RU2301066C2 - Лечение желудочно-кишечных стромальных опухолей - Google Patents

Лечение желудочно-кишечных стромальных опухолей Download PDF

Info

Publication number
RU2301066C2
RU2301066C2 RU2003114752/15A RU2003114752A RU2301066C2 RU 2301066 C2 RU2301066 C2 RU 2301066C2 RU 2003114752/15 A RU2003114752/15 A RU 2003114752/15A RU 2003114752 A RU2003114752 A RU 2003114752A RU 2301066 C2 RU2301066 C2 RU 2301066C2
Authority
RU
Russia
Prior art keywords
treatment
salt
methyl
benzamide
ylmethyl
Prior art date
Application number
RU2003114752/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2003114752A (ru
Inventor
Элизабет БУХДУНГЕР (DE)
Элизабет БУХДУНГЕР
Рено КАПДЕВИЛЛЬ (FR)
Рено КАПДЕВИЛЛЬ
Джордж Даниел ДЕМЕТРИ (US)
Джордж Даниел ДЕМЕТРИ
Саса ДИМИТРЬЕВИС (FR)
Саса ДИМИТРЬЕВИС
Брайан Дж. ДРУКЕР (US)
Брайан Дж. ДРУКЕР
Джонатан А. ФЛЕТЧЕР (US)
Джонатан А. ФЛЕТЧЕР
Хейкки ЙОЕНСУУ (FI)
Хейкки ЙОЕНСУУ
Сандра Лита СИЛБЕРМАН (US)
Сандра Лита СИЛБЕРМАН
Дейвид ТУВЕСОН (US)
Дейвид ТУВЕСОН
Майкл С. ХЕЙНРИЧ (US)
Майкл С. ХЕЙНРИЧ
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2301066(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2003114752A publication Critical patent/RU2003114752A/ru
Application granted granted Critical
Publication of RU2301066C2 publication Critical patent/RU2301066C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
RU2003114752/15A 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей RU2301066C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
US60/243,810 2000-10-27

Publications (2)

Publication Number Publication Date
RU2003114752A RU2003114752A (ru) 2004-09-10
RU2301066C2 true RU2301066C2 (ru) 2007-06-20

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003114752/15A RU2301066C2 (ru) 2000-10-27 2001-10-26 Лечение желудочно-кишечных стромальных опухолей

Country Status (25)

Country Link
US (1) US6958335B2 (enExample)
EP (1) EP1332137B1 (enExample)
JP (1) JP4386635B2 (enExample)
KR (1) KR100885129B1 (enExample)
CN (1) CN1276754C (enExample)
AT (1) ATE321556T1 (enExample)
AU (2) AU1826202A (enExample)
BR (1) BRPI0114870B8 (enExample)
CA (1) CA2424470C (enExample)
CY (1) CY1105055T1 (enExample)
CZ (1) CZ303944B6 (enExample)
DE (1) DE60118430T2 (enExample)
DK (1) DK1332137T3 (enExample)
ES (1) ES2260317T3 (enExample)
HU (1) HU229106B1 (enExample)
IL (2) IL155029A0 (enExample)
MX (1) MXPA03003703A (enExample)
NO (1) NO324948B1 (enExample)
NZ (1) NZ525254A (enExample)
PL (1) PL209733B1 (enExample)
PT (1) PT1332137E (enExample)
RU (1) RU2301066C2 (enExample)
SK (1) SK287335B6 (enExample)
WO (1) WO2002034727A2 (enExample)
ZA (1) ZA200302155B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
AU2002342335B2 (en) * 2001-05-16 2006-02-02 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
PT1401416E (pt) * 2001-06-29 2007-02-28 Ab Science Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
WO2003003006A2 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
JP2004530730A (ja) * 2001-06-29 2004-10-07 アブ サイエンス 腫瘍の血管新生を治療するための強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用法
ES2274993T3 (es) * 2001-06-29 2007-06-01 Ab Science Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas.
CA2460845A1 (en) * 2001-09-20 2003-03-27 Ab Science Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
EP1461032B1 (en) * 2001-09-20 2008-07-16 AB Science Use of c-kit inhibitors for promoting hair growth
PT1478380E (pt) * 2002-02-27 2006-12-29 Ab Science Utilização de inibidores de tirosina-cinases para tratar doenças do snc
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
DE602004030265D1 (de) * 2003-09-19 2011-01-05 Novartis Ag Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin
WO2007089716A2 (en) * 2006-02-01 2007-08-09 The Regents Of The University Of California Use of aminopyrimidine compounds in the treatment of immune disorders
WO2008033746A2 (en) * 2006-09-11 2008-03-20 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
SG174772A1 (en) * 2006-09-11 2011-10-28 Curis Inc Multi-functional small molecules as anti-proliferative agents
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
EP2680850B1 (en) 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use
CN102918029B (zh) 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
AU2013223749A1 (en) 2012-02-21 2014-09-11 Sun Pharmaceutical Industries Limited Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
IN2015MN00408A (enExample) 2012-07-27 2015-09-04 Antonius Martinus Gustave Bunt
CA3280124A1 (en) 2013-07-31 2025-10-31 Avalyn Pharma Inc. Aerosol imatinib compounds and uses thereof
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
CA3149796A1 (en) 2019-08-02 2021-02-11 Onehealthcompany, Inc. Anti-cancer agents for the treatment of canine cancers
US12691108B2 (en) 2019-08-12 2026-07-28 Deciphera Pharmaceuticals, Llc Methods for treating vascular malformations
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
FI4084779T3 (fi) 2019-12-30 2024-12-16 Deciphera Pharmaceuticals Llc 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (enExample) * 1992-04-03 1994-06-21 Ciba Geigy Ag
US6525072B1 (en) * 1998-08-31 2003-02-25 Sugen, Inc. Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1528449A1 (ru) * 1985-06-05 1989-12-15 Центральный институт усовершенствования врачей Способ релаксации илеоцекального отдела кишечника
WO1999003854A1 (en) * 1997-07-18 1999-01-28 Novartis Ag Crystal modification of a n-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
реферат Entrez PubMed: Miettine M et al. Immunohisto-chemical spectmm of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT).Mod Pathol. 2000 Oct; 13(10):1134-42. *

Also Published As

Publication number Publication date
ZA200302155B (en) 2004-04-22
BRPI0114870B8 (pt) 2021-05-25
IL155029A0 (en) 2003-10-31
PL362148A1 (en) 2004-10-18
EP1332137A2 (en) 2003-08-06
CA2424470C (en) 2009-06-09
DE60118430D1 (de) 2006-05-18
SK287335B6 (sk) 2010-07-07
PL209733B1 (pl) 2011-10-31
BR0114870A (pt) 2004-02-17
AU2002218262B2 (en) 2005-09-29
NO20031833L (no) 2003-04-24
IL155029A (en) 2009-09-22
HK1058193A1 (en) 2004-05-07
KR20030051656A (ko) 2003-06-25
KR100885129B1 (ko) 2009-02-23
CZ303944B6 (cs) 2013-07-10
PT1332137E (pt) 2006-07-31
US6958335B2 (en) 2005-10-25
SK5182003A3 (en) 2004-02-03
DE60118430T2 (de) 2006-10-26
ATE321556T1 (de) 2006-04-15
HUP0301512A2 (hu) 2003-11-28
CN1622808A (zh) 2005-06-01
NO324948B1 (no) 2008-01-07
WO2002034727A2 (en) 2002-05-02
EP1332137B1 (en) 2006-03-29
CN1276754C (zh) 2006-09-27
US20040023976A1 (en) 2004-02-05
ES2260317T3 (es) 2006-11-01
BRPI0114870B1 (pt) 2020-06-16
NZ525254A (en) 2006-02-24
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
HU229106B1 (en) 2013-07-29
JP4386635B2 (ja) 2009-12-16
CA2424470A1 (en) 2002-05-02
JP2004512328A (ja) 2004-04-22
MXPA03003703A (es) 2005-01-25
DK1332137T3 (da) 2006-07-17
CZ20031152A3 (en) 2004-04-14
CY1105055T1 (el) 2010-03-03
AU1826202A (en) 2002-05-06

Similar Documents

Publication Publication Date Title
CA2424470C (en) Treatment of gastrointestinal stromal tumors
AU2002218262A1 (en) Treatment of gastrointestinal stromal tumors
US9585893B2 (en) Flumazenil complexes, compositions comprising same and uses thereof
US12396995B2 (en) Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use
KR101868991B1 (ko) 피라졸 유도체 및 그 의약용도
TWI314053B (en) Use of compounds that are effective as selective opiate receptor modulators
JP2025106456A (ja) 胆管癌を治療するための方法
WO2003097031A1 (en) Obesity preventive or ameliorator containing methylidene hydrazide compound as active ingredient
TWI287986B (en) Use of Epothilones for the treatment of the carcinoid syndrome
ES3055126T3 (en) Therapeutic combinations of acalabrutinib and capivasertib to treat b-cell malignancies
SPIES et al. Vitamin B6 (Pyridoxin) Deficiency in Human Beings: Further Studies, with Special Emphasis on the Urinary Excretion of Pyridoxin
KR20240006600A (ko) 투약 요법
HK1058193B (en) Treatment of gastrointestinal stromal tumors
Mittal et al. Acute transient cerebral toxicity associated with administration of high-dose methotrexate
TWI676477B (zh) 苯并咪唑衍生物用於夜間酸突破的用途
WO2014091430A1 (es) Composición farmacéutica de una meglitinida y una tiazolidinediona y su uso

Legal Events

Date Code Title Description
PC41 Official registration of the transfer of exclusive right

Effective date: 20130211

TK4A Correction to the publication in the bulletin (patent)

Free format text: AMENDMENT TO CHAPTER -PC4A- IN JOURNAL: 8-2013 FOR TAG: (73)

MZ4A Patent is void

Effective date: 20150202