RU2479580C2 - Производные пиразинона и их применение для лечения легочных заболеваний - Google Patents

Производные пиразинона и их применение для лечения легочных заболеваний Download PDF

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RU2479580C2
RU2479580C2 RU2009148673/04A RU2009148673A RU2479580C2 RU 2479580 C2 RU2479580 C2 RU 2479580C2 RU 2009148673/04 A RU2009148673/04 A RU 2009148673/04A RU 2009148673 A RU2009148673 A RU 2009148673A RU 2479580 C2 RU2479580 C2 RU 2479580C2
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cyclopropyl
amino
methyl
alkyl
oxo
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RU2009148673/04A
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RU2009148673A (ru
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Стивен БРАФ
Ричард Эванс
Тимоти Дж. ЛУКЕР
Пиотр РАУБО
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Астразенека Аб
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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
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  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
RU2009148673/04A 2007-06-27 2008-06-25 Производные пиразинона и их применение для лечения легочных заболеваний RU2479580C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US94641507P 2007-06-27 2007-06-27
US60/946,415 2007-06-27
US97816707P 2007-10-08 2007-10-08
US60/978,167 2007-10-08
US2944408P 2008-02-18 2008-02-18
US61/029,444 2008-02-18
PCT/GB2008/050491 WO2009001132A1 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases

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RU2009148673A RU2009148673A (ru) 2011-08-10
RU2479580C2 true RU2479580C2 (ru) 2013-04-20

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Families Citing this family (49)

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Publication number Priority date Publication date Assignee Title
SI2170848T1 (sl) 2007-06-27 2015-01-30 Astrazeneca Ab Derivati pirazinona in njihova uporaba pri zdravljenju bolezni pljuč
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010071583A1 (en) * 2008-12-18 2010-06-24 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
RU2602814C2 (ru) 2009-09-25 2016-11-20 Оризон Дженомикс С.А. Лизинспецифические ингибиторы деметилазы-1 и их применение
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9138441B2 (en) 2009-12-31 2015-09-22 Ira Milton Trachtman Compositions and method for treatment and prophylaxis of inflammatory bowel disease
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
MX2012012111A (es) 2010-04-19 2013-05-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especifica de lisina y su uso.
CA2806008C (en) 2010-07-29 2019-07-09 Oryzon Genomics S.A. Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
TWI535712B (zh) * 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
EP2712315B1 (en) 2011-02-08 2021-11-24 Oryzon Genomics, S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP2741741A2 (en) * 2011-05-19 2014-06-18 Oryzon Genomics, S.A. Lysine demethylase inhibitors for inflammatory diseases or conditions
CN103958474B (zh) 2011-10-20 2017-03-08 奥莱松基因组股份有限公司 作为lsd1抑制剂的(杂)芳基环丙基胺化合物
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
KR20150000900A (ko) 2012-04-10 2015-01-05 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규한 1-치환된 인다졸 유도체
RU2701156C9 (ru) 2012-07-18 2019-12-18 Саншайн Лейк Фарма Ко., Лтд. Азотсодержащие гетероциклические производные и их применение в фармацевтических препаратах
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
US9444925B2 (en) * 2013-04-05 2016-09-13 Microsoft Technology Licensing, Llc Smartphone proximity card emulation
ES2734209T3 (es) 2013-08-06 2019-12-04 Imago Biosciences Inc Inhibidores de KDM1A para el tratamiento de enfermedades
BR112016030697B1 (pt) * 2014-06-27 2023-03-21 Celgene Quanticel Research, Inc Compostos inibidores de desmetilase-1 lisina-específica, composição farmacêutica e seus usos
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
SI3256218T1 (sl) 2015-02-12 2025-03-31 Imago Biosciences Inc. Inhibitor kdm1a in njegova uporaba v terapiji
WO2017162304A1 (en) 2016-03-24 2017-09-28 Astrazeneca Ab Crystalline form
BR112018070536A2 (pt) * 2016-04-07 2019-02-12 Glaxosmithkline Intellectual Property (No. composto, composição farmacêutica, combinação, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, método de tratamento de uma doença ou condição
WO2018035259A1 (en) 2016-08-16 2018-02-22 Imago Biosciences, Inc. Methods and processes for the preparation of kdm1a inhibitors
WO2018051306A1 (en) 2016-09-19 2018-03-22 Novartis Ag Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
WO2018075598A1 (en) * 2016-10-19 2018-04-26 Constellation Pharmaceuticals, Inc. Synthesis of inhibitors of ezh2
CN106674029B (zh) * 2016-12-23 2018-08-21 四川久凌制药科技有限公司 一种他喷他多中间体的制备方法
EP4272740A1 (en) 2017-05-02 2023-11-08 Novartis AG Combination therapy comprising a raf inhibitor and trametinib
EP3790867B1 (en) * 2018-05-11 2024-03-27 Imago Biosciences Inc. Kdm1a inhibitors for the treatment of disease
PL3941903T3 (pl) * 2019-03-22 2025-11-12 Saniona A/S Nowe inhibitory kanałów potasowych
JP2022531969A (ja) 2019-05-13 2022-07-12 ノバルティス アーゲー 癌を治療するためのＲａｆ阻害剤としてのＮ－（３－（２－（２－ヒドロキシエトキシ）－６－モルホリノピリジン－４－イル）－４－メチルフェニル）－２－（トリフルオロメチル）イソニコチンアミドの新規な結晶形態
EP4122926B1 (en) * 2021-04-14 2025-06-04 Shionogi & Co., Ltd. Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same
CN113999129B (zh) * 2021-11-23 2023-09-01 长沙普济生物科技股份有限公司 一种含酚羟基氨基酸表面活性剂的合成方法
WO2025122555A1 (en) * 2023-12-05 2025-06-12 Valo Health, Inc. S1p 1 receptor agonists and uses thereof
CN119350255B (zh) * 2024-10-21 2025-12-09 海南大学 一种酮衍生物及其合成方法和用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2181360C2 (ru) * 1996-09-06 2002-04-20 Ниппон Каяку Кабусики Кайся Новые производные ацетамида, способ их получения, фармацевтический состав и ингибиторы протеаз на их основе

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
MXPA04008822A (es) 2002-03-14 2004-11-26 Bayer Healthcare Ag Aroilpiridinonas monociclicas.
DK1534391T3 (da) 2002-07-19 2007-06-11 Biovitrum Ab Nye piperazinyl-pyrazinonderivater til behandling af 5-HT2A-recptor-relaterede forstyrrelser
EP1670794A2 (en) 2003-09-30 2006-06-21 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP3962425B2 (ja) * 2003-10-14 2007-08-22 ファルマシア・コーポレーション 炎症治療用置換ピラジノン化合物
JP4808628B2 (ja) * 2003-12-03 2011-11-02 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド アゾール系キナーゼ阻害剤
GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
BRPI0512915A (pt) 2004-06-29 2008-04-15 Warner Lambert Co terapias de combinação utilizando inibidores benzamida do receptor p2x7
JP4496092B2 (ja) 2005-01-12 2010-07-07 信越化学工業株式会社 光ファイバ母材の製造方法及び装置
US8329704B2 (en) 2005-12-21 2012-12-11 Janssen Pharmaceutica, N.V. Substituted pyrazinone derivatives for use in MCH-1 mediated diseases
AU2007246869B2 (en) 2006-05-04 2012-10-18 Macrophage Pharma Limited p38 MAP kinase inhibitors
GB0608837D0 (en) 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of MAP kinase
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
US20090281099A1 (en) * 2006-05-22 2009-11-12 Andres-Gil Jose Ignacio Substituted pyrazinone derivatives for use as a medicine
KR20090031913A (ko) * 2006-06-21 2009-03-30 이 아이 듀폰 디 네모아 앤드 캄파니 세포 증식 억제제로서의 피라지논
TW200924754A (en) * 2006-06-21 2009-06-16 Du Pont Pyrazinones as cellular proliferation inhibitors
SI2170848T1 (sl) 2007-06-27 2015-01-30 Astrazeneca Ab Derivati pirazinona in njihova uporaba pri zdravljenju bolezni pljuč

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2181360C2 (ru) * 1996-09-06 2002-04-20 Ниппон Каяку Кабусики Кайся Новые производные ацетамида, способ их получения, фармацевтический состав и ингибиторы протеаз на их основе

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HENSON G. J. Inhibitors of p38 kinase. EXPERT OPINION ON THERAPEUTIC PATENTS. INFORMA HEALTHCARE. 01.01.1997, p.729-733. *

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