RU2301066C2 - Лечение желудочно-кишечных стромальных опухолей - Google Patents

Лечение желудочно-кишечных стромальных опухолей Download PDF

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Publication number
RU2301066C2
RU2301066C2 RU2003114752/15A RU2003114752A RU2301066C2 RU 2301066 C2 RU2301066 C2 RU 2301066C2 RU 2003114752/15 A RU2003114752/15 A RU 2003114752/15A RU 2003114752 A RU2003114752 A RU 2003114752A RU 2301066 C2 RU2301066 C2 RU 2301066C2
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RU
Russia
Prior art keywords
treatment
salt
methyl
benzamide
ylmethyl
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RU2003114752/15A
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English (en)
Russian (ru)
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RU2003114752A (ru
Inventor
Элизабет БУХДУНГЕР (DE)
Элизабет БУХДУНГЕР
Рено КАПДЕВИЛЛЬ (FR)
Рено КАПДЕВИЛЛЬ
Джордж Даниел ДЕМЕТРИ (US)
Джордж Даниел ДЕМЕТРИ
Саса ДИМИТРЬЕВИС (FR)
Саса ДИМИТРЬЕВИС
Брайан Дж. ДРУКЕР (US)
Брайан Дж. ДРУКЕР
Джонатан А. ФЛЕТЧЕР (US)
Джонатан А. ФЛЕТЧЕР
Хейкки ЙОЕНСУУ (FI)
Хейкки ЙОЕНСУУ
Сандра Лита СИЛБЕРМАН (US)
Сандра Лита СИЛБЕРМАН
Дейвид ТУВЕСОН (US)
Дейвид ТУВЕСОН
Майкл С. ХЕЙНРИЧ (US)
Майкл С. ХЕЙНРИЧ
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2003114752A publication Critical patent/RU2003114752A/ru
Application granted granted Critical
Publication of RU2301066C2 publication Critical patent/RU2301066C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
RU2003114752/15A 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей RU2301066C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
US60/243,810 2000-10-27

Publications (2)

Publication Number Publication Date
RU2003114752A RU2003114752A (ru) 2004-09-10
RU2301066C2 true RU2301066C2 (ru) 2007-06-20

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003114752/15A RU2301066C2 (ru) 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей

Country Status (25)

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US (1) US6958335B2 (enExample)
EP (1) EP1332137B1 (enExample)
JP (1) JP4386635B2 (enExample)
KR (1) KR100885129B1 (enExample)
CN (1) CN1276754C (enExample)
AT (1) ATE321556T1 (enExample)
AU (2) AU1826202A (enExample)
BR (1) BRPI0114870B8 (enExample)
CA (1) CA2424470C (enExample)
CY (1) CY1105055T1 (enExample)
CZ (1) CZ303944B6 (enExample)
DE (1) DE60118430T2 (enExample)
DK (1) DK1332137T3 (enExample)
ES (1) ES2260317T3 (enExample)
HU (1) HU229106B1 (enExample)
IL (2) IL155029A0 (enExample)
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NZ (1) NZ525254A (enExample)
PL (1) PL209733B1 (enExample)
PT (1) PT1332137E (enExample)
RU (1) RU2301066C2 (enExample)
SK (1) SK287335B6 (enExample)
WO (1) WO2002034727A2 (enExample)
ZA (1) ZA200302155B (enExample)

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US7727731B2 (en) * 2001-06-29 2010-06-01 Ab Science Potent, selective and non toxic c-kit inhibitors
PT1401413E (pt) * 2001-06-29 2007-02-28 Ab Science Uso de inibidores da tirosina cinase para tratar doenças alérgicas
DE60215648T2 (de) * 2001-06-29 2007-08-23 Ab Science Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
DE60212627T2 (de) * 2001-06-29 2007-06-14 Ab Science Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung von entzündlichen Krankheiten
EP1401412A2 (en) * 2001-06-29 2004-03-31 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
WO2003024386A2 (en) * 2001-09-20 2003-03-27 Ab Science Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
US20040242612A1 (en) * 2001-09-20 2004-12-02 Alain Moussy Use of tyrosine kinase inhibitors for promoting hair growth
ES2269994T3 (es) * 2002-02-27 2007-04-01 Ab Science Utilizacion de inhibidores de la tirosina quinasa, para el tratamiento de los trastornos del snc.
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
AU2004273605B2 (en) * 2003-09-19 2008-07-31 Novartis Ag Treatment of gastrointestinal stromal tumors with imatinib and midostaurin
WO2007089716A2 (en) * 2006-02-01 2007-08-09 The Regents Of The University Of California Use of aminopyrimidine compounds in the treatment of immune disorders
AU2007296743B2 (en) * 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
US20080221132A1 (en) * 2006-09-11 2008-09-11 Xiong Cai Multi-Functional Small Molecules as Anti-Proliferative Agents
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
BR112013022552B1 (pt) 2011-03-04 2021-11-23 Newgen Therapeutics, Inc Compostos de quinazolina substituídos com alcino, seu uso, composição farmacêutica, e kit
WO2012155339A1 (zh) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
WO2013124774A1 (en) 2012-02-21 2013-08-29 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
JP6464084B2 (ja) 2012-07-27 2019-02-06 イズミ テクノロジー，エルエルシー 排出阻害剤およびこれを用いる治療法
JP6799201B2 (ja) 2013-07-31 2020-12-16 アヴァリン ファーマ インク． エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用
WO2019016673A2 (en) 2017-07-20 2019-01-24 Kashiv Pharma Llc STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION OF IMATINIB
EP3746059A1 (en) 2018-01-31 2020-12-09 Deciphera Pharmaceuticals, LLC Combination therapy for the treatment of gastrointestinal stromal tumors
MX2020008015A (es) 2018-01-31 2020-10-16 Deciphera Pharmaceuticals Llc Terapia de combinación para el tratamiento de la mastocitosis.
CA3149796A1 (en) 2019-08-02 2021-02-11 Onehealthcompany, Inc. Anti-cancer agents for the treatment of canine cancers
NZ784949A (en) 2019-08-12 2025-09-26 Deciphera Pharmaceuticals Llc Ripretinib for treating gastrointestinal stromal tumors
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
KR20250057151A (ko) 2019-12-30 2025-04-28 데시페라 파마슈티칼스, 엘엘씨 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의조성물
MX2022008103A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
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SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

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JP2002523455A (ja) * 1998-08-31 2002-07-30 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体

Patent Citations (2)

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SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

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Also Published As

Publication number Publication date
CN1622808A (zh) 2005-06-01
PT1332137E (pt) 2006-07-31
SK287335B6 (sk) 2010-07-07
CA2424470C (en) 2009-06-09
PL362148A1 (en) 2004-10-18
CN1276754C (zh) 2006-09-27
KR100885129B1 (ko) 2009-02-23
CZ303944B6 (cs) 2013-07-10
WO2002034727A2 (en) 2002-05-02
AU2002218262B2 (en) 2005-09-29
US6958335B2 (en) 2005-10-25
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
IL155029A (en) 2009-09-22
AU1826202A (en) 2002-05-06
MXPA03003703A (es) 2005-01-25
DK1332137T3 (da) 2006-07-17
US20040023976A1 (en) 2004-02-05
PL209733B1 (pl) 2011-10-31
JP4386635B2 (ja) 2009-12-16
CZ20031152A3 (en) 2004-04-14
ZA200302155B (en) 2004-04-22
ATE321556T1 (de) 2006-04-15
HUP0301512A2 (hu) 2003-11-28
BRPI0114870B8 (pt) 2021-05-25
ES2260317T3 (es) 2006-11-01
CY1105055T1 (el) 2010-03-03
HK1058193A1 (en) 2004-05-07
NO324948B1 (no) 2008-01-07
IL155029A0 (en) 2003-10-31
CA2424470A1 (en) 2002-05-02
EP1332137B1 (en) 2006-03-29
BRPI0114870B1 (pt) 2020-06-16
BR0114870A (pt) 2004-02-17
HU229106B1 (en) 2013-07-29
JP2004512328A (ja) 2004-04-22
DE60118430T2 (de) 2006-10-26
NZ525254A (en) 2006-02-24
EP1332137A2 (en) 2003-08-06
DE60118430D1 (de) 2006-05-18
NO20031833L (no) 2003-04-24
SK5182003A3 (en) 2004-02-03
KR20030051656A (ko) 2003-06-25

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Effective date: 20130211

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MZ4A Patent is void

Effective date: 20150202