DE69517332T2 - Gefriergetrocknete ondansetron zubereitungen - Google Patents
Gefriergetrocknete ondansetron zubereitungenInfo
- Publication number
- DE69517332T2 DE69517332T2 DE69517332T DE69517332T DE69517332T2 DE 69517332 T2 DE69517332 T2 DE 69517332T2 DE 69517332 T DE69517332 T DE 69517332T DE 69517332 T DE69517332 T DE 69517332T DE 69517332 T2 DE69517332 T2 DE 69517332T2
- Authority
- DE
- Germany
- Prior art keywords
- ondansetron
- dosage form
- free base
- pharmaceutically acceptable
- freeze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 208000028173 post-traumatic stress disease Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
- 229960000624 procarbazine Drugs 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- LZFIOSVZIQOVFW-UHFFFAOYSA-N propyl 2-hydroxybenzoate Chemical class CCCOC(=O)C1=CC=CC=C1O LZFIOSVZIQOVFW-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 201000001716 specific phobia Diseases 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
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- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 208000027491 vestibular disease Diseases 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9423511A GB9423511D0 (en) | 1994-11-22 | 1994-11-22 | Compositions |
| PCT/EP1995/004550 WO1996015785A1 (en) | 1994-11-22 | 1995-11-20 | Freeze-dried ondansetron compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69517332D1 DE69517332D1 (de) | 2000-07-06 |
| DE69517332T2 true DE69517332T2 (de) | 2000-11-30 |
Family
ID=10764757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69517332T Expired - Lifetime DE69517332T2 (de) | 1994-11-22 | 1995-11-20 | Gefriergetrocknete ondansetron zubereitungen |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US5955488A (enExample) |
| EP (1) | EP0793495B1 (enExample) |
| JP (1) | JP3001264B2 (enExample) |
| KR (1) | KR970706814A (enExample) |
| CN (1) | CN1080118C (enExample) |
| AT (1) | ATE193444T1 (enExample) |
| AU (1) | AU704160B2 (enExample) |
| BE (1) | BE1010250A3 (enExample) |
| BR (1) | BR9509808A (enExample) |
| CY (1) | CY2166B1 (enExample) |
| CZ (1) | CZ285250B6 (enExample) |
| DE (1) | DE69517332T2 (enExample) |
| DK (1) | DK0793495T3 (enExample) |
| ES (1) | ES2147309T3 (enExample) |
| FI (1) | FI119355B (enExample) |
| FR (1) | FR2727016B1 (enExample) |
| GB (2) | GB9423511D0 (enExample) |
| GR (1) | GR3033937T3 (enExample) |
| HU (1) | HU226891B1 (enExample) |
| IL (1) | IL116084A (enExample) |
| IT (1) | IT1282352B1 (enExample) |
| MX (1) | MX9703735A (enExample) |
| NO (1) | NO306893B1 (enExample) |
| NZ (1) | NZ296982A (enExample) |
| PL (1) | PL181179B1 (enExample) |
| PT (1) | PT793495E (enExample) |
| RU (1) | RU2159614C2 (enExample) |
| TW (1) | TW398976B (enExample) |
| WO (1) | WO1996015785A1 (enExample) |
| ZA (1) | ZA959821B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976577A (en) * | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
| CA2306024C (en) * | 1997-10-01 | 2011-04-26 | Flemington Pharmaceutical Corporation | Buccal, polar and non-polar spray or capsule |
| US20040136914A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing ondansetron |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US6630006B2 (en) * | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
| DE60024491T2 (de) * | 1999-12-01 | 2006-08-10 | Natco Pharma Ltd., Banjara Hills | Schnell-wirkende, gefrier-trocknete, orale, pharmazeutische formulierung für die behandlung von migräne |
| RU2162847C1 (ru) * | 2000-07-14 | 2001-02-10 | ООО с иностранными инвестициями "Редди-Биомед лимитед" | Способ получения ондансетрона и его фармацевтически приемлемых солей |
| IL155644A0 (en) * | 2000-10-30 | 2003-11-23 | Teva Pharma | Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation |
| US20020115707A1 (en) * | 2001-01-11 | 2002-08-22 | Rami Lidor-Hadas | Process for preparing pure ondansetron hydrochloride dihydrate |
| CN1665823A (zh) * | 2002-04-29 | 2005-09-07 | 特瓦药厂有限公司 | 制备1,2,3,9－四氢－9－甲基－3－[(2－甲基－1h－咪唑－1－基)甲基]－4h－咔唑－4－酮的方法 |
| MXPA04010845A (es) * | 2002-04-30 | 2005-01-25 | Biogal Gyogyszergyar | Formas cristalinas novedosas de ondansetron, procesos para su preparacion, composiciones farmaceuticas que contienen las formas novedosas y metodos para tratar las nauseas utilizando las mismas. |
| US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
| WO2004045615A1 (en) * | 2002-11-15 | 2004-06-03 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| TWI355936B (en) | 2003-02-18 | 2012-01-11 | Helsinn Healthcare Sa | Uses of palonosetron hydrochloride |
| US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
| JP2007508271A (ja) | 2003-10-10 | 2007-04-05 | シントン・ベスローテン・フェンノートシャップ | 固体状態のモンテルカスト |
| US20050272720A1 (en) * | 2004-01-27 | 2005-12-08 | Rolf Keltjens | Process for making olanzapine Form I |
| AR047459A1 (es) * | 2004-01-27 | 2006-01-18 | Synthon Bv | Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina) |
| US20060167072A1 (en) * | 2004-01-30 | 2006-07-27 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
| US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
| JP2008509226A (ja) * | 2004-05-24 | 2008-03-27 | ジェンボールト コーポレイション | 回収可能な形式での安定なタンパク質保管および安定な核酸保管 |
| US20060068010A1 (en) * | 2004-09-30 | 2006-03-30 | Stephen Turner | Method for improving the bioavailability of orally delivered therapeutics |
| GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
| WO2007020080A1 (en) * | 2005-08-17 | 2007-02-22 | Synthon B.V. | A process for making olanzapine form i |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| WO2007107297A1 (en) * | 2006-03-17 | 2007-09-27 | Synthon B.V. | Montelukast amantadine salt |
| US20070293479A1 (en) * | 2006-05-18 | 2007-12-20 | Osinga Niels J | Olanzapine pharmaceutical composition |
| TWI343262B (en) * | 2006-09-26 | 2011-06-11 | Schering Corp | Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist |
| AR063043A1 (es) * | 2006-09-29 | 2008-12-23 | Synthon Bv | Composicion farmaceutica de olanzapina |
| EP2813144A1 (en) | 2006-10-09 | 2014-12-17 | Charleston Laboratories, Inc. | Analgesic compositions comprising an antihistamine |
| WO2008049552A1 (en) * | 2006-10-24 | 2008-05-02 | Helsinn Healthcare S.A. | Soft capsules comprising palonosetron hydrochloride having improved stability and bioavailability |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| RU2363463C1 (ru) * | 2007-11-14 | 2009-08-10 | Федеральное государственное унитарное предприятие Научно-производственный центр "Фармзащита" Федерального медико-биологического агентства | Лекарственное средство |
| EP3090743A1 (en) | 2008-01-09 | 2016-11-09 | Charleston Laboratories, Inc. | Pharmaceutical compositions for treating headache and eliminating nausea |
| WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
| ES2432618T3 (es) * | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
| JP5955767B2 (ja) * | 2009-05-20 | 2016-07-20 | インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） | 損傷性前庭障害の処置における使用のためのセロトニン５−ｈｔ３受容体拮抗薬 |
| EP2451274B1 (en) | 2009-07-08 | 2017-10-04 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| US10172833B2 (en) | 2015-08-11 | 2019-01-08 | Insys Development Company, Inc. | Sublingual ondansetron spray |
| EP3423041A4 (en) | 2016-03-04 | 2019-09-11 | Charleston Laboratories, Inc. | PHARMACEUTICAL COMPOSITIONS |
| FI3442537T3 (fi) | 2016-04-14 | 2024-04-04 | Sensorion | (+)-Atsasetroni käytettäväksi korvaan liittyvien häiriöiden hoitoon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE24964T1 (de) * | 1981-12-11 | 1987-01-15 | Wyeth John & Brother Ltd | Verfahren zur herstellung von festen formgegenstaenden. |
| US5785989A (en) * | 1985-05-01 | 1998-07-28 | University Utah Research Foundation | Compositions and methods of manufacturing of oral dissolvable medicaments |
| US5288497A (en) * | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| GB8516083D0 (en) * | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
| GB8917556D0 (en) * | 1989-08-01 | 1989-09-13 | Glaxo Group Ltd | Medicaments |
| US5188825A (en) * | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
| EP0450757A3 (en) * | 1990-02-22 | 1993-09-15 | Glaxo Group Limited | Use of 5-hydroxytryptamine-antagonists in the treatment of mental disorders originating in childhood |
| US5046618A (en) * | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
-
1994
- 1994-11-22 GB GB9423511A patent/GB9423511D0/en active Pending
-
1995
- 1995-11-20 AU AU41739/96A patent/AU704160B2/en not_active Expired
- 1995-11-20 KR KR1019970703399A patent/KR970706814A/ko not_active Expired - Lifetime
- 1995-11-20 CN CN95197226A patent/CN1080118C/zh not_active Expired - Lifetime
- 1995-11-20 PL PL95320295A patent/PL181179B1/pl unknown
- 1995-11-20 CZ CZ971549A patent/CZ285250B6/cs not_active IP Right Cessation
- 1995-11-20 FR FR9513723A patent/FR2727016B1/fr not_active Expired - Lifetime
- 1995-11-20 JP JP8516560A patent/JP3001264B2/ja not_active Expired - Lifetime
- 1995-11-20 WO PCT/EP1995/004550 patent/WO1996015785A1/en not_active Ceased
- 1995-11-20 ZA ZA959821A patent/ZA959821B/xx unknown
- 1995-11-20 PT PT95940208T patent/PT793495E/pt unknown
- 1995-11-20 BR BR9509808A patent/BR9509808A/pt active IP Right Grant
- 1995-11-20 ES ES95940208T patent/ES2147309T3/es not_active Expired - Lifetime
- 1995-11-20 IT IT95RM000762A patent/IT1282352B1/it active IP Right Grant
- 1995-11-20 EP EP95940208A patent/EP0793495B1/en not_active Expired - Lifetime
- 1995-11-20 AT AT95940208T patent/ATE193444T1/de active
- 1995-11-20 NZ NZ296982A patent/NZ296982A/en not_active IP Right Cessation
- 1995-11-20 DK DK95940208T patent/DK0793495T3/da active
- 1995-11-20 GB GB9523667A patent/GB2295318B/en not_active Expired - Lifetime
- 1995-11-20 HU HU9702135A patent/HU226891B1/hu unknown
- 1995-11-20 RU RU97110065/14A patent/RU2159614C2/ru active
- 1995-11-20 DE DE69517332T patent/DE69517332T2/de not_active Expired - Lifetime
- 1995-11-21 IL IL11608495A patent/IL116084A/xx not_active IP Right Cessation
- 1995-11-21 BE BE9500955A patent/BE1010250A3/fr active
- 1995-11-30 TW TW084112791A patent/TW398976B/zh not_active IP Right Cessation
-
1997
- 1997-05-21 FI FI972167A patent/FI119355B/fi not_active IP Right Cessation
- 1997-05-21 MX MX9703735A patent/MX9703735A/es unknown
- 1997-05-21 NO NO972325A patent/NO306893B1/no not_active IP Right Cessation
-
1998
- 1998-04-28 US US09/066,762 patent/US5955488A/en not_active Expired - Lifetime
-
1999
- 1999-01-28 US US09/238,165 patent/US6063802A/en not_active Expired - Lifetime
-
2000
- 2000-05-02 CY CY0000011A patent/CY2166B1/xx unknown
- 2000-07-12 GR GR20000401622T patent/GR3033937T3/el unknown
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