JP5140154B2 - ピラジノン誘導体および肺疾患の処置におけるそれらの使用 - Google Patents

ピラジノン誘導体および肺疾患の処置におけるそれらの使用 Download PDF

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JP5140154B2
JP5140154B2 JP2010514138A JP2010514138A JP5140154B2 JP 5140154 B2 JP5140154 B2 JP 5140154B2 JP 2010514138 A JP2010514138 A JP 2010514138A JP 2010514138 A JP2010514138 A JP 2010514138A JP 5140154 B2 JP5140154 B2 JP 5140154B2
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methyl
cyclopropyl
amino
alkyl
oxo
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JP2010531345A (ja
JP2010531345A5 (enExample
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スティーブン・ブロー
リチャード・エバンス
ティモシー・ジョン・ルーカー
ピョートル・ラウボ
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AstraZeneca AB
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JP2010514138A 2007-06-27 2008-06-25 ピラジノン誘導体および肺疾患の処置におけるそれらの使用 Expired - Fee Related JP5140154B2 (ja)

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US94641507P 2007-06-27 2007-06-27
US60/946,415 2007-06-27
US97816707P 2007-10-08 2007-10-08
US60/978,167 2007-10-08
US2944408P 2008-02-18 2008-02-18
US61/029,444 2008-02-18
PCT/GB2008/050491 WO2009001132A1 (en) 2007-06-27 2008-06-25 Pyrazinone derivatives and their use in the treatment of lung diseases

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JP2010531345A5 JP2010531345A5 (enExample) 2012-07-19
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JP2012211413A Expired - Fee Related JP5539473B2 (ja) 2007-06-27 2012-09-25 ピラジノン誘導体および肺疾患の処置におけるそれらの使用

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RU2479580C2 (ru) 2007-06-27 2013-04-20 Астразенека Аб Производные пиразинона и их применение для лечения легочных заболеваний
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
AR073711A1 (es) 2008-10-01 2010-11-24 Astrazeneca Ab Derivados de isoquinolina
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8969350B2 (en) * 2008-12-18 2015-03-03 Astrazeneca Ab Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
US8859555B2 (en) 2009-09-25 2014-10-14 Oryzon Genomics S.A. Lysine Specific Demethylase-1 inhibitors and their use
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9138441B2 (en) 2009-12-31 2015-09-22 Ira Milton Trachtman Compositions and method for treatment and prophylaxis of inflammatory bowel disease
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
MX2012012111A (es) 2010-04-19 2013-05-30 Oryzon Genomics Sa Inhibidores de demetilasa-1 especifica de lisina y su uso.
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
SI2598482T1 (sl) 2010-07-29 2018-09-28 Oryzon Genomics, S.A. Inhibitorji demetilaze lsd1 na osnovi arilciklopropilamina in njihova medicinska uporaba
TWI535712B (zh) * 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
EP2741741A2 (en) * 2011-05-19 2014-06-18 Oryzon Genomics, S.A. Lysine demethylase inhibitors for inflammatory diseases or conditions
CN107266345B (zh) 2011-10-20 2021-08-17 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
RS58475B1 (sr) 2011-10-20 2019-04-30 Oryzon Genomics Sa Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori
BR112014025201A2 (pt) 2012-04-10 2017-07-11 Sumitomo Dainippon Pharma Co Ltd derivado de indazol 1-substituído
ES2716008T3 (es) 2012-07-18 2019-06-07 Sunshine Lake Pharma Co Ltd Derivados heterocíclicos nitrogenados y su aplicación en fármacos
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
US20140302819A1 (en) * 2013-04-05 2014-10-09 Microsoft Corporation Techniques for selecting a proximity card of a mobile device for access
AU2014306149B2 (en) 2013-08-06 2019-09-19 Imago Biosciences Inc. KDM1A inhibitors for the treatment of disease
MX376632B (es) * 2014-06-27 2025-03-07 Celgene Quanticel Res Inc Inhibidores de demetilasa-1 especifica de lisina.
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
KR102626978B1 (ko) 2015-02-12 2024-01-18 이마고 바이오사이언시즈 인코포레이티드 질환 치료를 위한 kdm1a 저해제
JP6691972B2 (ja) * 2016-03-24 2020-05-13 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 結晶形態
CN108884070B (zh) * 2016-04-07 2021-07-02 葛兰素史克知识产权第二有限公司 作为溴结构域抑制剂的吡啶基衍生物
US11390590B2 (en) 2016-08-16 2022-07-19 Imago Biosciences, Inc. Methods and processes for the preparation of KDM1A inhibitors
EP3515446B1 (en) 2016-09-19 2023-12-20 Novartis AG Therapeutic combinations comprising a raf inhibitor and a erk inhibitor
EP3529242A1 (en) * 2016-10-19 2019-08-28 Constellation Pharmaceuticals, Inc. Synthesis of inhibitors of ezh2
CN106674029B (zh) * 2016-12-23 2018-08-21 四川久凌制药科技有限公司 一种他喷他多中间体的制备方法
US11266653B2 (en) 2017-05-02 2022-03-08 Novartis Ag Combination therapy
KR102684364B1 (ko) 2018-05-11 2024-07-11 이마고 바이오사이언시즈 인코포레이티드 질환의 치료를 위한 kdm1a 저해제
KR102865950B1 (ko) * 2019-03-22 2025-09-30 사니오나 에이/에스 신규의 칼륨 채널 억제제
ES3025633T3 (en) 2019-05-13 2025-06-09 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
DK4122926T3 (da) * 2021-04-14 2025-06-30 Shionogi & Co Triazinderivater med virusreplikationsinhiberende aktivitet og farmaceutisk sammensætning, der omfatter disse
CN113999129B (zh) * 2021-11-23 2023-09-01 长沙普济生物科技股份有限公司 一种含酚羟基氨基酸表面活性剂的合成方法
WO2025122555A1 (en) * 2023-12-05 2025-06-12 Valo Health, Inc. S1p 1 receptor agonists and uses thereof
CN119350255B (zh) * 2024-10-21 2025-12-09 海南大学 一种酮衍生物及其合成方法和用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4199309B2 (ja) * 1996-09-06 2008-12-17 日本化薬株式会社 新規アセトアミド誘導体およびプロテアーゼ阻害
TWI328007B (en) 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
MXPA04008822A (es) 2002-03-14 2004-11-26 Bayer Healthcare Ag Aroilpiridinonas monociclicas.
MXPA05000784A (es) 2002-07-19 2005-06-17 Biovitrum Ab Derivados de piperazinil-pirazinona novedosos para el tratamiento de los trastornos relacionados con el receptor 5-ht2a.
MXPA06003615A (es) 2003-09-30 2006-06-05 Amgen Inc Ligandos del receptor vanilloide y su uso en tratamientos.
WO2005035527A1 (en) * 2003-10-14 2005-04-21 Pharmacia Corporation Substituted pyrazinone compounds for the treatment of inflammation
NZ545694A (en) * 2003-12-03 2010-04-30 Ym Bioscience Australia Pty Lt Azole-based kinase inhibitors
GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
CA2572119A1 (en) 2004-06-29 2006-01-12 Warner-Lambert Company Llc Combination therapies utilizing benzamide inhibitors of the p2x7 receptor
JP4496092B2 (ja) 2005-01-12 2010-07-07 信越化学工業株式会社 光ファイバ母材の製造方法及び装置
ES2412007T3 (es) 2005-12-21 2013-07-09 Janssen Pharmaceutica, N.V. Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1
GB0608837D0 (en) 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of MAP kinase
NZ573348A (en) 2006-05-04 2012-01-12 Chroma Therapeutics Ltd p38 MAP KINASE INHIBITORS
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
JP2009537602A (ja) * 2006-05-22 2009-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤として用いるための置換ピラジノン誘導体
TW200924754A (en) * 2006-06-21 2009-06-16 Du Pont Pyrazinones as cellular proliferation inhibitors
EP2034993A2 (en) * 2006-06-21 2009-03-18 E.I. Du Pont De Nemours And Company Pyrazinones as cellular proliferation inhibitors
RU2479580C2 (ru) * 2007-06-27 2013-04-20 Астразенека Аб Производные пиразинона и их применение для лечения легочных заболеваний

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