RU2604809C2 - Аналоги паратиреоидного гормона и их применение - Google Patents
Аналоги паратиреоидного гормона и их применение Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/37—Parathyroid hormone [PTH]
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33431910P | 2010-05-13 | 2010-05-13 | |
| US61/334,319 | 2010-05-13 | ||
| US41514110P | 2010-11-18 | 2010-11-18 | |
| US61/415,141 | 2010-11-18 | ||
| PCT/US2011/036222 WO2011143406A2 (en) | 2010-05-13 | 2011-05-12 | Parathyroid hormone analogs and uses thereof |
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| Publication Number | Publication Date |
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| RU2012153768A RU2012153768A (ru) | 2014-06-20 |
| RU2604809C2 true RU2604809C2 (ru) | 2016-12-10 |
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| RU2012153768/10A RU2604809C2 (ru) | 2010-05-13 | 2011-05-12 | Аналоги паратиреоидного гормона и их применение |
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| US (1) | US9492508B2 (enExample) |
| EP (1) | EP2569003B1 (enExample) |
| JP (1) | JP5941040B2 (enExample) |
| KR (1) | KR101900078B1 (enExample) |
| CN (1) | CN103002906B (enExample) |
| BR (1) | BR112012028949B1 (enExample) |
| MX (1) | MX358161B (enExample) |
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| RU2806753C2 (ru) * | 2018-05-18 | 2023-11-07 | Асцендис Фарма Боун Дизизис А/С | Способ лечения или контроля гипопаратиреоза с помощью конъюгата паратиреоидного гормона (ртн) |
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| SI3423103T1 (sl) | 2016-03-01 | 2024-12-31 | Ascendis Pharma Bone Diseases A/S | Predzdravila PTH |
| KR102611820B1 (ko) | 2016-09-29 | 2023-12-07 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
| JP7039574B2 (ja) | 2016-09-29 | 2022-03-22 | アセンディス ファーマ ボーン ディジージズ エー／エス | 放出制御ｐｔｈ化合物の漸増用量設定 |
| HUE063235T2 (hu) | 2016-09-29 | 2024-01-28 | Ascendis Pharma Bone Diseases As | Adagolási rendszer szabályozott leadású PTH vegyülethez |
| GB201706781D0 (en) * | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| EP3655104A4 (en) | 2017-07-15 | 2021-03-17 | The Regents of the University of California | OSTEOADSORPTIVE FLUOROGENIC SUBSTRATE FROM CATHEPSIN K FOR IMAGING OSTEOCLAST ACTIVITY AND MIGRATION |
| US11975050B2 (en) | 2018-03-16 | 2024-05-07 | The General Hospital Corporation | Parathyroid hormone polypeptide conjugates and methods of their use |
| AU2020221491B2 (en) | 2019-02-11 | 2025-02-27 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of PTH conjugates |
| WO2021030196A1 (en) * | 2019-08-09 | 2021-02-18 | Phasebio Pharmaceuticals, Inc. | Elp fusion proteins comprising parathyroid hormone for controlled and sustained release |
| US12344649B2 (en) | 2019-08-09 | 2025-07-01 | Flagship Pioneering Innovations Vi, Llc | Modulators of parathyroid hormone receptor (PTHR1) |
| JP2023510790A (ja) * | 2020-01-13 | 2023-03-15 | アセンディス ファーマ ボーン ディジージズ エー／エス | 副甲状腺機能低下症の治療 |
| IL301411A (en) * | 2020-09-28 | 2023-05-01 | Ascendis Pharma Bone Diseases As | Improvement of physical and mental well-being of patients with hypoparathyroidism |
| CN116847870A (zh) * | 2020-09-28 | 2023-10-03 | 阿森迪斯药物骨疾病股份有限公司 | 甲状旁腺功能减退症患者身体及心理健康的改善 |
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| JP2025537527A (ja) | 2022-11-02 | 2025-11-18 | アセンディス ファーマ ボーン ディジージズ エー／エス | ２つのｐｔｈ化合物を含むｐｔｈ治療レジメン |
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| AU2005287139A1 (en) | 2004-09-16 | 2006-03-30 | Osteotrophin Llc | Treatment of bone disorders with skeletal anabolic drugs |
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- 2011-05-12 CN CN201180023887.0A patent/CN103002906B/zh active Active
- 2011-05-12 WO PCT/US2011/036222 patent/WO2011143406A2/en not_active Ceased
- 2011-05-12 RU RU2012153768/10A patent/RU2604809C2/ru active
- 2011-05-12 KR KR1020127032010A patent/KR101900078B1/ko active Active
- 2011-05-12 EP EP11781266.9A patent/EP2569003B1/en active Active
- 2011-05-12 US US13/697,249 patent/US9492508B2/en active Active
- 2011-05-12 MX MX2012013232A patent/MX358161B/es active IP Right Grant
- 2011-05-12 JP JP2013510293A patent/JP5941040B2/ja active Active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2806753C2 (ru) * | 2018-05-18 | 2023-11-07 | Асцендис Фарма Боун Дизизис А/С | Способ лечения или контроля гипопаратиреоза с помощью конъюгата паратиреоидного гормона (ртн) |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012013232A (es) | 2013-05-01 |
| EP2569003A4 (en) | 2013-11-27 |
| WO2011143406A3 (en) | 2011-12-22 |
| US9492508B2 (en) | 2016-11-15 |
| CN103002906B (zh) | 2017-12-29 |
| KR101900078B1 (ko) | 2018-09-18 |
| US20130116180A1 (en) | 2013-05-09 |
| RU2012153768A (ru) | 2014-06-20 |
| BR112012028949B1 (pt) | 2020-11-17 |
| EP2569003A2 (en) | 2013-03-20 |
| MX358161B (es) | 2018-08-06 |
| KR20140031778A (ko) | 2014-03-13 |
| JP2013526864A (ja) | 2013-06-27 |
| WO2011143406A2 (en) | 2011-11-17 |
| CN103002906A (zh) | 2013-03-27 |
| EP2569003B1 (en) | 2017-10-25 |
| JP5941040B2 (ja) | 2016-06-29 |
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