RU2223970C2 - Лечение ожирения - Google Patents
Лечение ожирения Download PDFInfo
- Publication number
- RU2223970C2 RU2223970C2 RU2000109265/04A RU2000109265A RU2223970C2 RU 2223970 C2 RU2223970 C2 RU 2223970C2 RU 2000109265/04 A RU2000109265/04 A RU 2000109265/04A RU 2000109265 A RU2000109265 A RU 2000109265A RU 2223970 C2 RU2223970 C2 RU 2223970C2
- Authority
- RU
- Russia
- Prior art keywords
- peptide
- cys
- arg
- val
- gly
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title claims abstract 5
- 235000020824 obesity Nutrition 0.000 title claims abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 21
- 150000001413 amino acids Chemical group 0.000 claims abstract 10
- 150000007522 mineralic acids Chemical class 0.000 claims abstract 6
- 150000007524 organic acids Chemical class 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 6
- 102000018997 Growth Hormone Human genes 0.000 claims abstract 5
- 108010051696 Growth Hormone Proteins 0.000 claims abstract 5
- 241001465754 Metazoa Species 0.000 claims abstract 5
- 125000004122 cyclic group Chemical group 0.000 claims abstract 5
- 239000000122 growth hormone Substances 0.000 claims abstract 5
- 102000002265 Human Growth Hormone Human genes 0.000 claims abstract 4
- 108010000521 Human Growth Hormone Proteins 0.000 claims abstract 4
- 239000000854 Human Growth Hormone Substances 0.000 claims abstract 4
- 125000000539 amino acid group Chemical group 0.000 claims abstract 3
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 235000001014 amino acid Nutrition 0.000 claims 8
- 229940024606 amino acid Drugs 0.000 claims 8
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 244000137850 Marrubium vulgare Species 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical compound CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- XUJNEKJLAYXESH-UWTATZPHSA-N D-Cysteine Chemical compound SC[C@@H](N)C(O)=O XUJNEKJLAYXESH-UWTATZPHSA-N 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- -1 His Chemical compound 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- VVNCNSJFMMFHPL-GSVOUGTGSA-N L-penicillamine Chemical compound CC(C)(S)[C@H](N)C(O)=O VVNCNSJFMMFHPL-GSVOUGTGSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 229960001639 penicillamine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Materials For Photolithography (AREA)
- Reverberation, Karaoke And Other Acoustics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Percussion Or Vibration Massage (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO9001 | 1997-09-08 | ||
| AUPO9001A AUPO900197A0 (en) | 1997-09-08 | 1997-09-08 | Treatment of obesity |
| AUPP0398 | 1997-11-13 | ||
| AUPP0398A AUPP039897A0 (en) | 1997-11-13 | 1997-11-13 | Treatment of obesity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000109265A RU2000109265A (ru) | 2002-03-10 |
| RU2223970C2 true RU2223970C2 (ru) | 2004-02-20 |
Family
ID=25645599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000109265/04A RU2223970C2 (ru) | 1997-09-08 | 1998-09-04 | Лечение ожирения |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6737407B1 (enExample) |
| EP (1) | EP1012189B1 (enExample) |
| JP (1) | JP4334761B2 (enExample) |
| CN (1) | CN1195776C (enExample) |
| AT (1) | ATE377026T1 (enExample) |
| BR (1) | BR9811755A (enExample) |
| CA (1) | CA2303395C (enExample) |
| DE (1) | DE69838647T2 (enExample) |
| ES (1) | ES2296342T3 (enExample) |
| NZ (1) | NZ502993A (enExample) |
| RU (1) | RU2223970C2 (enExample) |
| WO (1) | WO1999012969A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2450825C2 (ru) * | 2005-02-23 | 2012-05-20 | Университат Де-Лес-Ильес Балеарс | Применение лептина для предотвращения избыточной массы тела и композиции, содержащие лептин |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ387599A0 (en) | 1999-11-05 | 1999-12-02 | Metabolic Pharmaceuticals Limited | Product and method for control of obesity |
| GB0121709D0 (en) * | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| GB0315182D0 (en) * | 2003-06-28 | 2003-08-06 | Asterion Ltd | Cytokine variant polypeptides |
| WO2005007859A2 (en) * | 2003-07-11 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF ACETYL-COA CARBOXYLASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP4931802B2 (ja) * | 2004-05-04 | 2012-05-16 | メタボリック・ファーマシューティカルズ・リミテッド | 骨障害を予防または治療するための方法 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| JP2009502976A (ja) * | 2005-08-02 | 2009-01-29 | メタボリック・ファーマシューティカルズ・リミテッド | 親水性ペプチド鎮痛薬の経口送達のためのペプチドコンジュゲート |
| WO2007068039A1 (en) * | 2005-12-12 | 2007-06-21 | Metabolic Pharmaceuticals Limited | Treatment of weight gain in estrogen deficient mammals |
| BRPI0807046A2 (pt) | 2007-02-09 | 2015-05-26 | Tranzyme Pharma Inc | Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit. |
| WO2008098280A1 (en) * | 2007-02-16 | 2008-08-21 | Polychip Pharmaceuticals Pty Ltd | Methods for the synthesis of dicarba bridges in growth hormone peptides |
| EP2340050A2 (en) * | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymer conjugates of aod-like peptides |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| CN110448683A (zh) * | 2011-12-09 | 2019-11-15 | 麦特保利药业有限公司 | 生长激素片段的用途 |
| CN102827290A (zh) * | 2012-09-07 | 2012-12-19 | 浙江大学 | 人血清白蛋白与人生长激素脂肪分解结构域的融合蛋白 |
| GB2507341A (en) * | 2012-10-29 | 2014-04-30 | Peter Kenny | Fat loss composition comprising a prostaglandin F2 alpha analogue and a fragment of amino acids 176-191 of human growth hormone |
| WO2019136528A1 (en) * | 2018-01-15 | 2019-07-18 | Lateral IP Pty Ltd | Peptides and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG49718A3 (bg) | 1983-07-15 | 1992-01-15 | Bio- Technology General Corp | Метод за получаване на полипептид със супероксиддисмутазна активност |
| US4863901A (en) | 1986-01-09 | 1989-09-05 | Brigham & Women's Hospital | Use of growth hormone for nitrogen retention under hypocaloric conditions |
| US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| US5126324A (en) | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
| AU693478B2 (en) * | 1994-11-10 | 1998-07-02 | Metabolic Pharmaceuticals Limited | Treatment of obesity |
-
1998
- 1998-09-04 DE DE69838647T patent/DE69838647T2/de not_active Expired - Lifetime
- 1998-09-04 RU RU2000109265/04A patent/RU2223970C2/ru active
- 1998-09-04 JP JP2000510774A patent/JP4334761B2/ja not_active Expired - Fee Related
- 1998-09-04 CA CA002303395A patent/CA2303395C/en not_active Expired - Lifetime
- 1998-09-04 EP EP98941152A patent/EP1012189B1/en not_active Expired - Lifetime
- 1998-09-04 CN CNB988100894A patent/CN1195776C/zh not_active Expired - Lifetime
- 1998-09-04 US US09/508,054 patent/US6737407B1/en not_active Expired - Lifetime
- 1998-09-04 AT AT98941152T patent/ATE377026T1/de not_active IP Right Cessation
- 1998-09-04 ES ES98941152T patent/ES2296342T3/es not_active Expired - Lifetime
- 1998-09-04 BR BR9811755-6A patent/BR9811755A/pt not_active Application Discontinuation
- 1998-09-04 WO PCT/AU1998/000724 patent/WO1999012969A1/en not_active Ceased
- 1998-09-04 NZ NZ502993A patent/NZ502993A/xx not_active IP Right Cessation
-
2004
- 2004-05-11 US US10/842,485 patent/US20040192608A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| G.Y.W.Ma et al., Biochimica at Biophysica Acta, 1982, v.716, p. 400-409. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2450825C2 (ru) * | 2005-02-23 | 2012-05-20 | Университат Де-Лес-Ильес Балеарс | Применение лептина для предотвращения избыточной массы тела и композиции, содержащие лептин |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2303395A1 (en) | 1999-03-18 |
| US6737407B1 (en) | 2004-05-18 |
| DE69838647D1 (de) | 2007-12-13 |
| JP2002501004A (ja) | 2002-01-15 |
| EP1012189A4 (en) | 2004-10-20 |
| CN1275132A (zh) | 2000-11-29 |
| EP1012189B1 (en) | 2007-10-31 |
| ATE377026T1 (de) | 2007-11-15 |
| CN1195776C (zh) | 2005-04-06 |
| JP4334761B2 (ja) | 2009-09-30 |
| EP1012189A1 (en) | 2000-06-28 |
| WO1999012969A1 (en) | 1999-03-18 |
| BR9811755A (pt) | 2000-08-29 |
| NZ502993A (en) | 2002-12-20 |
| DE69838647T2 (de) | 2008-08-28 |
| CA2303395C (en) | 2008-12-02 |
| US20040192608A1 (en) | 2004-09-30 |
| ES2296342T3 (es) | 2008-04-16 |
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