CN101679934B - 具有经修饰的岩藻糖基化的糖蛋白的生产 - Google Patents

具有经修饰的岩藻糖基化的糖蛋白的生产 Download PDF

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CN101679934B
CN101679934B CN200880014608.2A CN200880014608A CN101679934B CN 101679934 B CN101679934 B CN 101679934B CN 200880014608 A CN200880014608 A CN 200880014608A CN 101679934 B CN101679934 B CN 101679934B
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glcnac
host cell
signal peptide
catalyst structure
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CN101679934A (zh
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S·哈米尔顿
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Glycofi Inc
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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CN200880014608.2A 2007-03-07 2008-03-03 具有经修饰的岩藻糖基化的糖蛋白的生产 Expired - Fee Related CN101679934B (zh)

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Application Number Priority Date Filing Date Title
US90534507P 2007-03-07 2007-03-07
US60/905,345 2007-03-07
PCT/US2008/002787 WO2008112092A2 (en) 2007-03-07 2008-03-03 Production of glycoproteins with modified fucosylation

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CN101679934A CN101679934A (zh) 2010-03-24
CN101679934B true CN101679934B (zh) 2014-04-02

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US (1) US20100028951A1 (enExample)
EP (1) EP2134834B1 (enExample)
JP (1) JP2010519930A (enExample)
KR (1) KR20090130029A (enExample)
CN (1) CN101679934B (enExample)
AU (1) AU2008227024A1 (enExample)
CA (1) CA2679732A1 (enExample)
RU (1) RU2479629C2 (enExample)
SG (1) SG187521A1 (enExample)
WO (1) WO2008112092A2 (enExample)
ZA (1) ZA200905728B (enExample)

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CN102858949B (zh) 2010-02-24 2016-07-06 默沙东公司 用于增加在巴氏毕赤酵母中生产的治疗性糖蛋白上的n-糖基化位点占据的方法
TW201209160A (en) * 2010-04-27 2012-03-01 Lonza Ag Improved glycosylation of proteins in host cells
EP2678440B1 (en) 2011-02-25 2018-05-23 Merck Sharp & Dohme Corp. Yeast strain for the production of proteins with modified o-glycosylation
AU2012226398B9 (en) * 2011-03-06 2017-04-13 Merck Serono S.A. Low fucose cell lines and uses thereof
WO2012127045A1 (en) 2011-03-23 2012-09-27 Glycode A yeast recombinant cell capable of producing gdp-fucose
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
TWI682033B (zh) 2014-03-17 2020-01-11 泉盛生物科技股份有限公司 製造具有經修飾的糖苷化作用之重組糖蛋白之方法
CA2954974A1 (en) 2014-07-21 2016-01-28 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3042952A1 (en) 2015-01-07 2016-07-13 CEVEC Pharmaceuticals GmbH O-glycan sialylated recombinant glycoproteins and cell lines for producing the same
CA3019588A1 (en) 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
EP3382014A1 (en) 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
KR20210061341A (ko) 2018-09-13 2021-05-27 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 신규한 lilrb4 항체 및 이의 용도
CA3175140A1 (en) 2020-03-12 2021-09-16 Immune-Onc Therapeutics, Inc. Novel anti-lilrb4 antibodies and derivative products
WO2022120064A1 (en) 2020-12-03 2022-06-09 The Board Of Regents Of The University Of Texas System Methods for identifying lilrb-blocking antibodies
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US20040191256A1 (en) * 1997-06-24 2004-09-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
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JP4334141B2 (ja) * 1998-04-20 2009-09-30 グリカート バイオテクノロジー アクチェンゲゼルシャフト 抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
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Publication number Publication date
CN101679934A (zh) 2010-03-24
CA2679732A1 (en) 2008-09-18
KR20090130029A (ko) 2009-12-17
AU2008227024A1 (en) 2008-09-18
EP2134834A2 (en) 2009-12-23
US20100028951A1 (en) 2010-02-04
SG187521A1 (en) 2013-02-28
JP2010519930A (ja) 2010-06-10
ZA200905728B (en) 2010-05-26
WO2008112092A3 (en) 2008-11-06
WO2008112092A2 (en) 2008-09-18
EP2134834B1 (en) 2013-04-17
RU2479629C2 (ru) 2013-04-20
RU2009136982A (ru) 2011-04-20

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