HK1040715A1 - 製備吡唑並[4，3-d]嘧啶-7-酮化合物的方法及其中間體 - Google Patents

製備吡唑並[4，3-d]嘧啶-7-酮化合物的方法及其中間體 Download PDF

Info

Publication number
HK1040715A1
HK1040715A1 HK02102460.5A HK02102460A HK1040715A1 HK 1040715 A1 HK1040715 A1 HK 1040715A1 HK 02102460 A HK02102460 A HK 02102460A HK 1040715 A1 HK1040715 A1 HK 1040715A1
Authority
HK
Hong Kong
Prior art keywords
lower alkyl
het
group
optionally substituted
compound
Prior art date
Application number
HK02102460.5A
Other languages
English (en)
Chinese (zh)
Inventor
C‧M‧N‧艾尔勒顿
C‧M‧N‧艾爾勒頓
C‧G‧巴伯
K‧M‧迪福利斯
L‧J‧哈里斯
P‧C‧勒维特
J‧T‧奈格里
D‧J‧劳森
L‧J‧哈裡斯
A‧S‧伍德
P‧C‧勒維特
J‧T‧奈格裡
D‧J‧勞森
Original Assignee
辉瑞大药厂
輝瑞大藥廠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0018660A external-priority patent/GB0018660D0/en
Priority claimed from GB0107526A external-priority patent/GB0107526D0/en
Priority claimed from GB0110251A external-priority patent/GB0110251D0/en
Application filed by 辉瑞大药厂, 輝瑞大藥廠 filed Critical 辉瑞大药厂
Publication of HK1040715A1 publication Critical patent/HK1040715A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02102460.5A 2000-07-28 2002-04-03 製備吡唑並[4，3-d]嘧啶-7-酮化合物的方法及其中間體 HK1040715A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0018660A GB0018660D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
GB0107526A GB0107526D0 (en) 2001-03-26 2001-03-26 Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
GB0107526.6 2001-03-26
GB0110251.6 2001-04-26
GB0110251A GB0110251D0 (en) 2001-04-26 2001-04-26 Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1040715A1 true HK1040715A1 (zh) 2002-06-21

Family

ID=27255823

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102460.5A HK1040715A1 (zh) 2000-07-28 2002-04-03 製備吡唑並[4，3-d]嘧啶-7-酮化合物的方法及其中間體

Country Status (17)

Country Link
EP (1) EP1176147A1 (enExample)
JP (1) JP2002105076A (enExample)
KR (1) KR20020010102A (enExample)
CN (1) CN1335317A (enExample)
AR (1) AR035650A1 (enExample)
AU (1) AU754962B2 (enExample)
BR (1) BR0103072A (enExample)
CA (1) CA2354175A1 (enExample)
CZ (1) CZ20012713A3 (enExample)
HK (1) HK1040715A1 (enExample)
HU (1) HUP0103075A3 (enExample)
IL (1) IL144516A0 (enExample)
IN (1) IN191315B (enExample)
MX (1) MXPA01007676A (enExample)
PL (1) PL348935A1 (enExample)
RU (1) RU2224759C2 (enExample)
YU (1) YU51701A (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
US6831074B2 (en) 2001-03-16 2004-12-14 Pfizer Inc Pharmaceutically active compounds
DK1620437T3 (da) 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
US7569572B2 (en) 2004-04-07 2009-08-04 Pfizer Inc Pyrazolo[4,3-D]pyrimidines
WO2007057316A2 (en) * 2005-11-16 2007-05-24 F. Hoffmann-La Roche Ag Novel process for the preparation of thoc
GB2450268B (en) * 2006-03-17 2011-01-12 Cipla Ltd Synthesis of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile and 4-[1-(1,2,4-triazol-1-yl)methyl]benzonitrile intermediate
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
EP2185544B1 (en) * 2007-07-19 2014-11-26 Cymabay Therapeutics, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the rup3 or gpr119 for the treatment of diabetes and metabolic disorders
EP2483281B1 (en) 2009-10-01 2014-06-04 Cymabay Therapeutics, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
BR112012032248A2 (pt) 2010-06-23 2016-09-13 Metabolex Inc composições de 5-etil-2-{4-[-4(-4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2089971A (en) * 1937-08-17 Condensation products of
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
JP2003511452A (ja) * 1999-10-11 2003-03-25 ファイザー・インク ホスホジエステラーゼ阻害剤としての５−（２−置換−５−ヘテロシクリルスルホニルピリド−３−イル）−ジヒドロピラゾロ［４，３−ｄ］ピリミジン−７−オン

Also Published As

Publication number Publication date
EP1176147A1 (en) 2002-01-30
AU754962B2 (en) 2002-11-28
IN191315B (enExample) 2003-11-22
AU5767201A (en) 2002-01-31
IL144516A0 (en) 2002-05-23
JP2002105076A (ja) 2002-04-10
HUP0103075A2 (hu) 2002-07-29
PL348935A1 (en) 2002-02-11
BR0103072A (pt) 2002-04-09
CZ20012713A3 (cs) 2002-04-17
HUP0103075A3 (en) 2003-04-28
CN1335317A (zh) 2002-02-13
CA2354175A1 (en) 2002-01-28
RU2224759C2 (ru) 2004-02-27
HU0103075D0 (en) 2001-10-28
AR035650A1 (es) 2004-06-23
KR20020010102A (ko) 2002-02-02
YU51701A (sh) 2003-12-31
MXPA01007676A (es) 2002-10-23

Similar Documents

Publication Publication Date Title
CN100347170C (zh) 具有dpp－iv抑制活性的氮杂二环辛烷与壬烷衍生物
HK1049834A1 (zh) 用作磷酸二酯酶抑制剂的5-(2-取代的-5-杂环基磺酰基吡啶-3-基)-二氢吡唑并[4，3-d]嘧啶-7-酮类化合物
CN1014789B (zh) 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法
HK1040715A1 (zh) 製備吡唑並[4，3-d]嘧啶-7-酮化合物的方法及其中間體
JPH08311061A (ja) 含窒素二環化合物の製造方法
EP2307377A1 (en) Nicotinamide derivatives
EP1483257A1 (en) Quinazoline compounds useful in therapy
CN1368969A (zh) 作为抗组胺剂和抗过敏剂的吲哚基哌啶衍生物
JP3488155B2 (ja) 成長ホルモン分泌促進物質の製造及び中間体
AU705683B2 (en) Piperazino derivatives as neurokinin antagonists
CN1167682C (zh) 毒蕈碱拮抗剂
CA2269128C (en) Piperazino derivatives as neurokinin antagonists
CN1437589A (zh) 吡唑并嘧啶酮类的制备方法
CN1774250A (zh) 作为治疗诸如类风湿性关节炎的炎性疾病的p38激酶抑制剂的(6－(苯氧基)－吡啶并[3,4－d]嘧啶－2－基)－胺衍生物
KR100395718B1 (ko) 피라졸로[4,3-ｄ]피리미딘-7-온-3-피리딜술포닐 화합물 및그의 중간체의 제조 방법
US6809200B2 (en) Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
WO2008000818A1 (en) Fluorinated indoleamides useful as ligands of the orl-1 receptor
CN1135232C (zh) 作为神经激肽拮抗剂的哌嗪衍生物
WO2017057717A1 (ja) 複素芳香環誘導体
CN1240447A (zh) 用作神经激肽拮抗剂的螺取代的氮杂环取代的哌嗪子基衍生物
HK1035899A (en) Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof
CN1692114A (zh) 吡唑并嘧啶酮类的新型制备方法
HK1029585A (en) Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists
HK1079198B (en) Novel process for the preparation of pyrazolopyrimidinones
HK1079198A1 (en) Novel process for the preparation of pyrazolopyrimidinones