RU2136682C1 - Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции - Google Patents

Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции Download PDF

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RU2136682C1
RU2136682C1 RU95118439A RU95118439A RU2136682C1 RU 2136682 C1 RU2136682 C1 RU 2136682C1 RU 95118439 A RU95118439 A RU 95118439A RU 95118439 A RU95118439 A RU 95118439A RU 2136682 C1 RU2136682 C1 RU 2136682C1
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RU
Russia
Prior art keywords
pyridine
formula
compounds
methylbenzylamino
dimethylimidazo
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RU95118439A
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English (en)
Russian (ru)
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RU95118439A (ru
Inventor
Постиус Стефан
Ридель Рихард
Симон Вольфганг-Александер
Сэнн-Бильфингер Йорг
Грундлер Герхард
Райнер Георг
Original Assignee
Бик Гульден Ломберг Хемише Фабрик ГмбХ
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Publication of RU95118439A publication Critical patent/RU95118439A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU95118439A 1993-02-15 1994-02-07 Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции RU2136682C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH453/93-0 1993-02-15
CH45393 1993-02-15
CH1945/93-3 1993-06-29
CH194593 1993-06-29
PCT/EP1994/000335 WO1994018199A1 (de) 1993-02-15 1994-02-07 Imidazopyridine und ihre anwendung zur behandlung von magen-darm krankheiten

Publications (2)

Publication Number Publication Date
RU95118439A RU95118439A (ru) 1997-09-20
RU2136682C1 true RU2136682C1 (ru) 1999-09-10

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RU95118439A RU2136682C1 (ru) 1993-02-15 1994-02-07 Имидазопиридины, способ их получения, фармацевтическая композиция на их основе и способ получения фармацевтической композиции

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US (1) US5665730A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0683780B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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RO (1) RO117917B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2136682C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG55184A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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UA (1) UA43841C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1994018199A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2241710C1 (ru) * 2003-04-24 2004-12-10 Ярославский государственный технический университет Способ получения замещенных пиридо[1,2-а][1,3]бензимидазолов
RU2268888C2 (ru) * 2000-04-20 2006-01-27 Грюненталь Гмбх Соли бициклических n-ацилированных имидазо-3-аминов или имидазо-5-аминов, способ их получения и фармацевтическая композиция на их основе
RU2294935C2 (ru) * 2001-08-22 2007-03-10 Астразенека Аб Имидазопиридиновые производные для применения в терапии в качестве лекарственного средства, ингибирующего протонный насос, и промежуточные соединения для их получения

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US5840732A (en) * 1994-06-20 1998-11-24 Takeda Chemical Industries Ltd. Imidazopyridine or imidazopyrimidine compounds, their production and use
PL180278B1 (pl) * 1994-07-28 2001-01-31 Byk Gulden Lomberg Chem Fab Nowe imidazopirydyno-azolidynony, sposób ich wytwarzania oraz srodek farmaceutyczny PL PL PL PL PL PL PL
AU700737B2 (en) * 1994-07-28 1999-01-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzylimidazopyridines
WO1996005199A1 (de) * 1994-08-12 1996-02-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Imidazopyridinsalz
US6132768A (en) * 1995-07-05 2000-10-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors
JP2949474B2 (ja) * 1995-08-28 1999-09-13 隆久 古田 ペプシノーゲンｉ／ｉｉ比の変化率を基礎としたヘリコバクター・ピロリ除菌判定方法
AU1545297A (en) * 1996-01-26 1997-08-20 Byk Gulden Imidazopyridine halides
EP0882048B1 (de) * 1996-01-26 2005-05-04 ALTANA Pharma AG 3-alkylimidazopyridine
DE19602855A1 (de) * 1996-01-26 1997-07-31 Byk Gulden Lomberg Chem Fab Neue 3-Methylimidazopyridine
WO1998042707A1 (en) * 1997-03-24 1998-10-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydropyrido compounds
JP4138022B2 (ja) * 1997-03-24 2008-08-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング テトラヒドロピリド化合物
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2370231A1 (en) 1999-04-17 2000-10-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Haloalkoxy imidazonaphthyridines
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
SE0003186D0 (sv) * 2000-09-07 2000-09-07 Astrazeneca Ab New process
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
DE10145457A1 (de) 2001-09-14 2003-04-03 Basf Ag Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
WO2004012659A2 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
AR043063A1 (es) * 2002-12-13 2005-07-13 Altana Pharma Ag Bencimidazoles 6-sustituidos y su uso como inhibidores de secreciones gastricas
BRPI0406427B8 (pt) 2003-03-10 2021-05-25 Astrazeneca Ab processo para a preparação de roflumilast
CN1874772A (zh) 2003-11-03 2006-12-06 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物
AR049168A1 (es) * 2004-05-18 2006-07-05 Altana Pharma Ag Derivados de benzimidazol
US8663694B2 (en) * 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast

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EP0033094A1 (en) * 1980-01-23 1981-08-05 Schering Corporation Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
EP0268989A1 (en) * 1986-11-26 1988-06-01 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof
EP0308917A2 (en) * 1987-09-24 1989-03-29 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compound, a process for preparation thereof and pharmaceutical compositions comprising them

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WO1986003720A1 (en) * 1984-12-14 1986-07-03 Moebius Ulrich Ski binding
EP0228006A1 (en) * 1985-12-16 1987-07-08 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof

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EP0033094A1 (en) * 1980-01-23 1981-08-05 Schering Corporation Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
EP0268989A1 (en) * 1986-11-26 1988-06-01 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compounds and processes for preparation thereof
EP0308917A2 (en) * 1987-09-24 1989-03-29 Fujisawa Pharmaceutical Co., Ltd. Imidazopyridine compound, a process for preparation thereof and pharmaceutical compositions comprising them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2268888C2 (ru) * 2000-04-20 2006-01-27 Грюненталь Гмбх Соли бициклических n-ацилированных имидазо-3-аминов или имидазо-5-аминов, способ их получения и фармацевтическая композиция на их основе
RU2294935C2 (ru) * 2001-08-22 2007-03-10 Астразенека Аб Имидазопиридиновые производные для применения в терапии в качестве лекарственного средства, ингибирующего протонный насос, и промежуточные соединения для их получения
RU2241710C1 (ru) * 2003-04-24 2004-12-10 Ярославский государственный технический университет Способ получения замещенных пиридо[1,2-а][1,3]бензимидазолов

Also Published As

Publication number Publication date
JP3447292B2 (ja) 2003-09-16
RO117917B1 (ro) 2002-09-30
WO1994018199A1 (de) 1994-08-18
CA2156078C (en) 2005-02-01
HU219395B (hu) 2001-04-28
CZ287313B6 (en) 2000-10-11
PL175932B1 (pl) 1999-03-31
HUT72436A (en) 1996-04-29
IL108520A (en) 1997-09-30
NZ261579A (en) 1997-03-24
FI953838A0 (fi) 1995-08-14
TW293008B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-12-11
DK0683780T3 (da) 2000-09-25
CZ208895A3 (en) 1995-12-13
CA2156078A1 (en) 1994-08-18
CN1119863A (zh) 1996-04-03
FI953838L (fi) 1995-09-06
JPH08506333A (ja) 1996-07-09
NO953187D0 (no) 1995-08-14
BG99855A (bg) 1996-04-30
PT683780E (pt) 2000-10-31
ES2148317T3 (es) 2000-10-16
GR3033846T3 (en) 2000-10-31
SK99795A3 (en) 1995-12-06
UA43841C2 (uk) 2002-01-15
EP0683780A1 (de) 1995-11-29
FI109537B (fi) 2002-08-30
ATE192151T1 (de) 2000-05-15
KR960701051A (ko) 1996-02-24
BG62773B1 (bg) 2000-07-31
CN1052005C (zh) 2000-05-03
KR100297057B1 (ko) 2001-10-24
DE59409312D1 (de) 2000-05-31
NO953187L (no) 1995-08-14
IL108520A0 (en) 1994-05-30
EP0683780B1 (de) 2000-04-26
PL310171A1 (en) 1995-11-27
AU678434B2 (en) 1997-05-29
US5665730A (en) 1997-09-09
NO304889B1 (no) 1999-03-01
AU6039194A (en) 1994-08-29
MY111201A (en) 1999-09-30
SK280822B6 (sk) 2000-08-14
SG55184A1 (en) 1998-12-21

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Effective date: 20060208