RU2412935C2 - Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar - Google Patents

Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar Download PDF

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RU2412935C2
RU2412935C2 RU2007147050/04A RU2007147050A RU2412935C2 RU 2412935 C2 RU2412935 C2 RU 2412935C2 RU 2007147050/04 A RU2007147050/04 A RU 2007147050/04A RU 2007147050 A RU2007147050 A RU 2007147050A RU 2412935 C2 RU2412935 C2 RU 2412935C2
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Сёрен ЭБДРУП (DK)
Сёрен ЭБДРУП
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Хай Пойнт Фармасьютикалс, ЛЛС
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Abstract

В настоящем изобретении описаны феноксиуксусные кислоты формулы I
Figure 00000153
где Х выбран из S и SCH2, X1 представляет собой О, R1 представляет собой C1-6алкил, R2 представляет собой -C≡C-R2a, R2a представляет собой С1-4алкил, замещенный морфолинилом, R3 выбран из хлора и метила, R4a представляет собой Н, R4b представляет собой Н, R4c представляет собой Н, R5a представляет собой Н, R5b представляет собой Н, R5c представляет собой Н, R5d представляет собой Н и R5e представляет собой H,
и содержащие их фармацевтические композиции. Феноксиуксусные кислоты являются активаторами PPAR-δ и могут быть полезны для лечения состояний, опосредованных ими. 2 н. и 4 з.п. ф-лы.

Description

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Claims (6)

1. Соединение формулы I:
Figure 00000151

или его фармацевтически приемлемая соль, где
X выбран из S и SCH2;
X1 представляет собой О;
R1 представляет собой C1-6алкил;
R2 представляет собой -C≡C-R2a;
R2a представляет собой С1-4алкил, замещенный морфолинилом;
R3 выбран из хлора и метила;
R4a представляет собой Н;
R4b представляет собой Н;
R4c представляет собой Н;
R5a представляет собой Н;
R5b представляет собой Н;
R5c представляет собой Н;
R5d представляет собой Н; и
R5e представляет собой Н.
2. Соединение по п.1, где это соединение имеет формулу Iа:
Figure 00000152

или его фармацевтически приемлемая соль.
3. Соединение по п.2, где Х представляет собой S.
4. Соединение по п.1, где это соединение представляет собой:
{4-[3-Изобутокси-5-(3-морфолин-4-ил-проп-1-инил)-фенилсульфанил]-2-метилфенокси}-уксусной кислоты
или его фармацевтически приемлемую соль.
5. Соединение по п.1, где это соединение представляет собой:
{4-[3-Изобутокси-5-(3-морфолин-4-ил-проп-1-инил)-бензилсульфанил]-2-метилфенокси}-уксусной кислоты
или его фармацевтически приемлемую соль.
6. Фармацевтическая композиция, активирующая дельта рецепторы PPAR, содержащая фармацевтически приемлемый носитель и соединение по любому из пп.1-5.
RU2007147050/04A 2005-06-30 2006-06-29 Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar RU2412935C2 (ru)

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EP1979311B1 (en) 2005-12-22 2012-06-13 High Point Pharmaceuticals, LLC Phenoxy acetic acids as ppar delta activators
CA2645719A1 (en) 2006-03-09 2007-09-13 High Point Pharmaceuticals, Llc Compounds that modulate ppar activity, their preparation and use
US9317222B1 (en) 2006-04-24 2016-04-19 Emc Corporation Centralized content addressed storage
US9235477B1 (en) 2006-04-24 2016-01-12 Emc Corporation Virtualized backup solution
US8065273B2 (en) 2006-05-10 2011-11-22 Emc Corporation Automated priority restores
US9684739B1 (en) 2006-05-11 2017-06-20 EMC IP Holding Company LLC View generator for managing data storage
US8987328B2 (en) * 2008-10-30 2015-03-24 Trinity Laboratories, Inc. Esters of capsaicinoids as dietary supplements
CN103298799B (zh) * 2010-12-28 2015-05-13 卡迪拉保健有限公司 适用于治疗血脂异常的杂环化合物
CA2923422C (en) 2013-09-09 2021-09-07 Vtv Therapeutics Llc Use of a ppar-delta agonist for treating muscle atrophy
CN105092770B (zh) * 2015-01-12 2017-03-29 上海中医药大学 一种筛选二肽基肽酶四抑制剂的方法
JP2023534835A (ja) 2020-07-22 2023-08-14 レネオ ファーマシューティカルズ，インク． 結晶性ｐｐａｒデルタアゴニスト
MX2023006123A (es) * 2020-11-25 2023-06-02 Reneo Pharmaceuticals Inc Metodos para elaborar un agonista de ppar-delta.
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920132A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5324743A (en) 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
GB2279659B (en) 1993-07-05 1998-04-22 Merck Patent Gmbh Liquid crystalline material
WO1997026265A1 (en) 1996-01-17 1997-07-24 Novo Nordisk A/S Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
ES2217392T3 (es) 1996-02-02 2004-11-01 MERCK & CO., INC. Agentes antidiabeticos.
CA2245529A1 (en) 1996-02-02 1997-08-07 Soumya P. Sahoo Antidiabetic agents
AU712607B2 (en) 1996-02-02 1999-11-11 Merck & Co., Inc. Method of treating diabetes and related disease states
AU708055B2 (en) 1996-02-02 1999-07-29 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
DE122009000079I2 (de) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
ATE319440T1 (de) 1996-12-23 2006-03-15 Merck & Co Inc Antidiabetische mittel
JP2003514508A (ja) 1997-07-01 2003-04-15 ノボ ノルディスク アクティーゼルスカブ グルカゴン拮抗剤／逆作用剤
KR20010021936A (ko) 1997-07-16 2001-03-15 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 융합된 1,2,4-티아디아진 유도체, 그의 제조와 사용
DE69840510D1 (de) 1997-07-24 2009-03-12 Astellas Pharma Inc Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung
PL344977A1 (en) 1997-10-17 2001-11-19 Aventis Pharm Prod Inc Therapeutic uses of quinoline derivatives
JP2003500432A (ja) 1999-06-01 2003-01-07 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター ジフェニルエーテル誘導体を用いて脱毛症を処置する方法
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
WO2001025226A1 (en) 1999-10-05 2001-04-12 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
WO2001034200A1 (fr) 1999-11-10 2001-05-17 Takeda Chemical Industries, Ltd Inhibiteurs de prise de poids
CZ20021551A3 (cs) 1999-11-11 2003-02-12 Eli Lilly And Company Onkolytické kombinace pro léčení rakoviny
AU784722B2 (en) 2000-02-18 2006-06-01 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
IL151517A0 (en) 2000-03-09 2003-04-10 Aventis Pharma Gmbh Therapeutic uses of ppar mediators
US6448293B1 (en) 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
JP2001354671A (ja) 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
ATE542805T1 (de) 2000-08-11 2012-02-15 Nippon Chemiphar Co Ppar-delta aktivatoren
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
GB0024361D0 (en) 2000-10-05 2000-11-22 Glaxo Group Ltd Medicaments
WO2002046154A1 (en) 2000-12-05 2002-06-13 Nippon Chemiphar Co., Ltd. Peroxisome proliferator activated receptor d activators
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031107D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
EP1357115B1 (en) 2000-12-28 2009-06-17 Takeda Pharmaceutical Company Limited Alkanoic acid derivatives, process for their production and use thereof
EP1357914A2 (en) 2001-02-02 2003-11-05 SmithKline Beecham Corporation Treatment of ppar mediated diseases
EP1371650A4 (en) 2001-03-23 2005-05-04 Nippon Chemiphar Co ACTIVATED RECEPTOR ACTIVATOR BY PEROXYSOME PROLIFIERS
WO2002079162A1 (fr) 2001-03-28 2002-10-10 Eisai Co., Ltd. Acides carboxyliques
WO2002080899A1 (fr) 2001-03-30 2002-10-17 Eisai Co., Ltd. Agent de traitement de maladie digestive
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
FR2826574B1 (fr) 2001-06-29 2005-08-26 Oreal Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles
CA2457054C (en) 2001-08-10 2011-10-11 Nippon Chemiphar Co., Ltd. Activator of peroxisome proliferator-activated receptor .delta.
EP1452521A4 (en) 2001-08-17 2007-03-14 Eisai R&D Man Co Ltd CYCLIC COMPOUND AND AGONIST OF PPAR RECEPTOR
JP4269052B2 (ja) 2001-09-14 2009-05-27 アムジエン・インコーポレーテツド 連結ビアリール化合物
AU2002335231B2 (en) 2001-10-12 2008-05-08 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor delta
PL370244A1 (en) 2001-10-17 2005-05-16 Novo Nordisk A/S Dicarboxylic acid derivatives, their preparation and therapeutic use
DE10151390A1 (de) 2001-10-18 2003-05-08 Bayer Ag Essigsäurederivate
JP2003171275A (ja) 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト
US6648293B1 (en) * 2001-12-20 2003-11-18 Braeside Plastics Corporation Foldable display container and method for assembling the same
EP1480640B1 (en) 2002-02-25 2007-08-15 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
WO2003074495A1 (en) 2002-03-01 2003-09-12 Smithkline Beecham Corporation Hppars activators
US20030207924A1 (en) 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
DE10222034A1 (de) 2002-05-17 2003-11-27 Bayer Ag Tetrahydroisochinolin-Derivate
GB0214149D0 (en) 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
GB0214254D0 (en) 2002-06-20 2002-07-31 Glaxo Group Ltd Chemical compounds
DE10229777A1 (de) 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
WO2004007439A1 (ja) * 2002-07-10 2004-01-22 Sumitomo Pharmaceuticals Co., Ltd. ビアリール誘導体
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
JP2006510687A (ja) 2002-12-20 2006-03-30 ノボ　ノルディスク　アクティーゼルスカブ 新規化合物、その調製および使用
US20060241157A1 (en) 2003-01-06 2006-10-26 Conner Scott E Heterocyclic ppar modulators
DE10300099A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Indol-Phenylsulfonamid-Derivate
EP1594847A2 (en) 2003-02-12 2005-11-16 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
WO2004073606A2 (en) 2003-02-14 2004-09-02 Eli Lilly And Company Sulfonamide derivatives as ppar modulators
EP1604971A4 (en) 2003-03-11 2006-08-16 Ono Pharmaceutical Co PROCESS FOR ADDING ACTIVE CHARCOAL IN WATER PURIFICATION AND WATER PURIFICATION METHOD
WO2004080947A1 (ja) 2003-03-13 2004-09-23 Ono Pharmaceutical Co., Ltd. イミノエーテル誘導体化合物およびその化合物を有効成分として含有する薬剤
WO2004092117A1 (en) 2003-04-07 2004-10-28 Kalypsys, Inc. Para-sulfonyl substituted phenyl compounds as modulators of ppars
ATE339205T1 (de) 2003-04-17 2006-10-15 Kalypsys Inc (3-ä3-'(2,4-bis-trifluormethyl-benzyl)-(5-ethyl pyrimidin-2-yl)-amino)-propoxyü-phenyl)- essigsäure und verwandte verbindungen als modulatoren von ppars und verfahren zur behandlung von stoffwechselstörungen
US7244763B2 (en) 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
WO2004099170A2 (en) 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
WO2005054176A1 (en) 2003-11-25 2005-06-16 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
JP4813460B2 (ja) 2004-04-01 2011-11-09 アベンティス・ファーマスーティカルズ・インコーポレイテツド ＰＰＡＲδモジュレーターとしての１，３，４−オキサジアゾール−２−オン及びその使用
MXPA06011218A (es) 2004-04-01 2007-01-16 Aventis Pharma Inc Uso de agonistas del receptor delta activado por el proliferador de peroxisoma para el tratamiento de esclerosis multiple y otras enfermedades de desmielinizacion.
CN1956984B (zh) 2004-04-01 2010-06-09 安万特药物公司 1,3,4-二唑-2-酮作为PPAR-δ调节剂
ES2352085T3 (es) 2004-05-05 2011-02-15 High Point Pharmaceuticals, Llc Nuevos compuestos, su preparación y uso.
AU2005245418B2 (en) 2004-05-14 2008-11-27 Irm Llc Compounds and compositions as PPAR modulators
CA2645719A1 (en) 2006-03-09 2007-09-13 High Point Pharmaceuticals, Llc Compounds that modulate ppar activity, their preparation and use

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