RU2318004C2 - Добавки в виде полиалкиленгликолевой кислоты - Google Patents
Добавки в виде полиалкиленгликолевой кислоты Download PDFInfo
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- RU2318004C2 RU2318004C2 RU2005105580/04A RU2005105580A RU2318004C2 RU 2318004 C2 RU2318004 C2 RU 2318004C2 RU 2005105580/04 A RU2005105580/04 A RU 2005105580/04A RU 2005105580 A RU2005105580 A RU 2005105580A RU 2318004 C2 RU2318004 C2 RU 2318004C2
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- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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| RU2476439C2 (ru) * | 2007-07-17 | 2013-02-27 | Ф.Хоффманн-Ля Рош Аг | Очистка пегилированных полипептидов |
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| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| PT2298278E (pt) | 2002-06-07 | 2016-02-25 | Dyax Corp | Prevenção e redução da perda de sangue e resposta inflamatória |
| CN100337689C (zh) * | 2002-07-24 | 2007-09-19 | 弗·哈夫曼-拉罗切有限公司 | 聚亚烷基二醇酸加合物 |
| CA3050564A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| CA2537113A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
| EP1725262B1 (en) * | 2004-03-15 | 2021-05-26 | Nektar Therapeutics | Polymer-based compositions and conjugates of hiv entry inhibitors |
| US20080255305A1 (en) * | 2004-05-17 | 2008-10-16 | Mcmaster University | Biological Molecule-Reactive Hydrophilic Silicone Surface |
| WO2006019950A2 (en) | 2004-07-16 | 2006-02-23 | Nektar Therapeutics Al, Corporation | Conjugates of a gm-csf moiety and a polymer |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| DE602006005686D1 (de) * | 2005-08-26 | 2009-04-23 | Novo Nordisk As | Verfahren zur modifizierung eines makromolekularen systems |
| JP5021649B2 (ja) * | 2005-08-26 | 2012-09-12 | ノヴォ ノルディスク アクティーゼルスカブ | 高分子システムを変性する方法 |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
| WO2009026334A2 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| KR101671537B1 (ko) * | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| JP2013516389A (ja) | 2009-01-06 | 2013-05-13 | ダイアックス コーポレーション | カリクレイン阻害剤による粘膜炎治療 |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| US10040761B2 (en) * | 2010-06-25 | 2018-08-07 | Nof Corporation | Branched hetero polyethylene glycol and intermediate |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| US20130331443A1 (en) | 2010-12-22 | 2013-12-12 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| KR102011156B1 (ko) | 2011-01-06 | 2019-08-16 | 다이액스 코포레이션 | 혈장 칼리크레인 결합 단백질 |
| WO2013151776A1 (en) | 2012-04-03 | 2013-10-10 | Sangart, Inc. | Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins |
| CN102816227A (zh) * | 2012-08-30 | 2012-12-12 | 深圳赛保尔生物药业有限公司 | 回收促红细胞生成素的方法 |
| EP2968597B1 (en) | 2013-03-15 | 2021-08-18 | Schindler, William | Polyalkylene oxide valerate hemoglobin conjugates |
| IL247942B (en) | 2014-03-27 | 2022-09-01 | Dyax Corp | Compositions and methods for drops in macular edema as a result of diabetes |
| US11286307B2 (en) | 2015-12-11 | 2022-03-29 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| WO2020203583A1 (ja) * | 2019-03-29 | 2020-10-08 | 日油株式会社 | 末端カルボキシル基含有ポリエチレングリコールの製造方法および活性化ポリエチレングリコールの製造方法 |
| AU2021209045A1 (en) | 2020-01-13 | 2022-07-28 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
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| JP2531661B2 (ja) | 1987-02-25 | 1996-09-04 | 味の素株式会社 | 酸素運搬剤 |
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| HUT75533A (en) * | 1993-11-10 | 1997-05-28 | Schering Corp | Improved interferon polymer conjugates |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| WO2000044785A1 (en) | 1999-01-29 | 2000-08-03 | F. Hoffmann-La Roche Ag | Gcsf conjugates |
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| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
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| CN100337689C (zh) * | 2002-07-24 | 2007-09-19 | 弗·哈夫曼-拉罗切有限公司 | 聚亚烷基二醇酸加合物 |
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2003
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- 2003-07-16 BR BR0313212-9A patent/BR0313212A/pt not_active Application Discontinuation
- 2003-07-16 EP EP03766196A patent/EP1526872A1/en not_active Withdrawn
- 2003-07-16 JP JP2004525225A patent/JP4451308B2/ja not_active Expired - Fee Related
- 2003-07-16 WO PCT/EP2003/007736 patent/WO2004012773A1/en not_active Ceased
- 2003-07-16 MX MXPA05000796A patent/MXPA05000796A/es active IP Right Grant
- 2003-07-16 KR KR1020057001328A patent/KR100608415B1/ko not_active Expired - Fee Related
- 2003-07-16 CA CA2492775A patent/CA2492775C/en not_active Expired - Fee Related
- 2003-07-16 RU RU2005105580/04A patent/RU2318004C2/ru not_active IP Right Cessation
- 2003-07-16 PL PL03375265A patent/PL375265A1/xx unknown
- 2003-07-16 AU AU2003258518A patent/AU2003258518B2/en not_active Ceased
- 2003-07-22 US US10/625,033 patent/US7193031B2/en not_active Expired - Fee Related
- 2003-07-22 AR AR20030102624A patent/AR040654A1/es not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4670417A (en) * | 1985-06-19 | 1987-06-02 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| RU2177950C2 (ru) * | 1996-10-25 | 2002-01-10 | Нексстар Фармасьютикалз, Инк. | Комплексы нуклеиновых кислот - лигандов сосудистого эндотелиального фактора роста (vegf) |
| WO2001046291A1 (en) * | 1999-12-22 | 2001-06-28 | Shearwater Corporation | Sterically hindered derivatives of water soluble polymers |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2476439C2 (ru) * | 2007-07-17 | 2013-02-27 | Ф.Хоффманн-Ля Рош Аг | Очистка пегилированных полипептидов |
Also Published As
| Publication number | Publication date |
|---|---|
| US7193031B2 (en) | 2007-03-20 |
| AR040654A1 (es) | 2005-04-13 |
| US20060167218A1 (en) | 2006-07-27 |
| PL375265A1 (en) | 2005-11-28 |
| AU2003258518A1 (en) | 2004-02-23 |
| RU2005105580A (ru) | 2006-01-20 |
| US7504477B2 (en) | 2009-03-17 |
| JP2006502250A (ja) | 2006-01-19 |
| KR20050025663A (ko) | 2005-03-14 |
| JP4451308B2 (ja) | 2010-04-14 |
| CN1671422A (zh) | 2005-09-21 |
| JP2009062516A (ja) | 2009-03-26 |
| KR100608415B1 (ko) | 2006-08-02 |
| US20040106747A1 (en) | 2004-06-03 |
| CA2492775A1 (en) | 2004-02-12 |
| CN100337689C (zh) | 2007-09-19 |
| MXPA05000796A (es) | 2005-04-19 |
| WO2004012773A1 (en) | 2004-02-12 |
| JP5112203B2 (ja) | 2013-01-09 |
| CA2492775C (en) | 2011-06-21 |
| AU2003258518B2 (en) | 2007-01-18 |
| BR0313212A (pt) | 2005-06-28 |
| EP1526872A1 (en) | 2005-05-04 |
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