RU2497507C2 - Ингаляционные фармацевтические композиции в форме сухих порошков, растворов или суспензий, полученных из них, и способ их получения - Google Patents
Ингаляционные фармацевтические композиции в форме сухих порошков, растворов или суспензий, полученных из них, и способ их получения Download PDFInfo
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- RU2497507C2 RU2497507C2 RU2008120018/15A RU2008120018A RU2497507C2 RU 2497507 C2 RU2497507 C2 RU 2497507C2 RU 2008120018/15 A RU2008120018/15 A RU 2008120018/15A RU 2008120018 A RU2008120018 A RU 2008120018A RU 2497507 C2 RU2497507 C2 RU 2497507C2
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- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| ITMI2005A001999 | 2005-10-21 | ||
| ITMI20051999 ITMI20051999A1 (it) | 2005-10-21 | 2005-10-21 | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| PCT/EP2006/067619 WO2007045689A2 (en) | 2005-10-21 | 2006-10-20 | Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions |
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| RU2008120018A RU2008120018A (ru) | 2009-11-27 |
| RU2497507C2 true RU2497507C2 (ru) | 2013-11-10 |
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Country Status (13)
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| US (1) | US9138407B2 (https=) |
| EP (1) | EP1937229B1 (https=) |
| JP (1) | JP5873616B2 (https=) |
| CY (1) | CY1116503T1 (https=) |
| DK (1) | DK1937229T3 (https=) |
| ES (1) | ES2537777T3 (https=) |
| HU (1) | HUE026045T2 (https=) |
| IT (1) | ITMI20051999A1 (https=) |
| PL (1) | PL1937229T3 (https=) |
| PT (1) | PT1937229E (https=) |
| RU (1) | RU2497507C2 (https=) |
| SI (1) | SI1937229T1 (https=) |
| WO (1) | WO2007045689A2 (https=) |
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|---|---|---|---|---|
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| JP5570996B2 (ja) | 2007-12-14 | 2014-08-13 | エアロデザインズ インコーポレイテッド | エアロゾル化可能な食料品の送達 |
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| FI4188327T3 (fi) * | 2020-07-31 | 2025-07-25 | Chemo Res S L | Yhdistelmähoito inhalaatioannosteluun |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2237661C2 (ru) * | 1996-09-06 | 2004-10-10 | Аста Медика Акциенгезельшафт | N-замещенные индол-3-глиоксиламиды и лекарственный препарат, обладающие противоастматическим, противоаллергическим и иммунодепрессивным/иммуномодуляторным действием, способ получения соединений(варианты) и способ получения лекарственного препарата |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3009598B2 (ja) * | 1994-02-18 | 2000-02-14 | 武田薬品工業株式会社 | プレフィルドシリンジ |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| CN1169520C (zh) | 1997-09-29 | 2004-10-06 | 耐科塔医药公司 | 多孔微粒及其使用方法 |
| CA2336139C (en) | 1998-06-24 | 2008-10-14 | Advanced Inhalation Research, Inc. | Large porous particles emitted from an inhaler |
| AU763041B2 (en) | 1999-08-25 | 2003-07-10 | Alkermes, Inc. | Modulation of release from dry powder formulations |
| DE60025019T2 (de) | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| GB9929486D0 (en) | 1999-12-15 | 2000-02-09 | Glaxo Group Ltd | Inhalation delivery apparatus and method |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| CA2413692C (en) * | 2000-06-27 | 2011-10-18 | Vectura Limited | Method of making particles for use in a pharmaceutical composition |
| PT1296651E (pt) | 2000-06-27 | 2008-02-12 | Vectura Ltd | Método para fazer partículas para serem usadas numa composição farmacêutica |
| US20020103139A1 (en) * | 2000-12-01 | 2002-08-01 | M. Weisspapir | Solid self-emulsifying controlled release drug delivery system composition for enhanced delivery of water insoluble phytosterols and other hydrophobic natural compounds for body weight and cholestrol level control |
| US20110123574A1 (en) * | 2002-03-20 | 2011-05-26 | Alkermes, Inc. | Inhalable sustained therapeutic formulations |
| EP1487411B1 (en) | 2002-03-20 | 2019-01-02 | Civitas Therapeutics, Inc. | Inhalable sustained therapeutic formulations |
| WO2004002551A2 (en) | 2002-06-28 | 2004-01-08 | Advanced Inhalation Research, Inc. | Inhalable epinephrine |
| WO2004030659A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
| TR200502522T2 (tr) * | 2002-12-31 | 2005-09-21 | Nektar Therapeutics | Çözünmez bir aktif madde içeren farmasötik formülasyon |
| JP2006522634A (ja) | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| NZ545484A (en) * | 2003-09-15 | 2009-09-25 | Vectura Ltd | Pharmaceutical compositions for treating premature ejaculation by pulmonary inhalation |
| EP1663164A2 (en) | 2003-09-15 | 2006-06-07 | Vectura Limited | Methods for preparing pharmaceutical compositions |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| ITMI20040795A1 (it) | 2004-04-23 | 2004-07-23 | Eratech S R L | Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa |
-
2005
- 2005-10-21 IT ITMI20051999 patent/ITMI20051999A1/it unknown
-
2006
- 2006-10-20 HU HUE06807435A patent/HUE026045T2/hu unknown
- 2006-10-20 PT PT68074350T patent/PT1937229E/pt unknown
- 2006-10-20 DK DK06807435.0T patent/DK1937229T3/da active
- 2006-10-20 SI SI200631930T patent/SI1937229T1/sl unknown
- 2006-10-20 US US12/090,899 patent/US9138407B2/en active Active
- 2006-10-20 ES ES06807435.0T patent/ES2537777T3/es active Active
- 2006-10-20 WO PCT/EP2006/067619 patent/WO2007045689A2/en not_active Ceased
- 2006-10-20 PL PL06807435T patent/PL1937229T3/pl unknown
- 2006-10-20 EP EP06807435.0A patent/EP1937229B1/en active Active
- 2006-10-20 JP JP2008536060A patent/JP5873616B2/ja active Active
- 2006-10-20 RU RU2008120018/15A patent/RU2497507C2/ru not_active Application Discontinuation
-
2015
- 2015-06-10 CY CY20151100506T patent/CY1116503T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2237661C2 (ru) * | 1996-09-06 | 2004-10-10 | Аста Медика Акциенгезельшафт | N-замещенные индол-3-глиоксиламиды и лекарственный препарат, обладающие противоастматическим, противоаллергическим и иммунодепрессивным/иммуномодуляторным действием, способ получения соединений(варианты) и способ получения лекарственного препарата |
Non-Patent Citations (1)
| Title |
|---|
| Young PM., et al. The development of a novel high-dose pressurized aerosol dry-powder device (PADD) for the delivery of pumactant for inhalation therapy. J Aerosol Med. 2004 Summer; 17(2): 123-8. * |
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| RU2539374C1 (ru) * | 2013-11-29 | 2015-01-20 | Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) | Высокодисперсная комбинированная фармацевтическая композиция беклометазона и сальбутамола с бета-глицином и способ ее получения |
| RU2729043C2 (ru) * | 2015-10-20 | 2020-08-04 | Б. Браун Мельзунген Аг | Водная композиция, содержащая дантролен |
| US11844782B2 (en) | 2015-10-20 | 2023-12-19 | Spepharm Ag | Aqueous composition comprising dantrolene |
| RU2741309C2 (ru) * | 2016-06-30 | 2021-01-25 | Филип Моррис Продактс С.А. | Никотиносодержащие частицы |
| US11458093B2 (en) | 2016-06-30 | 2022-10-04 | Philip Morris Products S.A. | Nicotine particles |
| US12048762B2 (en) | 2016-06-30 | 2024-07-30 | Philip Morris Products S.A. | Nicotine particles |
| RU2770039C2 (ru) * | 2017-03-07 | 2022-04-14 | Филип Моррис Продактс С.А. | Вдыхаемые составы на основе никотина и способы их получения и применения |
| WO2020150685A1 (en) * | 2019-01-18 | 2020-07-23 | Milne Iii Donald A | Micronized aspirin formulation |
| RU2730488C1 (ru) * | 2019-08-20 | 2020-08-24 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) | Фармацевтическая композиция на основе глюкокортикостероида будесонида и фосфатидилхолина для сухой ингаляции |
| RU2735502C1 (ru) * | 2020-01-09 | 2020-11-03 | Федеральное государственное бюджетное учреждение науки Удмуртский федеральный исследовательский центр Уральского отделения Российской академии наук | Аэрозоль для ингаляций при обструктивном бронхите |
Also Published As
| Publication number | Publication date |
|---|---|
| SI1937229T1 (sl) | 2015-08-31 |
| DK1937229T3 (da) | 2015-06-22 |
| HUE026045T2 (hu) | 2016-05-30 |
| JP5873616B2 (ja) | 2016-03-01 |
| ITMI20051999A1 (it) | 2007-04-22 |
| WO2007045689A2 (en) | 2007-04-26 |
| RU2008120018A (ru) | 2009-11-27 |
| CY1116503T1 (el) | 2017-03-15 |
| US9138407B2 (en) | 2015-09-22 |
| WO2007045689A3 (en) | 2007-09-07 |
| US20080226736A1 (en) | 2008-09-18 |
| JP2009512663A (ja) | 2009-03-26 |
| ES2537777T3 (es) | 2015-06-12 |
| EP1937229A2 (en) | 2008-07-02 |
| EP1937229B1 (en) | 2015-03-11 |
| PT1937229E (pt) | 2015-07-16 |
| PL1937229T3 (pl) | 2015-08-31 |
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