013-02-12 EP EP13709499.1A patent/EP2814469B1/en active Active
- 2013-02-12 RU RU2014130866A patent/RU2619869C2/ru active
- 2013-02-12 NZ NZ627468A patent/NZ627468A/en unknown
- 2013-02-12 CN CN201910452557.1A patent/CN110141557A/zh active Pending
- 2013-02-12 RS RS20200578A patent/RS60346B1/sr unknown
- 2013-02-12 JP JP2014556141A patent/JP6293678B2/ja active Active
- 2013-02-12 CN CN201380008921.6A patent/CN104105481A/zh active Pending
- 2013-02-12 LT LTEP13709499.1T patent/LT2814469T/lt unknown
- 2013-02-12 ME MEP-2020-122A patent/ME03742B/me unknown
- 2013-02-12 NZ NZ715616A patent/NZ715616A/en unknown
- 2013-02-12 DK DK13709499.1T patent/DK2814469T3/da active
- 2013-02-12 PL PL13709499T patent/PL2814469T3/pl unknown
- 2013-02-12 AU AU2013220139A patent/AU2013220139B2/en active Active
-
2014
- 2014-08-11 IL IL234061A patent/IL234061B/en active IP Right Grant
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2015
- 2015-05-06 HK HK15104320.6A patent/HK1203824A1/xx unknown
- 2015-11-30 ZA ZA2015/08728A patent/ZA201508728B/en unknown
-
2016
- 2016-05-09 IL IL245546A patent/IL245546A0/en unknown
-
2017
- 2017-07-05 US US15/641,650 patent/US10166194B2/en active Active
-
2020
- 2020-05-06 CY CY20201100418T patent/CY1123202T1/el unknown
- 2020-05-13 HR HRP20200780TT patent/HRP20200780T1/hr unknown
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