RU2321588C2 - Карбаматные производные хинуклидина, фармацевтическая композиция на их основе и применение - Google Patents

Карбаматные производные хинуклидина, фармацевтическая композиция на их основе и применение Download PDF

Info

Publication number
RU2321588C2
RU2321588C2 RU2005101409/04A RU2005101409A RU2321588C2 RU 2321588 C2 RU2321588 C2 RU 2321588C2 RU 2005101409/04 A RU2005101409/04 A RU 2005101409/04A RU 2005101409 A RU2005101409 A RU 2005101409A RU 2321588 C2 RU2321588 C2 RU 2321588C2
Authority
RU
Russia
Prior art keywords
ylmethyl
azoniabicyclo
octane
carbamoyloxy
thiophen
Prior art date
Application number
RU2005101409/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2005101409A (ru
Inventor
Мари ПРАТ-КИНОНЕС (ES)
Мария Прат-Кинонес
Мари -Антони БУИЛЬ-АЛЬБЕРО (ES)
Мария-Антония БУИЛЬ-АЛЬБЕРО
Мари -Долорс ФЕРНАНДЕС-ФОРНЕР (ES)
Мария-Долорс ФЕРНАНДЕС-ФОРНЕР
Original Assignee
Альмираль АГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альмираль АГ filed Critical Альмираль АГ
Publication of RU2005101409A publication Critical patent/RU2005101409A/ru
Application granted granted Critical
Publication of RU2321588C2 publication Critical patent/RU2321588C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2005101409/04A 2002-06-21 2003-06-18 Карбаматные производные хинуклидина, фармацевтическая композиция на их основе и применение RU2321588C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200201439 2002-06-21
ES200201439A ES2203327B1 (es) 2002-06-21 2002-06-21 Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.

Publications (2)

Publication Number Publication Date
RU2005101409A RU2005101409A (ru) 2005-11-20
RU2321588C2 true RU2321588C2 (ru) 2008-04-10

Family

ID=29797397

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005101409/04A RU2321588C2 (ru) 2002-06-21 2003-06-18 Карбаматные производные хинуклидина, фармацевтическая композиция на их основе и применение

Country Status (21)

Country Link
US (3) US7435742B2 (cg-RX-API-DMAC10.html)
EP (1) EP1515968A2 (cg-RX-API-DMAC10.html)
JP (1) JP2005533799A (cg-RX-API-DMAC10.html)
CN (1) CN100363363C (cg-RX-API-DMAC10.html)
AR (1) AR040275A1 (cg-RX-API-DMAC10.html)
AU (1) AU2003279384A1 (cg-RX-API-DMAC10.html)
BR (1) BR0312169A (cg-RX-API-DMAC10.html)
CA (1) CA2490082A1 (cg-RX-API-DMAC10.html)
EC (1) ECSP045484A (cg-RX-API-DMAC10.html)
ES (1) ES2203327B1 (cg-RX-API-DMAC10.html)
IL (1) IL165775A0 (cg-RX-API-DMAC10.html)
MX (1) MXPA04012272A (cg-RX-API-DMAC10.html)
NO (1) NO20050217L (cg-RX-API-DMAC10.html)
NZ (1) NZ537252A (cg-RX-API-DMAC10.html)
PE (1) PE20040579A1 (cg-RX-API-DMAC10.html)
RU (1) RU2321588C2 (cg-RX-API-DMAC10.html)
TW (1) TW200401776A (cg-RX-API-DMAC10.html)
UA (1) UA85541C2 (cg-RX-API-DMAC10.html)
UY (1) UY27850A1 (cg-RX-API-DMAC10.html)
WO (1) WO2004000840A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200410211B (cg-RX-API-DMAC10.html)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1345937B1 (en) * 2000-12-22 2005-09-28 Almirall Prodesfarma AG Quinuclidine carbamate derivatives and their use as m3 antagonists
ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
EP1781298B1 (de) * 2004-04-22 2012-01-04 Boehringer Ingelheim International GmbH Arzneinmittelkombinationen enthaltend benzoxazine zur behandlung von atemwegserkrankungen
WO2006005057A2 (en) * 2004-06-30 2006-01-12 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1917253B1 (de) 2005-08-15 2015-01-07 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von betamimetika
DE102006028286A1 (de) * 2006-06-20 2007-12-27 Wirsich, Konrad, Dipl.-Ing. (FH) Drehmoment- und rutschfest verbundene aus zwei Teilen bestehende Schaltzahnräder
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
WO2008096870A1 (ja) * 2007-02-09 2008-08-14 Astellas Pharma Inc. アザ架橋環化合物
KR101495708B1 (ko) * 2007-02-23 2015-02-25 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 무스카린 수용체 안타고니스트로 유용한 4차 암모늄 디페닐메틸 화합물
EP2065385A1 (en) * 2007-11-28 2009-06-03 Laboratorios SALVAT, S.A. Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
ES2655083T3 (es) * 2010-01-28 2018-02-16 Theron Pharmaceuticals, Inc. Derivados de 7-azoniabiciclo [2.2.1]heptano, métodos de producción, y usos farmacéuticos de estos
LT2685986T (lt) * 2011-03-18 2020-03-10 Genzyme Corporation Gliukozilceramido sintazės slopiklis
EP2631674A1 (de) * 2012-02-23 2013-08-28 ELMOS Semiconductor AG Verfahren und Sensorsystem zur Vermessung der Eigenschaften einer Übertragungsstrecke eines Messsystems zwischen Sender und Empfänger
MA37975B2 (fr) 2012-09-11 2021-03-31 Genzyme Corp Inhibiteurs de synthase de glucosylcéramide
RU2641285C2 (ru) * 2013-07-13 2018-01-17 Бэйцзин Фсвэлкам Текнолоджи Девелопмент Ко., Лтд Соединения хинина, способ их получения и их медицинское применение
US10570127B1 (en) 2018-11-05 2020-02-25 Renexxion, Llc Material and methods for the treatment of gastro-intestinal disorders
PT3920912T (pt) 2019-02-04 2025-09-09 Genzyme Corp Tratamento de ciliopatias usando inibidores da glucosilceramida sintase (gcs)
IL295255A (en) 2020-02-03 2022-10-01 Genzyme Corp Methods for treating neurological symptoms associated with lysosomal storage diseases
CN115605202B (zh) 2020-03-26 2025-10-28 盐野义制药株式会社 具有血清素受体结合活性的芳香族杂环衍生物
IL300090A (en) 2020-07-24 2023-03-01 Genzyme Corp Pharmaceutical preparations containing VENGLUSTAT
WO2022145408A1 (ja) * 2020-12-28 2022-07-07 塩野義製薬株式会社 セロトニン受容体結合活性を有する環状アミン誘導体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2143432C1 (ru) * 1994-12-28 1999-12-27 Яманоути Фармасьютикал Ко., Лтд. Новые производные хинуклидина и медицинские композиции, содержащие их
WO2001004118A2 (en) * 1999-07-14 2001-01-18 Almirall Prodesfarma S.A. Quinuclidine derivatives and their use as muscarinic m3 receptor ligands
WO2002000652A1 (es) * 2000-06-27 2002-01-03 Laboratorios S.A.L.V.A.T., S.A. Carbamatos derivados de arilalquilaminas

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2762796A (en) * 1956-09-11 Iminodibenzyl derivative
GB1219606A (en) 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
GB1246606A (en) 1969-04-28 1971-09-15 Starogardzkie Zakl Farma Dibenzo-azepine derivatives
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
GB8923590D0 (en) 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators
GB9201751D0 (en) 1992-01-28 1992-03-11 Smithkline Beecham Plc Compounds
GB9202443D0 (en) 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
AU7545894A (en) * 1993-09-02 1995-03-22 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
AU685225B2 (en) * 1994-02-10 1998-01-15 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
ATE205490T1 (de) 1995-10-13 2001-09-15 Banyu Pharma Co Ltd Substituierte heteroaromatische derivate
AUPN862996A0 (en) 1996-03-13 1996-04-04 Fujisawa Pharmaceutical Co., Ltd. A novel substituted-acetamide compound
PE92198A1 (es) 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
EP1345937B1 (en) * 2000-12-22 2005-09-28 Almirall Prodesfarma AG Quinuclidine carbamate derivatives and their use as m3 antagonists
SI1353919T1 (sl) 2000-12-28 2006-12-31 Almirall Prodesfarma Ag Novi derivati kinuklidina in medicinske zmesi, kijih vsebujejo.
CA2470956C (en) * 2001-12-20 2011-08-02 Laboratorios S.A.L.V.A.T., S.A. 1-alkyl-1-azoniabicyclo[2.2.2]octane carbamate derivatives and their use as muscarinic receptor antagonists
ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2143432C1 (ru) * 1994-12-28 1999-12-27 Яманоути Фармасьютикал Ко., Лтд. Новые производные хинуклидина и медицинские композиции, содержащие их
WO2001004118A2 (en) * 1999-07-14 2001-01-18 Almirall Prodesfarma S.A. Quinuclidine derivatives and their use as muscarinic m3 receptor ligands
WO2002000652A1 (es) * 2000-06-27 2002-01-03 Laboratorios S.A.L.V.A.T., S.A. Carbamatos derivados de arilalquilaminas

Also Published As

Publication number Publication date
US20060094751A1 (en) 2006-05-04
US20090005412A1 (en) 2009-01-01
ZA200410211B (en) 2005-09-06
WO2004000840A2 (en) 2003-12-31
IL165775A0 (en) 2006-01-15
CN100363363C (zh) 2008-01-23
US20090054480A1 (en) 2009-02-26
UY27850A1 (es) 2003-11-28
AU2003279384A1 (en) 2004-01-06
MXPA04012272A (es) 2005-04-08
EP1515968A2 (en) 2005-03-23
ES2203327B1 (es) 2005-06-16
ECSP045484A (es) 2005-01-28
US7435742B2 (en) 2008-10-14
ES2203327A1 (es) 2004-04-01
RU2005101409A (ru) 2005-11-20
JP2005533799A (ja) 2005-11-10
NO20050217L (no) 2005-03-18
CA2490082A1 (en) 2003-12-31
TW200401776A (en) 2004-02-01
AR040275A1 (es) 2005-03-23
UA85541C2 (ru) 2009-02-10
PE20040579A1 (es) 2004-09-08
NZ537252A (en) 2006-07-28
CN1675206A (zh) 2005-09-28
WO2004000840A3 (en) 2004-02-19
BR0312169A (pt) 2005-03-29

Similar Documents

Publication Publication Date Title
RU2005101409A (ru) Новые карбаматные производные хинуклидина и фармацевтические композиции, содержащие эти соединения
RU2003122341A (ru) Новые производные карбамата хинуклидина и лекарственные композиции, содержащие названные производные
JP2005533826A5 (cg-RX-API-DMAC10.html)
RU2003123120A (ru) Новые производные хинуклидина и содержащие их лекарственные композиции
RU2391341C2 (ru) Индазолы, бензотиазолы, бензоизотиазолы, их получение и применение
RU2005102585A (ru) Новые производные хинуклидинамида
JP2005533799A5 (cg-RX-API-DMAC10.html)
KR950704320A (ko) Crf 길항제로서의 피롤로피리미딘(pyrrolopyrimidines as crf antagonists)
CN109963854A (zh) 杂芳基并[4,3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
RU2005104435A (ru) Производные 1-гетероциклилалкил-3-сульфонилазаиндола или - азаиндазола в качестве лигандов 5-гидрокситриптамина-6
JP2003530345A (ja) 急性、慢性疼痛及び／またはニューロパシー性疼痛及び片頭痛の治療のための医薬組成物
KR910009699A (ko) 신규 삼환식 화합물
RU2264401C3 (ru) Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения и промежуточные вещества
RU2007120454A (ru) Производные хинуклидина и их применение в качестве антагонистов мускариновых рецепторов м3
RU2001133004A (ru) Применение селективных антагонистов альфа1b-адренергического рецептора для улучшения состояния при сексуальной дисфункции
RU2004136979A (ru) (имидазол-1-илметил)пиридазин в качестве блокатора nmda рецептора
JPH083041A (ja) ストレス関連障害治療剤
EP1874292A2 (en) Methods for modulating bladder function
WO2006116148A2 (en) (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse
RU2006136085A (ru) Новые сложные эфиры кватернизованного хинуклидина
JP2007529444A5 (cg-RX-API-DMAC10.html)
CN102816165A (zh) 氨基-氮杂-金刚烷衍生物和使用方法
RU2008102155A (ru) ЗАМЕЩЕННЫЕ 3-СУЛЬФОНИЛ-[1,2,3]ТРИАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-НТ6 РЕЦЕПТОРОВ, ЛЕКАРСТВЕННАЯ СУБСТАНЦИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ЛЕКАРСТВЕННЫЙ ПРЕПАРАТ И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
RU98104276A (ru) Новые конденсированные изохинолины в качестве лигандов для допаминовых рецепторов
EP0637242A1 (en) Agents for treating substance abuse disorders

Legal Events

Date Code Title Description
PC4A Invention patent assignment

Effective date: 20080725

MM4A The patent is invalid due to non-payment of fees

Effective date: 20090619