CN1195776C - 肥胖症的治疗 - Google Patents

肥胖症的治疗 Download PDF

Info

Publication number
CN1195776C
CN1195776C CNB988100894A CN98810089A CN1195776C CN 1195776 C CN1195776 C CN 1195776C CN B988100894 A CNB988100894 A CN B988100894A CN 98810089 A CN98810089 A CN 98810089A CN 1195776 C CN1195776 C CN 1195776C
Authority
CN
China
Prior art keywords
cys
ser
peptide
arg
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB988100894A
Other languages
English (en)
Chinese (zh)
Other versions
CN1275132A (zh
Inventor
F·M－W·恩格
姜伟家
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolic Pharmaceuticals Pty Ltd
Original Assignee
Metabolic Pharmaceuticals Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPO9001A external-priority patent/AUPO900197A0/en
Priority claimed from AUPP0398A external-priority patent/AUPP039897A0/en
Application filed by Metabolic Pharmaceuticals Pty Ltd filed Critical Metabolic Pharmaceuticals Pty Ltd
Publication of CN1275132A publication Critical patent/CN1275132A/zh
Application granted granted Critical
Publication of CN1195776C publication Critical patent/CN1195776C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Reverberation, Karaoke And Other Acoustics (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Percussion Or Vibration Massage (AREA)
CNB988100894A 1997-09-08 1998-09-04 肥胖症的治疗 Expired - Lifetime CN1195776C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPO9001 1997-09-08
AUPO9001A AUPO900197A0 (en) 1997-09-08 1997-09-08 Treatment of obesity
AUPP0398A AUPP039897A0 (en) 1997-11-13 1997-11-13 Treatment of obesity
AUPP0398 1997-11-13

Publications (2)

Publication Number Publication Date
CN1275132A CN1275132A (zh) 2000-11-29
CN1195776C true CN1195776C (zh) 2005-04-06

Family

ID=25645599

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988100894A Expired - Lifetime CN1195776C (zh) 1997-09-08 1998-09-04 肥胖症的治疗

Country Status (12)

Country Link
US (2) US6737407B1 (enExample)
EP (1) EP1012189B1 (enExample)
JP (1) JP4334761B2 (enExample)
CN (1) CN1195776C (enExample)
AT (1) ATE377026T1 (enExample)
BR (1) BR9811755A (enExample)
CA (1) CA2303395C (enExample)
DE (1) DE69838647T2 (enExample)
ES (1) ES2296342T3 (enExample)
NZ (1) NZ502993A (enExample)
RU (1) RU2223970C2 (enExample)
WO (1) WO1999012969A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ387599A0 (en) 1999-11-05 1999-12-02 Metabolic Pharmaceuticals Limited Product and method for control of obesity
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
GB0315182D0 (en) * 2003-06-28 2003-08-06 Asterion Ltd Cytokine variant polypeptides
WO2005007859A2 (en) * 2003-07-11 2005-01-27 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF ACETYL-COA CARBOXYLASE GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP1755637B8 (en) * 2004-05-04 2012-10-03 Metabolic Pharmaceuticals Ltd. Methods for preventing or treating bone disorders
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
ES2258923B1 (es) * 2005-02-23 2007-11-01 Universitat De Les Illes Balears Uso de la leptina para la prevencion del exceso de peso corporal y composicion que contiene leptina.
US20110092448A1 (en) * 2005-08-02 2011-04-21 Metabolic Pharmaceuticals Limited Peptide Conjugate for Oral Delivery of Hydrophilic Peptide Analgesics
WO2007068039A1 (en) * 2005-12-12 2007-06-21 Metabolic Pharmaceuticals Limited Treatment of weight gain in estrogen deficient mammals
ES2602789T3 (es) 2007-02-09 2017-02-22 Ocera Therapeutics, Inc. Productos intermedios conectores para la síntesis de moduladores macrocíclicos del receptor de la grelina
WO2008098280A1 (en) * 2007-02-16 2008-08-21 Polychip Pharmaceuticals Pty Ltd Methods for the synthesis of dicarba bridges in growth hormone peptides
AU2009292651A1 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of AOD-like peptides
EP2350118B1 (en) 2008-09-19 2016-03-30 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
KR102148910B1 (ko) * 2011-12-09 2020-08-28 메타볼릭 파마슈티칼즈 피티와이 엘티디 성장 호르몬 단편들의 사용
CN102827290A (zh) * 2012-09-07 2012-12-19 浙江大学 人血清白蛋白与人生长激素脂肪分解结构域的融合蛋白
GB2507341A (en) * 2012-10-29 2014-04-30 Peter Kenny Fat loss composition comprising a prostaglandin F2 alpha analogue and a fragment of amino acids 176-191 of human growth hormone
WO2019136528A1 (en) * 2018-01-15 2019-07-18 Lateral IP Pty Ltd Peptides and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG49718A3 (bg) 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
US4863901A (en) 1986-01-09 1989-09-05 Brigham & Women's Hospital Use of growth hormone for nitrogen retention under hypocaloric conditions
US5534617A (en) * 1988-10-28 1996-07-09 Genentech, Inc. Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
US5126324A (en) 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity

Also Published As

Publication number Publication date
DE69838647T2 (de) 2008-08-28
ES2296342T3 (es) 2008-04-16
EP1012189A4 (en) 2004-10-20
EP1012189A1 (en) 2000-06-28
WO1999012969A1 (en) 1999-03-18
JP4334761B2 (ja) 2009-09-30
RU2223970C2 (ru) 2004-02-20
DE69838647D1 (de) 2007-12-13
US6737407B1 (en) 2004-05-18
NZ502993A (en) 2002-12-20
BR9811755A (pt) 2000-08-29
JP2002501004A (ja) 2002-01-15
ATE377026T1 (de) 2007-11-15
US20040192608A1 (en) 2004-09-30
CN1275132A (zh) 2000-11-29
CA2303395C (en) 2008-12-02
EP1012189B1 (en) 2007-10-31
CA2303395A1 (en) 1999-03-18

Similar Documents

Publication Publication Date Title
CN1305897C (zh) 新肽化合物和其制备方法及含有它们的药物组合物
CN1183158C (zh) Exendin类似物,其制备方法及含有它们的药物制剂
CN1275132A (zh) 肥胖症的治疗
CN1034080C (zh) 胰岛素类似物的制备方法
CN1052731C (zh) 具有生长激素释放特性的化合物
CN1261281A (zh) 肽甲状旁腺激素类似物
CN1163504C (zh) 制备与树脂结合的环状肽的方法
CN1495198A (zh) 胰高血糖素样肽-1的类似物
CN1176947C (zh) 用于治疗骨质疏松症的甲状旁腺激素类似物
CN1099801A (zh) 甲状旁腺素类似物，它们的生产方法和含有它们的药物组合物
CN1832959A (zh) 聚乙二醇连接的glp－1化合物
CN1622822A (zh) 含有生长素释放肽的药物组合物
CN1909930A (zh) 转谷氨酰胺酶介导的肽的接合
CN1073684A (zh) 新的多肽化合物的制备方法
CN1041950A (zh) 新型肽酶抑制剂
CN1293096C (zh) 合成甲状旁腺素类似物和甲状旁腺素相关肽的方法
CN1209437A (zh) 获得具有正确键合的胱氨酸键的胰岛素前体的改进的方法
CN1196061A (zh) 胰岛素衍生物
CN1703424A (zh) Glp－1衍生物及其经粘膜吸收的制剂
CN85109722A (zh) 制造敌诺芬(dynophine)衍生物的方法
CN1863920A (zh) 肽的缀合
CN1871020A (zh) Gh－rh的拮抗类似物(2003)
CN1049166A (zh) Magainin肽的取代类似物
CN1150028C (zh) 三-、四-、五-和多肽以及它们作为抗抑郁剂的治疗应用
CN101062954A (zh) 具有抗血管生成作用的融合蛋白及其编码基因与应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20050406

CX01 Expiry of patent term