CN101842361B - 吡嗪酮衍生物及其在治疗肺病中的用途 - Google Patents
吡嗪酮衍生物及其在治疗肺病中的用途 Download PDFInfo
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- CN101842361B CN101842361B CN2008801051412A CN200880105141A CN101842361B CN 101842361 B CN101842361 B CN 101842361B CN 2008801051412 A CN2008801051412 A CN 2008801051412A CN 200880105141 A CN200880105141 A CN 200880105141A CN 101842361 B CN101842361 B CN 101842361B
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- 0 CC(*)(c1ccccc1*)NC1=NC=CN(c2cc(C(N*)=O)cc(*)c2*)C1=O Chemical compound CC(*)(c1ccccc1*)NC1=NC=CN(c2cc(C(N*)=O)cc(*)c2*)C1=O 0.000 description 7
- WSVJPDBLZWRJSI-UHFFFAOYSA-N CC(C)(c1ccccc1)NC1=NC=CN(c2c(C)ccc(C(NOC)=O)c2)C1=O Chemical compound CC(C)(c1ccccc1)NC1=NC=CN(c2c(C)ccc(C(NOC)=O)c2)C1=O WSVJPDBLZWRJSI-UHFFFAOYSA-N 0.000 description 1
- DACYSVHWVYWSEK-WXVAWEFUSA-N C[C@@H](CN1CCCC1)[C@H](c1cccc(C)c1)NC1=NC=CN(c2c(C)ccc(C(NC3CC3)=O)c2)C1=O Chemical compound C[C@@H](CN1CCCC1)[C@H](c1cccc(C)c1)NC1=NC=CN(c2c(C)ccc(C(NC3CC3)=O)c2)C1=O DACYSVHWVYWSEK-WXVAWEFUSA-N 0.000 description 1
- NKWLHXCEWCDLGM-UHFFFAOYSA-N Cc(c(F)cc(C(NC1=CC1)=O)c1)c1N(C=CN=C1NC2(CC2)c2cc(F)ccc2OCCNCCO)C1=O Chemical compound Cc(c(F)cc(C(NC1=CC1)=O)c1)c1N(C=CN=C1NC2(CC2)c2cc(F)ccc2OCCNCCO)C1=O NKWLHXCEWCDLGM-UHFFFAOYSA-N 0.000 description 1
- WIWRVKCBTWTPIZ-QFIPXVFZSA-N Cc(c(N(C=CN=C1NC2(CC2)c(cccc2)c2OC[C@H](CNCCO)O)C1=O)c1)ccc1C(NC1CC1)=O Chemical compound Cc(c(N(C=CN=C1NC2(CC2)c(cccc2)c2OC[C@H](CNCCO)O)C1=O)c1)ccc1C(NC1CC1)=O WIWRVKCBTWTPIZ-QFIPXVFZSA-N 0.000 description 1
- LMBGMFZGZYGFOV-UHFFFAOYSA-N Cc(ccc(C(NC1CC1)=O)c1)c1N(C=CN=C1N(CCN(C)C)Cc2ccccc2)C1=O Chemical compound Cc(ccc(C(NC1CC1)=O)c1)c1N(C=CN=C1N(CCN(C)C)Cc2ccccc2)C1=O LMBGMFZGZYGFOV-UHFFFAOYSA-N 0.000 description 1
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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| US94641507P | 2007-06-27 | 2007-06-27 | |
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| US97816707P | 2007-10-08 | 2007-10-08 | |
| US60/978,167 | 2007-10-08 | ||
| US2944408P | 2008-02-18 | 2008-02-18 | |
| US61/029,444 | 2008-02-18 | ||
| PCT/GB2008/050491 WO2009001132A1 (en) | 2007-06-27 | 2008-06-25 | Pyrazinone derivatives and their use in the treatment of lung diseases |
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| Publication Number | Publication Date |
|---|---|
| CN101842361A CN101842361A (zh) | 2010-09-22 |
| CN101842361B true CN101842361B (zh) | 2013-06-05 |
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| CN2008801051412A Expired - Fee Related CN101842361B (zh) | 2007-06-27 | 2008-06-25 | 吡嗪酮衍生物及其在治疗肺病中的用途 |
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| JP5140154B2 (ja) * | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
| US20090011994A1 (en) | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
| AR073711A1 (es) | 2008-10-01 | 2010-11-24 | Astrazeneca Ab | Derivados de isoquinolina |
| EP2361242B1 (en) | 2008-10-17 | 2018-08-01 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| WO2010071583A1 (en) * | 2008-12-18 | 2010-06-24 | Astrazeneca Ab | Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| CA2812683C (en) | 2009-09-25 | 2017-10-10 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| MX348611B (es) | 2009-12-31 | 2017-06-21 | Milton Trachtman Ira | Forma de dosificación oral para usarse en el tratamiento de enfermedad inflamatoria de intestino debido a una infección bacteriana. |
| WO2011106573A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| WO2011106105A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
| HUE030938T2 (en) | 2010-04-19 | 2017-06-28 | Oryzon Genomics Sa | Lysine-specific demethylase-1 inhibitors and their use |
| WO2012013727A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| MX341732B (es) | 2010-07-29 | 2016-08-30 | Oryzon Genomics S A * | Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos. |
| TWI535712B (zh) * | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| EP3981395A1 (en) | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| EP2741741A2 (en) * | 2011-05-19 | 2014-06-18 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for inflammatory diseases or conditions |
| WO2013057322A1 (en) | 2011-10-20 | 2013-04-25 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
| BR112014009306B1 (pt) | 2011-10-20 | 2021-07-20 | Oryzon Genomics S.A. | Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1 |
| KR20150000900A (ko) | 2012-04-10 | 2015-01-05 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 신규한 1-치환된 인다졸 유도체 |
| KR102057877B1 (ko) | 2012-07-18 | 2019-12-20 | 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 | 질소함유 헤테로고리 유도체 및 그의 약물에서의 용도 |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| US20140302819A1 (en) * | 2013-04-05 | 2014-10-09 | Microsoft Corporation | Techniques for selecting a proximity card of a mobile device for access |
| MX383590B (es) | 2013-08-06 | 2025-03-11 | Imago Biosciences Inc | Inhibidores de kdm1a para el tratamiento de enfermedades. |
| RS60658B1 (sr) * | 2014-06-27 | 2020-09-30 | Celgene Quanticel Research Inc | Inhibitori lizin specifične demetilaze-1 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| RS66458B1 (sr) | 2015-02-12 | 2025-02-28 | Imago Biosciences Inc | Kdm1a inhibitor i njegova primena u terapiji |
| RU2018135607A (ru) | 2016-03-24 | 2020-04-24 | Астразенека Аб | Кристаллическая форма |
| KR20180132682A (ko) * | 2016-04-07 | 2018-12-12 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 브로모도메인 억제제로서의 피리딜 유도체 |
| WO2018035259A1 (en) | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Methods and processes for the preparation of kdm1a inhibitors |
| AU2017329090B9 (en) | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
| CA3039059A1 (en) * | 2016-10-19 | 2018-04-26 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
| CN106674029B (zh) * | 2016-12-23 | 2018-08-21 | 四川久凌制药科技有限公司 | 一种他喷他多中间体的制备方法 |
| US11266653B2 (en) | 2017-05-02 | 2022-03-08 | Novartis Ag | Combination therapy |
| EP3790867B1 (en) * | 2018-05-11 | 2024-03-27 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
| WO2020193419A1 (en) * | 2019-03-22 | 2020-10-01 | Saniona A/S | Novel potassium channel inhibitors |
| CA3138123A1 (en) | 2019-05-13 | 2020-11-19 | Novartis Ag | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| WO2022138988A1 (ja) * | 2021-04-14 | 2022-06-30 | 塩野義製薬株式会社 | ウイルス増殖阻害作用を有するトリアジン誘導体およびそれらを含有する医薬組成物 |
| CN113999129B (zh) * | 2021-11-23 | 2023-09-01 | 长沙普济生物科技股份有限公司 | 一种含酚羟基氨基酸表面活性剂的合成方法 |
| WO2025122555A1 (en) * | 2023-12-05 | 2025-06-12 | Valo Health, Inc. | S1p 1 receptor agonists and uses thereof |
| CN119350255B (zh) * | 2024-10-21 | 2025-12-09 | 海南大学 | 一种酮衍生物及其合成方法和用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101505747A (zh) * | 2006-06-21 | 2009-08-12 | 杜邦公司 | 作为细胞增殖抑制剂的吡嗪酮 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2263198A1 (en) * | 1996-09-06 | 1998-03-12 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivatives and protease inhibitors |
| TWI328007B (en) | 2002-01-16 | 2010-08-01 | Astrazeneca Ab | Novel compounds |
| JP2005526068A (ja) | 2002-03-14 | 2005-09-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 抗炎症剤としての単環式アロイルピリジノン類 |
| WO2004009586A1 (en) | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
| JP2007533635A (ja) | 2003-09-30 | 2007-11-22 | アムジエン・インコーポレーテツド | バニロイド受容体リガンドおよび治療おけるこれらの使用 |
| ES2284054T3 (es) * | 2003-10-14 | 2007-11-01 | Pharmacia Corporation | Compuestos de pirazinona sustituidos para el tratamiento de la inflamacion. |
| NZ545694A (en) * | 2003-12-03 | 2010-04-30 | Ym Bioscience Australia Pty Lt | Azole-based kinase inhibitors |
| GB0402812D0 (en) * | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
| JP2008504363A (ja) | 2004-06-29 | 2008-02-14 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | P2x7受容体のベンズアミド阻害剤を利用する併用療法 |
| JP4496092B2 (ja) | 2005-01-12 | 2010-07-07 | 信越化学工業株式会社 | 光ファイバ母材の製造方法及び装置 |
| RU2008129679A (ru) | 2005-12-21 | 2010-01-27 | Янссен Фармацевтика Н.В. (Be) | Новые замещенные пиразиноновые производные для применения при мсн-1-опосредованных заболеваниях |
| JP5340918B2 (ja) | 2006-05-04 | 2013-11-13 | クロマ セラピューティクス リミテッド | p38MAPキナーゼ阻害剤 |
| GB0608837D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | Inhibitors of MAP kinase |
| TW200808771A (en) * | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| MX2008014921A (es) * | 2006-05-22 | 2008-12-09 | Janssen Pharmaceutica Nv | Derivados de piracinona sustituidos para uso como un medicamento. |
| TW200924754A (en) * | 2006-06-21 | 2009-06-16 | Du Pont | Pyrazinones as cellular proliferation inhibitors |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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