RU2479629C2 - Продукция гликопротеинов с модифицированным фукозилированием - Google Patents
Продукция гликопротеинов с модифицированным фукозилированием Download PDFInfo
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- RU2479629C2 RU2479629C2 RU2009136982/10A RU2009136982A RU2479629C2 RU 2479629 C2 RU2479629 C2 RU 2479629C2 RU 2009136982/10 A RU2009136982/10 A RU 2009136982/10A RU 2009136982 A RU2009136982 A RU 2009136982A RU 2479629 C2 RU2479629 C2 RU 2479629C2
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2704830C2 (ru) * | 2014-03-17 | 2019-10-31 | Уаннесс Биотек Ко. Лтд | Способы получения рекомбинантных гликопротеинов с модифицированным гликозилированием |
| RU2714209C2 (ru) * | 2015-01-07 | 2020-02-13 | Сивек Фармасьютикалз Гмбх | Рекомбинантные гликопротеины с сиалированными о-гликанами и линии клеток для их продукции |
| US11193156B2 (en) | 2017-03-29 | 2021-12-07 | Cevec Pharmaceutical GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| US12060561B2 (en) | 2017-08-08 | 2024-08-13 | Cevec Pharmaceuticals Gmbh | Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines |
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| NZ593448A (en) | 2008-12-19 | 2012-06-29 | Jennewein Biotechnologie Gmbh | Synthesis of fucosylated compounds |
| PL2438171T3 (pl) | 2009-06-02 | 2015-04-30 | Regeneron Pharma | Komórki z niedoborem fukozylacji |
| CN102858949B (zh) | 2010-02-24 | 2016-07-06 | 默沙东公司 | 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法 |
| TW201209160A (en) * | 2010-04-27 | 2012-03-01 | Lonza Ag | Improved glycosylation of proteins in host cells |
| EP2678440B1 (en) | 2011-02-25 | 2018-05-23 | Merck Sharp & Dohme Corp. | Yeast strain for the production of proteins with modified o-glycosylation |
| AU2012226398B9 (en) * | 2011-03-06 | 2017-04-13 | Merck Serono S.A. | Low fucose cell lines and uses thereof |
| WO2012127045A1 (en) | 2011-03-23 | 2012-09-27 | Glycode | A yeast recombinant cell capable of producing gdp-fucose |
| DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
| CA2954974A1 (en) | 2014-07-21 | 2016-01-28 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| CA3019588A1 (en) | 2016-04-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Cmv neutralizing antigen binding proteins |
| KR20210061341A (ko) | 2018-09-13 | 2021-05-27 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 신규한 lilrb4 항체 및 이의 용도 |
| CA3175140A1 (en) | 2020-03-12 | 2021-09-16 | Immune-Onc Therapeutics, Inc. | Novel anti-lilrb4 antibodies and derivative products |
| WO2022120064A1 (en) | 2020-12-03 | 2022-06-09 | The Board Of Regents Of The University Of Texas System | Methods for identifying lilrb-blocking antibodies |
| WO2025144785A2 (en) * | 2023-12-28 | 2025-07-03 | Dsm Ip Assets B.V. | Cells and methods for the production of glycosylated compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2250263C1 (ru) * | 2003-08-05 | 2005-04-20 | Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных (ФГУ ВНИИЗЖ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК p30NE2, КОДИРУЮЩАЯ 181-АМИНОКИСЛОТНЫЙ N-КОНЦЕВОЙ ФРАГМЕНТ ГЛИКОПРОТЕИНА E2 ВИРУСА КЛАССИЧЕСКОЙ ЧУМЫ СВИНЕЙ И ОБЕСПЕЧИВАЮЩАЯ ЕГО ЭКСПРЕССИЮ В КЛЕТКАХ БАКТЕРИЙ E.coli |
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| US20040191256A1 (en) * | 1997-06-24 | 2004-09-30 | Genentech, Inc. | Methods and compositions for galactosylated glycoproteins |
| US20040136986A1 (en) * | 1997-10-31 | 2004-07-15 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| JP4334141B2 (ja) * | 1998-04-20 | 2009-09-30 | グリカート バイオテクノロジー アクチェンゲゼルシャフト | 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作 |
| US6994966B2 (en) * | 2000-02-17 | 2006-02-07 | Glycominds Ltd. | Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof |
| CA2369292C (en) * | 1999-04-09 | 2010-09-21 | Kyowa Hakko Kogyo Co. Ltd. | Method of modulating the activity of functional immune molecules |
| DE60139467D1 (de) * | 2000-05-17 | 2009-09-17 | Mitsubishi Tanabe Pharma Corp | Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein |
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| KR100787073B1 (ko) | 2000-06-28 | 2007-12-21 | 글리코파이, 인크. | 변형된 당단백질의 제조방법 |
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| US8697394B2 (en) * | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
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| US20020132320A1 (en) * | 2001-01-10 | 2002-09-19 | Wang Peng George | Glycoconjugate synthesis using a pathway-engineered organism |
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| ATE430580T1 (de) * | 2001-10-25 | 2009-05-15 | Genentech Inc | Glycoprotein-zusammensetzungen |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2704830C2 (ru) * | 2014-03-17 | 2019-10-31 | Уаннесс Биотек Ко. Лтд | Способы получения рекомбинантных гликопротеинов с модифицированным гликозилированием |
| US10745729B2 (en) | 2014-03-17 | 2020-08-18 | Oneness Biotech Co. Ltd. | Methods for producing recombinant glycoproteins with modified glycosylation |
| RU2714209C2 (ru) * | 2015-01-07 | 2020-02-13 | Сивек Фармасьютикалз Гмбх | Рекомбинантные гликопротеины с сиалированными о-гликанами и линии клеток для их продукции |
| US10793839B2 (en) | 2015-01-07 | 2020-10-06 | Cevec Pharmaceuticals Gmbh | O-glycan sialylated recombinant glycoproteins |
| US11193156B2 (en) | 2017-03-29 | 2021-12-07 | Cevec Pharmaceutical GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| US12060561B2 (en) | 2017-08-08 | 2024-08-13 | Cevec Pharmaceuticals Gmbh | Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines |
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| KR20090130029A (ko) | 2009-12-17 |
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| EP2134834B1 (en) | 2013-04-17 |
| CN101679934B (zh) | 2014-04-02 |
| RU2009136982A (ru) | 2011-04-20 |
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