RU2401661C9 - Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор - Google Patents

Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор Download PDF

Info

Publication number
RU2401661C9
RU2401661C9 RU2007105987/14A RU2007105987A RU2401661C9 RU 2401661 C9 RU2401661 C9 RU 2401661C9 RU 2007105987/14 A RU2007105987/14 A RU 2007105987/14A RU 2007105987 A RU2007105987 A RU 2007105987A RU 2401661 C9 RU2401661 C9 RU 2401661C9
Authority
RU
Russia
Prior art keywords
cells
poly
apoptosis
tlr
tlr3
Prior art date
Application number
RU2007105987/14A
Other languages
English (en)
Russian (ru)
Other versions
RU2401661C2 (ru
RU2007105987A (ru
Inventor
Серж ЛЕБЕК (FR)
Серж ЛЕБЕК
Туфик РЕННО (FR)
Туфик РЕННО
Брюно САЛОН (CH)
Брюно САЛОН
Изабель КОСТ-ИНВЕРНИЦЦИ (FR)
Изабель КОСТ-ИНВЕРНИЦЦИ
Мари-Клотильд РИССОАН (FR)
Мари-Клотильд РИССОАН
Original Assignee
Шеринг Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шеринг Корпорейшн filed Critical Шеринг Корпорейшн
Publication of RU2007105987A publication Critical patent/RU2007105987A/ru
Publication of RU2401661C2 publication Critical patent/RU2401661C2/ru
Application granted granted Critical
Publication of RU2401661C9 publication Critical patent/RU2401661C9/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2007105987/14A 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор RU2401661C9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58961604P 2004-07-20 2004-07-20
US60/589,616 2004-07-20

Publications (3)

Publication Number Publication Date
RU2007105987A RU2007105987A (ru) 2008-08-27
RU2401661C2 RU2401661C2 (ru) 2010-10-20
RU2401661C9 true RU2401661C9 (ru) 2011-01-27

Family

ID=35229744

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007105987/14A RU2401661C9 (ru) 2004-07-20 2005-07-19 Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор

Country Status (12)

Country Link
US (2) US20060147456A1 (OSRAM)
EP (1) EP1768699A1 (OSRAM)
JP (1) JP2008507530A (OSRAM)
KR (1) KR20070043795A (OSRAM)
CN (1) CN101018567B (OSRAM)
AT (1) ATE511859T1 (OSRAM)
AU (2) AU2005269733B2 (OSRAM)
CA (1) CA2574176A1 (OSRAM)
MX (1) MX2007000770A (OSRAM)
NO (1) NO20070945L (OSRAM)
RU (1) RU2401661C9 (OSRAM)
WO (1) WO2006014653A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258712A3 (en) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
US20060172959A1 (en) * 2003-03-26 2006-08-03 Dan Smith Selected rna motifs to include cell death and/or apoptosis
WO2006054129A1 (en) 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
US20120189643A1 (en) * 2004-11-30 2012-07-26 Carton Jill M Toll Like Receptor 3 Antagonists, Methods and Uses
WO2007100304A1 (en) 2006-03-02 2007-09-07 Agency For Science, Technology And Research Methods for cancer therapy and stem cell modulation
WO2007133800A2 (en) 2006-05-15 2007-11-22 University Of Kentucky Toll-like receptor (tlr) stimulation for ocular angiogenesis and macular degeneration
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
US20080124366A1 (en) * 2006-08-06 2008-05-29 Ohlfest John R Methods and Compositions for Treating Tumors
JP5115921B2 (ja) * 2007-02-28 2013-01-09 株式会社ペルセウスプロテオミクス 腎癌の診断薬および治療薬
EP2327801A1 (en) * 2007-04-24 2011-06-01 John Wayne Cancer Institute Functional toll-like receptors (TLR) on melanocytes and melanoma cells and uses thereof
CN101909630A (zh) * 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
CN101896276A (zh) * 2007-11-28 2010-11-24 智能管公司 用于生物标本的收集、刺激、稳定化和分析的装置、系统和方法
US8481508B2 (en) 2008-02-21 2013-07-09 University Of Kentucky Research Foundation Ultra-small RNAs as toll-like receptor-3 antagonists
EP2281043B1 (en) 2008-04-25 2013-03-13 Innate Pharma Improved tlr3 agonist compositions
EP2316032A1 (en) * 2008-08-20 2011-05-04 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for predicting the response to anti-cancer treatment with an agonist of tlr7 or an agonist of tlr8
GB0820698D0 (en) * 2008-11-12 2008-12-17 Ludwig Inst Cancer Res Uses of immunomodulators
US8628762B2 (en) 2008-12-10 2014-01-14 Icahn School Of Medicine At Mount Sinai T-helper cell type 17 lineage-specific adjuvants, compositions and methods
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
WO2011072871A1 (en) * 2009-12-18 2011-06-23 Bavarian Nordic A/S Production of ifn-lambda by conventional dendritic cells and uses thereof
KR101250419B1 (ko) * 2010-12-16 2013-04-05 강원대학교산학협력단 Ｔｌｒ 작동제를 포함하는 유방암 방사선 치료 보조제
US20140255341A1 (en) * 2011-07-22 2014-09-11 Pawel Kalinski Tumor Selective Chemokine Modulation
CN102652802A (zh) * 2012-04-18 2012-09-05 南京中医药大学 癌毒方在制备调控肝癌细胞TLRs／NF-κB信号转导药物中的应用
EP2879669A4 (en) * 2012-07-29 2016-04-13 Univ Colorado Regents ANTAGONISTS OF THE TOLL LIKE RECEPTOR 1/2 COMPLEX
US10105305B2 (en) * 2014-02-19 2018-10-23 The Johns Hopkins University Compositions and methods for promoting skin regeneration and hair growth
US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
CN105796594A (zh) * 2016-03-28 2016-07-27 南京大学 一种组合物在制备治疗肿瘤药物中的应用及该组合物的使用方法
CN106191238B (zh) * 2016-07-08 2020-01-10 中国医学科学院基础医学研究所 Tlr3预测肿瘤转移、评估预后和选择防治方案的应用
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN108295060A (zh) * 2018-04-08 2018-07-20 王长国 一种tlr7激动剂在增强cik细胞对肿瘤细胞杀伤力方面的应用
US11969402B2 (en) 2019-05-16 2024-04-30 The Johns Hopkins University Compositions and methods for skin rejuvenation
CN111117966A (zh) * 2020-03-02 2020-05-08 南通大学 一种利用乳酸的体外细胞培养方法
CN111579538B (zh) * 2020-04-22 2022-12-30 山东第一医科大学(山东省医学科学院) 一种利用凋亡试剂盒检测循环肿瘤细胞的方法
BR112023024392A2 (pt) * 2021-05-24 2024-02-15 Cha Vaccine Res Institute Co Ltd Uso de uma formulação de combinação farmacêutica, uso de lipopeptídeos e poli(i:c), e pelo menos um ingrediente ativo adicional

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136278C1 (ru) * 1998-04-07 1999-09-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Противоопухолевое средство

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
CN1040504A (zh) * 1988-06-22 1990-03-21 Hem研究公司 用双链核糖核酸调节淋巴激活素抗性细胞状态
US20040006242A1 (en) * 1999-02-01 2004-01-08 Hawkins Lynn D. Immunomodulatory compounds and method of use thereof
EP1412390A2 (en) * 2001-07-26 2004-04-28 Tanox, Inc. Agents that activate or inhibit toll-like receptor 9
TW200303759A (en) * 2001-11-27 2003-09-16 Schering Corp Methods for treating cancer
CA2506356A1 (en) * 2002-11-22 2004-06-10 Nuvelo, Inc. Methods of therapy and diagnosis
JP3810731B2 (ja) * 2002-11-29 2006-08-16 独立行政法人科学技術振興機構 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2136278C1 (ru) * 1998-04-07 1999-09-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Противоопухолевое средство

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANDRE F. et al. Targeting Toll like receptor 3 by double stranded RNA in breast cancer: Results from in vitro studies and randomized trial // Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition), vol 22, No 14S (July 15 Supplement), 2004: 9619, abstract. *
MATSUMOTO M. et al. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling // Biochem Biophys Res Commun. 2002 May 24; 293(5), p.1364-1369, abstract. CHO C-H et al. Antitumor Effect of Monophosphoryl Lipid A Polyadenylic - Polyuridylic Acid and Cisplatin on В 16 Melanoma - induced Pulmonary Metastasis in Mice // Journal of Bacteriology and Virology, 1994, vol.29, №2, p.231-244, abstract. YOUN J.K. et al. Adjuvant treatment of operable stomach cancer with polyadenylic. polyuridylic acid in addition to chemotherapeutic agents: a preliminary report // Int J Immunopharmacol. 1990; 12(3), p.289-295, abstract. MOTZER R.J. et al. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma // J Clin Oncol. 2002 Jan 1; 20(1), p.289-296, abstract. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2826262C2 (ru) * 2018-05-04 2024-09-09 Толлиз Лиганды tlr3, которые активируют как эпителиальные, так и миелоидные клетки

Also Published As

Publication number Publication date
AU2005269733A1 (en) 2006-02-09
RU2401661C2 (ru) 2010-10-20
KR20070043795A (ko) 2007-04-25
US20090285779A1 (en) 2009-11-19
AU2005269733B2 (en) 2008-10-30
NO20070945L (no) 2007-02-19
CN101018567B (zh) 2011-07-27
EP1768699A1 (en) 2007-04-04
WO2006014653A1 (en) 2006-02-09
JP2008507530A (ja) 2008-03-13
CN101018567A (zh) 2007-08-15
RU2007105987A (ru) 2008-08-27
ATE511859T1 (de) 2011-06-15
CA2574176A1 (en) 2006-02-09
AU2008249173A1 (en) 2008-12-11
US20060147456A1 (en) 2006-07-06
MX2007000770A (es) 2007-03-26

Similar Documents

Publication Publication Date Title
RU2401661C9 (ru) Индукция апоптоза в опухолевых клетках, экспрессирующих toll-подобный рецептор
US20240368607A1 (en) Synthetic rig-i-like receptor agonists
Murad et al. CpG oligodeoxynucleotides as TLR9 agonists: therapeutic applications in cancer
ES2902835T3 (es) Composiciones celulares mejoradas y métodos para la terapia contra el cáncer
US20090191185A1 (en) Reducing Cancer Cell Invasion Using an Inhibitor of Toll Like Receptor Signaling
US12234480B2 (en) Therapeutic methods involving modulating inflammasome activation of myeloid-derived suppressor cells
US11081235B2 (en) Extracellular matrix metalloproteinase inducer (EMMPRIN) peptides and binding antibodies
JP5665739B2 (ja) 炎症性疾患を治療するためのｃｄ９５インヒビターの使用
HK40023269A (en) Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd
Dalton et al. Bone Marrow Stroma Confers Resistance to
HK1256917B (en) Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor

Legal Events

Date Code Title Description
TH4A Reissue of patent specification
TK4A Correction to the publication in the bulletin (patent)

Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 3-2011

MM4A The patent is invalid due to non-payment of fees

Effective date: 20120720