RU2159614C2 - Высушенные замораживанием композиции ондансетрона и способ лечения млекопитающих - Google Patents

Высушенные замораживанием композиции ондансетрона и способ лечения млекопитающих Download PDF

Info

Publication number
RU2159614C2
RU2159614C2 RU97110065/14A RU97110065A RU2159614C2 RU 2159614 C2 RU2159614 C2 RU 2159614C2 RU 97110065/14 A RU97110065/14 A RU 97110065/14A RU 97110065 A RU97110065 A RU 97110065A RU 2159614 C2 RU2159614 C2 RU 2159614C2
Authority
RU
Russia
Prior art keywords
vomiting
ondansetron
patients
free base
ondasteron
Prior art date
Application number
RU97110065/14A
Other languages
English (en)
Russian (ru)
Other versions
RU97110065A (ru
Inventor
Айан Кейт Уинтерборн
Original Assignee
Глаксо Вэллкам Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10764757&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2159614(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксо Вэллкам Инк. filed Critical Глаксо Вэллкам Инк.
Publication of RU97110065A publication Critical patent/RU97110065A/ru
Application granted granted Critical
Publication of RU2159614C2 publication Critical patent/RU2159614C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fertilizers (AREA)
RU97110065/14A 1994-11-22 1995-11-20 Высушенные замораживанием композиции ондансетрона и способ лечения млекопитающих RU2159614C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423511A GB9423511D0 (en) 1994-11-22 1994-11-22 Compositions
GB9423511.6 1994-11-22

Publications (2)

Publication Number Publication Date
RU97110065A RU97110065A (ru) 1999-06-10
RU2159614C2 true RU2159614C2 (ru) 2000-11-27

Family

ID=10764757

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97110065/14A RU2159614C2 (ru) 1994-11-22 1995-11-20 Высушенные замораживанием композиции ондансетрона и способ лечения млекопитающих

Country Status (30)

Country Link
US (2) US5955488A (enExample)
EP (1) EP0793495B1 (enExample)
JP (1) JP3001264B2 (enExample)
KR (1) KR970706814A (enExample)
CN (1) CN1080118C (enExample)
AT (1) ATE193444T1 (enExample)
AU (1) AU704160B2 (enExample)
BE (1) BE1010250A3 (enExample)
BR (1) BR9509808A (enExample)
CY (1) CY2166B1 (enExample)
CZ (1) CZ285250B6 (enExample)
DE (1) DE69517332T2 (enExample)
DK (1) DK0793495T3 (enExample)
ES (1) ES2147309T3 (enExample)
FI (1) FI119355B (enExample)
FR (1) FR2727016B1 (enExample)
GB (2) GB9423511D0 (enExample)
GR (1) GR3033937T3 (enExample)
HU (1) HU226891B1 (enExample)
IL (1) IL116084A (enExample)
IT (1) IT1282352B1 (enExample)
MX (1) MX9703735A (enExample)
NO (1) NO306893B1 (enExample)
NZ (1) NZ296982A (enExample)
PL (1) PL181179B1 (enExample)
PT (1) PT793495E (enExample)
RU (1) RU2159614C2 (enExample)
TW (1) TW398976B (enExample)
WO (1) WO1996015785A1 (enExample)
ZA (1) ZA959821B (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976577A (en) * 1997-07-11 1999-11-02 Rp Scherer Corporation Process for preparing fast dispersing solid oral dosage form
US7632517B2 (en) 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
ES2293875T3 (es) * 1997-10-01 2008-04-01 Novadel Pharma Inc. Aerosol bucal no polar.
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
EP1246668B1 (en) * 1999-12-01 2005-11-30 Natco Pharma Limited An rapid acting freeze dired oral pharmaceutical composition for treating migraine
RU2162847C1 (ru) * 2000-07-14 2001-02-10 ООО с иностранными инвестициями "Редди-Биомед лимитед" Способ получения ондансетрона и его фармацевтически приемлемых солей
CN1498216A (zh) * 2000-10-30 2004-05-19 ������ҩ��ҵ���޹�˾ 新的奥丹西隆盐酸盐晶体和溶剂化物及其制备方法
US20020115707A1 (en) * 2001-01-11 2002-08-22 Rami Lidor-Hadas Process for preparing pure ondansetron hydrochloride dihydrate
DE60314400T2 (de) * 2002-04-29 2008-02-07 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Verfahren zur herstellung von 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-on
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
HRP20041136A2 (en) * 2002-04-30 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Novel crystal forms of ondansetron, processes fortheir preparation, pharmaceutical compositions containing the novel forms and methods for treating nausea using them
JP5690461B2 (ja) * 2002-11-15 2015-03-25 ヘルシン ヘルスケア ソシエテ アノニム 化学療法誘導嘔吐を治療するためのパロノセトロン
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
TWI355936B (en) 2003-02-18 2012-01-11 Helsinn Healthcare Sa Uses of palonosetron hydrochloride
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
EP1678139B1 (en) * 2003-10-10 2011-08-31 Synhton B.V. Solid-state montelukast
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
US20050272720A1 (en) * 2004-01-27 2005-12-08 Rolf Keltjens Process for making olanzapine Form I
US20060167072A1 (en) * 2004-01-30 2006-07-27 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
CA2567720A1 (en) * 2004-05-24 2005-12-08 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
US20060068010A1 (en) * 2004-09-30 2006-03-30 Stephen Turner Method for improving the bioavailability of orally delivered therapeutics
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
EP1919923A1 (en) * 2005-08-17 2008-05-14 Synthon B.V. A process for making olanzapine form i
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
CN101432267A (zh) * 2006-03-17 2009-05-13 斯索恩有限公司 孟鲁司特金刚烷胺盐
WO2007134845A2 (en) * 2006-05-18 2007-11-29 Synthon B.V. Olanzapine pharmaceutical composition
TWI343262B (en) * 2006-09-26 2011-06-11 Schering Corp Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
AR063043A1 (es) * 2006-09-29 2008-12-23 Synthon Bv Composicion farmaceutica de olanzapina
EP2124556B1 (en) 2006-10-09 2014-09-03 Charleston Laboratories, Inc. Pharmaceutical compositions
ES2325339T3 (es) * 2006-10-24 2009-09-01 Helsinn Healthcare S.A. Capsulas blandas que comprenden hidrocloruro de palonosetron que tienen una estabilidad y una biodisponibilidad mejoradas.
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
RU2363463C1 (ru) * 2007-11-14 2009-08-10 Федеральное государственное унитарное предприятие Научно-производственный центр "Фармзащита" Федерального медико-биологического агентства Лекарственное средство
US8124126B2 (en) 2008-01-09 2012-02-28 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2009130056A1 (en) * 2008-04-25 2009-10-29 Synthon B.V. Process for making montelukast intermediates
RU2608458C2 (ru) * 2009-05-20 2017-01-18 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Антагонисты серотониновых 5-нт3-рецепторов для применения при лечении вестибулярных нарушений с повреждениями
EP2253316B1 (en) * 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
US10172833B2 (en) 2015-08-11 2019-01-08 Insys Development Company, Inc. Sublingual ondansetron spray
EP3423041A4 (en) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. PHARMACEUTICAL COMPOSITIONS
ES2975016T3 (es) 2016-04-14 2024-07-02 Sensorion (+)-Azasetrón para uso en el tratamiento de trastornos del oído

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0450757A2 (en) * 1990-02-22 1991-10-09 Glaxo Group Limited Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood
RU2002745C1 (ru) * 1989-06-28 1993-11-15 Глэксо Груп Лимитед (Gв) Способ получени кристаллов дигидрата гидрохлорида ондансетрона уменьшенного размера

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0084705B1 (en) * 1981-12-11 1987-01-14 JOHN WYETH & BROTHER LIMITED Process for preparing solid shaped articles
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US5785989A (en) * 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8917556D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5188825A (en) * 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
US5046618A (en) * 1990-11-19 1991-09-10 R. P. Scherer Corporation Child-resistant blister pack

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2002745C1 (ru) * 1989-06-28 1993-11-15 Глэксо Груп Лимитед (Gв) Способ получени кристаллов дигидрата гидрохлорида ондансетрона уменьшенного размера
EP0450757A2 (en) * 1990-02-22 1991-10-09 Glaxo Group Limited Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood

Also Published As

Publication number Publication date
FI972167L (fi) 1997-05-21
FI119355B (fi) 2008-10-31
HU226891B1 (en) 2010-01-28
HK1009591A1 (en) 1999-06-04
PL181179B1 (pl) 2001-06-29
TW398976B (en) 2000-07-21
JP3001264B2 (ja) 2000-01-24
CZ154997A3 (en) 1997-10-15
EP0793495B1 (en) 2000-05-31
US5955488A (en) 1999-09-21
KR970706814A (ko) 1997-12-01
EP0793495A1 (en) 1997-09-10
CZ285250B6 (cs) 1999-06-16
PL320295A1 (en) 1997-09-15
WO1996015785A1 (en) 1996-05-30
GB2295318A (en) 1996-05-29
GB9423511D0 (en) 1995-01-11
DK0793495T3 (da) 2000-10-09
CY2166B1 (en) 2002-08-23
NO972325D0 (no) 1997-05-21
JPH10508864A (ja) 1998-09-02
IT1282352B1 (it) 1998-03-20
AU704160B2 (en) 1999-04-15
FR2727016A1 (fr) 1996-05-24
PT793495E (pt) 2000-10-31
IL116084A (en) 2000-01-31
GB9523667D0 (en) 1996-01-24
US6063802A (en) 2000-05-16
NO306893B1 (no) 2000-01-10
FI972167A0 (fi) 1997-05-21
ES2147309T3 (es) 2000-09-01
NZ296982A (en) 1998-06-26
NO972325L (no) 1997-05-22
CN1080118C (zh) 2002-03-06
IL116084A0 (en) 1996-01-31
BR9509808A (pt) 1997-10-21
HUT77886A (hu) 1998-09-28
GB2295318B (en) 1998-10-28
DE69517332T2 (de) 2000-11-30
AU4173996A (en) 1996-06-17
ZA959821B (en) 1996-07-31
CN1171741A (zh) 1998-01-28
ITRM950762A1 (it) 1997-05-20
MX9703735A (es) 1998-07-31
ITRM950762A0 (enExample) 1995-11-20
DE69517332D1 (de) 2000-07-06
BE1010250A3 (fr) 1998-04-07
FR2727016B1 (fr) 1998-04-03
GR3033937T3 (en) 2000-11-30
ATE193444T1 (de) 2000-06-15

Similar Documents

Publication Publication Date Title
RU2159614C2 (ru) Высушенные замораживанием композиции ондансетрона и способ лечения млекопитающих
RU2145853C1 (ru) Содержащие ондансетрон составы для перорального введения
EP1246668B1 (en) An rapid acting freeze dired oral pharmaceutical composition for treating migraine
US5593685A (en) Ranitidine compositions
EP0524579B1 (en) Improved oral dosing formulations of dideoxy purine nucleosides
EP0550083B1 (en) Medicaments for treating inflammatory conditions or for analgesia containing a NSAID and ranitidine bismuth citrate
EA001878B1 (ru) Способ лечения бактериальных инфекций у детей
JP2004534050A (ja) 細胞ストレスに関連する疾病及び状態を予防及び治療する方法
JPH0428245B2 (enExample)
JP2001501222A (ja) 液体アレンドロネート製剤
JP2001509791A (ja) 胃腸障害の治療用組成物及び方法
CA2205600C (en) Freeze-dried ondansetron compositions
WO1996008238A1 (en) Use of paracellular absorption enhancers such as glucose for enhaincing the absorption of histamine h2-antagonists
US4812455A (en) Antiinflammatory compositions and methods
JP2900056B2 (ja) 非ステロイド抗炎症剤により生じる胃疾患の予防用医薬組成物
JP4102467B2 (ja) 抗潰瘍剤

Legal Events

Date Code Title Description
PC43 Official registration of the transfer of the exclusive right without contract for inventions

Effective date: 20150529