ZA200905728B - Production of glycoproteins with modified fucosylation - Google Patents

Production of glycoproteins with modified fucosylation

Info

Publication number
ZA200905728B
ZA200905728B ZA200905728A ZA200905728A ZA200905728B ZA 200905728 B ZA200905728 B ZA 200905728B ZA 200905728 A ZA200905728 A ZA 200905728A ZA 200905728 A ZA200905728 A ZA 200905728A ZA 200905728 B ZA200905728 B ZA 200905728B
Authority
ZA
South Africa
Prior art keywords
glycoproteins
production
modified fucosylation
fucosylation
modified
Prior art date
Application number
ZA200905728A
Other languages
English (en)
Inventor
Stephen Hamilton
Original Assignee
Glycofi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycofi Inc filed Critical Glycofi Inc
Publication of ZA200905728B publication Critical patent/ZA200905728B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA200905728A 2007-03-07 2009-08-18 Production of glycoproteins with modified fucosylation ZA200905728B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90534507P 2007-03-07 2007-03-07

Publications (1)

Publication Number Publication Date
ZA200905728B true ZA200905728B (en) 2010-05-26

Family

ID=39639063

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905728A ZA200905728B (en) 2007-03-07 2009-08-18 Production of glycoproteins with modified fucosylation

Country Status (11)

Country Link
US (1) US20100028951A1 (enExample)
EP (1) EP2134834B1 (enExample)
JP (1) JP2010519930A (enExample)
KR (1) KR20090130029A (enExample)
CN (1) CN101679934B (enExample)
AU (1) AU2008227024A1 (enExample)
CA (1) CA2679732A1 (enExample)
RU (1) RU2479629C2 (enExample)
SG (1) SG187521A1 (enExample)
WO (1) WO2008112092A2 (enExample)
ZA (1) ZA200905728B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ593448A (en) 2008-12-19 2012-06-29 Jennewein Biotechnologie Gmbh Synthesis of fucosylated compounds
PL2438171T3 (pl) 2009-06-02 2015-04-30 Regeneron Pharma Komórki z niedoborem fukozylacji
CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
TW201209160A (en) * 2010-04-27 2012-03-01 Lonza Ag Improved glycosylation of proteins in host cells
EP2678440B1 (en) 2011-02-25 2018-05-23 Merck Sharp & Dohme Corp. Yeast strain for the production of proteins with modified o-glycosylation
AU2012226398B9 (en) * 2011-03-06 2017-04-13 Merck Serono S.A. Low fucose cell lines and uses thereof
WO2012127045A1 (en) 2011-03-23 2012-09-27 Glycode A yeast recombinant cell capable of producing gdp-fucose
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
TWI682033B (zh) 2014-03-17 2020-01-11 泉盛生物科技股份有限公司 製造具有經修飾的糖苷化作用之重組糖蛋白之方法
CA2954974A1 (en) 2014-07-21 2016-01-28 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3042952A1 (en) 2015-01-07 2016-07-13 CEVEC Pharmaceuticals GmbH O-glycan sialylated recombinant glycoproteins and cell lines for producing the same
CA3019588A1 (en) 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
KR20210061341A (ko) 2018-09-13 2021-05-27 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 신규한 lilrb4 항체 및 이의 용도
CA3175140A1 (en) 2020-03-12 2021-09-16 Immune-Onc Therapeutics, Inc. Novel anti-lilrb4 antibodies and derivative products
WO2022120064A1 (en) 2020-12-03 2022-06-09 The Board Of Regents Of The University Of Texas System Methods for identifying lilrb-blocking antibodies
WO2025144785A2 (en) * 2023-12-28 2025-07-03 Dsm Ip Assets B.V. Cells and methods for the production of glycosylated compounds

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1994023021A1 (fr) * 1993-03-29 1994-10-13 Kyowa Hakko Kogyo Co., Ltd. α-1,3-FUCOSYLTRANSFERASE
US20040191256A1 (en) * 1997-06-24 2004-09-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
US20040136986A1 (en) * 1997-10-31 2004-07-15 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
JP4334141B2 (ja) * 1998-04-20 2009-09-30 グリカート バイオテクノロジー アクチェンゲゼルシャフト 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
US6994966B2 (en) * 2000-02-17 2006-02-07 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
CA2369292C (en) * 1999-04-09 2010-09-21 Kyowa Hakko Kogyo Co. Ltd. Method of modulating the activity of functional immune molecules
DE60139467D1 (de) * 2000-05-17 2009-09-17 Mitsubishi Tanabe Pharma Corp Verfahren zur herstellung von proteinen unter reduktion von mannosephosphat in der zuckerkette und dadurch hergestelltes glykoprotein
US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
KR100787073B1 (ko) 2000-06-28 2007-12-21 글리코파이, 인크. 변형된 당단백질의 제조방법
US7863020B2 (en) * 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7795002B2 (en) * 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US6946292B2 (en) * 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US20020132320A1 (en) * 2001-01-10 2002-09-19 Wang Peng George Glycoconjugate synthesis using a pathway-engineered organism
CA2455365C (en) * 2001-08-03 2014-07-29 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
ATE430580T1 (de) * 2001-10-25 2009-05-15 Genentech Inc Glycoprotein-zusammensetzungen
US20040093621A1 (en) * 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
KR101001243B1 (ko) * 2001-12-27 2010-12-17 글리코파이, 인크. 포유동물-유형 탄수화물 구조의 설계 방법
WO2003085119A1 (en) * 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
PL224786B1 (pl) * 2003-01-22 2017-01-31 Glycart Biotechnology Ag Wyizolowany kwas nukleinowy, ssaczy wektor ekspresyjny, komórki gospodarza, fuzja polipeptydowa i sposób jej wytwarzania, sposoby in vitro i ex vivo modyfikowania profilu glikozylacji polipeptydu wytwarzanego przez komórki gospodarza
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
RU2250263C1 (ru) * 2003-08-05 2005-04-20 Федеральное государственное учреждение Всероссийский научно-исследовательский институт защиты животных (ФГУ ВНИИЗЖ) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК p30NE2, КОДИРУЮЩАЯ 181-АМИНОКИСЛОТНЫЙ N-КОНЦЕВОЙ ФРАГМЕНТ ГЛИКОПРОТЕИНА E2 ВИРУСА КЛАССИЧЕСКОЙ ЧУМЫ СВИНЕЙ И ОБЕСПЕЧИВАЮЩАЯ ЕГО ЭКСПРЕССИЮ В КЛЕТКАХ БАКТЕРИЙ E.coli
CA2548140A1 (en) * 2003-12-05 2005-06-23 University Of Massachusetts Oligosaccharide compositions and use thereof in the treatment of infection
EP2341128A1 (en) * 2003-12-24 2011-07-06 GlycoFi, Inc. Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
JP4258662B2 (ja) * 2004-04-23 2009-04-30 独立行政法人産業技術総合研究所 Ｏ−フコース結合型タンパク質合成系遺伝子が導入された酵母形質転換体
US7465577B2 (en) * 2004-04-29 2008-12-16 Glycofi, Inc. Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins
KR20080021590A (ko) * 2005-03-24 2008-03-07 네오스 테크놀로지스, 인크. 가용성이고 활성인 진핵생물 글리코실트랜스퍼라제의원핵생물 유기체 내에서의 발현

Also Published As

Publication number Publication date
CN101679934A (zh) 2010-03-24
CA2679732A1 (en) 2008-09-18
KR20090130029A (ko) 2009-12-17
AU2008227024A1 (en) 2008-09-18
EP2134834A2 (en) 2009-12-23
US20100028951A1 (en) 2010-02-04
SG187521A1 (en) 2013-02-28
JP2010519930A (ja) 2010-06-10
WO2008112092A3 (en) 2008-11-06
WO2008112092A2 (en) 2008-09-18
EP2134834B1 (en) 2013-04-17
CN101679934B (zh) 2014-04-02
RU2479629C2 (ru) 2013-04-20
RU2009136982A (ru) 2011-04-20

Similar Documents

Publication Publication Date Title
ZA200905728B (en) Production of glycoproteins with modified fucosylation
IL196252A0 (en) Production of glycoproteins
EP2435577A4 (en) GLYCOPROTEIN PRODUCTION
EP2438185A4 (en) METHODS FOR MODULATING FUCOSYLATION OF GLYCOPROTEINS
IL217381A0 (en) Optimizing the production of antibodies
IL200030A0 (en) Improvement of protein production
ZA201002000B (en) Production of isoprenoids
GB0915371D0 (en) Fastener assembly
ZA201200409B (en) Compounds for the reduction of b-amyloid production
GB0909984D0 (en) Fastener
PL2252642T3 (pl) Wytwarzanie poliestru
PL2326844T3 (pl) Sprężarka śrubowa
EP2099924A4 (en) BIODIESEL PRODUCTION
EP2283043A4 (en) PROCESSES FOR RECOMBINANT PRODUCTION OF GLYCOPROTEINS
SI2496735T1 (sl) Proizvodnja ogljikovodikov
GB2458818B (en) Production of butanol
TWM371791U (en) Screw compressor
GB2473823B (en) Fastener assembly
GB0900971D0 (en) Fastener
GB2463291B (en) Production of hydroelectricity
SI2041270T1 (sl) Proizvodnja glikoproteinov
GB0812595D0 (en) Production of butanol
PL383205A1 (pl) Sposób wytwarzania siloksanów o regularnej strukturze
PL381668A1 (pl) Sposób wytwarzania biopaliw
TWM369684U (en) Improvement of pin structure