RU2213732C2 - Гетероциклические производные и фармацевтическая композиция - Google Patents
Гетероциклические производные и фармацевтическая композиция Download PDFInfo
- Publication number
- RU2213732C2 RU2213732C2 RU99112135/04A RU99112135A RU2213732C2 RU 2213732 C2 RU2213732 C2 RU 2213732C2 RU 99112135/04 A RU99112135/04 A RU 99112135/04A RU 99112135 A RU99112135 A RU 99112135A RU 2213732 C2 RU2213732 C2 RU 2213732C2
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- Prior art keywords
- compounds
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- formula
- alkyl
- heterocyclic ring
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- 125000000623 heterocyclic group Chemical group 0.000 title claims abstract 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 125000002950 monocyclic group Chemical group 0.000 claims abstract 6
- 125000005843 halogen group Chemical group 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims abstract 2
- 125000004429 atom Chemical group 0.000 claims abstract 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims abstract 2
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 5
- 125000004043 oxo group Chemical group O=* 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 108010074860 Factor Xa Proteins 0.000 claims 1
- CCNMQUSWXAEDAK-UHFFFAOYSA-N [4-(6-bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-(4-pyridazin-4-ylphenyl)methanone Chemical compound C1=CC2=CC(Br)=CC=C2C=C1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1C1=CC=NN=C1 CCNMQUSWXAEDAK-UHFFFAOYSA-N 0.000 claims 1
- SGUBDMZIXCTGGS-UHFFFAOYSA-N [4-(6-bromonaphthalen-2-yl)sulfonylpiperazin-1-yl]-(4-pyrimidin-4-ylphenyl)methanone Chemical compound C1=CC2=CC(Br)=CC=C2C=C1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1C1=CC=NC=N1 SGUBDMZIXCTGGS-UHFFFAOYSA-N 0.000 claims 1
- PSTBXECIKAJFMC-UHFFFAOYSA-N [4-(6-chloronaphthalen-2-yl)sulfonylpiperazin-1-yl]-(4-pyridin-4-ylphenyl)methanone Chemical compound C1=CC2=CC(Cl)=CC=C2C=C1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1C1=CC=NC=C1 PSTBXECIKAJFMC-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- -1 cyano- Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623283.0A GB9623283D0 (en) | 1996-11-08 | 1996-11-08 | Heterocyclic derivatives |
| GB9623283.0 | 1996-11-08 | ||
| GBGB9715893.5A GB9715893D0 (en) | 1997-07-29 | 1997-07-29 | Heterocyclic derivatives |
| GB9715893.5 | 1997-07-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99112135A RU99112135A (ru) | 2001-04-10 |
| RU2213732C2 true RU2213732C2 (ru) | 2003-10-10 |
Family
ID=26310361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99112135/04A RU2213732C2 (ru) | 1996-11-08 | 1997-11-04 | Гетероциклические производные и фармацевтическая композиция |
| RU2003115094/04A RU2003115094A (ru) | 1996-11-08 | 2003-05-21 | Гетероциклические производные |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003115094/04A RU2003115094A (ru) | 1996-11-08 | 2003-05-21 | Гетероциклические производные |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6300330B1 (enExample) |
| EP (2) | EP1358909A1 (enExample) |
| JP (1) | JP2001504113A (enExample) |
| KR (1) | KR20000053128A (enExample) |
| CN (1) | CN1220682C (enExample) |
| AT (1) | ATE258167T1 (enExample) |
| AU (1) | AU731929B2 (enExample) |
| BG (1) | BG64258B1 (enExample) |
| BR (1) | BR9712672A (enExample) |
| CA (1) | CA2266890A1 (enExample) |
| CZ (1) | CZ296342B6 (enExample) |
| DE (1) | DE69727308T2 (enExample) |
| DK (1) | DK0937048T3 (enExample) |
| ES (1) | ES2213208T3 (enExample) |
| HU (1) | HUP0001098A3 (enExample) |
| IL (1) | IL129706A (enExample) |
| MY (1) | MY124122A (enExample) |
| NO (1) | NO312894B1 (enExample) |
| NZ (1) | NZ334710A (enExample) |
| PL (1) | PL189703B1 (enExample) |
| PT (1) | PT937048E (enExample) |
| RU (2) | RU2213732C2 (enExample) |
| SK (1) | SK284665B6 (enExample) |
| TR (1) | TR199901006T2 (enExample) |
| TW (1) | TW458968B (enExample) |
| UA (1) | UA56197C2 (enExample) |
| WO (1) | WO1998021188A1 (enExample) |
| YU (1) | YU20999A (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| WO1997028128A1 (en) | 1996-02-02 | 1997-08-07 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
| DK0966462T3 (da) | 1997-02-13 | 2003-09-22 | Astrazeneca Ab | Heterocykliske forbindelser, der er egnede som oxidosqualencyklaseinhibitorer |
| WO1998054164A1 (en) | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
| GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| ATE314347T1 (de) * | 1997-09-30 | 2006-01-15 | Daiichi Seiyaku Co | Sulfonylderivate |
| HUP0101810A3 (en) * | 1998-01-27 | 2002-05-28 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl factor xa inhibitors and pharmaceutical compositions containing them |
| EP1054005A4 (en) | 1998-02-05 | 2003-02-05 | Takeda Chemical Industries Ltd | SULPHONAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION AND THEIR USE |
| GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
| GB9809350D0 (en) * | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Novel salt |
| SI1082321T1 (en) * | 1998-05-02 | 2005-06-30 | Astrazeneca Ab | Heterocyclic derivatives which inhibit factor xa |
| WO2000009480A1 (en) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
| EP1058549A4 (en) | 1998-12-23 | 2003-11-12 | Bristol Myers Squibb Pharma Co | FACTOR Xa OR THROMBIN INHIBITORS |
| GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
| TW200404789A (en) | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
| GB9914342D0 (en) * | 1999-06-19 | 1999-08-18 | Zeneca Ltd | Compound |
| WO2000078747A1 (en) | 1999-06-22 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Acylhydrazine derivatives, process for preparing the same and use thereof |
| GB9917344D0 (en) * | 1999-07-24 | 1999-09-22 | Zeneca Ltd | Novel salt |
| HUP0203375A3 (en) * | 1999-07-28 | 2005-03-29 | Aventis Pharm Prod Inc | Substituted oxoazaheterocyclyl compounds |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| GB0012448D0 (en) * | 2000-05-24 | 2000-07-12 | Astrazeneca Ab | New process |
| WO2002026734A1 (en) * | 2000-09-29 | 2002-04-04 | Cor Therapeutics, Inc. | PIPERAZIN-2-ONE AMIDES AS INHIBITORS OF FACTOR Xa |
| DE60108164T2 (de) | 2000-11-02 | 2006-03-02 | F. Hoffmann-La Roche Ag | Cholesterin senkende Benzo[b]thiophene und Benzo[d]isothiazole |
| EP1383748A2 (en) | 2000-12-22 | 2004-01-28 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as cathepsin inhibitors |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| US7365205B2 (en) * | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| JP2005503416A (ja) | 2001-09-17 | 2005-02-03 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ６−ｏ−カルバメート−１１，１２−ラクト−ケトライド抗菌剤 |
| KR20050044497A (ko) | 2001-11-14 | 2005-05-12 | 아벤티스 파마슈티칼스 인크. | 올리고펩티드 및 카텝신 ｓ 억제제로서 이를 포함하는조성물 |
| RU2004117082A (ru) | 2001-12-05 | 2005-04-10 | Орто-Макнейл Фармасьютикал, Инк. (Us) | Кетолидные 6-0-ацил-производные эритромицина в качестве антибактериальных средств |
| EP1569912B1 (en) | 2002-12-03 | 2015-04-29 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| PL374971A1 (en) * | 2002-08-09 | 2005-11-14 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
| RU2333203C2 (ru) * | 2002-12-25 | 2008-09-10 | Дайити Фармасьютикал Ко., Лтд. | Диаминовые производные |
| WO2005014532A1 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions and methods of use |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| CN101128428A (zh) * | 2005-02-24 | 2008-02-20 | 詹森药业有限公司 | 作为钾离子通道打开剂的新的吡啶衍生物 |
| WO2007008145A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
| JP4987324B2 (ja) * | 2006-03-03 | 2012-07-25 | エヌ・イーケムキャット株式会社 | 炭素−炭素結合の生成方法 |
| GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
| SMT202400527T1 (it) | 2019-07-01 | 2025-01-14 | Tonix Pharma Ltd | Anticorpi anti-cd154 e loro usi |
| CA3207098A1 (en) | 2021-01-06 | 2022-07-14 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
| WO2025248134A1 (en) | 2024-05-31 | 2025-12-04 | Tonix Pharma Limited | Treatment methods comprising administration of modified cd154 antibodies |
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- 1997-04-11 UA UA99063121A patent/UA56197C2/uk unknown
- 1997-11-04 RU RU99112135/04A patent/RU2213732C2/ru not_active IP Right Cessation
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- 1997-11-04 ES ES97911333T patent/ES2213208T3/es not_active Expired - Lifetime
- 1997-11-04 WO PCT/GB1997/003033 patent/WO1998021188A1/en not_active Ceased
- 1997-11-04 PT PT97911333T patent/PT937048E/pt unknown
- 1997-11-04 IL IL12970697A patent/IL129706A/en not_active IP Right Cessation
- 1997-11-04 HU HU0001098A patent/HUP0001098A3/hu unknown
- 1997-11-04 CA CA002266890A patent/CA2266890A1/en not_active Abandoned
- 1997-11-04 SK SK613-99A patent/SK284665B6/sk unknown
- 1997-11-04 EP EP03011815A patent/EP1358909A1/en not_active Withdrawn
- 1997-11-04 DK DK97911333T patent/DK0937048T3/da active
- 1997-11-04 JP JP52227498A patent/JP2001504113A/ja not_active Ceased
- 1997-11-04 CN CNB971994269A patent/CN1220682C/zh not_active Expired - Fee Related
- 1997-11-04 DE DE69727308T patent/DE69727308T2/de not_active Expired - Lifetime
- 1997-11-04 EP EP97911333A patent/EP0937048B1/en not_active Expired - Lifetime
- 1997-11-04 AT AT97911333T patent/ATE258167T1/de not_active IP Right Cessation
- 1997-11-04 YU YU20999A patent/YU20999A/sh unknown
- 1997-11-04 CZ CZ0163499A patent/CZ296342B6/cs not_active IP Right Cessation
- 1997-11-04 AU AU48748/97A patent/AU731929B2/en not_active Ceased
- 1997-11-04 NZ NZ334710A patent/NZ334710A/xx unknown
- 1997-11-04 KR KR1019990704055A patent/KR20000053128A/ko not_active Ceased
- 1997-11-04 US US09/297,768 patent/US6300330B1/en not_active Expired - Fee Related
- 1997-11-04 PL PL97333241A patent/PL189703B1/pl not_active IP Right Cessation
- 1997-11-04 BR BR9712672-1A patent/BR9712672A/pt not_active Application Discontinuation
- 1997-11-05 TW TW086116467A patent/TW458968B/zh not_active IP Right Cessation
- 1997-11-06 MY MYPI97005268A patent/MY124122A/en unknown
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1999
- 1999-05-07 NO NO19992230A patent/NO312894B1/no unknown
- 1999-05-25 BG BG103430A patent/BG64258B1/bg unknown
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2003
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