RU2342140C2 - Комбинированное введение индолинона с химиотерапевтическим средством при нарушениях, вызванных клеточной пролиферацией - Google Patents

Комбинированное введение индолинона с химиотерапевтическим средством при нарушениях, вызванных клеточной пролиферацией Download PDF

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RU2342140C2
RU2342140C2 RU2005118417/14A RU2005118417A RU2342140C2 RU 2342140 C2 RU2342140 C2 RU 2342140C2 RU 2005118417/14 A RU2005118417/14 A RU 2005118417/14A RU 2005118417 A RU2005118417 A RU 2005118417A RU 2342140 C2 RU2342140 C2 RU 2342140C2
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combined administration
indolinone
caused
conditions
cell proliferation
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Тини АБРАМС (US)
Тиния АБРАМС
Лесли МЮРРЭЙ (US)
Лесли МЮРРЭЙ
Нэнси ПРАЙЕР (US)
Нэнси ПРАЙЕР
Джули М. ЧЕРРИНГТОН (US)
Джули М. Черрингтон
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Суджен, Инк.
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Изобретения относятся к медицине, а именно к онкологии, и могут быть использованы для лечения злокачественных образований, в частности рака молочной железы у млекопитающих. Варианты способа включают введение комбинации (2-диэтиламиноэтила)амида 5-(5-фтор-2-оксо-1,2-дигидроиндол-3-илиденметил)-2,4-диметил-1Н-пиррол-3-карбоновой кислоты и доцетаксела в низких дозах, неэффективных при монотерапии. При сочетанном введении данных препаратов развивается синергический противоопухолевый эффект, что позволяет уменьшить дозу каждого из них. 2 н.п. ф-лы, 8 ил., 8 табл.

Description

Текст описания приведен в факсимильном виде.
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Claims (2)

1. Способ лечения злокачественного новообразования у млекопитающего, включающий введение ему комбинации (2-диэтиламиноэтил)амида 5-(5-фтор-2-оксо-1,2-дигидроиндол-3-илиденметил)-2,4-диметил-1Н-пиррол-3-карбоновой кислоты и доцетаксела в низких дозах, неэффективных при монотерапии указанными средствами.
2. Способ лечения рака молочной железы у млекопитающего, включающий введение ему комбинации (2-диэтиламиноэтил)амида 5-(5-фтор-2-оксо-1,2-дигидроиндол-3-илиденметил)-2,4-диметил-1Н-пиррол-3-карбоновой кислоты и доцетаксела в низких дозах, неэффективных при монотерапии указанными средствами.
RU2005118417/14A 2002-11-15 2003-11-14 Комбинированное введение индолинона с химиотерапевтическим средством при нарушениях, вызванных клеточной пролиферацией RU2342140C2 (ru)

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US60/426,386 2002-11-15

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KR20050086594A (ko) 2005-08-30
AU2003290943A1 (en) 2004-06-15
US20040152759A1 (en) 2004-08-05
CN100430060C (zh) 2008-11-05
NO20052578L (no) 2005-05-27
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GT200300245A (es) 2004-06-23
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ZA200503841B (en) 2006-09-27
CO5700778A2 (es) 2006-11-30
EP1562600A2 (en) 2005-08-17
WO2004045523A2 (en) 2004-06-03
CN1711089A (zh) 2005-12-21
EP1562600A4 (en) 2008-06-25
CN101259131A (zh) 2008-09-10
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