RU2337917C1 - Способ получения производного d-эритро-2,2-дифторо-2-дезокси-1-оксорибозы - Google Patents

Способ получения производного d-эритро-2,2-дифторо-2-дезокси-1-оксорибозы Download PDF

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Publication number
RU2337917C1
RU2337917C1 RU2007106848/04A RU2007106848A RU2337917C1 RU 2337917 C1 RU2337917 C1 RU 2337917C1 RU 2007106848/04 A RU2007106848/04 A RU 2007106848/04A RU 2007106848 A RU2007106848 A RU 2007106848A RU 2337917 C1 RU2337917 C1 RU 2337917C1
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RU
Russia
Prior art keywords
formula
compound
iii
mixture
biphenylcarbonyl
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RU2007106848/04A
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English (en)
Russian (ru)
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RU2007106848A (ru
Inventor
Дзаехеон ЛИ (KR)
Дзаехеон Ли
Га-Сеунг ПАРК (KR)
Га-Сеунг ПАРК
Моонсуб ЛИ (KR)
Моонсуб ЛИ
Чеол-Кионг КИМ (KR)
Чеол-Кионг КИМ
Дзае-Чул ЛИ (KR)
Дзае-Чул Ли
Янг-Кил ЧАНГ (KR)
Янг-Кил Чанг
Гван-Сун ЛИ (KR)
Гван-Сун ЛИ
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Ханми Фарм. Ко., Лтд.
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Application filed by Ханми Фарм. Ко., Лтд. filed Critical Ханми Фарм. Ко., Лтд.
Publication of RU2007106848A publication Critical patent/RU2007106848A/ru
Application granted granted Critical
Publication of RU2337917C1 publication Critical patent/RU2337917C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/08—Deoxysugars; Unsaturated sugars; Osones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Quinoline Compounds (AREA)
RU2007106848/04A 2004-07-23 2005-06-23 Способ получения производного d-эритро-2,2-дифторо-2-дезокси-1-оксорибозы RU2337917C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2004-0057711 2004-07-23
KR1020040057711A KR100578616B1 (ko) 2004-07-23 2004-07-23 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법

Publications (2)

Publication Number Publication Date
RU2007106848A RU2007106848A (ru) 2008-09-10
RU2337917C1 true RU2337917C1 (ru) 2008-11-10

Family

ID=35785434

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007106848/04A RU2337917C1 (ru) 2004-07-23 2005-06-23 Способ получения производного d-эритро-2,2-дифторо-2-дезокси-1-оксорибозы

Country Status (15)

Country Link
US (1) US7638642B2 (zh)
EP (1) EP1781677B1 (zh)
JP (1) JP4674297B2 (zh)
KR (1) KR100578616B1 (zh)
CN (1) CN1989147B (zh)
AU (1) AU2005264678B2 (zh)
BR (1) BRPI0513712A (zh)
CA (1) CA2574401C (zh)
ES (1) ES2431631T3 (zh)
HK (1) HK1101587A1 (zh)
IL (1) IL180893A (zh)
MX (1) MX2007000914A (zh)
NO (1) NO20071012L (zh)
RU (1) RU2337917C1 (zh)
WO (1) WO2006009353A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
KR100741310B1 (ko) * 2006-08-01 2007-08-01 (주) 유일팜테크 젬시타빈의 합성에 유용한 신규한나프탈렌-2-카르복실레이트 유도체와 그의 제조방법
KR101357409B1 (ko) * 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
KR100858842B1 (ko) * 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
KR100863463B1 (ko) * 2007-03-23 2008-10-16 동우신테크 주식회사 광학적으로 순수한 옥소라이보스유도체의 제조방법
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN102153601A (zh) * 2011-02-26 2011-08-17 湖南欧亚生物有限公司 一种高选择性的制备盐酸吉西他滨以及其中间体的方法
CN103232508A (zh) * 2012-05-22 2013-08-07 湖北一半天制药有限公司 工业化盐酸吉西他滨的合成方法
WO2018002948A1 (en) * 2016-06-30 2018-01-04 Hindustan Petroleum Corporation Ltd. Mannitol based gelators for oil spillage applications
CN113461657B (zh) * 2021-08-17 2022-05-17 天津大学 一种有机小分子凝胶剂及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES416865A1 (es) * 1972-07-13 1976-03-01 Pfizer Procedimiento para preparar w-pentanorprostaglandinas sus- tituidas en la posicion 15.
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856158T2 (de) * 1987-08-28 1998-08-20 Lilly Co Eli Verfahren zur Herstellung von Zwischenverbindungen verwendbar in der Herstellung von 2',2'-Difluoronucleosiden
US5223608A (en) 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
IL106075A (en) * 1992-06-22 2000-12-06 Lilly Co Eli Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-difluoro-alpha-D-erythropentofuranose derivatives
US5401861A (en) 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
CA2136788C (en) 1993-11-30 2005-01-25 Thomas Charles Britton Process for preparing 2,2-difluoroketene silyl acetals and .alpha.,.alpha.-difluoro-.beta.-silyloxy-1,3-dioxolane-4-propanoic acid esters
US5428176A (en) 1994-04-14 1995-06-27 Eli Lilly And Company Process for preparing 2,2-difluoroketene silyl O,S-acetals and α,α-difluoro-β-silyloxy-1,3-dioxolane-4-propanoic acid O,S-esters

Also Published As

Publication number Publication date
JP4674297B2 (ja) 2011-04-20
KR100578616B1 (ko) 2006-05-10
ES2431631T3 (es) 2013-11-27
US7638642B2 (en) 2009-12-29
EP1781677B1 (en) 2013-08-07
HK1101587A1 (en) 2007-10-18
IL180893A (en) 2010-12-30
CN1989147A (zh) 2007-06-27
IL180893A0 (en) 2007-07-04
CA2574401A1 (en) 2006-01-26
US20080058509A1 (en) 2008-03-06
MX2007000914A (es) 2007-04-13
WO2006009353A1 (en) 2006-01-26
NO20071012L (no) 2007-02-22
JP2008507506A (ja) 2008-03-13
EP1781677A4 (en) 2012-05-02
AU2005264678B2 (en) 2008-06-12
EP1781677A1 (en) 2007-05-09
RU2007106848A (ru) 2008-09-10
CA2574401C (en) 2011-03-29
KR20060008056A (ko) 2006-01-26
AU2005264678A1 (en) 2006-01-26
CN1989147B (zh) 2010-05-12
BRPI0513712A (pt) 2008-05-13

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Effective date: 20110420

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Effective date: 20140624

PD4A Correction of name of patent owner