RU2104039C1 - Заменитель живой кожи, способ его получения и способ обработки повреждений живой кожи - Google Patents

Заменитель живой кожи, способ его получения и способ обработки повреждений живой кожи Download PDF

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RU2104039C1
RU2104039C1 RU94046192A RU94046192A RU2104039C1 RU 2104039 C1 RU2104039 C1 RU 2104039C1 RU 94046192 A RU94046192 A RU 94046192A RU 94046192 A RU94046192 A RU 94046192A RU 2104039 C1 RU2104039 C1 RU 2104039C1
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Prior art keywords
microspheres
cells
skin
substitute
suspension
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RU94046192A
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Russian (ru)
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RU94046192A (ru
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Дэвид Армстронг
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Нэшнл Ресеч Консил оф Канада
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11Encapsulated compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985Skin or skin outgrowth, e.g. hair, nails
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698Skin equivalents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/412Microsized, i.e. having sizes between 0.1 and 100 microns
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/09Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323Adult fibroblasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00Microcarriers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
    • C12N2533/40Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU94046192A 1992-05-18 1993-04-23 Заменитель живой кожи, способ его получения и способ обработки повреждений живой кожи RU2104039C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9210574.1 1992-05-18
GB929210574A GB9210574D0 (en) 1992-05-18 1992-05-18 Biotherapeutic cell-coated microspheres for wound/burn and prothesis implant applications
PCT/CA1993/000187 WO1993023088A1 (en) 1992-05-18 1993-04-23 Biotherapeutic cell-coated microspheres

Publications (2)

Publication Number Publication Date
RU94046192A RU94046192A (ru) 1996-10-10
RU2104039C1 true RU2104039C1 (ru) 1998-02-10

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RU94046192A RU2104039C1 (ru) 1992-05-18 1993-04-23 Заменитель живой кожи, способ его получения и способ обработки повреждений живой кожи

Country Status (16)

Country Link
US (1) US5830507A (enExample)
EP (1) EP0641223B1 (enExample)
JP (1) JP2820796B2 (enExample)
KR (1) KR950701533A (enExample)
AT (1) ATE203916T1 (enExample)
BR (1) BR9306375A (enExample)
CA (1) CA2135999C (enExample)
DE (1) DE69330562T2 (enExample)
DK (1) DK0641223T3 (enExample)
ES (1) ES2161229T3 (enExample)
GB (1) GB9210574D0 (enExample)
GR (1) GR3036741T3 (enExample)
NZ (1) NZ252661A (enExample)
PT (1) PT641223E (enExample)
RU (1) RU2104039C1 (enExample)
WO (1) WO1993023088A1 (enExample)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2184492C2 (ru) * 2000-06-13 2002-07-10 Озерская Ольга Сергеевна Способ дерматохирургического лечения гипотрофических рубцов
RU2184491C2 (ru) * 2000-03-10 2002-07-10 Озерская Ольга Сергеевна Способ устранения косметических дефектов кожного покрова
RU2195889C2 (ru) * 1999-05-24 2003-01-10 Парамонов Борис Алексеевич Способ дермабразии
RU2202362C2 (ru) * 1998-03-07 2003-04-20 Даевунг Фармасьютикал Ко., Лтд. Композиция для местного применения, содержащая фактор роста эпидермиса человека
RU2210389C1 (ru) * 2002-09-10 2003-08-20 Общество с ограниченной ответственностью "Мединтер Плюс" Спасательное покрывало
RU2223790C2 (ru) * 2001-10-25 2004-02-20 ГФУН "Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена" Способ стерилизации биологических трансплантатов окисью этилена в жидкой среде
RU2240809C1 (ru) * 2003-08-26 2004-11-27 Государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Способ получения бесклеточного дермального матрикса
RU2244005C2 (ru) * 1998-04-17 2005-01-10 Сосьете Де Продюи Нестле С.А. Клеточная линия иммортализованных кератиноцитов человека (варианты) и способ иммортализации клеток кожи человека
RU2316290C2 (ru) * 2005-11-21 2008-02-10 Институт биохимии им. А.Н. Баха РАН Сетчатый эндопротез для восстановительной хирургии
EA014044B1 (ru) * 2008-07-09 2010-08-30 Общество С Ограниченной Ответственностью "Аква-Альянс" Наносомальная лекарственная форма препарата пролонгированного действия для лечения гепатита с (варианты)
RU2404799C2 (ru) * 2003-07-15 2010-11-27 Бар-Илан Юнивесити Способы и фармакологические композиции для заживления ран
US8093211B2 (en) 2000-07-31 2012-01-10 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US8349793B2 (en) 2010-01-11 2013-01-08 Heal0r, Ltd. Method for treatment of inflammatory disease and disorder
US8367606B2 (en) 2005-08-29 2013-02-05 Healor Ltd. Method and compositions for prevention and treatment of diabetic and aged skin
US8507431B2 (en) 2003-08-07 2013-08-13 Healor Ltd. Methods for accelerating wound healing by administration of a preadipocyte modulator or an adipocyte modulator
US9155702B2 (en) 2007-03-27 2015-10-13 Peptron Co., Ltd Composition and microsphere for controlled-release of exendin, and method preparing the same
RU2616866C1 (ru) * 2015-12-31 2017-04-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Биорезорбируемый микроноситель для доставки клеток в область заживления и регенерации ран
RU2644633C1 (ru) * 2016-12-28 2018-02-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ восстановления кожного покрова
RU2658707C1 (ru) * 2016-12-28 2018-06-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ восстановления кожного покрова
RU2725890C2 (ru) * 2009-12-04 2020-07-07 Магле Аб Микросферы гидролизованного крахмала с эндогенными заряженными лигандами

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
IL115728A0 (en) * 1994-10-25 1996-01-19 Boehringer Mannheim Gmbh Biomaterial containing epithelial cells and use thereof as a transplant
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US20020037566A1 (en) * 1997-04-16 2002-03-28 Rees Riley S. Cell-coated supports
US5972332A (en) 1997-04-16 1999-10-26 The Regents Of The University Of Michigan Wound treatment with keratinocytes on a solid support enclosed in a porous material
US5861149A (en) * 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
WO1999021963A1 (en) * 1997-10-25 1999-05-06 Roche Diagnostics Gmbh Autodegradable microcarriers and their use
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
CN1379681A (zh) * 1998-04-17 2002-11-13 安乔格尼克斯公司 治疗性的血管生成因子及其使用方法
EP1041970B1 (en) * 1998-10-23 2013-07-03 Polyheal Ltd. Compositions of microspheres for wound healing
DE19937102A1 (de) * 1999-08-06 2001-02-15 Universitaetsklinikum Freiburg Gewebeersatz und Verfahren zu seiner Herstellung
US7056503B2 (en) * 1999-08-19 2006-06-06 Regents Of The University Of Michigan Enclosures housing cell-coated supports for treating tumors
DE19949290A1 (de) * 1999-10-12 2001-04-26 Albrecht Bettermann Partikuläres Konstrukt zur Verwendung in der Transplantationsmedizin
KR20010110945A (ko) 2000-06-09 2001-12-15 김정용 음경 확대 방법
US6719970B1 (en) * 2000-07-10 2004-04-13 Alkermes Controlled Therapeutics, Inc. Method of generating cartilage
US20100129332A1 (en) * 2000-07-31 2010-05-27 Tamar Tennenbaum Methods and pharmaceutical compositions for healing wounds
US20030148924A1 (en) * 2002-07-09 2003-08-07 Tamar Tennenbaum Methods and pharmaceutical compositions of healing wounds
US20060258562A1 (en) * 2000-07-31 2006-11-16 Healor Ltd. Methods and pharmaceutical compositions for healing wounds
JP2002281964A (ja) * 2000-12-26 2002-10-02 Sanyo Chem Ind Ltd 細胞生産方法
AUPR289601A0 (en) * 2001-02-05 2001-03-01 Commonwealth Scientific And Industrial Research Organisation Method of tissue repair
US20050129776A1 (en) * 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
US7402323B2 (en) * 2002-08-21 2008-07-22 Akpharma, Inc. Compositions and methods for treating skin conditions
WO2004103333A1 (de) * 2003-05-24 2004-12-02 Juvena (International) Ag Gewebekulturmedien als bestandteil von kosmetika
WO2005001073A1 (de) * 2003-06-23 2005-01-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur differenzierung von stammzellen in zellen, die ein pankreatisches hormon produzieren
AU2003289475A1 (en) * 2003-10-20 2005-05-05 Jms Co., Ltd. Cell handling device, human tissue regeneration composition, and human tissue regeneration method
WO2008073614A2 (en) * 2006-11-02 2008-06-19 Akpharma Inc. Composition and method for enhancing skin cell growth, proliferation and repair
WO2008154141A2 (en) * 2007-05-22 2008-12-18 Prelief Inc. Compositions and methods for preventing, minimizing and healing skin irritation and trauma
NZ582556A (en) * 2007-07-30 2013-02-22 Healor Ltd Pharmaceutical composition for treating wounds and related methods
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
WO2009086535A2 (en) * 2007-12-27 2009-07-09 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
CA2721507C (en) 2008-04-18 2017-10-03 Collplant Ltd. Methods of generating and using procollagen
WO2009150883A1 (ja) 2008-06-13 2009-12-17 株式会社資生堂 皮膚代替膜、金型及び皮膚外用剤の評価方法
JP5241764B2 (ja) * 2010-03-31 2013-07-17 テルモ株式会社 生体適合性材料の評価方法
CN110960513A (zh) * 2019-11-29 2020-04-07 苏州瑞微生物科技有限公司 一种微球阵列及其制备方法和用途
CN113201481B (zh) * 2021-04-19 2023-10-13 清华大学深圳国际研究生院 皮肤微球及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461002A1 (fr) * 1979-07-13 1981-01-30 Inst Nat Sante Rech Med Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
EP0215274B1 (en) * 1985-08-14 1993-03-31 Memorial Hospital for Cancer and Allied Diseases Epidermal cell extracts and method to enhance wound healing and regenerate epidermis
FR2597499A1 (fr) * 1986-04-18 1987-10-23 Merieux Inst Procede de culture microbiologique sur supports de collagene, supports pour ce procede et produits obtenus
NZ235556A (en) * 1986-11-05 1991-06-25 Ethicon Inc Breast milk substitute containing recombinant human egf
US5015584A (en) * 1987-10-14 1991-05-14 Board Of Regents, The University Of Texas System Epidermal graft system
GB8803697D0 (en) * 1988-02-17 1988-03-16 Deltanine Research Ltd Clinical developments using amniotic membrane cells
CA1307225C (en) * 1988-07-19 1992-09-08 David W. Armstrong Cell culture bioreactor
US5135915A (en) * 1988-10-14 1992-08-04 Genentech, Inc. Method for the treatment of grafts prior to transplantation using TGF-.beta.
CA2031532C (en) * 1989-04-25 2003-02-25 Joseph P. Vacanti Method for implanting large volumes of cells on polymeric matrices
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2202362C2 (ru) * 1998-03-07 2003-04-20 Даевунг Фармасьютикал Ко., Лтд. Композиция для местного применения, содержащая фактор роста эпидермиса человека
RU2244005C2 (ru) * 1998-04-17 2005-01-10 Сосьете Де Продюи Нестле С.А. Клеточная линия иммортализованных кератиноцитов человека (варианты) и способ иммортализации клеток кожи человека
RU2195889C2 (ru) * 1999-05-24 2003-01-10 Парамонов Борис Алексеевич Способ дермабразии
RU2184491C2 (ru) * 2000-03-10 2002-07-10 Озерская Ольга Сергеевна Способ устранения косметических дефектов кожного покрова
RU2184492C2 (ru) * 2000-06-13 2002-07-10 Озерская Ольга Сергеевна Способ дерматохирургического лечения гипотрофических рубцов
US8093211B2 (en) 2000-07-31 2012-01-10 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
RU2223790C2 (ru) * 2001-10-25 2004-02-20 ГФУН "Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена" Способ стерилизации биологических трансплантатов окисью этилена в жидкой среде
RU2210389C1 (ru) * 2002-09-10 2003-08-20 Общество с ограниченной ответственностью "Мединтер Плюс" Спасательное покрывало
RU2404799C2 (ru) * 2003-07-15 2010-11-27 Бар-Илан Юнивесити Способы и фармакологические композиции для заживления ран
US8507431B2 (en) 2003-08-07 2013-08-13 Healor Ltd. Methods for accelerating wound healing by administration of a preadipocyte modulator or an adipocyte modulator
RU2240809C1 (ru) * 2003-08-26 2004-11-27 Государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Способ получения бесклеточного дермального матрикса
US8367606B2 (en) 2005-08-29 2013-02-05 Healor Ltd. Method and compositions for prevention and treatment of diabetic and aged skin
RU2316290C2 (ru) * 2005-11-21 2008-02-10 Институт биохимии им. А.Н. Баха РАН Сетчатый эндопротез для восстановительной хирургии
US9155702B2 (en) 2007-03-27 2015-10-13 Peptron Co., Ltd Composition and microsphere for controlled-release of exendin, and method preparing the same
EA014044B1 (ru) * 2008-07-09 2010-08-30 Общество С Ограниченной Ответственностью "Аква-Альянс" Наносомальная лекарственная форма препарата пролонгированного действия для лечения гепатита с (варианты)
RU2725890C2 (ru) * 2009-12-04 2020-07-07 Магле Аб Микросферы гидролизованного крахмала с эндогенными заряженными лигандами
US8349793B2 (en) 2010-01-11 2013-01-08 Heal0r, Ltd. Method for treatment of inflammatory disease and disorder
RU2616866C1 (ru) * 2015-12-31 2017-04-18 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Биорезорбируемый микроноситель для доставки клеток в область заживления и регенерации ран
RU2644633C1 (ru) * 2016-12-28 2018-02-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ восстановления кожного покрова
RU2658707C1 (ru) * 2016-12-28 2018-06-22 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ восстановления кожного покрова

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KR950701533A (ko) 1995-04-28
EP0641223B1 (en) 2001-08-08
WO1993023088A1 (en) 1993-11-25
PT641223E (pt) 2001-12-28
AU4257993A (en) 1993-12-13
AU668959B2 (en) 1996-05-23
ATE203916T1 (de) 2001-08-15
RU94046192A (ru) 1996-10-10
ES2161229T3 (es) 2001-12-01
CA2135999C (en) 1999-07-13
DK0641223T3 (da) 2001-10-01
BR9306375A (pt) 1997-03-04
CA2135999A1 (en) 1993-11-25
JPH07507063A (ja) 1995-08-03
US5830507A (en) 1998-11-03
EP0641223A1 (en) 1995-03-08
KR100381207B1 (enExample) 2003-10-23
NZ252661A (en) 1996-09-25
GB9210574D0 (en) 1992-07-01
JP2820796B2 (ja) 1998-11-05
DE69330562D1 (de) 2001-09-13
GR3036741T3 (en) 2001-12-31
DE69330562T2 (de) 2002-05-29

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