RU2119915C1 - Производные пиридила, их энантиомеры, цис- или транс-изомеры и их соли и фармацевтическая композиция - Google Patents

Производные пиридила, их энантиомеры, цис- или транс-изомеры и их соли и фармацевтическая композиция Download PDF

Info

Publication number
RU2119915C1
RU2119915C1 RU92004567A RU92004567A RU2119915C1 RU 2119915 C1 RU2119915 C1 RU 2119915C1 RU 92004567 A RU92004567 A RU 92004567A RU 92004567 A RU92004567 A RU 92004567A RU 2119915 C1 RU2119915 C1 RU 2119915C1
Authority
RU
Russia
Prior art keywords
group
pyridyl
carbon atoms
phenyl
hex
Prior art date
Application number
RU92004567A
Other languages
English (en)
Russian (ru)
Other versions
RU92004567A (ru
Inventor
Зойка Райнер
Мюллер Томас
Вейзенбергер Иоганнес
Original Assignee
Др. Карл Томэ ГмбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4141377A external-priority patent/DE4141377A1/de
Application filed by Др. Карл Томэ ГмбХ filed Critical Др. Карл Томэ ГмбХ
Publication of RU92004567A publication Critical patent/RU92004567A/ru
Application granted granted Critical
Publication of RU2119915C1 publication Critical patent/RU2119915C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Silicon Polymers (AREA)
  • Electroluminescent Light Sources (AREA)
RU92004567A 1991-12-14 1992-12-14 Производные пиридила, их энантиомеры, цис- или транс-изомеры и их соли и фармацевтическая композиция RU2119915C1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DEP4141377.6 1991-12-14
DE4141377A DE4141377A1 (de) 1991-12-14 1991-12-14 Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4216364A DE4216364A1 (de) 1991-12-14 1992-05-18 Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DEP4216364.1 1992-05-18
DE4216829A DE4216829A1 (de) 1991-12-14 1992-05-21 Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DEP4216829.5 1992-05-21

Publications (2)

Publication Number Publication Date
RU92004567A RU92004567A (ru) 1995-03-27
RU2119915C1 true RU2119915C1 (ru) 1998-10-10

Family

ID=27203214

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004567A RU2119915C1 (ru) 1991-12-14 1992-12-14 Производные пиридила, их энантиомеры, цис- или транс-изомеры и их соли и фармацевтическая композиция

Country Status (18)

Country Link
US (1) US5482948A (fr)
EP (1) EP0547517B1 (fr)
JP (1) JP2965425B2 (fr)
KR (1) KR100227441B1 (fr)
AT (1) ATE122658T1 (fr)
AU (1) AU653455B2 (fr)
CA (1) CA2085201C (fr)
DE (3) DE4216364A1 (fr)
DK (1) DK0547517T3 (fr)
ES (1) ES2074323T3 (fr)
FI (1) FI100882B (fr)
HU (3) HU9203949D0 (fr)
IL (1) IL104066A (fr)
NO (1) NO179173C (fr)
NZ (1) NZ245445A (fr)
PL (3) PL171463B1 (fr)
RU (1) RU2119915C1 (fr)
TW (1) TW293816B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ288002B6 (cs) * 1995-01-11 2001-03-14 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující
JP3032303B2 (ja) * 1996-06-29 2000-04-17 サムジン ファーマシューチカル カンパニー，リミテッド ピペラジン誘導体及びその製造方法
US5955548A (en) * 1997-05-07 1999-09-21 Novo Nordisk A/S Substituted 3, 3-diamino-2-propenenitriles, their preparation and use
CA2289099A1 (fr) * 1997-05-07 1998-11-12 John Bondo Hansen 3,3-diamino-2-propenenitriles, preparation et utilisation de ces derniers
GB0022215D0 (en) * 2000-09-11 2000-10-25 Boehringer Ingelheim Pharma Method for the treatment of thromboembolic disorders in patients with aspirin« resistance
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
EP1450901A4 (fr) * 2001-12-10 2005-05-25 Bristol Myers Squibb Co Composes de (1-phenyl-2-heteroaryl)ethyl-guanidine utiles en tant qu'inhibiteurs de la f1f0 atp hydrolase mitochondriale
DE10209982A1 (de) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
JP2009503020A (ja) 2005-08-03 2009-01-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 肥満症の治療におけるフリバンセリンの使用
WO2008000760A1 (fr) 2006-06-30 2008-01-03 Boehringer Ingelheim International Gmbh Flibansérine dans le traitement de l'incontinence urinaire et des maladies associées
PE20091188A1 (es) 2007-09-12 2009-08-31 Boehringer Ingelheim Int Compuesto 1-[2-(4-(3-trifluorometil-fenil)piperazin-1-il)etil]-2,3-dihidro-1h-benzimidazol-2-ona (flibanserina), sus sales de adicion y composiciones farmaceuticas que los contienen
AU2008350907A1 (en) 2007-12-11 2009-08-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CA2686480A1 (fr) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh Nouveaux sels
WO2014015157A2 (fr) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Nouveaux ligands du récepteur sigma et procédés de modulation de l'homéostase de protéine cellulaire à l'aide de ceux-ci
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3932403A1 (de) * 1989-05-12 1991-04-11 Thomae Gmbh Dr K Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL94805A (en) * 1989-06-28 1994-04-12 Ciba Geigy Ag Certain translocated carboxylic acids (a) Arylsulfonamide - and pyridyl - or imidazolil (), process for their preparation and pharmaceutical preparations containing them
DE4037112A1 (de) * 1990-11-22 1992-05-27 Thomae Gmbh Dr K Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Trombosis and Haemostasis, 1989, т. 61, N 1, с. 43-49. *

Also Published As

Publication number Publication date
EP0547517A1 (fr) 1993-06-23
HUT68032A (en) 1995-05-29
FI100882B (fi) 1998-03-13
TW293816B (fr) 1996-12-21
FI925665A (fi) 1993-06-15
PL296896A1 (en) 1993-11-29
PL171512B1 (pl) 1997-05-30
PL171500B1 (en) 1997-05-30
ATE122658T1 (de) 1995-06-15
JP2965425B2 (ja) 1999-10-18
JPH06199793A (ja) 1994-07-19
FI925665A0 (fi) 1992-12-14
KR100227441B1 (ko) 1999-11-01
CA2085201A1 (fr) 1993-06-15
NO924800L (no) 1993-06-15
DE59202241D1 (de) 1995-06-22
IL104066A0 (en) 1993-05-13
ES2074323T3 (es) 1995-09-01
IL104066A (en) 1996-07-23
HU9203949D0 (en) 1993-03-29
EP0547517B1 (fr) 1995-05-17
DE4216829A1 (de) 1993-11-25
NO179173B (no) 1996-05-13
NZ245445A (en) 1995-06-27
NO924800D0 (no) 1992-12-11
CA2085201C (fr) 2004-07-06
NO179173C (no) 1996-08-21
HU211230A9 (en) 1995-11-28
AU3005892A (en) 1993-06-17
US5482948A (en) 1996-01-09
PL171463B1 (pl) 1997-05-30
AU653455B2 (en) 1994-09-29
DK0547517T3 (da) 1995-09-04
DE4216364A1 (de) 1993-11-25

Similar Documents

Publication Publication Date Title
RU2119915C1 (ru) Производные пиридила, их энантиомеры, цис- или транс-изомеры и их соли и фармацевтическая композиция
US5358948A (en) Benzanilide derivatives
JP2568361B2 (ja) Ｈｉｖ逆転写酵素の阻害剤
RU2114620C1 (ru) Ингибитор атеросклеротического утолщения внутренней оболочки сосудов
GB2276162A (en) Aniline and benazilide derivatives
US5286736A (en) Pyridyl compounds and pharmaceutical compositions containing these compounds
IL227662A (en) 5– (Phenyl / Pyridinyl – Ethinyl) –2 – Pyridine / 2 – Primidine – Carboxamides as 5mglur modulators
JPH1180131A (ja) エチニルピリミジン誘導体
CS235306B2 (en) Method of new aminocompounds production
GB2276163A (en) Pyridine compounds.
US4495357A (en) Pyridyl-substituted-benzofurans
JPH04243856A (ja) 置換されたフエニルアセチレン、これを含有する薬剤、この化合物及び薬剤を製造する方法
NZ240677A (en) Pyridine derivatives and pharmaceutical compositions
JPH02275878A (ja) ピラゾロピリジン系メバロノラクトン類
US4767865A (en) 3'-pyridinylalkylinden- and 3'-pyridinylalkylindol-2-carboxylic acids and analogs
JPH02196767A (ja) ヒドロキサム酸誘導体
JPS6168488A (ja) 新規なピリジルエチル‐ジヒドロピリジン類
US4882433A (en) 3'-pyridinylalkylinden- and 3'-pyridinylalkylindol-2-carboxylic acids and analogs
US5019597A (en) Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides
US5198435A (en) Azabicycloalkyl and azatricycloalkyl amides
NO313280B1 (no) Butadien- og pyrrolidinderivater og fremgangsmåter for fremstilling derav
DE4141377A1 (de) Neue pyridylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JP2001187777A (ja) スクシンアミド酸誘導体
ZA200403402B (en) Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible NO-synthase.

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20111215