RU2412934C2 - Применение антагонистов crth2 в терапии - Google Patents

Применение антагонистов crth2 в терапии Download PDF

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RU2412934C2
RU2412934C2 RU2006109769/04A RU2006109769A RU2412934C2 RU 2412934 C2 RU2412934 C2 RU 2412934C2 RU 2006109769/04 A RU2006109769/04 A RU 2006109769/04A RU 2006109769 A RU2006109769 A RU 2006109769A RU 2412934 C2 RU2412934 C2 RU 2412934C2
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Russia
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acetic acid
alkyl
fluoro
compound
methyl
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RU2006109769/04A
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Russian (ru)
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RU2006109769A (ru
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Девид МИДЛЕМИС (GB)
Девид МИДЛЕМИС
Марк Ричард ЭШТОН (GB)
Марк Ричард Эштон
Эдвард Эндрю БОЙД (GB)
Эдвард Эндрю Бойд
Фредерик Артур БРУКФИЛД (GB)
Фредерик Артур Брукфилд
Эрик Рой ПЕТИФЕР (GB)
Эрик Рой ПЕТИФЕР
Марк ВИТТАКЕР (GB)
Марк ВИТТАКЕР
Кристофер ПАЛМЕР (GB)
Кристофер Палмер
Мик ХАНТЕР (GB)
Мик ХАНТЕР
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Оксаген Лимитед
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    • C07ORGANIC CHEMISTRY
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    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/04Indoles; Hydrogenated indoles
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Ophthalmology & Optometry (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2006109769/04A 2003-10-23 2004-10-19 Применение антагонистов crth2 в терапии RU2412934C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0324763.2 2003-10-23
GBGB0324763.2A GB0324763D0 (en) 2003-10-23 2003-10-23 Use of compounds in therapy

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RU2006109769A RU2006109769A (ru) 2007-11-27
RU2412934C2 true RU2412934C2 (ru) 2011-02-27

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US (5) US7582672B2 (https=)
EP (2) EP1682121B1 (https=)
JP (1) JP4313819B2 (https=)
KR (1) KR20060096145A (https=)
CN (1) CN101141956B (https=)
AT (1) ATE439129T1 (https=)
AU (1) AU2004287245B2 (https=)
BR (1) BRPI0415374B8 (https=)
CA (1) CA2543199C (https=)
CY (1) CY1109980T1 (https=)
DE (1) DE602004022579D1 (https=)
DK (1) DK1682121T3 (https=)
ES (1) ES2330113T3 (https=)
GB (1) GB0324763D0 (https=)
HR (1) HRP20090577T8 (https=)
IL (1) IL175085A0 (https=)
NO (1) NO335228B1 (https=)
NZ (1) NZ547319A (https=)
PL (1) PL1682121T3 (https=)
PT (1) PT1682121E (https=)
RU (1) RU2412934C2 (https=)
SI (1) SI1682121T1 (https=)
UA (1) UA86602C2 (https=)
WO (1) WO2005044260A1 (https=)
ZA (1) ZA200603235B (https=)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
RU2616000C2 (ru) * 2011-03-07 2017-04-12 Атопикс Терапьютикс Лимитед Аморфная (5-фтор-2-метил-3-хинолин-2-илметилиндол-1-ил)-уксусная кислота
US11091806B2 (en) 2015-07-23 2021-08-17 Merck Sharp & Dohme Corp. Genetic markers associated with response to CRTH2 receptor antagonists
RU2756270C2 (ru) * 2016-07-21 2021-09-29 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Производное индола, используемое в качестве ингибитора CRTH2

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GB0605743D0 (en) * 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
EP2037967B1 (en) 2006-06-16 2016-12-07 The Trustees Of The University Of Pennsylvania Prostaglandin d2 receptor antagonists for treating androgenetic alopecia
US7999119B2 (en) 2006-07-22 2011-08-16 Oxagen Limited Compounds having CRTH2 antagonist activity
BRPI0715179A2 (pt) 2006-08-07 2013-06-11 Actelion Pharmaceuticals Ltd composto, composiÇço farmacÊutica e uso de um composto
US20100010034A1 (en) * 2006-12-21 2010-01-14 George Hynd Crth2 antagonists
US20100137300A1 (en) * 2007-03-21 2010-06-03 George Hynd Indolizine Acetic Acid Derivatives as CRTH2 Antagonists
US8273746B2 (en) * 2007-03-23 2012-09-25 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibitors
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UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
WO2009061730A2 (en) 2007-11-05 2009-05-14 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid
US20110124683A1 (en) * 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
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GB0722203D0 (en) * 2007-11-13 2007-12-19 Oxagen Ltd Use of CRTH2 antagonist compounds
PT2229358E (pt) 2007-12-14 2011-06-29 Pulmagen Therapeutics Asthma Ltd Indoles e sua utilização terapêutica
AU2009204700B2 (en) 2008-01-18 2013-07-04 Atopix Therapeutics Limited Compounds having CRTH2 antagonist activity
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EP2265581A1 (en) * 2008-01-22 2010-12-29 Oxagen Limited Compounds having crth2 antagonist activity
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Crth2アンタゴニスト活性を有する化合物
CN101952244B (zh) 2008-02-01 2014-11-05 潘米拉制药公司 前列腺素d2受体的n,n-二取代氨基烷基联苯拮抗剂
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JP2011513242A (ja) 2008-02-25 2011-04-28 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体アンタゴニスト
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