RU2524341C2 - Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора - Google Patents

Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора Download PDF

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RU2524341C2
RU2524341C2 RU2012137489/04A RU2012137489A RU2524341C2 RU 2524341 C2 RU2524341 C2 RU 2524341C2 RU 2012137489/04 A RU2012137489/04 A RU 2012137489/04A RU 2012137489 A RU2012137489 A RU 2012137489A RU 2524341 C2 RU2524341 C2 RU 2524341C2
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dihydro
diazaspiro
inden
acetyl
nonane
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RU2012137489/04A
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RU2012137489A (ru
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Самит Кумар Бхаттачарья
Кимберли О'Киф КЭМЕРОН
Дилини Прасадини ФЕРНАНДО
Дэниел Вей-Шун КАН
Эллин Тимоти ЛОНДРЕГАН
Ким Фрэнсис Макклюр
Суви Туула Марьюкка СИМИЛА
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Пфайзер Инк.
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D491/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2012137489/04A 2010-03-19 2011-03-11 Производные 2,3-дигидро-1н-инден-1-ил-2,7-диазаспиро[3.5]нонана и их применение в качестве антагонистов или обратных агонистов грелинового рецептора RU2524341C2 (ru)

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Application Number Priority Date Filing Date Title
US31552210P 2010-03-19 2010-03-19
US61/315,522 2010-03-19
US201161444401P 2011-02-18 2011-02-18
US61/444,401 2011-02-18
PCT/IB2011/051035 WO2011114271A1 (en) 2010-03-19 2011-03-11 2,3 dihydro-1h-inden-1-yl- 2,7-diazaspiro [3.6] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor

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RU2012137489A RU2012137489A (ru) 2014-04-27
RU2524341C2 true RU2524341C2 (ru) 2014-07-27

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WO2011114271A8 (en) 2012-11-08
JP5496409B2 (ja) 2014-05-21
BR112012023664B1 (pt) 2020-01-28
IL221952A (en) 2016-02-29
SG183812A1 (en) 2012-10-30
WO2011114271A1 (en) 2011-09-22
MX2012010772A (es) 2012-11-06
TW201144312A (en) 2011-12-16
US20110230461A1 (en) 2011-09-22
RS54383B1 (sr) 2016-04-28
CA2792234C (en) 2014-05-27
ME02330B (me) 2016-06-20
HK1182094A1 (zh) 2013-11-22
AR080688A1 (es) 2012-05-02
US8609680B2 (en) 2013-12-17
CA2792234A1 (en) 2011-09-22
AU2011228699A1 (en) 2012-09-20
SI2547679T1 (sl) 2015-12-31
AU2011228699B2 (en) 2016-05-19
RU2012137489A (ru) 2014-04-27
ES2557895T3 (es) 2016-01-29
DK2547679T3 (en) 2016-01-11
KR20130001276A (ko) 2013-01-03
JP2013522354A (ja) 2013-06-13
PT2547679E (pt) 2016-01-27
CY1118721T1 (el) 2017-07-12
US20140080756A1 (en) 2014-03-20
HRP20151232T1 (hr) 2015-12-18
TWI410423B (zh) 2013-10-01
PL2547679T3 (pl) 2016-02-29
EP2547679A1 (en) 2013-01-23
PH12012501800A1 (en) 2012-12-10
KR101455917B1 (ko) 2014-11-03
EP2547679B1 (en) 2015-11-04
HUE025774T2 (en) 2016-05-30
BR112012023664A2 (pt) 2016-08-16
CN102939290A (zh) 2013-02-20

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