PT937048E - Derivados heterociclicos que inibem factor xa - Google Patents
Derivados heterociclicos que inibem factor xaInfo
- Publication number
- PT937048E PT937048E PT97911333T PT97911333T PT937048E PT 937048 E PT937048 E PT 937048E PT 97911333 T PT97911333 T PT 97911333T PT 97911333 T PT97911333 T PT 97911333T PT 937048 E PT937048 E PT 937048E
- Authority
- PT
- Portugal
- Prior art keywords
- heterocyclic derivatives
- inhibit factor
- relates
- antithrombotic
- anticoagulant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9623283.0A GB9623283D0 (en) | 1996-11-08 | 1996-11-08 | Heterocyclic derivatives |
GBGB9715893.5A GB9715893D0 (en) | 1997-07-29 | 1997-07-29 | Heterocyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
PT937048E true PT937048E (pt) | 2004-05-31 |
Family
ID=26310361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97911333T PT937048E (pt) | 1996-11-08 | 1997-11-04 | Derivados heterociclicos que inibem factor xa |
Country Status (28)
Country | Link |
---|---|
US (2) | US6300330B1 (pt) |
EP (2) | EP1358909A1 (pt) |
JP (1) | JP2001504113A (pt) |
KR (1) | KR20000053128A (pt) |
CN (1) | CN1220682C (pt) |
AT (1) | ATE258167T1 (pt) |
AU (1) | AU731929B2 (pt) |
BG (1) | BG64258B1 (pt) |
BR (1) | BR9712672A (pt) |
CA (1) | CA2266890A1 (pt) |
CZ (1) | CZ296342B6 (pt) |
DE (1) | DE69727308T2 (pt) |
DK (1) | DK0937048T3 (pt) |
ES (1) | ES2213208T3 (pt) |
HU (1) | HUP0001098A3 (pt) |
IL (1) | IL129706A (pt) |
MY (1) | MY124122A (pt) |
NO (1) | NO312894B1 (pt) |
NZ (1) | NZ334710A (pt) |
PL (1) | PL189703B1 (pt) |
PT (1) | PT937048E (pt) |
RU (2) | RU2213732C2 (pt) |
SK (1) | SK284665B6 (pt) |
TR (1) | TR199901006T2 (pt) |
TW (1) | TW458968B (pt) |
UA (1) | UA56197C2 (pt) |
WO (1) | WO1998021188A1 (pt) |
YU (1) | YU20999A (pt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
DK0966462T3 (da) | 1997-02-13 | 2003-09-22 | Astrazeneca Ab | Heterocykliske forbindelser, der er egnede som oxidosqualencyklaseinhibitorer |
US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
EP0986551B1 (en) | 1997-05-30 | 2006-08-02 | Takeda Pharmaceutical Company Limited | Sulfonamide derivatives, their production and use |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
BR9815377A (pt) * | 1997-09-30 | 2001-01-16 | Daiichi Pharmaceutical Co Ltda | Derivados de sulfonil |
EP1051176B1 (en) | 1998-01-27 | 2006-11-22 | Aventis Pharmaceuticals Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
US6403595B1 (en) | 1998-02-05 | 2002-06-11 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, processes for producing the same and utilization thereof |
GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
EP1082321B1 (en) * | 1998-05-02 | 2004-11-17 | AstraZeneca AB | Heterocyclic derivatives which inhibit factor xa |
GB9809350D0 (en) * | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Novel salt |
WO2000009480A1 (fr) * | 1998-08-11 | 2000-02-24 | Daiichi Pharmaceutical Co., Ltd. | Nouveaux derives sulfonyle |
WO2000039102A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
TW200404789A (en) | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
GB9914342D0 (en) * | 1999-06-19 | 1999-08-18 | Zeneca Ltd | Compound |
DE60027718T2 (de) | 1999-06-22 | 2007-05-16 | Takeda Pharmaceutical Co. Ltd. | Acylhydrazinderivate, verfahren zu ihrer herstellung und ihre verwendung |
GB9917344D0 (en) * | 1999-07-24 | 1999-09-22 | Zeneca Ltd | Novel salt |
EP1208097B1 (en) * | 1999-07-28 | 2009-02-18 | Aventis Pharmaceuticals Inc. | Substituted oxoazaheterocyclyl compounds |
TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
GB0012448D0 (en) * | 2000-05-24 | 2000-07-12 | Astrazeneca Ab | New process |
CA2422873A1 (en) * | 2000-09-29 | 2002-04-04 | Wenhao Li | Piperazin-2-one amides as inhibitors of factor xa |
DE60108164T2 (de) | 2000-11-02 | 2006-03-02 | F. Hoffmann-La Roche Ag | Cholesterin senkende Benzo[b]thiophene und Benzo[d]isothiazole |
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
US7064123B1 (en) | 2000-12-22 | 2006-06-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
CN1589277A (zh) | 2001-09-17 | 2005-03-02 | 奥索-麦克尼尔药品公司 | 6-o-氨基甲酸酯-11,12-内酯-酮内酯抗菌剂 |
US6977256B2 (en) | 2001-11-14 | 2005-12-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin S inhibitors |
US6825170B2 (en) | 2001-12-05 | 2004-11-30 | Ortho-Mcneil Pharmaceutical, Inc. | 6-O-acyl ketolide antibacterials |
CN1703395A (zh) * | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
KR20050110612A (ko) * | 2002-12-25 | 2005-11-23 | 다이이찌 세이야꾸 가부시기가이샤 | 디아민 유도체 |
US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
US7459472B2 (en) * | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
CN101128428A (zh) * | 2005-02-24 | 2008-02-20 | 詹森药业有限公司 | 作为钾离子通道打开剂的新的吡啶衍生物 |
WO2007008145A1 (en) * | 2005-07-08 | 2007-01-18 | Astrazeneca Ab | Heterocyclic sulfonamide derivatives as inhibitors of factor xa |
JP4987324B2 (ja) * | 2006-03-03 | 2012-07-25 | エヌ・イーケムキャット株式会社 | 炭素−炭素結合の生成方法 |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
AU2020300002A1 (en) | 2019-07-01 | 2022-02-24 | Tonix Pharma Limited | Anti-CD154 antibodies and uses thereof |
US20240059781A1 (en) | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
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TW257757B (pt) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
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1997
- 1997-04-11 UA UA99063121A patent/UA56197C2/uk unknown
- 1997-11-04 CA CA002266890A patent/CA2266890A1/en not_active Abandoned
- 1997-11-04 EP EP03011815A patent/EP1358909A1/en not_active Withdrawn
- 1997-11-04 BR BR9712672-1A patent/BR9712672A/pt not_active Application Discontinuation
- 1997-11-04 ES ES97911333T patent/ES2213208T3/es not_active Expired - Lifetime
- 1997-11-04 AT AT97911333T patent/ATE258167T1/de not_active IP Right Cessation
- 1997-11-04 DE DE69727308T patent/DE69727308T2/de not_active Expired - Lifetime
- 1997-11-04 JP JP52227498A patent/JP2001504113A/ja not_active Ceased
- 1997-11-04 PT PT97911333T patent/PT937048E/pt unknown
- 1997-11-04 IL IL12970697A patent/IL129706A/en not_active IP Right Cessation
- 1997-11-04 DK DK97911333T patent/DK0937048T3/da active
- 1997-11-04 HU HU0001098A patent/HUP0001098A3/hu unknown
- 1997-11-04 CZ CZ0163499A patent/CZ296342B6/cs not_active IP Right Cessation
- 1997-11-04 CN CNB971994269A patent/CN1220682C/zh not_active Expired - Fee Related
- 1997-11-04 AU AU48748/97A patent/AU731929B2/en not_active Ceased
- 1997-11-04 WO PCT/GB1997/003033 patent/WO1998021188A1/en active IP Right Grant
- 1997-11-04 TR TR1999/01006T patent/TR199901006T2/xx unknown
- 1997-11-04 RU RU99112135/04A patent/RU2213732C2/ru not_active IP Right Cessation
- 1997-11-04 KR KR1019990704055A patent/KR20000053128A/ko active Search and Examination
- 1997-11-04 NZ NZ334710A patent/NZ334710A/xx unknown
- 1997-11-04 US US09/297,768 patent/US6300330B1/en not_active Expired - Fee Related
- 1997-11-04 YU YU20999A patent/YU20999A/sh unknown
- 1997-11-04 SK SK613-99A patent/SK284665B6/sk unknown
- 1997-11-04 PL PL97333241A patent/PL189703B1/pl not_active IP Right Cessation
- 1997-11-04 EP EP97911333A patent/EP0937048B1/en not_active Expired - Lifetime
- 1997-11-05 TW TW086116467A patent/TW458968B/zh not_active IP Right Cessation
- 1997-11-06 MY MYPI97005268A patent/MY124122A/en unknown
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1999
- 1999-05-07 NO NO19992230A patent/NO312894B1/no unknown
- 1999-05-25 BG BG103430A patent/BG64258B1/bg unknown
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2001
- 2001-09-27 US US09/963,686 patent/US6936610B2/en not_active Expired - Fee Related
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2003
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