RU2224759C2 - Способ получения производных пиразоло [4,3-d]пиримидин-7-она и промежуточные соединения - Google Patents

Способ получения производных пиразоло [4,3-d]пиримидин-7-она и промежуточные соединения Download PDF

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Publication number
RU2224759C2
RU2224759C2 RU2001121162/04A RU2001121162A RU2224759C2 RU 2224759 C2 RU2224759 C2 RU 2224759C2 RU 2001121162/04 A RU2001121162/04 A RU 2001121162/04A RU 2001121162 A RU2001121162 A RU 2001121162A RU 2224759 C2 RU2224759 C2 RU 2224759C2
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Russia
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formula
compound
alcohol
lower alkyl
residue
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RU2001121162/04A
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English (en)
Russian (ru)
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RU2001121162A (ru
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Шарлотт Мойра Норфор АЛЛЕРТОН (GB)
Шарлотт Мойра Норфор Аллертон
Кристофер Гордон БАРБЕР (GB)
Кристофер Гордон Барбер
Кейт Майкл ДЕВРИС (GB)
Кейт Майкл ДЕВРИС
Лоуренс Джеймс ХАРРИС (GB)
Лоуренс Джеймс ХАРРИС
Филип Чарльз ЛЕВЕТТ (GB)
Филип Чарльз Леветт
Джоанна Тереза НЕГРИ (GB)
Джоанна Тереза Негри
Дэвид Джеймс РОУСОН (GB)
Дэвид Джеймс Роусон
Альберт Шо ВУД (GB)
Альберт Шо Вуд
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Пфайзер Инк.
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Priority claimed from GB0018660A external-priority patent/GB0018660D0/en
Priority claimed from GB0107526A external-priority patent/GB0107526D0/en
Priority claimed from GB0110251A external-priority patent/GB0110251D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of RU2001121162A publication Critical patent/RU2001121162A/ru
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Publication of RU2224759C2 publication Critical patent/RU2224759C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2001121162/04A 2000-07-28 2001-07-27 Способ получения производных пиразоло [4,3-d]пиримидин-7-она и промежуточные соединения RU2224759C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0018660A GB0018660D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
GB0018660.1 2000-07-28
GB0107526A GB0107526D0 (en) 2001-03-26 2001-03-26 Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
GB0107526.6 2001-03-26
GB0110251.6 2001-04-26
GB0110251A GB0110251D0 (en) 2001-04-26 2001-04-26 Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof

Publications (2)

Publication Number Publication Date
RU2001121162A RU2001121162A (ru) 2003-07-20
RU2224759C2 true RU2224759C2 (ru) 2004-02-27

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RU2001121162/04A RU2224759C2 (ru) 2000-07-28 2001-07-27 Способ получения производных пиразоло [4,3-d]пиримидин-7-она и промежуточные соединения

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EP (1) EP1176147A1 (enExample)
JP (1) JP2002105076A (enExample)
KR (1) KR20020010102A (enExample)
CN (1) CN1335317A (enExample)
AR (1) AR035650A1 (enExample)
AU (1) AU754962B2 (enExample)
BR (1) BR0103072A (enExample)
CA (1) CA2354175A1 (enExample)
CZ (1) CZ20012713A3 (enExample)
HK (1) HK1040715A1 (enExample)
HU (1) HUP0103075A3 (enExample)
IL (1) IL144516A0 (enExample)
IN (1) IN191315B (enExample)
MX (1) MXPA01007676A (enExample)
PL (1) PL348935A1 (enExample)
RU (1) RU2224759C2 (enExample)
YU (1) YU51701A (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
DK1620437T3 (da) 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
JP2006219373A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
ES2317209T3 (es) 2004-04-07 2009-04-16 Pfizer Inc. Pirazolo(4,3-) pirimidinas.
ATE464289T1 (de) * 2005-11-16 2010-04-15 Hoffmann La Roche Neues verfahren zur herstellung von thoc
WO2007107733A1 (en) * 2006-03-17 2007-09-27 Cipla Limited Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-tr1azol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US8183381B2 (en) 2007-07-19 2012-05-22 Metabolex Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
EP2483281B1 (en) 2009-10-01 2014-06-04 Cymabay Therapeutics, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
WO2011163090A1 (en) 2010-06-23 2011-12-29 Metabolex, Inc. Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114114C1 (ru) * 1990-06-20 1998-06-27 Пфайзер Инк. Пиразолопиримидиноновые соединения, фармацевтическая композиция и способ лечения
RU2114113C1 (ru) * 1991-07-09 1998-06-27 Пфайзер Инк. Пиразолопиримидиноны, фармацевтическая композиция и способ ингибирования фосфодиэстеразы циклического гуанозин-3',5'-монофосфата
WO2001027112A1 (en) * 1999-10-11 2001-04-19 Pfizer Limited 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2089971A (en) * 1937-08-17 Condensation products of
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2114114C1 (ru) * 1990-06-20 1998-06-27 Пфайзер Инк. Пиразолопиримидиноновые соединения, фармацевтическая композиция и способ лечения
RU2114113C1 (ru) * 1991-07-09 1998-06-27 Пфайзер Инк. Пиразолопиримидиноны, фармацевтическая композиция и способ ингибирования фосфодиэстеразы циклического гуанозин-3',5'-монофосфата
WO2001027112A1 (en) * 1999-10-11 2001-04-19 Pfizer Limited 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
кол. 7-8. DUMAITRE В., DODIC N. Synthesis and cyclic GMP phosphodiesterase inhibitory activity of series of 6-phenylpyrasolo[3,4-d]pyrimidones. J. Med. Chem. V.39, no.8, 1996, p.1635-1644. HAMILTON H.W. et.al. Synthesis and structure-activity relationships of pyrasolo[3,4-d]pyrimidin-7-ones as adenosine reseptor antagonist. J. Med. Chem. V.30, no.1, 1987, p.91-96. *
кол.16-17. *

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AR035650A1 (es) 2004-06-23
IL144516A0 (en) 2002-05-23
YU51701A (sh) 2003-12-31
JP2002105076A (ja) 2002-04-10
BR0103072A (pt) 2002-04-09
CN1335317A (zh) 2002-02-13
MXPA01007676A (es) 2002-10-23
HK1040715A1 (zh) 2002-06-21
CZ20012713A3 (cs) 2002-04-17
AU754962B2 (en) 2002-11-28
KR20020010102A (ko) 2002-02-02
HU0103075D0 (en) 2001-10-28
HUP0103075A3 (en) 2003-04-28
CA2354175A1 (en) 2002-01-28
IN191315B (enExample) 2003-11-22
EP1176147A1 (en) 2002-01-30
HUP0103075A2 (hu) 2002-07-29
PL348935A1 (en) 2002-02-11
AU5767201A (en) 2002-01-31

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Effective date: 20040728