RU2419601C2 - Способ фторирования анилидных производных и фторированные производные бензотиазола в качестве in vivo визуализирующих агентов - Google Patents
Способ фторирования анилидных производных и фторированные производные бензотиазола в качестве in vivo визуализирующих агентов Download PDFInfo
- Publication number
- RU2419601C2 RU2419601C2 RU2008103989/04A RU2008103989A RU2419601C2 RU 2419601 C2 RU2419601 C2 RU 2419601C2 RU 2008103989/04 A RU2008103989/04 A RU 2008103989/04A RU 2008103989 A RU2008103989 A RU 2008103989A RU 2419601 C2 RU2419601 C2 RU 2419601C2
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- alkyl
- fluoro
- hydrogen
- Prior art date
Links
- PEXVQZMLRAXKOE-UHFFFAOYSA-N [O-][N+](c(cc(cc1)C(Nc(cc2)ccc2O)=O)c1Cl)=O Chemical compound [O-][N+](c(cc(cc1)C(Nc(cc2)ccc2O)=O)c1Cl)=O PEXVQZMLRAXKOE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/46—Aniline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0516564.2A GB0516564D0 (en) | 2005-08-12 | 2005-08-12 | Fluorination process |
| GB0516564.2 | 2005-08-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008103989A RU2008103989A (ru) | 2009-09-20 |
| RU2419601C2 true RU2419601C2 (ru) | 2011-05-27 |
Family
ID=35098197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008103989/04A RU2419601C2 (ru) | 2005-08-12 | 2006-08-11 | Способ фторирования анилидных производных и фторированные производные бензотиазола в качестве in vivo визуализирующих агентов |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US8410312B2 (zh) |
| EP (1) | EP1915330B1 (zh) |
| JP (2) | JP5566605B2 (zh) |
| KR (2) | KR101409608B1 (zh) |
| CN (2) | CN101282920B (zh) |
| AU (1) | AU2006281216B2 (zh) |
| BR (1) | BRPI0614752B1 (zh) |
| CA (1) | CA2618448C (zh) |
| DK (1) | DK1915330T3 (zh) |
| ES (1) | ES2527864T3 (zh) |
| GB (1) | GB0516564D0 (zh) |
| HK (1) | HK1177463A1 (zh) |
| IL (1) | IL188933A0 (zh) |
| MX (2) | MX341173B (zh) |
| NO (1) | NO341560B1 (zh) |
| NZ (1) | NZ565333A (zh) |
| PL (1) | PL1915330T3 (zh) |
| PT (1) | PT1915330E (zh) |
| RU (1) | RU2419601C2 (zh) |
| WO (1) | WO2007020400A1 (zh) |
| ZA (1) | ZA200801860B (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
| WO2008106442A1 (en) * | 2007-02-27 | 2008-09-04 | Ge Healthcare Limited | Synthesis of [18f] fluoromethyl benzene using benzyl pentafluorobenzenesulfonate |
| DK2182988T3 (da) * | 2007-08-30 | 2014-05-26 | Ge Healthcare Ltd | Radiofarmaceutisk præparat |
| EP2238074A2 (en) | 2008-01-03 | 2010-10-13 | GE Healthcare UK Limited | Fluoride processing method |
| ES2540536T3 (es) | 2008-09-23 | 2015-07-10 | Wista Laboratories Ltd. | Ligandos para moléculas tau agregadas |
| GB0921967D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel Aryloxyanilide Derivatives |
| GB201019303D0 (en) | 2010-11-15 | 2010-12-29 | Strom Hans E P | Agents and methods for visualising analytes |
| CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
| WO2016087653A1 (en) | 2014-12-04 | 2016-06-09 | Ge Healthcare Limited | Method of removing acetaldehyde from radioactive pharmaceuticals |
| JP6485914B2 (ja) * | 2015-10-28 | 2019-03-20 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
| JP6955347B2 (ja) | 2017-02-28 | 2021-10-27 | 日本メジフィジックス株式会社 | フルテメタモルの製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878206A (en) * | 1973-06-06 | 1975-04-15 | Morton Norwich Products Inc | 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines |
| FR2449677B1 (fr) | 1979-02-26 | 1986-03-28 | Fabre Sa Pierre | Nouveaux derives de benzoyl-2 glycylanilides substitues, leur preparation et leur application en tant que medicaments anxiolytiques |
| FR2693781B1 (fr) * | 1992-07-15 | 1994-10-28 | Otis Elevator Co | Dispositif de réglage de la tension d'un câble faisant boucle. |
| DE4402056A1 (de) | 1994-01-25 | 1995-07-27 | Basf Ag | p-Phenylendiamin-Derivate und sie enthaltende fungizide Mittel |
| US7270800B2 (en) * | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
| RU2440995C2 (ru) * | 2003-03-14 | 2012-01-27 | Юнивесити Оф Питсбэг | Производные бензотиазола, фармацевтическая композиция, обладающая свойством связывать амилоид, и способ детекции отложений амилоида у млекопитающего |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| PT1771208E (pt) * | 2004-07-02 | 2013-09-24 | Univ Pittsburgh | Utilização de derivados de tioflavina radiorotulados em imagiologia amiloide para avaliar terapias anti-amiloide |
| GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
-
2005
- 2005-08-12 GB GBGB0516564.2A patent/GB0516564D0/en not_active Ceased
-
2006
- 2006-08-11 RU RU2008103989/04A patent/RU2419601C2/ru active
- 2006-08-11 US US12/063,470 patent/US8410312B2/en active Active
- 2006-08-11 AU AU2006281216A patent/AU2006281216B2/en active Active
- 2006-08-11 WO PCT/GB2006/003009 patent/WO2007020400A1/en active Application Filing
- 2006-08-11 BR BRPI0614752-6A patent/BRPI0614752B1/pt active IP Right Grant
- 2006-08-11 JP JP2008525644A patent/JP5566605B2/ja active Active
- 2006-08-11 ES ES06765263.6T patent/ES2527864T3/es active Active
- 2006-08-11 MX MX2013013741A patent/MX341173B/es unknown
- 2006-08-11 CA CA2618448A patent/CA2618448C/en active Active
- 2006-08-11 CN CN200680037139.7A patent/CN101282920B/zh active Active
- 2006-08-11 DK DK06765263.6T patent/DK1915330T3/en active
- 2006-08-11 CN CN201210177977.1A patent/CN102731432B/zh active Active
- 2006-08-11 NZ NZ565333A patent/NZ565333A/en unknown
- 2006-08-11 KR KR1020137025584A patent/KR101409608B1/ko active IP Right Grant
- 2006-08-11 PL PL06765263T patent/PL1915330T3/pl unknown
- 2006-08-11 EP EP06765263.6A patent/EP1915330B1/en active Active
- 2006-08-11 MX MX2008002068A patent/MX2008002068A/es active IP Right Grant
- 2006-08-11 PT PT67652636T patent/PT1915330E/pt unknown
-
2008
- 2008-01-22 IL IL188933A patent/IL188933A0/en active IP Right Grant
- 2008-02-11 KR KR1020087003263A patent/KR101392538B1/ko active Protection Beyond IP Right Term
- 2008-02-27 ZA ZA200801860A patent/ZA200801860B/xx unknown
- 2008-03-05 NO NO20081167A patent/NO341560B1/no unknown
-
2013
- 2013-03-22 US US13/848,877 patent/US9126961B2/en active Active
- 2013-04-17 HK HK13104661.5A patent/HK1177463A1/zh unknown
- 2013-09-24 JP JP2013196384A patent/JP2014028837A/ja not_active Withdrawn
-
2015
- 2015-07-27 US US14/809,497 patent/US9468694B2/en active Active
Non-Patent Citations (1)
| Title |
|---|
| D.A.FORSYTH et al, Intrinsic and Equilibrium NMR Isotope Shift Evidence for Negative Hyperconjugation, J. AM. CHEM. SOC., 1986, 108, 2157-2161. A.ZAKRZEWSKA et al, 4-Fluoroanilines: synthesis and decomposition, J. FLUORINE CHEM., 2001, 111, 1-10. E.D.BERGMANN et al, An improved method for the preparation of fluorine-substituted aromatic amines, J. ORG. CHEM., 1954, 19, 1594-1599. M.ZHANG et al, Synthesis of 3-Methylkynurenic Acid Derivatives, CHINESE J. ORG. CHEM., 2004, 24, No.4, 440-443. S.STAVBER et al, New, mild, directed and high yield method for the fluorofunctionalisation of aromatic molecules, J. FLUORINE CHEM., 1991, 54, 268-268. D.J.MILNER, Fluoroaromatics from arylamines, a convenient one-pot conversion using nitrosonium tetrafluoroborate, SYNTH. COMMUN., 1992, 22, 73-82. * |
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