RU2369604C2 - Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора - Google Patents
Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора Download PDFInfo
- Publication number
- RU2369604C2 RU2369604C2 RU2006139946/04A RU2006139946A RU2369604C2 RU 2369604 C2 RU2369604 C2 RU 2369604C2 RU 2006139946/04 A RU2006139946/04 A RU 2006139946/04A RU 2006139946 A RU2006139946 A RU 2006139946A RU 2369604 C2 RU2369604 C2 RU 2369604C2
- Authority
- RU
- Russia
- Prior art keywords
- dihydro
- inden
- methylpiperidin
- carbonyl
- methylpiperazin
- Prior art date
Links
- 0 Cc(cc1)c(C)c(C)*1O Chemical compound Cc(cc1)c(C)c(C)*1O 0.000 description 6
- PGJHUVLPGSBXJO-UHFFFAOYSA-N C1Cc2cc(-c3ncc[s]3)ccc2C1 Chemical compound C1Cc2cc(-c3ncc[s]3)ccc2C1 PGJHUVLPGSBXJO-UHFFFAOYSA-N 0.000 description 1
- ROUYFJUVMYHXFJ-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1=O)=O ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
- FMLPQHJYUZTHQS-UHFFFAOYSA-N CC(C1)NCCN1C(OC(C)(C)C)=O Chemical compound CC(C1)NCCN1C(OC(C)(C)C)=O FMLPQHJYUZTHQS-UHFFFAOYSA-N 0.000 description 1
- OEVVVGVHIVLUQG-DJZRFWRSSA-N CCNCCC(C)(C)N(CC1)C[C@H](C)N1C(CC1)c(cc2)c1cc2Br Chemical compound CCNCCC(C)(C)N(CC1)C[C@H](C)N1C(CC1)c(cc2)c1cc2Br OEVVVGVHIVLUQG-DJZRFWRSSA-N 0.000 description 1
- DZQIWHOPBLPYBS-UHFFFAOYSA-N CCOC(Cc1c2ccc(Br)c1)C2N(CC1)C(C)CN1C(C)(CC1)CCN1C(c1ccnc2c1cccn2)=O Chemical compound CCOC(Cc1c2ccc(Br)c1)C2N(CC1)C(C)CN1C(C)(CC1)CCN1C(c1ccnc2c1cccn2)=O DZQIWHOPBLPYBS-UHFFFAOYSA-N 0.000 description 1
- WNWJBYYOLYMCFJ-IBGZPJMESA-N C[C@@H](C1)N(Cc2ccccc2)CCN1C(C)(CC1)CCN1C(OC(C)(C)C)=O Chemical compound C[C@@H](C1)N(Cc2ccccc2)CCN1C(C)(CC1)CCN1C(OC(C)(C)C)=O WNWJBYYOLYMCFJ-IBGZPJMESA-N 0.000 description 1
- WLNOFRXLATWAAY-ZDUSSCGKSA-N C[C@@H](C1)NCCN1C(C)(CC1)CCN1C(OC(C)(C)C)=O Chemical compound C[C@@H](C1)NCCN1C(C)(CC1)CCN1C(OC(C)(C)C)=O WLNOFRXLATWAAY-ZDUSSCGKSA-N 0.000 description 1
- FMLPQHJYUZTHQS-QMMMGPOBSA-N C[C@@H](C1)NCCN1C(OC(C)(C)C)=O Chemical compound C[C@@H](C1)NCCN1C(OC(C)(C)C)=O FMLPQHJYUZTHQS-QMMMGPOBSA-N 0.000 description 1
- PFFXFWWUMFDGQL-HXBUSHRASA-N C[C@@H](CN(CC1)C(C)(CC2)CCN2C(OC(C)(C)C)=O)N1C(CC1)c2c1ccc(C(F)(F)F)c2 Chemical compound C[C@@H](CN(CC1)C(C)(CC2)CCN2C(OC(C)(C)C)=O)N1C(CC1)c2c1ccc(C(F)(F)F)c2 PFFXFWWUMFDGQL-HXBUSHRASA-N 0.000 description 1
- GKOUVGCZPNKSGU-CWQZNGJJSA-N C[C@@H](CN(CC1)C(OC(C)(C)C)=O)N1C(CC1)c(cc2)c1cc2Br Chemical compound C[C@@H](CN(CC1)C(OC(C)(C)C)=O)N1C(CC1)c(cc2)c1cc2Br GKOUVGCZPNKSGU-CWQZNGJJSA-N 0.000 description 1
- JGEODYUVEMNPPY-NSHDSACASA-N C[C@@H]1N(Cc2ccccc2)CCNC1 Chemical compound C[C@@H]1N(Cc2ccccc2)CCNC1 JGEODYUVEMNPPY-NSHDSACASA-N 0.000 description 1
- HOPRXXXSABQWAV-UHFFFAOYSA-N Cc1c(C)c(C)ncc1 Chemical compound Cc1c(C)c(C)ncc1 HOPRXXXSABQWAV-UHFFFAOYSA-N 0.000 description 1
- NWPNXBQSRGKSJB-UHFFFAOYSA-N Cc1ccccc1C#N Chemical compound Cc1ccccc1C#N NWPNXBQSRGKSJB-UHFFFAOYSA-N 0.000 description 1
- GSDGOTCNZNJXPN-UHFFFAOYSA-N FC(c1ccc(CCC2Cl)c2c1)(F)F Chemical compound FC(c1ccc(CCC2Cl)c2c1)(F)F GSDGOTCNZNJXPN-UHFFFAOYSA-N 0.000 description 1
- IOWGHQGLUMEZKG-UHFFFAOYSA-N OCc1ccccc1Br Chemical compound OCc1ccccc1Br IOWGHQGLUMEZKG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56169704P | 2004-04-13 | 2004-04-13 | |
| US60/561,697 | 2004-04-13 | ||
| US57222104P | 2004-05-18 | 2004-05-18 | |
| US60/572,221 | 2004-05-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006139946A RU2006139946A (ru) | 2008-05-20 |
| RU2369604C2 true RU2369604C2 (ru) | 2009-10-10 |
Family
ID=35150660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006139946/04A RU2369604C2 (ru) | 2004-04-13 | 2005-04-12 | Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US7678798B2 (https=) |
| EP (1) | EP1734966B1 (https=) |
| JP (2) | JP4948395B2 (https=) |
| KR (1) | KR101235090B1 (https=) |
| CN (1) | CN103012374B (https=) |
| AU (1) | AU2005234596B8 (https=) |
| BR (1) | BRPI0509803A (https=) |
| CA (1) | CA2562235C (https=) |
| CR (1) | CR8680A (https=) |
| EA (1) | EA015517B1 (https=) |
| EC (1) | ECSP066925A (https=) |
| ES (1) | ES2431524T3 (https=) |
| GE (1) | GEP20094680B (https=) |
| HU (1) | HU229709B1 (https=) |
| IL (1) | IL178622A (https=) |
| MX (1) | MXPA06011722A (https=) |
| NO (1) | NO337788B1 (https=) |
| NZ (1) | NZ550370A (https=) |
| RU (1) | RU2369604C2 (https=) |
| WO (1) | WO2005101838A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1565436B1 (en) | 2002-11-27 | 2012-04-25 | Incyte Corporation | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
| EA015517B1 (ru) | 2004-04-13 | 2011-08-30 | Инсайт Корпорейшн | Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора |
| WO2006071875A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
| US7910108B2 (en) | 2006-06-05 | 2011-03-22 | Incyte Corporation | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases |
| WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
| CN101293820B (zh) * | 2007-04-27 | 2012-10-10 | 天津药明康德新药开发有限公司 | 5-三氟甲基-1-茚酮的合成方法 |
| WO2009012259A1 (en) * | 2007-07-16 | 2009-01-22 | Incyte Corporation | Pentafluorosulfanyl-substituted piperazinylpiperidine derivatives as chemokine receptor antagonists |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| KR101374409B1 (ko) * | 2011-10-17 | 2014-03-18 | 성균관대학교산학협력단 | 비유전성 항생제 내성 저해제 및 이의 용도 |
| AR104555A1 (es) | 2015-05-07 | 2017-07-26 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULARES DE RORg |
| EP3523279A1 (en) | 2016-10-10 | 2019-08-14 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
| WO2018073248A1 (en) | 2016-10-17 | 2018-04-26 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Prognosis of demyelinating diseases patients and treatment thereof |
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| US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
| RU2135491C1 (ru) * | 1993-10-01 | 1999-08-27 | Новартис Аг | Производные n-фенил-2-пиримидинамина, способ их получения, фармацевтическая композиция на их основе и способ ингибирования (лечения) опухоли |
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| WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| US5510332A (en) * | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
| AU2964295A (en) | 1994-07-11 | 1996-02-09 | Athena Neurosciences, Inc. | Inhibitors of leukocyte adhesion |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| WO1996031206A2 (en) | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| GB9522372D0 (en) | 1995-11-01 | 1996-01-03 | Merck Sharp & Dohme | Therapeutic agents |
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| AU729415B2 (en) | 1996-07-12 | 2001-02-01 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
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