RU2544856C2 - НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents
НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ Download PDFInfo
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- RU2544856C2 RU2544856C2 RU2008102993/04A RU2008102993A RU2544856C2 RU 2544856 C2 RU2544856 C2 RU 2544856C2 RU 2008102993/04 A RU2008102993/04 A RU 2008102993/04A RU 2008102993 A RU2008102993 A RU 2008102993A RU 2544856 C2 RU2544856 C2 RU 2544856C2
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- 0 *C1C=CC(N)=CC1 Chemical compound *C1C=CC(N)=CC1 0.000 description 3
- VRJHQPZVIGNGMX-UHFFFAOYSA-O O=C1CC[NH2+]CC1 Chemical compound O=C1CC[NH2+]CC1 VRJHQPZVIGNGMX-UHFFFAOYSA-O 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Oncology (AREA)
- Pulmonology (AREA)
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- Immunology (AREA)
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Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008102993/04A RU2544856C2 (ru) | 2008-01-25 | 2008-01-25 | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
PCT/US2009/032065 WO2009094668A1 (en) | 2008-01-25 | 2009-01-26 | New 2,3,4,5-terahydro-1h-pyrido[ 4,3-b] indole compounds and methods of use thereof |
EP09704753.4A EP2244708B1 (en) | 2008-01-25 | 2009-01-26 | New 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole compounds and methods of use thereof |
BRPI0905783A BRPI0905783A2 (pt) | 2008-01-25 | 2009-01-26 | Composto, método pata travar uma perturbação cognitiva, perturbação psicótica, perturbação mediada por neurotransmissor ou uma perturbação neuronal em um indivíduo, composição farmacêutica e kit |
CA2713997A CA2713997A1 (en) | 2008-01-25 | 2009-01-26 | New 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole compounds and methods of use thereof |
PE2009000103A PE20091435A1 (es) | 2008-01-25 | 2009-01-26 | Compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol como moduladores del receptor de histamina |
CL2009000161A CL2009000161A1 (es) | 2008-01-25 | 2009-01-26 | Compuestos derivados de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol; composicion farmaceutica que los comprende; uso en el tratamiento de trastornos neurodegenerativos, cognitivos o psicoticos, enfermedad de alzheimer, entre otros; y un kit que contiene a los compuestos. |
JP2010544471A JP2011510932A (ja) | 2008-01-25 | 2009-01-26 | 新規2,3,4,5−テトラヒドロ−1H−ピリド[4,3−b]インドール化合物およびその使用方法 |
US12/360,061 US9115137B2 (en) | 2008-01-25 | 2009-01-26 | 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof |
UY031614A UY31614A1 (es) | 2008-01-25 | 2009-01-26 | Nuevos compuestos de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol y métodos de uso de los mismos. |
CN200980110565.2A CN101983059B (zh) | 2008-01-25 | 2009-01-26 | 2,3,4,5- 四氢 -1h- 吡啶并 [4,3-b] 吲哚化合物及其使用方法 |
AU2009206246A AU2009206246C1 (en) | 2008-01-25 | 2009-01-26 | New 2,3,4,5-tetrahydro-1H-pyrido[ 4,3-b] indole compounds and methods of use thereof |
ARP090100234A AR072042A1 (es) | 2008-01-25 | 2009-01-26 | Compuestos de 2,3,4,5-tetrahidro-1h-pirido(4,3-b)indol y metodos de uso de los mismos |
HK11104402.1A HK1150388A1 (zh) | 2008-01-25 | 2011-05-03 | 新型 -四氫- -吡啶並 吲哚化合物以及使用它們的方法 |
HK11108641.3A HK1154490A1 (zh) | 2008-01-25 | 2011-08-16 | -四氫- -吡啶並 吲哚化合物及其使用方法 |
US13/789,604 US20130190347A1 (en) | 2008-01-25 | 2013-03-07 | 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole compounds and methods of use thereof |
US13/791,835 US20130190348A1 (en) | 2008-01-25 | 2013-03-08 | New 2,3,4,5-tetrahydro-1h-pyrido [4,3-b] indole compounds and methods of use thereof |
JP2014046474A JP5666036B2 (ja) | 2008-01-25 | 2014-03-10 | 新規2,3,4,5−テトラヒドロ−1H−ピリド[4,3−b]インドール化合物およびその使用方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008102993/04A RU2544856C2 (ru) | 2008-01-25 | 2008-01-25 | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2008102993A RU2008102993A (ru) | 2009-07-27 |
RU2544856C2 true RU2544856C2 (ru) | 2015-03-20 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008102993/04A RU2544856C2 (ru) | 2008-01-25 | 2008-01-25 | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
Country Status (13)
Country | Link |
---|---|
US (3) | US9115137B2 (zh) |
EP (1) | EP2244708B1 (zh) |
JP (1) | JP2011510932A (zh) |
CN (1) | CN101983059B (zh) |
AR (1) | AR072042A1 (zh) |
AU (1) | AU2009206246C1 (zh) |
BR (1) | BRPI0905783A2 (zh) |
CA (1) | CA2713997A1 (zh) |
CL (1) | CL2009000161A1 (zh) |
PE (1) | PE20091435A1 (zh) |
RU (1) | RU2544856C2 (zh) |
UY (1) | UY31614A1 (zh) |
WO (1) | WO2009094668A1 (zh) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2007139634A (ru) * | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
RU2544856C2 (ru) | 2008-01-25 | 2015-03-20 | Сергей Олегович Бачурин | НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
CL2009000724A1 (es) | 2008-03-24 | 2009-05-29 | Medivation Technologies Inc | Compuestos derivados de 1,2,3,4-tetrahidro-pirido[3,4-b]indol, moduladores del receptor de histamina, serotonina y dopamina; composicion farmaceutica; kit farmaceutico; y uso para tratar un trastorno cognitivo, psicotico, mediado por neurotransmisores y/o neurologico. |
CA2718790A1 (en) | 2008-03-24 | 2009-10-01 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
EP2346332A4 (en) * | 2008-10-31 | 2012-08-08 | Medivation Technologies Inc | PYRIDOÝ4,3-BINDOLES CONTAINING RIGID FRAGMENTS |
AR073924A1 (es) * | 2008-10-31 | 2010-12-09 | Medivation Technologies Inc | Azepino[4, 5-b]indoles, una composicion farmaceutica y kits que los comprenden y su uso en la modulacion de un receptor de histamina. |
US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9095572B2 (en) * | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US8604074B2 (en) | 2009-01-09 | 2013-12-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
CA2752073A1 (en) * | 2009-02-11 | 2010-08-19 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
EP2424366B1 (en) | 2009-04-29 | 2016-02-17 | Medivation Technologies, Inc. | Pyrido [4, 3-b]indoles and methods of use |
CN102480955B (zh) | 2009-04-29 | 2015-08-05 | 梅迪维新技术公司 | 吡啶并[4,3-b]吲哚类和使用方法 |
WO2011031816A2 (en) * | 2009-09-11 | 2011-03-17 | Sepracor Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
WO2011038164A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
JP5779183B2 (ja) | 2009-09-23 | 2015-09-16 | メディベイション テクノロジーズ, インコーポレイテッド | ピリド[4,3−b]インドールおよび使用方法 |
AU2010298168B2 (en) | 2009-09-23 | 2015-11-19 | Medivation Technologies, Inc. | Pyrido(3,4-b)indoles and methods of use |
EP2480079A4 (en) * | 2009-09-23 | 2015-04-08 | Medivation Technologies Inc | PYRIDO- (3,4-B-) INDOLE AND USE METHOD THEREFOR |
US20130172320A1 (en) * | 2010-02-18 | 2013-07-04 | Sarvajit Chakravarty | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103433A1 (en) | 2010-02-18 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
WO2011103448A1 (en) * | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Methods and compositions for treating psychotic disorders using antipsychotic combination therapy |
WO2011103430A1 (en) * | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
EP2630682A4 (en) * | 2010-10-22 | 2014-10-01 | Commw Scient Ind Res Org | ORGANIC ELECTROLUMINESCENCE DEVICE |
US20140303144A1 (en) | 2011-02-18 | 2014-10-09 | Medivation Technologies, Inc. | Compounds and methods of treating hypertension |
WO2012112963A1 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
IN2013MN01699A (zh) | 2011-02-18 | 2015-06-12 | Medivation Technologies Inc | |
WO2012112964A2 (en) | 2011-02-18 | 2012-08-23 | Medivation Technologies, Inc. | PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE |
WO2014031986A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
EP2925129A4 (en) * | 2012-08-24 | 2016-06-08 | Univ Texas | PRO-NEUROGENIC COMPOUNDS |
WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
EP3148543B1 (en) * | 2014-05-30 | 2020-04-08 | Icahn School of Medicine at Mount Sinai | Small molecule transcription modulators of bromodomains |
JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
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CN111087399A (zh) * | 2019-12-24 | 2020-05-01 | 温州大学新材料与产业技术研究院 | 一种吲哚稠合的七元内酰胺化合物的制备方法 |
WO2021222150A2 (en) | 2020-04-28 | 2021-11-04 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
EP4216949A1 (en) * | 2020-09-28 | 2023-08-02 | Yale University | Selective agonists of 5-ht2a receptor and methods of use |
WO2023141225A1 (en) * | 2022-01-19 | 2023-07-27 | Onsero Therapeutics Inc. | Fused heterocycles as 5-ht2a receptor agonists |
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CA2713997A1 (en) | 2009-07-30 |
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EP2244708A4 (en) | 2012-01-04 |
JP2011510932A (ja) | 2011-04-07 |
EP2244708B1 (en) | 2015-01-14 |
UY31614A1 (es) | 2009-08-31 |
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CL2009000161A1 (es) | 2009-09-25 |
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