AU2008269516B2 - Pyrazinone derivatives and their use in the treatment of lung diseases - Google Patents

Pyrazinone derivatives and their use in the treatment of lung diseases Download PDF

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Publication number
AU2008269516B2
AU2008269516B2 AU2008269516A AU2008269516A AU2008269516B2 AU 2008269516 B2 AU2008269516 B2 AU 2008269516B2 AU 2008269516 A AU2008269516 A AU 2008269516A AU 2008269516 A AU2008269516 A AU 2008269516A AU 2008269516 B2 AU2008269516 B2 AU 2008269516B2
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Prior art keywords
methyl
alkyl
cyclopropyl
amino
oxo
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Ceased
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AU2008269516A
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AU2008269516A1 (en
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Stephen Brough
Richard Evans
Timothy Jon Luker
Piotr Raubo
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AstraZeneca AB
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AstraZeneca AB
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
AU2008269516A 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases Ceased AU2008269516B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US94641507P 2007-06-27 2007-06-27
US60/946,415 2007-06-27
US97816707P 2007-10-08 2007-10-08
US60/978,167 2007-10-08
US2944408P 2008-02-18 2008-02-18
US61/029,444 2008-02-18
PCT/GB2008/050491 WO2009001132A1 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases

Publications (2)

Publication Number Publication Date
AU2008269516A1 AU2008269516A1 (en) 2008-12-31
AU2008269516B2 true AU2008269516B2 (en) 2011-11-17

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AU2008269516A Ceased AU2008269516B2 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases

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EP (1) EP2170848B1 (enExample)
JP (2) JP5140154B2 (enExample)
KR (1) KR101541203B1 (enExample)
CN (1) CN101842361B (enExample)
AR (1) AR067444A1 (enExample)
AU (1) AU2008269516B2 (enExample)
BR (1) BRPI0813244B8 (enExample)
CA (1) CA2691215C (enExample)
CL (1) CL2008001898A1 (enExample)
CO (1) CO6251251A2 (enExample)
CY (1) CY1115836T1 (enExample)
DK (1) DK2170848T3 (enExample)
EC (1) ECSP109903A (enExample)
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RU (1) RU2479580C2 (enExample)
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US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8969350B2 (en) * 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
BR112012006572A2 (pt) 2009-09-25 2016-04-26 Oryzon Genomics Sa inibidores de demetilase-1 de lisina específicos e seu uso
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
EP2519108A4 (en) 2009-12-31 2013-10-16 Ira Milton Trachtman COMPOSITIONS AND METHODS FOR THE TREATMENT AND PROPHYLAXIS OF INFLAMMATORY INTESTINAL DISEASE
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